Compounds > helioscopinolide a
Page last updated: 2024-11-12

helioscopinolide a

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

helioscopinolide A: from Euphorbia pubescens; exhibited significant antibacterial activity against Staphylococcus aureus; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
EuphorbiagenusA large plant genus of the family EUPHORBIACEAE, order Euphorbiales, subclass Rosidae. They have a milky sap and a female flower consisting of a single pistil surrounded by numerous male flowers of one stamen each. Euphorbia hirta is rarely called milkweed but that name is normally used for ASCLEPIAS.[MeSH]EuphorbiaceaeThe spurge family of flowering plants in the order Malpighiales. The family consists of annual and perennial herbs and woody shrubs or trees. Members contain securinine.[MeSH]

Cross-References

ID SourceID
PubMed CID10245246
CHEMBL ID469645
SCHEMBL ID21753428
MeSH IDM0467994

Synonyms (6)

Synonym
helioscopinolide a
CHEMBL469645
(3r,4as,10ar,11ar,11bs)-3-hydroxy-4,4,8,11b-tetramethyl-2,3,4a,5,6,10a,11,11a-octahydro-1h-naphtho[2,1-f][1]benzofuran-9-one
SCHEMBL21753428
DTXSID701316116
(3r,4as,10ar,11ar,11bs)-3-hydroxy-4,4,8,11b-tetramethyl-2,3,4a,5,6,10a,11,11a-octahydro-1h-naphtho[2,1-f]benzofuran-9-one
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (12)

Assay IDTitleYearJournalArticle
AID402541Growth inhibition of human SF268 cells at 100 uM after 48 hrs by SRB assay2004Journal of natural products, May, Volume: 67, Issue:5
Bioactive diterpenoids, a new jatrophane and two ent-abietanes, and other constituents from Euphorbia pubescens.
AID382852Cytotoxicity against human MDA-MB-231 cells by MTT method2008Journal of natural products, May, Volume: 71, Issue:5
Cytotoxic diterpenoids from Euphorbia helioscopia.
AID402619Growth inhibition of human SF268 cells after 48 hrs by SRB assay2004Journal of natural products, May, Volume: 67, Issue:5
Bioactive diterpenoids, a new jatrophane and two ent-abietanes, and other constituents from Euphorbia pubescens.
AID471323Cytotoxicity against human A2780 cells after 4 days by MTT assay2009Journal of natural products, Sep, Volume: 72, Issue:9
Chemical Constituents of the Roots of Euphorbia micractina.
AID402542Antibacterial activity against Staphylococcus aureus ATCC 6538P at 2.5 ug/spot after 24 hrs by bioautographic agar overlay method2004Journal of natural products, May, Volume: 67, Issue:5
Bioactive diterpenoids, a new jatrophane and two ent-abietanes, and other constituents from Euphorbia pubescens.
AID402540Growth inhibition of human NCI-H460 cells after 48 hrs by SRB assay2004Journal of natural products, May, Volume: 67, Issue:5
Bioactive diterpenoids, a new jatrophane and two ent-abietanes, and other constituents from Euphorbia pubescens.
AID402539Growth inhibition of human MCF7 cells after 48 hrs by SRB assay2004Journal of natural products, May, Volume: 67, Issue:5
Bioactive diterpenoids, a new jatrophane and two ent-abietanes, and other constituents from Euphorbia pubescens.
AID382851Cytotoxicity against human HeLa cells by MTT method2008Journal of natural products, May, Volume: 71, Issue:5
Cytotoxic diterpenoids from Euphorbia helioscopia.
AID402544Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 at 40 ug/spot after 24 hrs by bioautographic agar overlay method2004Journal of natural products, May, Volume: 67, Issue:5
Bioactive diterpenoids, a new jatrophane and two ent-abietanes, and other constituents from Euphorbia pubescens.
AID471325Antiviral activity against HIV-1 NL4-3 expressing VSV-G envelope infected in human 293T cells assessed as inhibition of viral replication after 48 hrs by Luciferase reporter gene assay2009Journal of natural products, Sep, Volume: 72, Issue:9
Chemical Constituents of the Roots of Euphorbia micractina.
AID402543Antibacterial activity against Escherichia coli ATCC 25922 at 40 ug/spot after 24 hrs by bioautographic agar overlay method2004Journal of natural products, May, Volume: 67, Issue:5
Bioactive diterpenoids, a new jatrophane and two ent-abietanes, and other constituents from Euphorbia pubescens.
AID471324Inhibition of GST-tagged human PTP1B2009Journal of natural products, Sep, Volume: 72, Issue:9
Chemical Constituents of the Roots of Euphorbia micractina.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (50.00)29.6817
2010's3 (50.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.43

