Page last updated: 2024-12-08
mokko lactone
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Description
mokko lactone: isolated from mokko, Saussurea lappa; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Related Flora
| Flora | Rank | Flora Definition | Family | Family Definition |
|---|---|---|---|---|
| Saussurea | genus | A plant genus of the family ASTERACEAE, order Asterales, subclass Asteridae. It is a source of costus root oil and should not be confused with the genus COSTUS.[MeSH] | Asteraceae | A large plant family of the order Asterales, subclass Asteridae, class Magnoliopsida. The family is also known as Compositae. Flower petals are joined near the base and stamens alternate with the corolla lobes. The common name of daisy refers to several genera of this family including Aster; CHRYSANTHEMUM; RUDBECKIA; TANACETUM.[MeSH] |
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 167495 |
| CHEMBL ID | 453274 |
| MeSH ID | M0256492 |
Synonyms (8)
| Synonym |
|---|
| 4955-03-7 |
| CHEMBL453274 |
| mokko lactone |
| mokkolactone |
| (3s,3as,6ar,9ar,9bs)-3-methyl-6,9-dimethylidene-3a,4,5,6a,7,8,9a,9b-octahydro-3h-azuleno[4,5-b]furan-2-one |
| azuleno(4,5-b)furan-2(3h)-one, decahydro-3-methyl-6,9-bis(methylene)-, (3s,3as,6ar,9ar,9bs)- |
| 3-methyl-6,9-dimethylidenedecahydroazuleno[4,5-b]furan-2(3h)-one |
| DTXSID80964252 |
Research Excerpts
Overview
Mokko lactone (ML) is a naturally occurring guainolide sesquiterpene with established antioxidant and anti-inflammatory actions.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Mokko lactone (ML) is a guainolide sesquiterpene with promising biological activities." | ( Mokko Lactone Attenuates Doxorubicin-Induced Hepatotoxicity in Rats: Emphasis on Sirt-1/FOXO1/NF-κB Axis. Abdallah, HM; Abdel-Naim, AB; Alamoudi, AJ; Eid, BG; Ibrahim, SRM; Kammoun, AK; Mohamed, GA; Shaik, RA; Sirwi, A, 2021) | 2.79 |
| "Mokko lactone (ML) is a naturally occurring guainolide sesquiterpene with established antioxidant and anti-inflammatory actions." | ( Mokko Lactone Alleviates Doxorubicin-Induced Cardiotoxicity in Rats via Antioxidant, Anti-Inflammatory, and Antiapoptotic Activities. Abdallah, HM; Abdel-Naim, AB; Alamoudi, AJ; Eid, BG; Elfaky, MA; Ibrahim, SRM; Mohamed, GA; Shaik, RA; Sirwi, A, 2022) | 2.89 |
Toxicity
| Excerpt | Reference | Relevance |
|---|---|---|
| "Doxorubicin (DOX), a common chemotherapeutic agent, suffers serious adverse effects including hepatotoxicity." | ( Mokko Lactone Attenuates Doxorubicin-Induced Hepatotoxicity in Rats: Emphasis on Sirt-1/FOXO1/NF-κB Axis. Abdallah, HM; Abdel-Naim, AB; Alamoudi, AJ; Eid, BG; Ibrahim, SRM; Kammoun, AK; Mohamed, GA; Shaik, RA; Sirwi, A, 2021) | 2.06 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Bioassays (2)
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID377925 | Inhibition of IL-1-beta-induced ICAM1 expression in human A549 cells | 1999 | Journal of natural products, Jan, Volume: 62, Issue:1 | Guaianolides as immunomodulators. Synthesis and biological activities of dehydrocostus lactone, mokko lactone, eremanthin, and their derivatives. |
| AID377924 | Inhibition of killing activity of CD8+ specific mouse CTL-OE4 cells | 1999 | Journal of natural products, Jan, Volume: 62, Issue:1 | Guaianolides as immunomodulators. Synthesis and biological activities of dehydrocostus lactone, mokko lactone, eremanthin, and their derivatives. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
Research
Studies (10)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 1 (10.00) | 18.7374 |
| 1990's | 2 (20.00) | 18.2507 |
| 2000's | 4 (40.00) | 29.6817 |
| 2010's | 1 (10.00) | 24.3611 |
| 2020's | 2 (20.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Market Indicators
Research Demand Index: 12.71
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.71) All Compounds (24.57) |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 10 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||