Compounds > 8,8'-biplumbagin
Page last updated: 2024-12-09

8,8'-biplumbagin

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Description

8,8'-biplumbagin: structure given in first source; isolated from the Bolivian plant Pera benesis [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
Peragenus[no description available]Peraceae[no description available]

Cross-References

ID SourceID
PubMed CID633024
CHEMBL ID512154
SCHEMBL ID15661147
MeSH IDM0213832

Synonyms (15)

Synonym
33927-59-2
(1,1'-binaphthalene)-5,5',8,8'-tetrone, 4,4'-dihydroxy-7,7'-dimethyl-
8,8'-biplumbagin
maritinone
xcrmwtkecydcod-uhfffaoysa-
inchi=1/c22h14o6/c1-9-7-15(25)19-13(23)5-3-11(17(19)21(9)27)12-4-6-14(24)20-16(26)8-10(2)22(28)18(12)20/h3-8,23-24h,1-2h3
CHEMBL512154
5-hydroxy-8-(4-hydroxy-7-methyl-5,8-dioxonaphthalen-1-yl)-2-methylnaphthalene-1,4-dione
5-hydroxy-8-(4-hydroxy-7-methyl-5,8-dioxo-1-naphthyl)-2-methyl-naphthalene-1,4-dione
SCHEMBL15661147
XCRMWTKECYDCOD-UHFFFAOYSA-N
4,4'-dihydroxy-6,6'-dimethyl-1,1'-binaphthalene-5,5',8,8'-tetrone
DTXSID20187549
4,4'-dihydroxy-7,7'-dimethyl-[1,1'-binaphthalene]-5,5',8,8'-tetraone
AKOS040748873
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (33)

