Compounds > pulsatilla saponin d
Page last updated: 2024-11-12

pulsatilla saponin d

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators
FloraRankFlora DefinitionFamilyFamily Definition
PulsatillagenusA plant genus of the family RANUNCULACEAE. Members contain cernuosides and other oleanane and hederagenin saponins.[MeSH]RanunculaceaeThe buttercup plant family of the order RANUNCULALES, class MAGNOLIOPSIDA. The leaves are usually alternate and stalkless. The flowers usually have two to five free sepals and may be radially symmetrical or irregular.[MeSH]

Cross-References

ID SourceID
PubMed CID11650910
CHEMBL ID479310
CHEBI ID66790
SCHEMBL ID4931339
MeSH IDM000610206

Synonyms (17)

Synonym
chebi:66790 ,
CHEMBL479310
pulsatilla saponin d ,
S9308
HY-N0834
SCHEMBL4931339
68027-15-6
AKOS030526876
pulsatilla saponin d?sb365?
mfcd28124361
Q27135421
(4as,6ar,6as,6br,8ar,9r,10s,12ar,14bs)-9-(hydroxymethyl)-10-[(2s,3r,4s,5s)-4-hydroxy-5-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3-[(2s,3r,4r,5r,6s)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-2,2,6a,6b,9,12a-hexamethyl-1,3
CCG-270569
hederagenin 3-o-alpha-l-rhamnopyranosyl(1-->2)-(beta-d-glucopyranosyl(1-->4))-alpha-l-arabinopyranoside
MS-31703
pulsatillasaponin d
DTXSID901315269

Research Excerpts

Bioavailability

ExcerptReferenceRelevance
" The method was successfully applied to assess the pharmacokinetics and oral bioavailability of Pulsatilla saponin D in rats."( A rapid and sensitive LC-MS/MS method for the determination of Pulsatilla saponin D in rat plasma and its application in a rat pharmacokinetic and bioavailability study.
Feng, Y; Guo, Y; He, M; Huang, X; Jiang, H; Ouyang, H; Yang, S; Zhang, J; Zhou, X, 2015)		0.87
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
metaboliteAny intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (1)

ClassDescription
triterpenoidAny terpenoid derived from a triterpene. The term includes compounds in which the C30 skeleton of the parent triterpene has been rearranged or modified by the removal of one or more skeletal atoms (generally methyl groups).
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (47)

