Compounds > nitidine chloride
Page last updated: 2024-12-06

nitidine chloride

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID25659
CHEMBL ID8443
SCHEMBL ID420918
MeSH IDM0312238

Synonyms (37)

Synonym
nitidine chloride
2,3-dimethoxy-12-methyl-(1,3)-benzodioxolo(5,6-c)phenanthridinium chloride
(1,3)-benzodioxolo(5,6-c)phenanthridinium, 2,3-dimethoxy-12-methyl-, chloride
13063-04-2
NSC146397 ,
wln: t g6 d6 c665 ek so uo thj e1 io1 jo1 &g
[1,6-c]phenanthridinium, 2,3-dimethoxy-12-methyl-, chloride
nsc-146397
nitidine, chloride
CHEMBL8443
unii-xo8wql69t8
xo8wql69t8 ,
2,3-dimethoxy-12-methyl-[1,3]dioxolo[4',5':4,5]benzo[1,2-c]phenanthridin-12-ium chloride
AKOS016003480
FT-0689357
SCHEMBL420918
nitidinechloride
Q-100120
Q-100770
nitidine-chloride
16,17-dimethoxy-21-methyl-5,7-dioxa-21-azapentacyclo[11.8.0.0(2),(1)?.0?,?.0(1)?,(1)?]henicosa-1(13),2(10),3,8,11,14(19),15,17,20-nonaen-21-ium chloride
AS-73875
angolinine
1,3)benzodioxolo(5,6-c)phenanthridinium, 2,3-dimethoxy-12-methyl-, chloride (1:1)
mfcd01659688
13063-04-2 (chloride)
2,3-dimethoxy-12-methyl-9h-[1,3]benzodioxolo[5,6-c]phenanthridin-12-ium chloride
DTXSID50926842
nitidine (chloride)
HY-N0498
2,3-dimethoxy-12-methyl-[1,3]dioxolo[4',5':4,5]-benzo[1,2-c]phenanthridin-12-ium chloride
A14701
[1,3]benzodioxolo[5,6-c]phenanthridinium, 2,3-dimethoxy-12-methyl-, chloride (1:1)
CCG-268448
CS-0009022
A909300
2,3-dimethoxy-12-methyl-[1,3]benzodioxolo[5,6-c]phenanthridin-12-ium;chloride
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (75)

Assay IDTitleYearJournalArticle
AID97920Evaluated for percentage test/control (%T/C) in survival tumor system against L1210 lymphoid leukemia1984Journal of medicinal chemistry, Apr, Volume: 27, Issue:4
Synthesis and biological activity of structural analogues of the anticancer benzophenanthridine alkaloid nitidine chloride.
AID380932Inhibition of AMV reverse transcriptase assessed as [3H]TMP incorporation by toluene-based scintillation fluid counting
AID1698175Inhibition of anti-human CD3/CD28/mAbs-stimulated human T-cell proliferation after 72 hrs by CFSE staining based flow cytometric analysis
AID400990Inhibition of AMV reverse transcriptase activity assessed as incorporation of dGMP in poly(rC)-oligo(dG) at 1 uM
AID600218Binding affinity to calf thymus DNA by circular dichroism analysis2011European journal of medicinal chemistry, Jun, Volume: 46, Issue:6
Synthesis and biological evaluation of N-substituted benzo[c]phenanthrolines and benzo[c]phenanthrolinones as antiproliferative agents.
AID338342In vivo antitumor activity against mouse P388 cells at 30 to 50 mg/kg, ip relative to control
AID380922Inhibition of reverse transcriptase from Rauscher murine leukemia virus propagated in JLS-V9 cells at 40 to 60 ug/ml
AID400991Inhibition of AMV reverse transcriptase activity assessed as incorporation of dGMP in poly(rC)-oligo(dG) at 10 uM
AID600209Inhibition of human recombinant topoisomerase 1-mediated relaxation of supercoiled pUC19 DNA assessed as formation of nicked DNA at 0.1 to 5 uM using ethidium bromide staining by agarose gel electrophoresis2011European journal of medicinal chemistry, Jun, Volume: 46, Issue:6
Synthesis and biological evaluation of N-substituted benzo[c]phenanthrolines and benzo[c]phenanthrolinones as antiproliferative agents.
AID400987Inhibition of AMV reverse transcriptase activity assessed as incorporation of dTMP in poly(rA)-oligo(dT) at 100 uM
AID1698176Cytotoxicity against human T-cell assessed reduction in cell viability at 10 uM after 72 hrs
AID333842Cytotoxicity against human KB cells
AID379847Antitumor activity against mouse P388 cells xenografted CDF1 mouse at 75 mg/kg, iv administered on day 1 after 30 days relative to control1999Journal of natural products, Jun, Volume: 62, Issue:6
Structural considerations of NK109, an antitumor benzo[c]phenanthridine alkaloid.