Assay IDTitleYearJournalArticle
AID403268Cytotoxicity against human Lu1 cells2004Journal of natural products, Jul, Volume: 67, Issue:7
Cytotoxic and antimicrobial constituents of the bark of Diospyros maritima collected in two geographical locations in Indonesia.
AID403297Toxicity in human LU1 cell xenografted mouse at 50 mg/kg2004Journal of natural products, Jul, Volume: 67, Issue:7
Cytotoxic and antimicrobial constituents of the bark of Diospyros maritima collected in two geographical locations in Indonesia.
AID403276Antimicrobial activity against Mycobacterium smegmatis assessed as 99.9 % growth inhibition after 18 hrs by zone-of-inhibition assay2004Journal of natural products, Jul, Volume: 67, Issue:7
Cytotoxic and antimicrobial constituents of the bark of Diospyros maritima collected in two geographical locations in Indonesia.
AID403273Antimicrobial activity against Staphylococcus aureus after 18 hrs by zone-of-inhibition assay2004Journal of natural products, Jul, Volume: 67, Issue:7
Cytotoxic and antimicrobial constituents of the bark of Diospyros maritima collected in two geographical locations in Indonesia.
AID403283Antifungal activity against Saccharomyces cerevisiae assessed as 99.9 % growth inhibition after 18 hrs by zone-of-inhibition assay2004Journal of natural products, Jul, Volume: 67, Issue:7
Cytotoxic and antimicrobial constituents of the bark of Diospyros maritima collected in two geographical locations in Indonesia.
AID403274Antimicrobial activity against Staphylococcus aureus assessed as 99.9 % growth inhibition after 18 hrs by zone-of-inhibition assay2004Journal of natural products, Jul, Volume: 67, Issue:7
Cytotoxic and antimicrobial constituents of the bark of Diospyros maritima collected in two geographical locations in Indonesia.
AID403294Toxicity in human LU1 cell xenografted mouse at 25 mg/kg2004Journal of natural products, Jul, Volume: 67, Issue:7
Cytotoxic and antimicrobial constituents of the bark of Diospyros maritima collected in two geographical locations in Indonesia.
AID403271Antimicrobial activity against Micrococcus luteus after 18 hrs by zone-of-inhibition assay2004Journal of natural products, Jul, Volume: 67, Issue:7
Cytotoxic and antimicrobial constituents of the bark of Diospyros maritima collected in two geographical locations in Indonesia.
AID660832Cytotoxicity against human ACHN cells assessed as cell death after 20 to 24 hrs by XTT assay in presence of 40 ng/ml TRAIL2012Journal of natural products, Mar-23, Volume: 75, Issue:3
Synergistic TRAIL sensitizers from Barleria alluaudii and Diospyros maritima.
AID403282Antifungal activity against Saccharomyces cerevisiae after 18 hrs by zone-of-inhibition assay2004Journal of natural products, Jul, Volume: 67, Issue:7
Cytotoxic and antimicrobial constituents of the bark of Diospyros maritima collected in two geographical locations in Indonesia.
AID403269Cytotoxicity against human LNCAP cells2004Journal of natural products, Jul, Volume: 67, Issue:7
Cytotoxic and antimicrobial constituents of the bark of Diospyros maritima collected in two geographical locations in Indonesia.
AID403290Antitumor activity against human Lu1 cell xenografted mouse by hollow fiber assay2004Journal of natural products, Jul, Volume: 67, Issue:7
Cytotoxic and antimicrobial constituents of the bark of Diospyros maritima collected in two geographical locations in Indonesia.
AID403267Cytotoxicity against human KB cells2004Journal of natural products, Jul, Volume: 67, Issue:7
Cytotoxic and antimicrobial constituents of the bark of Diospyros maritima collected in two geographical locations in Indonesia.
AID403295Toxicity in human KB cell xenografted mouse at 50 mg/kg2004Journal of natural products, Jul, Volume: 67, Issue:7
Cytotoxic and antimicrobial constituents of the bark of Diospyros maritima collected in two geographical locations in Indonesia.
AID657867Ratio of EC50 for human ACHN cells to EC50 for human ACHN cells in presence of 40 ng/ml TRAIL2012Journal of natural products, Mar-23, Volume: 75, Issue:3
Synergistic TRAIL sensitizers from Barleria alluaudii and Diospyros maritima.
AID403292Toxicity in human KB cell xenografted mouse at 25 mg/kg2004Journal of natural products, Jul, Volume: 67, Issue:7
Cytotoxic and antimicrobial constituents of the bark of Diospyros maritima collected in two geographical locations in Indonesia.
AID660831Cytotoxicity against human ACHN cells assessed as cell death after 20 to 24 hrs by XTT assay2012Journal of natural products, Mar-23, Volume: 75, Issue:3
Synergistic TRAIL sensitizers from Barleria alluaudii and Diospyros maritima.
AID403278Antimicrobial activity against Mycobacterium avium assessed as 99.9 % growth inhibition after 18 hrs by zone-of-inhibition assay2004Journal of natural products, Jul, Volume: 67, Issue:7