Assay IDTitleYearJournalArticle
AID1763663Induction of apoptosis in human L02 cells assessed as late apoptotic cells at 18 uM by annexin-V-FITC/PI staining based flow cytometry analysis (Rvb = 0.92 %)2021Bioorganic & medicinal chemistry letters, 07-01, Volume: 43Pulchinenosides: Correlation of surface activity-cytotoxicity and hepatocyte apoptosis mechanism study.
AID1493999Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay2018Journal of natural products, 03-23, Volume: 81, Issue:3
Cytotoxicity, Hemolytic Toxicity, and Mechanism of Action of Pulsatilla Saponin D and Its Synthetic Derivatives.
AID1763655Cytotoxicity against human L02 cells by MTT assay2021Bioorganic & medicinal chemistry letters, 07-01, Volume: 43Pulchinenosides: Correlation of surface activity-cytotoxicity and hepatocyte apoptosis mechanism study.
AID1763681Induction of cell cycle arrest in human L02 cells assessed as S phase accumulation at 24 uM by PI staining based flow cytometry analysis (Rvb = 38.23 %)2021Bioorganic & medicinal chemistry letters, 07-01, Volume: 43Pulchinenosides: Correlation of surface activity-cytotoxicity and hepatocyte apoptosis mechanism study.
AID381214Cytotoxicity against human HL-60 cells after 72 hrs by MTT assay1999Journal of natural products, Sep, Volume: 62, Issue:9
Triterpene saponins and lignans from the roots of Pulsatilla chinensis and their cytotoxic activity against HL-60 cells.
AID1763685Induction of cell cycle arrest in human L02 cells assessed as G2/M phase accumulation at 26 uM by PI staining based flow cytometry analysis (Rvb = 8 %)2021Bioorganic & medicinal chemistry letters, 07-01, Volume: 43Pulchinenosides: Correlation of surface activity-cytotoxicity and hepatocyte apoptosis mechanism study.
AID1763664Induction of apoptosis in human L02 cells assessed as early apoptotic cells at 24 uM by annexin-V-FITC/PI staining based flow cytometry analysis (Rvb = 3.81 %)2021Bioorganic & medicinal chemistry letters, 07-01, Volume: 43Pulchinenosides: Correlation of surface activity-cytotoxicity and hepatocyte apoptosis mechanism study.
AID1207065Cytotoxicity against human HL7702 cells assessed as inhibition of cell growth after 24 hrs by MTT assay2015Bioorganic & medicinal chemistry letters, Jun-15, Volume: 25, Issue:12
Synthesis, cytotoxicity and haemolytic activity of Pulsatilla saponin A, D derivatives.
AID1207066Hemolytic activity in rabbit RBC assessed as induction of hemolysis2015Bioorganic & medicinal chemistry letters, Jun-15, Volume: 25, Issue:12
Synthesis, cytotoxicity and haemolytic activity of Pulsatilla saponin A, D derivatives.
AID1493997Cytotoxicity against human KBVIN cells after 48 hrs by MTT assay2018Journal of natural products, 03-23, Volume: 81, Issue:3
Cytotoxicity, Hemolytic Toxicity, and Mechanism of Action of Pulsatilla Saponin D and Its Synthetic Derivatives.
AID354742Antifungal activity against Cryptococcus neoformans ATCC 36556 after 48 hrs by microplate broth assay1996Journal of natural products, Apr, Volume: 59, Issue:4
Antifungal and molluscicidal saponins from Serjania salzmanniana.
AID1763687Oil-water partition coefficient, logP of compound2021Bioorganic & medicinal chemistry letters, 07-01, Volume: 43Pulchinenosides: Correlation of surface activity-cytotoxicity and hepatocyte apoptosis mechanism study.
AID393220Cytotoxicity against human DLD1 cells after 48 hrs by resazurin reduction test2009Bioorganic & medicinal chemistry, Mar-01, Volume: 17, Issue:5
Haemolytic activity, cytotoxicity and membrane cell permeabilization of semi-synthetic and natural lupane- and oleanane-type saponins.
AID1493991Cytotoxicity against human A549 cells after 48 hrs by MTT assay2018Journal of natural products, 03-23, Volume: 81, Issue:3
Cytotoxicity, Hemolytic Toxicity, and Mechanism of Action of Pulsatilla Saponin D and Its Synthetic Derivatives.
AID1763654Hemolytic activity in rabbit erythrocytes2021Bioorganic & medicinal chemistry letters, 07-01, Volume: 43Pulchinenosides: Correlation of surface activity-cytotoxicity and hepatocyte apoptosis mechanism study.
AID393219Cytotoxicity against human A549 cells after 48 hrs by resazurin reduction test2009Bioorganic & medicinal chemistry, Mar-01, Volume: 17, Issue:5
Haemolytic activity, cytotoxicity and membrane cell permeabilization of semi-synthetic and natural lupane- and oleanane-type saponins.
AID354740Molluscicidal activity against Biomphalaria alexandrina assessed as number of dead snail at 10 ppm after 48 hrs1996Journal of natural products, Apr, Volume: 59, Issue:4
