Compounds > helioscopinolide b
Page last updated: 2024-11-12

helioscopinolide b

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

helioscopinolide B: from Euphorbia pubescens; exhibited significant antibacterial activity against Staphylococcus aureus; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
EuphorbiagenusA large plant genus of the family EUPHORBIACEAE, order Euphorbiales, subclass Rosidae. They have a milky sap and a female flower consisting of a single pistil surrounded by numerous male flowers of one stamen each. Euphorbia hirta is rarely called milkweed but that name is normally used for ASCLEPIAS.[MeSH]EuphorbiaceaeThe spurge family of flowering plants in the order Malpighiales. The family consists of annual and perennial herbs and woody shrubs or trees. Members contain securinine.[MeSH]

Cross-References

ID SourceID
PubMed CID10335933
CHEMBL ID451142
MeSH IDM0467997

Synonyms (5)

Synonym
CHEMBL451142
helioscopinolide b
84799-32-6
(3s,4as,10ar,11ar,11bs)-3-hydroxy-4,4,8,11b-tetramethyl-2,3,4a,5,6,10a,11,11a-octahydro-1h-naphtho[2,1-f][1]benzofuran-9-one
DTXSID401316117
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (24)

Assay IDTitleYearJournalArticle
AID402541Growth inhibition of human SF268 cells at 100 uM after 48 hrs by SRB assay2004Journal of natural products, May, Volume: 67, Issue:5
Bioactive diterpenoids, a new jatrophane and two ent-abietanes, and other constituents from Euphorbia pubescens.
AID1386855Modulation of human ABCB1 expressed in mouse L5178Y cells assessed as fluorescence activity ratio at 2 uM pretreated for 10 mins followed by rhodamine 123 addition and measured after 20 mins by flow cytometry (Rvb = 1.01 No_unit)2018Journal of natural products, 09-28, Volume: 81, Issue:9
Terpenoids from Euphorbia pedroi as Multidrug-Resistance Reversers.
AID402539Growth inhibition of human MCF7 cells after 48 hrs by SRB assay2004Journal of natural products, May, Volume: 67, Issue:5
Bioactive diterpenoids, a new jatrophane and two ent-abietanes, and other constituents from Euphorbia pubescens.
AID1386851Cytotoxicity against human COLO205 cells after 24 hrs by MTT assay2018Journal of natural products, 09-28, Volume: 81, Issue:9
Terpenoids from Euphorbia pedroi as Multidrug-Resistance Reversers.
AID1386860Modulation of human ABCB1 expressed in mouse L5178Y cells assessed as potentiation of doxorubicin-induced cytotoxicity by measuring combination index at ED50 measured after 48 hrs by MTT assay2018Journal of natural products, 09-28, Volume: 81, Issue:9
Terpenoids from Euphorbia pedroi as Multidrug-Resistance Reversers.
AID1386856Modulation of human ABCB1 expressed in mouse L5178Y cells assessed as fluorescence activity ratio at 20 uM pretreated for 10 mins followed by rhodamine 123 addition and measured after 20 mins by flow cytometry (Rvb = 1.01 No_unit)2018Journal of natural products, 09-28, Volume: 81, Issue:9
Terpenoids from Euphorbia pedroi as Multidrug-Resistance Reversers.
AID1386859Modulation of ABCB1 (unknown origin) expressed in human COLO320 cells co-expressing LRP assessed as fluorescence activity ratio at 20 uM pretreated for 10 mins followed by rhodamine 123 addition and measured after 20 mins by flow cytometry (Rvb = 0.79 No_2018Journal of natural products, 09-28, Volume: 81, Issue:9
Terpenoids from Euphorbia pedroi as Multidrug-Resistance Reversers.
AID1386858Modulation of ABCB1 (unknown origin) expressed in human COLO320 cells co-expressing LRP assessed as fluorescence activity ratio at 2 uM pretreated for 10 mins followed by rhodamine 123 addition and measured after 20 mins by flow cytometry (Rvb = 0.79 No_u2018Journal of natural products, 09-28, Volume: 81, Issue:9
Terpenoids from Euphorbia pedroi as Multidrug-Resistance Reversers.
AID402544Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 at 40 ug/spot after 24 hrs by bioautographic agar overlay method2004Journal of natural products, May, Volume: 67, Issue:5