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.43 (24.57)
Research Supply Index2.08 (2.92)
Research Growth Index4.51 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.43)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
oleanolic acid
[no description available]		2.0510hydroxy monocarboxylic acid;
pentacyclic triterpenoid		plant metabolite
camptothecin
NSC 100880: carboxylate (opened lactone) form of camptothecin; RN refers to (S)-isomer; structure given in first source		2.0510delta-lactone;
pyranoindolizinoquinoline;
quinoline alkaloid;
tertiary alcohol		antineoplastic agent;
EC 5.99.1.2 (DNA topoisomerase) inhibitor;
genotoxin;
plant metabolite
zidovudine
Zidovudine: A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse transcription. It improves immunologic function, partially reverses the HIV-induced neurological dysfunction, and improves certain other clinical abnormalities associated with AIDS. Its principal toxic effect is dose-dependent suppression of bone marrow, resulting in anemia and leukopenia.. zidovudine : A pyrimidine 2',3'-dideoxyribonucleoside compound having a 3'-azido substituent and thymine as the nucleobase.		2.0510azide;
pyrimidine 2',3'-dideoxyribonucleoside		antimetabolite;
antiviral drug;
HIV-1 reverse transcriptase inhibitor
1-triacontanol
1-triacontanol: constituent of Apocynum venetum leaf & Cirsium segetum. triacontan-1-ol : An ultra-long-chain primary fatty alcohol that is triacontane in which one of the terminal methyl hydrogens is replaced by a hydroxy group.		2.0510fatty alcohol 30:0;
ultra-long-chain primary fatty alcohol
betulin
betulin: isolated from various white birch bark (BETULA). betulin : A pentacyclic triterpenoid that is lupane having a double bond at position 20(29) as well as 3beta-hydroxy and 28-hydroxymethyl substituents.		2.0510diol;
pentacyclic triterpenoid		analgesic;
anti-inflammatory agent;
antineoplastic agent;
antiviral agent;
metabolite
uvaol
uvaol: from Vauquelinia corymbosa (Rosaceae)		2.0510triterpenoidmetabolite
erythrodiol
[no description available]		2.0510diol;
pentacyclic triterpenoid;
primary alcohol;
secondary alcohol		plant metabolite
sitosterol, (3beta)-isomer
Sobatum: tradename; active fraction of Solanum trilobatum; reduces side-effects of radiation-induced toxicity. sitosterol : A member of the class of phytosterols that is stigmast-5-ene substituted by a beta-hydroxy group at position 3.		2.05103beta-hydroxy-Delta(5)-steroid;
3beta-sterol;
C29-steroid;
phytosterols;
stigmastane sterol		anticholesteremic drug;
antioxidant;
mouse metabolite;
plant metabolite;
sterol methyltransferase inhibitor
e-z cinnamic acid
cinnamic acid : A monocarboxylic acid that consists of acrylic acid bearing a phenyl substituent at the 3-position. It is found in Cinnamomum cassia.. trans-cinnamic acid : The E (trans) isomer of cinnamic acid		2.0510cinnamic acidplant metabolite
dinoprostone
prostaglandin E2 : Prostaglandin F2alpha in which the hydroxy group at position 9 has been oxidised to the corresponding ketone. Prostaglandin E2 is the most common and most biologically potent of mammalian prostaglandins.		2.0610prostaglandins Ehuman metabolite;
mouse metabolite;
oxytocic
scopoletin
[no description available]		2.0510hydroxycoumarinplant growth regulator;
plant metabolite
helioscopinolide b
helioscopinolide B: from Euphorbia pubescens; exhibited significant antibacterial activity against Staphylococcus aureus; structure in first source		2.4420
4-methoxybenzoic acid 2-(4-hydroxyphenyl)ethyl ester
[no description available]		2.0510methoxybenzoic acid
latilagascene f
latilagascene F: structure in first source		2.0510
ConditionIndicatedRelationship StrengthStudiesTrials
Breast Cancer
[description not available]		02.0810
Breast Neoplasms
Tumors or cancer of the human BREAST.		02.0810
Innate Inflammatory Response
[description not available]		02.0610
Inflammation
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.		02.0610