AID379848Antitumor activity against mouse P388 cells xenografted CDF1 mouse at 50 mg/kg, iv administered on day 1 after 30 days relative to control1999Journal of natural products, Jun, Volume: 62, Issue:6
Structural considerations of NK109, an antitumor benzo[c]phenanthridine alkaloid.
AID39722Evaluated for percentage test/control (%T/C) in survival tumor system against B16 melanocarcinoma at dose 20 mg/Kg1984Journal of medicinal chemistry, Apr, Volume: 27, Issue:4
Synthesis and biological activity of structural analogues of the anticancer benzophenanthridine alkaloid nitidine chloride.
AID1236963Antiproliferative activity against human HL60 cells assessed as inhibition of cell viability after 48 hrs by WST-1 assay2015Bioorganic & medicinal chemistry letters, Jul-15, Volume: 25, Issue:14
Antiproliferative activity of O4-benzo[c]phenanthridine alkaloids against HCT-116 and HL-60 tumor cells.
AID600207Cytotoxicity against human HT-29 cells after 72 hrs by MTS assay2011European journal of medicinal chemistry, Jun, Volume: 46, Issue:6
Synthesis and biological evaluation of N-substituted benzo[c]phenanthrolines and benzo[c]phenanthrolinones as antiproliferative agents.
AID403283Antifungal activity against Saccharomyces cerevisiae assessed as 99.9 % growth inhibition after 18 hrs by zone-of-inhibition assay2004Journal of natural products, Jul, Volume: 67, Issue:7
Cytotoxic and antimicrobial constituents of the bark of Diospyros maritima collected in two geographical locations in Indonesia.
AID403280Antifungal activity against Cryptococcus neoformans after 18 hrs by zone-of-inhibition assay2004Journal of natural products, Jul, Volume: 67, Issue:7
Cytotoxic and antimicrobial constituents of the bark of Diospyros maritima collected in two geographical locations in Indonesia.
AID403298Antimicrobial activity against Candida albicans assessed as 99.9 % growth inhibition after 18 hrs by zone-of-inhibition assay2004Journal of natural products, Jul, Volume: 67, Issue:7
Cytotoxic and antimicrobial constituents of the bark of Diospyros maritima collected in two geographical locations in Indonesia.
AID248556In vitro inhibition against chloroquine-resistant Plasmodium falciparum V1/S; Range 0.1-0.4 uM2005Bioorganic & medicinal chemistry letters, Apr-15, Volume: 15, Issue:8
Antimalarial benzo[c]phenanthridines.
AID403273Antimicrobial activity against Staphylococcus aureus after 18 hrs by zone-of-inhibition assay2004Journal of natural products, Jul, Volume: 67, Issue:7
Cytotoxic and antimicrobial constituents of the bark of Diospyros maritima collected in two geographical locations in Indonesia.
AID397123Inhibition of HIV1 RT using poly A oligo(dT) template primer
AID397122Inhibition of HIV1 RT
AID1540637Inhibition of human DNA ligase 1 using 52-mer DNA/25-mer DNA/27-mer DNA as substrate by fluorescence assay2019European journal of medicinal chemistry, Nov-15, Volume: 182Recent advances in the targeting of human DNA ligase I as a potential new strategy for cancer treatment.
AID380930Inhibition of AMV reverse transcriptase assessed as [3H]TTP incorporation by toluene-based scintillation fluid counting in presence of 0.10 umole MnCl2
AID403285Antifungal activity against Aspergillus niger assessed as 99.9 % growth inhibition after 18 hrs by zone-of-inhibition assay2004Journal of natural products, Jul, Volume: 67, Issue:7
Cytotoxic and antimicrobial constituents of the bark of Diospyros maritima collected in two geographical locations in Indonesia.
AID248538In vitro inhibition against chloroquine-sensitive Plasmodium falciparum K39; Range 0.1-0.4 uM2005Bioorganic & medicinal chemistry letters, Apr-15, Volume: 15, Issue:8
Antimalarial benzo[c]phenanthridines.
AID403282Antifungal activity against Saccharomyces cerevisiae after 18 hrs by zone-of-inhibition assay2004Journal of natural products, Jul, Volume: 67, Issue:7
Cytotoxic and antimicrobial constituents of the bark of Diospyros maritima collected in two geographical locations in Indonesia.
AID247402Growth inhibitory activity against human cancer cell line in the NCI's anticancer drug screening program2005Journal of medicinal chemistry, Mar-10, Volume: 48, Issue:5
CHMIS-C: a comprehensive herbal medicine information system for cancer.
AID379849Antitumor activity against mouse P388 cells xenografted CDF1 mouse at 25 mg/kg, iv administered on day 1 after 30 days relative to control1999Journal of natural products, Jun, Volume: 62, Issue:6
Structural considerations of NK109, an antitumor benzo[c]phenanthridine alkaloid.