Antifungal and molluscicidal saponins from Serjania salzmanniana.
AID1207062Cytotoxicity against human A549 cells assessed as inhibition of cell growth after 24 hrs by MTT assay2015Bioorganic & medicinal chemistry letters, Jun-15, Volume: 25, Issue:12
Synthesis, cytotoxicity and haemolytic activity of Pulsatilla saponin A, D derivatives.
AID1763665Induction of apoptosis in human L02 cells assessed as late apoptotic cells at 24 uM by annexin-V-FITC/PI staining based flow cytometry analysis (Rvb = 0.92 %)2021Bioorganic & medicinal chemistry letters, 07-01, Volume: 43Pulchinenosides: Correlation of surface activity-cytotoxicity and hepatocyte apoptosis mechanism study.
AID1763678Induction of cell cycle arrest in human L02 cells assessed as S phase accumulation at 18 uM by PI staining based flow cytometry analysis (Rvb = 38.23 %)2021Bioorganic & medicinal chemistry letters, 07-01, Volume: 43Pulchinenosides: Correlation of surface activity-cytotoxicity and hepatocyte apoptosis mechanism study.
AID354737Molluscicidal activity against Biomphalaria alexandrina assessed as number of dead snail at 20 ppm after 24 hrs allowed to recover for an additional 24 hrs1996Journal of natural products, Apr, Volume: 59, Issue:4
Antifungal and molluscicidal saponins from Serjania salzmanniana.
AID1494001Hemolytic activity against New Zealand rabbit erythrocytes measured after 60 mins2018Journal of natural products, 03-23, Volume: 81, Issue:3
Cytotoxicity, Hemolytic Toxicity, and Mechanism of Action of Pulsatilla Saponin D and Its Synthetic Derivatives.
AID1763679Induction of cell cycle arrest in human L02 cells assessed as G2/M phase accumulation at 18 uM by PI staining based flow cytometry analysis (Rvb = 8 %)2021Bioorganic & medicinal chemistry letters, 07-01, Volume: 43Pulchinenosides: Correlation of surface activity-cytotoxicity and hepatocyte apoptosis mechanism study.
AID1763683Induction of cell cycle arrest in human L02 cells assessed as G0/G1 phase accumulation at 26 uM by PI staining based flow cytometry analysis (Rvb = 53.77 %)2021Bioorganic & medicinal chemistry letters, 07-01, Volume: 43Pulchinenosides: Correlation of surface activity-cytotoxicity and hepatocyte apoptosis mechanism study.
AID1763667Induction of apoptosis in human L02 cells assessed as late apoptotic cells at 26 uM by annexin-V-FITC/PI staining based flow cytometry analysis (Rvb = 0.92 %)2021Bioorganic & medicinal chemistry letters, 07-01, Volume: 43Pulchinenosides: Correlation of surface activity-cytotoxicity and hepatocyte apoptosis mechanism study.
AID1763666Induction of apoptosis in human L02 cells assessed as early apoptotic cells at 26 uM by annexin-V-FITC/PI staining based flow cytometry analysis (Rvb = 3.81 %)2021Bioorganic & medicinal chemistry letters, 07-01, Volume: 43Pulchinenosides: Correlation of surface activity-cytotoxicity and hepatocyte apoptosis mechanism study.
AID393218Toxicity in sheep erythrocytes assessed as induction of hemolysis2009Bioorganic & medicinal chemistry, Mar-01, Volume: 17, Issue:5
Haemolytic activity, cytotoxicity and membrane cell permeabilization of semi-synthetic and natural lupane- and oleanane-type saponins.
AID1763686Cytotoxicity against human L02 cells assessed as increase in LDH leakage by LDH assay2021Bioorganic & medicinal chemistry letters, 07-01, Volume: 43Pulchinenosides: Correlation of surface activity-cytotoxicity and hepatocyte apoptosis mechanism study.
AID1763662Induction of apoptosis in human L02 cells assessed as early apoptotic cells at 18 uM by annexin-V-FITC/PI staining based flow cytometry analysis (Rvb = 3.81 %)2021Bioorganic & medicinal chemistry letters, 07-01, Volume: 43Pulchinenosides: Correlation of surface activity-cytotoxicity and hepatocyte apoptosis mechanism study.
AID1207063Cytotoxicity against human Bel7402 cells assessed as inhibition of cell growth after 24 hrs by MTT assay2015Bioorganic & medicinal chemistry letters, Jun-15, Volume: 25, Issue:12
Synthesis, cytotoxicity and haemolytic activity of Pulsatilla saponin A, D derivatives.
AID393221Cytotoxicity against human WS1 cells after 48 hrs by resazurin reduction test2009Bioorganic & medicinal chemistry, Mar-01, Volume: 17, Issue:5
Haemolytic activity, cytotoxicity and membrane cell permeabilization of semi-synthetic and natural lupane- and oleanane-type saponins.
AID1763680Induction of cell cycle arrest in human L02 cells assessed as G0/G1 phase accumulation at 24 uM by PI staining based flow cytometry analysis (Rvb = 53.77 %)2021Bioorganic & medicinal chemistry letters, 07-01, Volume: 43Pulchinenosides: Correlation of surface activity-cytotoxicity and hepatocyte apoptosis mechanism study.