Bioactive diterpenoids, a new jatrophane and two ent-abietanes, and other constituents from Euphorbia pubescens.
AID1386852Cytotoxicity against mouse NIH/3T3 cells after 24 hrs by MTT assay2018Journal of natural products, 09-28, Volume: 81, Issue:9
Terpenoids from Euphorbia pedroi as Multidrug-Resistance Reversers.
AID471325Antiviral activity against HIV-1 NL4-3 expressing VSV-G envelope infected in human 293T cells assessed as inhibition of viral replication after 48 hrs by Luciferase reporter gene assay2009Journal of natural products, Sep, Volume: 72, Issue:9
Chemical Constituents of the Roots of Euphorbia micractina.
AID1377027Cytotoxicity against human KBv200 cells assessed as growth inhibition after 72 hrs by MTT assay2017Journal of natural products, 06-23, Volume: 80, Issue:6
Terpenoids from Euphorbia soongarica and Their Multidrug Resistance Reversal Activity.
AID471324Inhibition of GST-tagged human PTP1B2009Journal of natural products, Sep, Volume: 72, Issue:9
Chemical Constituents of the Roots of Euphorbia micractina.
AID1386849Antiproliferative activity against mouse L5178Y cells harboring human ABCB1 after 72 hrs by MTT assay2018Journal of natural products, 09-28, Volume: 81, Issue:9
Terpenoids from Euphorbia pedroi as Multidrug-Resistance Reversers.
AID1386850Cytotoxicity against human COLO320 cells after 24 hrs by MTT assay2018Journal of natural products, 09-28, Volume: 81, Issue:9
Terpenoids from Euphorbia pedroi as Multidrug-Resistance Reversers.
AID402543Antibacterial activity against Escherichia coli ATCC 25922 at 40 ug/spot after 24 hrs by bioautographic agar overlay method2004Journal of natural products, May, Volume: 67, Issue:5
Bioactive diterpenoids, a new jatrophane and two ent-abietanes, and other constituents from Euphorbia pubescens.
AID1377026Cytotoxicity against human KB cells assessed as growth inhibition after 72 hrs by MTT assay2017Journal of natural products, 06-23, Volume: 80, Issue:6
Terpenoids from Euphorbia soongarica and Their Multidrug Resistance Reversal Activity.
AID402540Growth inhibition of human NCI-H460 cells after 48 hrs by SRB assay2004Journal of natural products, May, Volume: 67, Issue:5
Bioactive diterpenoids, a new jatrophane and two ent-abietanes, and other constituents from Euphorbia pubescens.
AID402619Growth inhibition of human SF268 cells after 48 hrs by SRB assay2004Journal of natural products, May, Volume: 67, Issue:5
Bioactive diterpenoids, a new jatrophane and two ent-abietanes, and other constituents from Euphorbia pubescens.
AID471323Cytotoxicity against human A2780 cells after 4 days by MTT assay2009Journal of natural products, Sep, Volume: 72, Issue:9
Chemical Constituents of the Roots of Euphorbia micractina.
AID402542Antibacterial activity against Staphylococcus aureus ATCC 6538P at 2.5 ug/spot after 24 hrs by bioautographic agar overlay method2004Journal of natural products, May, Volume: 67, Issue:5
Bioactive diterpenoids, a new jatrophane and two ent-abietanes, and other constituents from Euphorbia pubescens.
AID1386853Cytotoxicity against human MRC5 cells after 24 hrs by MTT assay2018Journal of natural products, 09-28, Volume: 81, Issue:9
Terpenoids from Euphorbia pedroi as Multidrug-Resistance Reversers.
AID1386848Antiproliferative activity against mouse L5178Y cells after 72 hrs by MTT assay2018Journal of natural products, 09-28, Volume: 81, Issue:9
Terpenoids from Euphorbia pedroi as Multidrug-Resistance Reversers.
AID1377028Inhibition of P-gp in human KBv200 cells assessed as increase in intracellular rhodamine123 accumulation by measuring fluorescence activity ratio at 10 uM incubated for 4 hrs followed by rhodamine123 addition measured after 1 hr by flow cytometry2017Journal of natural products, 06-23, Volume: 80, Issue:6
Terpenoids from Euphorbia soongarica and Their Multidrug Resistance Reversal Activity.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (60.00)29.6817
2010's2 (40.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.47