AID379274Inhibition of calf thymus DNA topoisomerase 1-mediated supercoiled pSP64 plasmid DNA relaxation at 20 uM2000Journal of natural products, Feb, Volume: 63, Issue:2
Isolation and biochemical characterization of a new topoisomerase I inhibitor from Ocotea leucoxylon.
AID1236961Cytotoxicity against human HepG2 cells2015Bioorganic & medicinal chemistry letters, Jul-15, Volume: 25, Issue:14
Antiproliferative activity of O4-benzo[c]phenanthridine alkaloids against HCT-116 and HL-60 tumor cells.
AID380917Inhibition of AMV reverse transcriptase assessed as [3H]dGTP incorporation at 5 ug by toluene-based scintillation fluid counting in presence of poly rC.oligo dG template primer
AID102056Compound was evaluated for the anticancer activity against M5076 sarcoma in mouse at a dosage of 100 mg/kg percent1985Journal of medicinal chemistry, Aug, Volume: 28, Issue:8
Synthesis and antitumor activity of structural analogues of the anticancer benzophenanthridine alkaloid fagaronine chloride.
AID379854Toxicity against mouse P388 cells xenografted CDF1 mouse assessed as survival time at 50 mg/kg, iv1999Journal of natural products, Jun, Volume: 62, Issue:6
Structural considerations of NK109, an antitumor benzo[c]phenanthridine alkaloid.
AID403281Antifungal activity against Cryptococcus neoformans assessed as 99.9 % growth inhibition after 18 hrs by zone-of-inhibition assay2004Journal of natural products, Jul, Volume: 67, Issue:7
Cytotoxic and antimicrobial constituents of the bark of Diospyros maritima collected in two geographical locations in Indonesia.
AID153602Evaluated for percentage test/control (%T/C) in survival tumor system against P388 lymphocytic leukemia1984Journal of medicinal chemistry, Apr, Volume: 27, Issue:4
Synthesis and biological activity of structural analogues of the anticancer benzophenanthridine alkaloid nitidine chloride.
AID397594Therapeutic index, ratio of cytotoxicity against human CEM-SS cells to EC50 for HIV1 RF2001Journal of natural products, Feb, Volume: 64, Issue:2
Natural product-based anti-HIV drug discovery and development facilitated by the NCI developmental therapeutics program.
AID379853Toxicity against mouse P388 cells xenografted CDF1 mouse assessed as survival time at 75 mg/kg, iv1999Journal of natural products, Jun, Volume: 62, Issue:6
Structural considerations of NK109, an antitumor benzo[c]phenanthridine alkaloid.
AID400992Inhibition of AMV reverse transcriptase activity assessed as incorporation of dGMP in poly(rC)-oligo(dG) at 100 uM
AID400984Inhibition of AMV reverse transcriptase activity assessed as incorporation of dTMP in poly(rA)-oligo(dT) at 0.1 uM
AID379845Growth inhibition of human HeLa S3 cells after 72 hrs1999Journal of natural products, Jun, Volume: 62, Issue:6
Structural considerations of NK109, an antitumor benzo[c]phenanthridine alkaloid.
AID403271Antimicrobial activity against Micrococcus luteus after 18 hrs by zone-of-inhibition assay2004Journal of natural products, Jul, Volume: 67, Issue:7
Cytotoxic and antimicrobial constituents of the bark of Diospyros maritima collected in two geographical locations in Indonesia.
AID338343Cytotoxicity against mouse B16 cells
AID403276Antimicrobial activity against Mycobacterium smegmatis assessed as 99.9 % growth inhibition after 18 hrs by zone-of-inhibition assay2004Journal of natural products, Jul, Volume: 67, Issue:7
Cytotoxic and antimicrobial constituents of the bark of Diospyros maritima collected in two geographical locations in Indonesia.
AID380929Inhibition of AMV reverse transcriptase assessed as [3H]TTP incorporation at 5 ug by toluene-based scintillation fluid counting in presence of 2 to 20 ug poly rA.oligo dT template primer
AID1698177Cytotoxicity against human T-cell assessed reduction in cell viability at 30 uM after 72 hrs
AID403279Antifungal activity against Candida albicans after 18 hrs by zone-of-inhibition assay2004Journal of natural products, Jul, Volume: 67, Issue:7
Cytotoxic and antimicrobial constituents of the bark of Diospyros maritima collected in two geographical locations in Indonesia.
AID397593Antiviral activity against HIV1 RF in human CEM-SS cells assessed as inhibition of virus-induced cytopathic effect2001Journal of natural products, Feb, Volume: 64, Issue:2
Natural product-based anti-HIV drug discovery and development facilitated by the NCI developmental therapeutics program.
AID400993Inhibition of AMV reverse transcriptase activity assessed as incorporation of dGMP in poly(rC)-oligo(dG) at 1000 uM
AID379855Toxicity against mouse P388 cells xenografted CDF1 mouse assessed as survival time at 25 mg/kg, iv1999Journal of natural products, Jun, Volume: 62, Issue:6
Structural considerations of NK109, an antitumor benzo[c]phenanthridine alkaloid.