Cytotoxic and antimicrobial constituents of the bark of Diospyros maritima collected in two geographical locations in Indonesia.
AID403279Antifungal activity against Candida albicans after 18 hrs by zone-of-inhibition assay2004Journal of natural products, Jul, Volume: 67, Issue:7
Cytotoxic and antimicrobial constituents of the bark of Diospyros maritima collected in two geographical locations in Indonesia.
AID403293Toxicity in human LNCaP cell xenografted mouse at 25 mg/kg2004Journal of natural products, Jul, Volume: 67, Issue:7
Cytotoxic and antimicrobial constituents of the bark of Diospyros maritima collected in two geographical locations in Indonesia.
AID479263Larvicidal activity against Aedes aegypti fourth instar larvae after 24 hrs2010Bioorganic & medicinal chemistry letters, May-01, Volume: 20, Issue:9
Bioactivity-guided isolation of mosquitocidal constituents from the rhizomes of Plumbago capensis Thunb.
AID403291Antitumor activity against human LNCAP cell xenografted mouse by hollow fiber assay2004Journal of natural products, Jul, Volume: 67, Issue:7
Cytotoxic and antimicrobial constituents of the bark of Diospyros maritima collected in two geographical locations in Indonesia.
AID403296Toxicity in human LNCaP cell xenografted mouse at 50 mg/kg2004Journal of natural products, Jul, Volume: 67, Issue:7
Cytotoxic and antimicrobial constituents of the bark of Diospyros maritima collected in two geographical locations in Indonesia.
AID403289Antitumor activity against human KB cell xenografted mouse by hollow fiber assay2004Journal of natural products, Jul, Volume: 67, Issue:7
Cytotoxic and antimicrobial constituents of the bark of Diospyros maritima collected in two geographical locations in Indonesia.
AID403277Antimicrobial activity against Mycobacterium avium after 18 hrs by zone-of-inhibition assay2004Journal of natural products, Jul, Volume: 67, Issue:7
Cytotoxic and antimicrobial constituents of the bark of Diospyros maritima collected in two geographical locations in Indonesia.
AID403281Antifungal activity against Cryptococcus neoformans assessed as 99.9 % growth inhibition after 18 hrs by zone-of-inhibition assay2004Journal of natural products, Jul, Volume: 67, Issue:7
Cytotoxic and antimicrobial constituents of the bark of Diospyros maritima collected in two geographical locations in Indonesia.
AID403285Antifungal activity against Aspergillus niger assessed as 99.9 % growth inhibition after 18 hrs by zone-of-inhibition assay2004Journal of natural products, Jul, Volume: 67, Issue:7
Cytotoxic and antimicrobial constituents of the bark of Diospyros maritima collected in two geographical locations in Indonesia.
AID403275Antimicrobial activity against Mycobacterium smegmatis after 18 hrs by zone-of-inhibition assay2004Journal of natural products, Jul, Volume: 67, Issue:7
Cytotoxic and antimicrobial constituents of the bark of Diospyros maritima collected in two geographical locations in Indonesia.
AID403298Antimicrobial activity against Candida albicans assessed as 99.9 % growth inhibition after 18 hrs by zone-of-inhibition assay2004Journal of natural products, Jul, Volume: 67, Issue:7
Cytotoxic and antimicrobial constituents of the bark of Diospyros maritima collected in two geographical locations in Indonesia.
AID403280Antifungal activity against Cryptococcus neoformans after 18 hrs by zone-of-inhibition assay2004Journal of natural products, Jul, Volume: 67, Issue:7
Cytotoxic and antimicrobial constituents of the bark of Diospyros maritima collected in two geographical locations in Indonesia.
AID403270Cytotoxicity against human HUVEC2004Journal of natural products, Jul, Volume: 67, Issue:7
Cytotoxic and antimicrobial constituents of the bark of Diospyros maritima collected in two geographical locations in Indonesia.
AID403272Antimicrobial activity against Micrococcus luteus assessed as 99.9 % growth inhibition after 18 hrs by zone-of-inhibition assay2004Journal of natural products, Jul, Volume: 67, Issue:7
Cytotoxic and antimicrobial constituents of the bark of Diospyros maritima collected in two geographical locations in Indonesia.
AID403284Antifungal activity against Aspergillus niger after 18 hrs by zone-of-inhibition assay2004Journal of natural products, Jul, Volume: 67, Issue:7
Cytotoxic and antimicrobial constituents of the bark of Diospyros maritima collected in two geographical locations in Indonesia.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (16.67)18.2507
2000's1 (16.67)29.6817
2010's4 (66.67)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
rotenone