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.47 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.42 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.47)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
verapamil
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.. verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.. 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.		2.5720aromatic ether;
nitrile;
polyether;
tertiary amino compound
sucrose
Saccharum: A plant genus of the family POACEAE widely cultivated in the tropics for the sweet cane that is processed into sugar.		2.0310glycosyl glycosidealgal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
osmolyte;
Saccharomyces cerevisiae metabolite;
sweetening agent
oleanolic acid
[no description available]		2.4920hydroxy monocarboxylic acid;
pentacyclic triterpenoid		plant metabolite
camptothecin
NSC 100880: carboxylate (opened lactone) form of camptothecin; RN refers to (S)-isomer; structure given in first source		2.0510delta-lactone;
pyranoindolizinoquinoline;
quinoline alkaloid;
tertiary alcohol		antineoplastic agent;
EC 5.99.1.2 (DNA topoisomerase) inhibitor;
genotoxin;
plant metabolite
zidovudine
Zidovudine: A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse transcription. It improves immunologic function, partially reverses the HIV-induced neurological dysfunction, and improves certain other clinical abnormalities associated with AIDS. Its principal toxic effect is dose-dependent suppression of bone marrow, resulting in anemia and leukopenia.. zidovudine : A pyrimidine 2',3'-dideoxyribonucleoside compound having a 3'-azido substituent and thymine as the nucleobase.		2.0510azide;
pyrimidine 2',3'-dideoxyribonucleoside		antimetabolite;
antiviral drug;
HIV-1 reverse transcriptase inhibitor
paclitaxel
Taxus: Genus of coniferous yew trees or shrubs, several species of which have medicinal uses. Notable is the Pacific yew, Taxus brevifolia, which is used to make the anti-neoplastic drug taxol (PACLITAXEL).		2.1510taxane diterpenoid;
tetracyclic diterpenoid		antineoplastic agent;
human metabolite;
metabolite;
microtubule-stabilising agent
1-triacontanol
1-triacontanol: constituent of Apocynum venetum leaf & Cirsium segetum. triacontan-1-ol : An ultra-long-chain primary fatty alcohol that is triacontane in which one of the terminal methyl hydrogens is replaced by a hydroxy group.		2.0510fatty alcohol 30:0;
ultra-long-chain primary fatty alcohol
betulin
betulin: isolated from various white birch bark (BETULA). betulin : A pentacyclic triterpenoid that is lupane having a double bond at position 20(29) as well as 3beta-hydroxy and 28-hydroxymethyl substituents.		2.0510diol;
pentacyclic triterpenoid		analgesic;
anti-inflammatory agent;
antineoplastic agent;
antiviral agent;
metabolite
uvaol
uvaol: from Vauquelinia corymbosa (Rosaceae)		2.0510triterpenoidmetabolite
erythrodiol
[no description available]		2.0510diol;
pentacyclic triterpenoid;
primary alcohol;
secondary alcohol		plant metabolite
sitosterol, (3beta)-isomer
Sobatum: tradename; active fraction of Solanum trilobatum; reduces side-effects of radiation-induced toxicity. sitosterol : A member of the class of phytosterols that is stigmast-5-ene substituted by a beta-hydroxy group at position 3.		2.05103beta-hydroxy-Delta(5)-steroid;
3beta-sterol;
C29-steroid;
phytosterols;
stigmastane sterol		anticholesteremic drug;
antioxidant;
mouse metabolite;
plant metabolite;
sterol methyltransferase inhibitor
e-z cinnamic acid
cinnamic acid : A monocarboxylic acid that consists of acrylic acid bearing a phenyl substituent at the 3-position. It is found in Cinnamomum cassia.. trans-cinnamic acid : The E (trans) isomer of cinnamic acid		2.0510cinnamic acidplant metabolite
scopoletin
[no description available]		2.4420hydroxycoumarinplant growth regulator;
plant metabolite
24-ethyl-4-cholesten-3-one
stigmast-4-en-3-one: from the bark of Anacardium occidentale (cashew); structure in first source		2.1710C29-steroid;
steroid		metabolite
helioscopinolide a
helioscopinolide A: from Euphorbia pubescens; exhibited significant antibacterial activity against Staphylococcus aureus; structure in first source		2.4420
4-methoxybenzoic acid 2-(4-hydroxyphenyl)ethyl ester
[no description available]		2.0510methoxybenzoic acid
latilagascene f
latilagascene F: structure in first source		2.4920
ConditionIndicatedRelationship StrengthStudiesTrials