AID600210Inhibition of human recombinant topoisomerase 1 assessed as cleavage of 117-mer DNA fragment at 0.5 to 5 uM using ethidium bromide staining by agarose gel electrophoresis analysis2011European journal of medicinal chemistry, Jun, Volume: 46, Issue:6
Synthesis and biological evaluation of N-substituted benzo[c]phenanthrolines and benzo[c]phenanthrolinones as antiproliferative agents.
AID600212Inhibition of human topoisomerase 2 assessed as formation of nicked form of supercoiled pUC19 DNA at 100 uM after 45 mins using ethidium bromide staining by SDS-PAGE analysis2011European journal of medicinal chemistry, Jun, Volume: 46, Issue:6
Synthesis and biological evaluation of N-substituted benzo[c]phenanthrolines and benzo[c]phenanthrolinones as antiproliferative agents.
AID380931Inhibition of AMV reverse transcriptase assessed as [3H]TTP incorporation by toluene-based scintillation fluid counting in presence of 0.50 umole MnCl2
AID403274Antimicrobial activity against Staphylococcus aureus assessed as 99.9 % growth inhibition after 18 hrs by zone-of-inhibition assay2004Journal of natural products, Jul, Volume: 67, Issue:7
Cytotoxic and antimicrobial constituents of the bark of Diospyros maritima collected in two geographical locations in Indonesia.
AID154052Percentage of treated /control was determined against P-388 leukemia in BDG1 mice, at a dose of 100 mg/kg1982Journal of medicinal chemistry, Nov, Volume: 25, Issue:11
Synthesis and biological activity of benzothiazolo- and benzoxazolo[3,2-a]quinolinium salts.
AID403272Antimicrobial activity against Micrococcus luteus assessed as 99.9 % growth inhibition after 18 hrs by zone-of-inhibition assay2004Journal of natural products, Jul, Volume: 67, Issue:7
Cytotoxic and antimicrobial constituents of the bark of Diospyros maritima collected in two geographical locations in Indonesia.
AID400988Inhibition of AMV reverse transcriptase activity assessed as incorporation of dTMP in poly(rA)-oligo(dT) at 1000 uM
AID380918Inhibition of reverse transcriptase from Rauscher murine leukemia virus propagated in JLS-V9 cells at 5 to 10 ug/ml
AID403284Antifungal activity against Aspergillus niger after 18 hrs by zone-of-inhibition assay2004Journal of natural products, Jul, Volume: 67, Issue:7
Cytotoxic and antimicrobial constituents of the bark of Diospyros maritima collected in two geographical locations in Indonesia.
AID400985Inhibition of AMV reverse transcriptase activity assessed as incorporation of dTMP in poly(rA)-oligo(dT) at 1 uM
AID403275Antimicrobial activity against Mycobacterium smegmatis after 18 hrs by zone-of-inhibition assay2004Journal of natural products, Jul, Volume: 67, Issue:7
Cytotoxic and antimicrobial constituents of the bark of Diospyros maritima collected in two geographical locations in Indonesia.
AID1236962Antiproliferative activity against human HCT116 cells assessed as inhibition of cell viability after 48 hrs by MTT assay2015Bioorganic & medicinal chemistry letters, Jul-15, Volume: 25, Issue:14
Antiproliferative activity of O4-benzo[c]phenanthridine alkaloids against HCT-116 and HL-60 tumor cells.
AID380935Inhibition of AMV reverse transcriptase assessed as [3H]TTP incorporation at 5 ug by toluene-based scintillation fluid counting in presence of template primer
AID600214Inhibition of human topoisomerase 2 assessed as formation of linear form of supercoiled pUC19 DNA at 100 uM after 45 mins using ethidium bromide staining by SDS-PAGE analysis2011European journal of medicinal chemistry, Jun, Volume: 46, Issue:6
Synthesis and biological evaluation of N-substituted benzo[c]phenanthrolines and benzo[c]phenanthrolinones as antiproliferative agents.
AID403278Antimicrobial activity against Mycobacterium avium assessed as 99.9 % growth inhibition after 18 hrs by zone-of-inhibition assay2004Journal of natural products, Jul, Volume: 67, Issue:7
Cytotoxic and antimicrobial constituents of the bark of Diospyros maritima collected in two geographical locations in Indonesia.
AID400986Inhibition of AMV reverse transcriptase activity assessed as incorporation of dTMP in poly(rA)-oligo(dT) at 10 uM
AID380919Inhibition of AMV reverse transcriptase at 40 to 50 ug/ml
AID400989Inhibition of AMV reverse transcriptase activity assessed as incorporation of dGMP in poly(rC)-oligo(dG) at 0.1 uM
AID93919Activity against L1210 was reported.1985Journal of medicinal chemistry, Aug, Volume: 28, Issue:8
Synthesis and antitumor activity of structural analogues of the anticancer benzophenanthridine alkaloid fagaronine chloride.