AID1763684Induction of cell cycle arrest in human L02 cells assessed as S phase accumulation at 26 uM by PI staining based flow cytometry analysis (Rvb = 38.23 %)2021Bioorganic & medicinal chemistry letters, 07-01, Volume: 43Pulchinenosides: Correlation of surface activity-cytotoxicity and hepatocyte apoptosis mechanism study.
AID1763677Induction of cell cycle arrest in human L02 cells assessed as G0/G1 phase accumulation at 18 uM by PI staining based flow cytometry analysis (Rvb = 53.77 %)2021Bioorganic & medicinal chemistry letters, 07-01, Volume: 43Pulchinenosides: Correlation of surface activity-cytotoxicity and hepatocyte apoptosis mechanism study.
AID1207064Cytotoxicity against human SMMC7721 cells assessed as inhibition of cell growth after 24 hrs by MTT assay2015Bioorganic & medicinal chemistry letters, Jun-15, Volume: 25, Issue:12
Synthesis, cytotoxicity and haemolytic activity of Pulsatilla saponin A, D derivatives.
AID354741Antifungal activity against Candida albicans ATCC 10259 after 24 hrs by microplate broth assay1996Journal of natural products, Apr, Volume: 59, Issue:4
Antifungal and molluscicidal saponins from Serjania salzmanniana.
AID354743Antifungal activity against Aspergillus fumigatus ATCC 13073 after 48 hrs by microplate broth assay1996Journal of natural products, Apr, Volume: 59, Issue:4
Antifungal and molluscicidal saponins from Serjania salzmanniana.
AID354739Molluscicidal activity against Biomphalaria alexandrina assessed as number of dead snail at 20 ppm after 48 hrs1996Journal of natural products, Apr, Volume: 59, Issue:4
Antifungal and molluscicidal saponins from Serjania salzmanniana.
AID393222Cell membrane permeabilization in human A549 cells assessed as drug level causing decrease in calcein fluorescence2009Bioorganic & medicinal chemistry, Mar-01, Volume: 17, Issue:5
Haemolytic activity, cytotoxicity and membrane cell permeabilization of semi-synthetic and natural lupane- and oleanane-type saponins.
AID1207061Induction of hemolysis in erythrocytes (unknown origin)2015Bioorganic & medicinal chemistry letters, Jun-15, Volume: 25, Issue:12
Synthesis, cytotoxicity and haemolytic activity of Pulsatilla saponin A, D derivatives.
AID393223Cell membrane permeabilization in human DLD1 cells assessed as drug level causing decrease in calcein fluorescence2009Bioorganic & medicinal chemistry, Mar-01, Volume: 17, Issue:5
Haemolytic activity, cytotoxicity and membrane cell permeabilization of semi-synthetic and natural lupane- and oleanane-type saponins.
AID1493993Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay2018Journal of natural products, 03-23, Volume: 81, Issue:3
Cytotoxicity, Hemolytic Toxicity, and Mechanism of Action of Pulsatilla Saponin D and Its Synthetic Derivatives.
AID354735Molluscicidal activity against Biomphalaria alexandrina assessed as number of dead snail at 20 ppm after 24 hrs1996Journal of natural products, Apr, Volume: 59, Issue:4
Antifungal and molluscicidal saponins from Serjania salzmanniana.
AID1493995Cytotoxicity against human KB cells after 48 hrs by MTT assay2018Journal of natural products, 03-23, Volume: 81, Issue:3
Cytotoxicity, Hemolytic Toxicity, and Mechanism of Action of Pulsatilla Saponin D and Its Synthetic Derivatives.
AID1763688Oil-water apparent partition coefficient of the compound2021Bioorganic & medicinal chemistry letters, 07-01, Volume: 43Pulchinenosides: Correlation of surface activity-cytotoxicity and hepatocyte apoptosis mechanism study.
AID1763682Induction of cell cycle arrest in human L02 cells assessed as G2/M phase accumulation at 24 uM by PI staining based flow cytometry analysis (Rvb = 8 %)2021Bioorganic & medicinal chemistry letters, 07-01, Volume: 43Pulchinenosides: Correlation of surface activity-cytotoxicity and hepatocyte apoptosis mechanism study.
AID393224Cell membrane permeabilization in human WS1 cells assessed as drug level causing decrease in calcein fluorescence2009Bioorganic & medicinal chemistry, Mar-01, Volume: 17, Issue:5
Haemolytic activity, cytotoxicity and membrane cell permeabilization of semi-synthetic and natural lupane- and oleanane-type saponins.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (12)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's2 (16.67)18.2507
2000's1 (8.33)29.6817
2010's6 (50.00)24.3611
2020's3 (25.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 18.06