Derris: A plant genus of the family FABACEAE. The root is a source of rotenoids (ROTENONE) and flavonoids. Some species of Pongamia have been reclassified to this genus and some to MILLETTIA. Some species of Deguelia have been reclassified to this genus.. rotenoid : Members of the class of tetrahydrochromenochromene that consists of a cis-fused tetrahydrochromeno[3,4-b]chromene skeleton and its substituted derivatives. The term was originally restricted to natural products, but is now also used to describe semi-synthetic and fully synthetic compounds.		2.0510organic heteropentacyclic compound;
rotenones		antineoplastic agent;
metabolite;
mitochondrial NADH:ubiquinone reductase inhibitor;
phytogenic insecticide;
piscicide;
toxin
2-methylanthraquinone
2-methylanthraquinone: form Morinda officinalis How.. 2-methylanthraquinone : An anthraquinone that is 9,10-anthraquinone in which the hydrogen at position 2 is substituted by a methyl group.		2.0710anthraquinone
meglumine
Meglumine: 1-Deoxy-1-(methylamino)-D-glucitol. A derivative of sorbitol in which the hydroxyl group in position 1 is replaced by a methylamino group. Often used in conjunction with iodinated organic compounds as contrast medium.. N-methylglucamine : A hexosamine that is D-glucitol in which the hydroxy group at position 1 is substituted by the nitrogen of a methylamino group. A crystalline base, it is used in preparing salts of certain acids for use as diagnostic radiopaque media, while its antimonate is used as an antiprotozoal in the treatment of leishmaniasis.		1.9810hexosamine;
secondary amino compound
plumbagin
plumbagin: a superoxide anion generator. plumbagin : A hydroxy-1,4-naphthoquinone that is 1,4-naphthoquinone in which the hydrogens at positions 2 and 5 are substituted by methyl and hydroxy groups, respectively.		3.2960hydroxy-1,4-naphthoquinone;
phenols		anticoagulant;
antineoplastic agent;
immunological adjuvant;
metabolite
camptothecin
NSC 100880: carboxylate (opened lactone) form of camptothecin; RN refers to (S)-isomer; structure given in first source		2.0210delta-lactone;
pyranoindolizinoquinoline;
quinoline alkaloid;
tertiary alcohol		antineoplastic agent;
EC 5.99.1.2 (DNA topoisomerase) inhibitor;
genotoxin;
plant metabolite
nitidine chloride
[no description available]		2.0210
7-methyljuglone
7-methyljuglone: antineoplastic from roots of Euclea natalensis and Drosera aliciae; structure in first source		2.0210hydroxy-1,4-naphthoquinone
meglumine antimoniate
Meglumine Antimoniate: ANTIMONY salt of meglumine that is used in the treatment of LEISHMANIASIS.		1.9810
betulin
betulin: isolated from various white birch bark (BETULA). betulin : A pentacyclic triterpenoid that is lupane having a double bond at position 20(29) as well as 3beta-hydroxy and 28-hydroxymethyl substituents.		2.4520diol;
pentacyclic triterpenoid		analgesic;
anti-inflammatory agent;
antineoplastic agent;
antiviral agent;
metabolite
lupeol
[no description available]		2.4520pentacyclic triterpenoid;
secondary alcohol		anti-inflammatory drug;
plant metabolite
isoshinanolone
isoshinanolone: from crude extracts; structure in first source		2.0710tetralins
naphthoquinones
Naphthoquinones: Naphthalene rings which contain two ketone moieties in any position. They can be substituted in any position except at the ketone groups.		3.1450
scopoletin
[no description available]		2.0210hydroxycoumarinplant growth regulator;
plant metabolite
warfarin
Warfarin: An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide.. warfarin : A racemate comprising equal amounts of (R)- and (S)-warfarin. Extensively used as both an anticoagulant drug and as a pesticide against rats and mice.. 4-hydroxy-3-(3-oxo-1-phenylbutyl)-1-benzopyran-2-one : A member of the class of coumarins that is 4-hydroxycoumarin which is substituted at position 3 by a 1-phenyl-3-oxo-1-butyl group.		2.0210benzenes;
hydroxycoumarin;
methyl ketone
ConditionIndicatedRelationship StrengthStudiesTrials
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		01.9810
Leishmaniasis, American
[description not available]		01.9810
Leishmaniasis, Mucocutaneous
A disease characterized by the chronic, progressive spread of lesions from New World cutaneous leishmaniasis caused by species of the L. braziliensis complex to the nasal, pharyngeal, and buccal mucosa some time after the appearance of the initial cutaneous lesion. Nasal obstruction and epistaxis are frequent presenting symptoms.		01.9810
Leishmaniasis, Cutaneous
An endemic disease that is characterized by the development of single or multiple localized lesions on exposed areas of skin that typically ulcerate. The disease has been divided into Old and New World forms. Old World leishmaniasis is separated into three distinct types according to epidemiology and clinical manifestations and is caused by species of the L. tropica and L. aethiopica complexes as well as by species of the L. major genus. New World leishmaniasis, also called American leishmaniasis, occurs in South and Central America and is caused by species of the L. mexicana or L. braziliensis complexes.		01.9810