AID403277Antimicrobial activity against Mycobacterium avium after 18 hrs by zone-of-inhibition assay2004Journal of natural products, Jul, Volume: 67, Issue:7
Cytotoxic and antimicrobial constituents of the bark of Diospyros maritima collected in two geographical locations in Indonesia.
AID600205Binding affinity to calf thymus DNA at 20 uM by UV-vis spectrophotometry analysis2011European journal of medicinal chemistry, Jun, Volume: 46, Issue:6
Synthesis and biological evaluation of N-substituted benzo[c]phenanthrolines and benzo[c]phenanthrolinones as antiproliferative agents.
AID1794808Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL).2014Journal of biomolecular screening, Jul, Volume: 19, Issue:6
A High-Throughput Assay to Identify Inhibitors of the Apicoplast DNA Polymerase from Plasmodium falciparum.
AID1794808Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL).
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (15)

TimeframeStudies, This Drug (%)All Drugs %
pre-19903 (20.00)18.7374
1990's1 (6.67)18.2507
2000's5 (33.33)29.6817
2010's4 (26.67)24.3611
2020's2 (13.33)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 22.16

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index22.16 (24.57)
Research Supply Index3.04 (2.92)
Research Growth Index4.62 (4.65)
Search Engine Demand Index21.17 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (22.16)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews2 (10.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other18 (90.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
aristolochic acid i
aristolochic acid I: phospholipase A inhibitor. aristolochic acid A : An aristolochic acid that is phenanthrene-1-carboxylic acid that is substituted by a methylenedioxy group at the 3,4 positions, by a methoxy group at position 8, and by a nitro group at position 10. It is the most abundant of the aristolochic acids and is found in almost all Aristolochia (birthworts or pipevines) species. It has been tried in a number of treatments for inflammatory disorders, mainly in Chinese and folk medicine. However, there is concern over their use as aristolochic acid is both carcinogenic and nephrotoxic.		2.0210aristolochic acids;
aromatic ether;
C-nitro compound;
cyclic acetal;
monocarboxylic acid;
organic heterotetracyclic compound		carcinogenic agent;
metabolite;
mutagen;
nephrotoxin;
toxin
emodin
Emodin: Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as a laxative, but is now used mainly as a tool in toxicity studies.. emodin : A trihydroxyanthraquinone that is 9,10-anthraquinone which is substituted by hydroxy groups at positions 1, 3, and 8 and by a methyl group at position 6. It is present in the roots and barks of numerous plants (particularly rhubarb and buckthorn), moulds, and lichens. It is an active ingredient of various Chinese herbs.		2.0210trihydroxyanthraquinoneantineoplastic agent;
laxative;
plant metabolite;
tyrosine kinase inhibitor
colchicine
(S)-colchicine : A colchicine that has (S)-configuration. It is a secondary metabolite, has anti-inflammatory properties and is used to treat gout, crystal-induced joint inflammation, familial Mediterranean fever, and many other conditions.		2.0210alkaloid;
colchicine		anti-inflammatory agent;
gout suppressant;
mutagen
plumbagin
plumbagin: a superoxide anion generator. plumbagin : A hydroxy-1,4-naphthoquinone that is 1,4-naphthoquinone in which the hydrogens at positions 2 and 5 are substituted by methyl and hydroxy groups, respectively.		2.0210hydroxy-1,4-naphthoquinone;
phenols		anticoagulant;
antineoplastic agent;
immunological adjuvant;
metabolite
oleanolic acid
[no description available]		3.3110hydroxy monocarboxylic acid;
pentacyclic triterpenoid		plant metabolite
podophyllotoxin
Podophyllum: A genus of poisonous American herbs, family BERBERIDACEAE. The roots yield PODOPHYLLOTOXIN and other pharmacologically important agents. The plant was formerly used as a cholagogue and cathartic. It is different from the European mandrake, MANDRAGORA.		2.0210furonaphthodioxole;
lignan;
organic heterotetracyclic compound		antimitotic;
antineoplastic agent;
keratolytic drug;
microtubule-destabilising agent;
plant metabolite;
tubulin modulator
stavudine
Stavudine: A dideoxynucleoside analog that inhibits reverse transcriptase and has in vitro activity against HIV.. stavudine : A nucleoside analogue obtained by formal dehydration across positions 2 and 3 of thymidine. An inhibitor of HIV-1 reverse transcriptase		3.110dihydrofuran;
nucleoside analogue;
organic molecular entity		antimetabolite;
antiviral agent;
EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor
zalcitabine