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index18.06 (24.57)
Research Supply Index2.64 (2.92)
Research Growth Index5.52 (4.65)
Search Engine Demand Index10.37 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (18.06)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other13 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
oleanolic acid
[no description available]		2.7330hydroxy monocarboxylic acid;
pentacyclic triterpenoid		plant metabolite
trinitrobenzenesulfonic acid
Trinitrobenzenesulfonic Acid: A reagent that is used to neutralize peptide terminal amino groups.. 2,4,6-trinitrobenzenesulfonic acid : The arenesulfonic acid that is benzenesulfonic acid with three nitro substituents in the 2-, 4- and 6-positions.		2.2510arenesulfonic acid;
C-nitro compound		epitope;
explosive;
reagent
camptothecin
NSC 100880: carboxylate (opened lactone) form of camptothecin; RN refers to (S)-isomer; structure given in first source		7.2510delta-lactone;
pyranoindolizinoquinoline;
quinoline alkaloid;
tertiary alcohol		antineoplastic agent;
EC 5.99.1.2 (DNA topoisomerase) inhibitor;
genotoxin;
plant metabolite
paclitaxel
Taxus: Genus of coniferous yew trees or shrubs, several species of which have medicinal uses. Notable is the Pacific yew, Taxus brevifolia, which is used to make the anti-neoplastic drug taxol (PACLITAXEL).		2.1710taxane diterpenoid;
tetracyclic diterpenoid		antineoplastic agent;
human metabolite;
metabolite;
microtubule-stabilising agent
etoposide
[no description available]		210beta-D-glucoside;
furonaphthodioxole;
organic heterotetracyclic compound		antineoplastic agent;
DNA synthesis inhibitor
betulinic acid
[no description available]		2.0510hydroxy monocarboxylic acid;
pentacyclic triterpenoid		anti-HIV agent;
anti-inflammatory agent;
antimalarial;
antineoplastic agent;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
plant metabolite
betulin
betulin: isolated from various white birch bark (BETULA). betulin : A pentacyclic triterpenoid that is lupane having a double bond at position 20(29) as well as 3beta-hydroxy and 28-hydroxymethyl substituents.		2.0510diol;
pentacyclic triterpenoid		analgesic;
anti-inflammatory agent;
antineoplastic agent;
antiviral agent;
metabolite
pulsatilla saponin a
Pulsatilla saponin A: has antineoplastic activity; isolated from Pulsatilla chinensis; structure in first source. kalopanaxsaponin A : A triterpenoid saponin that is hederagenin attached to a 2-O-(6-deoxy-alpha-L-mannopyranosyl)-alpha-L-arabinopyranosyl residue at position 3 via a glycosidic linkage. It has been isolated from the stem bark of Kalopanax pictus.		2.9840disaccharide derivative;
hydroxy monocarboxylic acid;
pentacyclic triterpenoid;
triterpenoid saponin		anti-inflammatory agent;
plant metabolite
hederagenin
[no description available]		2.4920dihydroxy monocarboxylic acid;
pentacyclic triterpenoid;
sapogenin		plant metabolite
beta-peltatin
beta-peltatin : An organic heterotetracyclic compound that is alpha-peltatin in which the phenolic hydroxy group of the 4-hydroxy-3,5-dimethoxyphenyl substitutent had been converted into the corresponding methyl ether.		210furonaphthodioxole;
gamma-lactone;
lignan;
organic heterotetracyclic compound;
phenols		antineoplastic agent;
plant metabolite
3-o-(alpha-l-arabinopyranosyl)hederagenin
Akebia saponin PA: isolated from Dipsacus asperoides; structure in first source. hederagenin 3-O-arabinoside : A triterpenoid saponin that is hederagenin attached to an alpha-L-arabinopyranosyl residue at position 3 via a glycosidic linkage.		2.0510alpha-L-arabinopyranoside;
hydroxy monocarboxylic acid;
monosaccharide derivative;
pentacyclic triterpenoid;
triterpenoid saponin		plant metabolite
beta-hederin
beta-hederin: derived from beta-amyrin; other hederigenin based saponins are available		2.7430triterpenoid
beta-escin
[no description available]		3.6680
(-)-pinoresinol
(-)-pinoresinol : An enantiomer of pinoresinol having (-)-1R,3aS,4R,6aS-configuration.		210pinoresinolplant metabolite
ConditionIndicatedRelationship StrengthStudiesTrials
Extravascular Hemolysis
[description not available]		02.7930
Hemolysis
The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity.		02.7930
Cancer of Lung
[description not available]		02.1710
Lung Neoplasms
Tumors or cancer of the LUNG.		02.1710
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		02.6320
Astrocytoma, Grade IV
[description not available]		02.2110
Glioblastoma
A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.		02.2110
Breast Cancer
[description not available]		07.2510
Breast Neoplasms
Tumors or cancer of the human BREAST.		02.2510
Colitis Gravis
[description not available]		02.2510
Colitis, Ulcerative
Inflammation of the COLON that is predominantly confined to the MUCOSA. Its major symptoms include DIARRHEA, rectal BLEEDING, the passage of MUCUS, and ABDOMINAL PAIN.		02.2510
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)		02.1110
Cancer of Cervix
[description not available]		02.1110
Uterine Cervical Neoplasms
Tumors or cancer of the UTERINE CERVIX.		02.1110