Zalcitabine: A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication at low concentrations, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal toxic side effect is axonal degeneration resulting in peripheral neuropathy.. zalcitabine : A pyrimidine 2',3'-dideoxyribonucleoside compound having cytosine as the nucleobase.		3.110pyrimidine 2',3'-dideoxyribonucleosideantimetabolite;
antiviral drug;
HIV-1 reverse transcriptase inhibitor
camptothecin
NSC 100880: carboxylate (opened lactone) form of camptothecin; RN refers to (S)-isomer; structure given in first source		2.9440delta-lactone;
pyranoindolizinoquinoline;
quinoline alkaloid;
tertiary alcohol		antineoplastic agent;
EC 5.99.1.2 (DNA topoisomerase) inhibitor;
genotoxin;
plant metabolite
7-methyljuglone
7-methyljuglone: antineoplastic from roots of Euclea natalensis and Drosera aliciae; structure in first source		2.0210hydroxy-1,4-naphthoquinone
nigericin
Nigericin: A polyether antibiotic which affects ion transport and ATPase activity in mitochondria. It is produced by Streptomyces hygroscopicus. (From Merck Index, 11th ed). nigericin : A polyether antibiotic which affects ion transport and ATPase activity in mitochondria. It is produced by Streptomyces hygroscopicus.		3.110polycyclic etherantibacterial agent;
antimicrobial agent;
bacterial metabolite;
potassium ionophore
zidovudine
Zidovudine: A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse transcription. It improves immunologic function, partially reverses the HIV-induced neurological dysfunction, and improves certain other clinical abnormalities associated with AIDS. Its principal toxic effect is dose-dependent suppression of bone marrow, resulting in anemia and leukopenia.. zidovudine : A pyrimidine 2',3'-dideoxyribonucleoside compound having a 3'-azido substituent and thymine as the nucleobase.		3.110azide;
pyrimidine 2',3'-dideoxyribonucleoside		antimetabolite;
antiviral drug;
HIV-1 reverse transcriptase inhibitor
paclitaxel
Taxus: Genus of coniferous yew trees or shrubs, several species of which have medicinal uses. Notable is the Pacific yew, Taxus brevifolia, which is used to make the anti-neoplastic drug taxol (PACLITAXEL).		2.0210taxane diterpenoid;
tetracyclic diterpenoid		antineoplastic agent;
human metabolite;
metabolite;
microtubule-stabilising agent
etoposide
[no description available]		2.0610beta-D-glucoside;
furonaphthodioxole;
organic heterotetracyclic compound		antineoplastic agent;
DNA synthesis inhibitor
lamivudine
[no description available]		3.110monothioacetal;
nucleoside analogue;
oxacycle;
primary alcohol		allergen;
anti-HBV agent;
antiviral drug;
EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor;
HIV-1 reverse transcriptase inhibitor;
prodrug
kynostatin 272
kynostatin 272: structure given in first source; contains allophenylnorstatine as a transition-state mimic		3.110peptide
ursolic acid
[no description available]		3.3110hydroxy monocarboxylic acid;
pentacyclic triterpenoid		geroprotector;
plant metabolite
calanolide a
calanolide A: NSC 661122 and costatolide are isomers; a novel HIV-inhibitory class of coumarin derivatives from the tropical rainforest tree, Calophyllum lanigerum (Clusiaceae); structure in first source. (+)-calanolide A : An organic heterotetracyclic compound that is 11,12-dihydro-2H,6H,10H-dipyrano[2,3-f:2',3'-h]chromen-2-one substituted by a hydroxy group at position 12, methyl groups at positions 6, 6, 10 and 11 and a propyl group at position 4 (the 10R,11S,12S stereoisomer). Isolated from Calophyllum lanigerum var austrocoriaceum and Calophyllum brasiliense, it exhibits potent activity against HIV-1 reverse transcriptase.		3.110cyclic ether;
delta-lactone;
organic heterotetracyclic compound;
secondary alcohol		HIV-1 reverse transcriptase inhibitor;
plant metabolite
kynostatin 227
kynostatin 227: structure given in first source; contains allophenylnorstatine as a transition-state mimic		3.110
sanguinarine chloride
[no description available]		210
lodenosine
lodenosine: anti-HIV nucleoside analog, the flourine atom on lodenosine is located at 2-arabinoside location, while 2'-fluoro-2',3'-dideoxyadenosine has the flourine residue at the 2-ribose sugar location		3.110
chelerythrine chloride
[no description available]		2.7230
coptisine
coptisine: RN given refers to parent cpd		2.0210alkaloidmetabolite
betulin
betulin: isolated from various white birch bark (BETULA). betulin : A pentacyclic triterpenoid that is lupane having a double bond at position 20(29) as well as 3beta-hydroxy and 28-hydroxymethyl substituents.		2.0210diol;
pentacyclic triterpenoid		analgesic;
anti-inflammatory agent;
antineoplastic agent;
antiviral agent;
metabolite
narciclasine
narciclasine: antitumor alkaloid from bulbs of Narcissus species		2.0210phenanthridinesmetabolite
tetrandrine
tetrandrine: a bisbenzylisoquinoline that exhibits antifibrogenic activity		2.0210bisbenzylisoquinoline alkaloid;
isoquinolines
eburicoic acid
eburicoic acid: structure		2.0210
dihydronitidine
dihydronitidine: molecular structure given in first source		2.1110
dicentrine
dicentrine: structure given in first source; RN refers to (S)-isomer		210aporphine alkaloid
maprounic acid
maprounic acid: from Maprounea africana; structure given in first source. maprounic acid : A pentacyclic triterpenoid isolated from Maprounea africana and has been shown to exhibit inhibitory activity against HIV-1 reverse transcriptase.		3.3110hydroxy monocarboxylic acid;
pentacyclic triterpenoid		HIV-1 reverse transcriptase inhibitor;
plant metabolite
dicentrinone
dicentrinone: from Ocotea leucoxylon; structure in first source		210
lupeol
[no description available]		2.0210pentacyclic triterpenoid;
secondary alcohol		anti-inflammatory drug;
plant metabolite
homoharringtonine
Homoharringtonine: Semisynthetic derivative of harringtonine that acts as a protein synthesis inhibitor and induces APOPTOSIS in tumor cells. It is used in the treatment of MYELOID LEUKEMIA, CHRONIC.. omacetaxine mepesuccinate : A cephalotaxine-derived alkaloid ester obtained from Cephalotaxus harringtonia; used for the treatment of chronic or accelerated phase chronic myeloid leukaemia.		2.0210alkaloid ester;
enol ether;
organic heteropentacyclic compound;
tertiary alcohol		anticoronaviral agent;
antineoplastic agent;
apoptosis inducer;
protein synthesis inhibitor
retinol
Vitamin A: Retinol and derivatives of retinol that play an essential role in metabolic functioning of the retina, the growth of and differentiation of epithelial tissue, the growth of bone, reproduction, and the immune response. Dietary vitamin A is derived from a variety of CAROTENOIDS found in plants. It is enriched in the liver, egg yolks, and the fat component of dairy products.. vitamin A : Any member of a group of fat-soluble retinoids produced via metabolism of provitamin A carotenoids that exhibit biological activity against vitamin A deficiency. Vitamin A is involved in immune function, vision, reproduction, and cellular communication.. all-trans-retinol : A retinol in which all four exocyclic double bonds have E- (trans-) geometry.. retinol : A retinoid consisting of 3,7-dimethylnona-2,4,6,8-tetraen-1-ol substituted at position 9 by a 2,6,6-trimethylcyclohex-1-en-1-yl group (geometry of the four exocyclic double bonds is not specified).		2.0210retinol;
vitamin A		human metabolite;
mouse metabolite;
plant metabolite
oleic acid
Oleic Acid: An unsaturated fatty acid that is the most widely distributed and abundant fatty acid in nature. It is used commercially in the preparation of oleates and lotions, and as a pharmaceutical solvent. (Stedman, 26th ed). oleic acid : An octadec-9-enoic acid in which the double bond at C-9 has Z (cis) stereochemistry.		2.0210octadec-9-enoic acidantioxidant;
Daphnia galeata metabolite;
EC 3.1.1.1 (carboxylesterase) inhibitor;
Escherichia coli metabolite;
mouse metabolite;
plant metabolite;
solvent
12-deoxyphorbol 13-acetate
[no description available]		3.110phorbol estermetabolite
michellamine c
michellamine A: atropisomeric naphthylisoquinoline anti-HIV cytopathic alkaloid dimers; from tropical plant Ancistrocladus abbreviatus; structure given in first source. michellamine A : A dimeric isoquinoline alkaloid isolated from Ancistrocladus abbreviatus and has been shown to exhibit anti-HIV activity.		3.110
costatolide
(-)-calanolide B : An organic heterotetracyclic compound that is 11,12-dihydro-2H,6H,10H-dipyrano[2,3-f:2',3'-h]chromen-2-one substituted by a hydroxy group at position 12, methyl groups at positions 6, 6, 10 and 11 and a propyl group at position 4 (the 10S,11R,12S stereoisomer). Isolated from Calophyllum lanigerum var austrocoriaceum and Calophyllum brasiliense, it exhibits potent activity against HIV-1 reverse transcriptase.		3.110cyclic ether;
delta-lactone;
organic heterotetracyclic compound;
secondary alcohol		HIV-1 reverse transcriptase inhibitor;
plant metabolite
dihydrochelerythrine
dihydrochelerythrine: trypanocidal and antileishmanial dihydrochelerythrine derivative from Garcinia lucida; structure in first source		2.1110benzophenanthridine alkaloid
8,8'-biplumbagin
8,8'-biplumbagin: structure given in first source; isolated from the Bolivian plant Pera benesis		2.0210
scopoletin
[no description available]		2.0210hydroxycoumarinplant growth regulator;
plant metabolite
apigetrin
apigetrin: structure given in first source. apigenin 7-O-beta-D-glucoside : A glycosyloxyflavone that is apigenin substituted by a beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage.		2.0210beta-D-glucoside;
dihydroxyflavone;
glycosyloxyflavone;
monosaccharide derivative		antibacterial agent;
metabolite;
non-steroidal anti-inflammatory drug
fulvoplumierin
fulvoplumierin: structure		3.3110carbonyl compound;
pyrans
morin
morin: a light yellowish pigment found in the wood of old fustic (Chlorophora tinctoria). morin : A pentahydroxyflavone that is 7-hydroxyflavonol bearing three additional hydroxy substituents at positions 2' 4' and 5.		3.31107-hydroxyflavonol;
pentahydroxyflavone		angiogenesis modulating agent;
anti-inflammatory agent;
antibacterial agent;
antihypertensive agent;
antineoplastic agent;
antioxidant;
EC 5.99.1.2 (DNA topoisomerase) inhibitor;
hepatoprotective agent;
metabolite;
neuroprotective agent
myricetin
[no description available]		3.31107-hydroxyflavonol;
hexahydroxyflavone		antineoplastic agent;
antioxidant;
cyclooxygenase 1 inhibitor;
food component;
geroprotector;
hypoglycemic agent;
plant metabolite
ellagic acid
[no description available]		2.0210catechols;
cyclic ketone;
lactone;
organic heterotetracyclic compound;
polyphenol		antioxidant;
EC 1.14.18.1 (tyrosinase) inhibitor;
EC 2.3.1.5 (arylamine N-acetyltransferase) inhibitor;
EC 2.4.1.1 (glycogen phosphorylase) inhibitor;
EC 2.5.1.18 (glutathione transferase) inhibitor;
EC 2.7.1.127 (inositol-trisphosphate 3-kinase) inhibitor;
EC 2.7.1.151 (inositol-polyphosphate multikinase) inhibitor;
EC 2.7.4.6 (nucleoside-diphosphate kinase) inhibitor;
EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor;
EC 5.99.1.2 (DNA topoisomerase) inhibitor;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
food additive;
fungal metabolite;
geroprotector;
plant metabolite;
skin lightening agent
fumarprotocetraric acid
fumarprotocetraric acid: RN given refers to (E)-isomer; structure given in first source		3.110carbonyl compound
guttiferone a
guttiferone A: antibacterial from Clusiaceae family; structure in first source		3.110
pepstatin
pepstatin: inhibits the aspartic protease endothiapepsin		3.110pentapeptide;
secondary carboxamide		bacterial metabolite;
EC 3.4.23.* (aspartic endopeptidase) inhibitor
indigo carmine
3,5-di-O-(E)-caffeoylquinic acid: from roots of Lychnophora ericoides; structure in first source. 3,5-di-O-caffeoyl quinic acid : A carboxylic ester that is the diester obtained by the condensation of the hydroxy groups at positions 3 and 5 of (-)-quinic acid with the carboxy group of trans-caffeic acid. Isolated from Brazilian propolis and Suaeda glauca, it exhibits hepatoprotective and cytotoxic activities.		3.110
didanosine
Didanosine: A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. Didanosine is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase; ddI is then metabolized to dideoxyadenosine triphosphate, its putative active metabolite.. didanosine : A purine 2',3'-dideoxyribonucleoside that is inosine in which the hydroxy groups at both the 2' and the 3' positions on the sugar moiety have been replaced by hydrogen. An antiviral drug, it is used as a medication to treat HIV/AIDS.		3.110purine 2',3'-dideoxyribonucleosideantimetabolite;
antiviral drug;
EC 2.4.2.1 (purine-nucleoside phosphorylase) inhibitor;
geroprotector;
HIV-1 reverse transcriptase inhibitor
conocurvone
conocurvone: a trimeric naphthoquinone derivative; extracted from Conospermum incurvum; structure given in first source		3.110organic heterotricyclic compound;
organooxygen compound
ConditionIndicatedRelationship StrengthStudiesTrials
Leukemia P388
An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.		02.6630
Carcinoma, Anaplastic
[description not available]		01.9610
Cancer of Mouth
[description not available]		01.9610
Experimental Neoplasms
[description not available]		01.9610
Carcinoma
A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm and not a synonym for cancer.		01.9610
Mouth Neoplasms
Tumors or cancer of the MOUTH.		01.9610
Carcinoma, Ehrlich Tumor
A transplantable, poorly differentiated malignant tumor which appeared originally as a spontaneous breast carcinoma in a mouse. It grows in both solid and ascitic forms.		01.9610
Benign Neoplasms
[description not available]		03.3920
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		03.3920
Plasmodium falciparum Malaria
[description not available]		02.110
Malaria, Falciparum
Malaria caused by PLASMODIUM FALCIPARUM. This is the severest form of malaria and is associated with the highest levels of parasites in the blood. This disease is characterized by irregularly recurring febrile paroxysms that in extreme cases occur with acute cerebral, renal, or gastrointestinal manifestations.		02.110