Compounds > 3 beta-o-acetylursolic acid
Page last updated: 2024-12-11

3 beta-o-acetylursolic acid

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID6475119
CHEMBL ID410525
CHEBI ID175831
SCHEMBL ID10951133
MeSH IDM0467616

Synonyms (21)

Synonym
(1s,2r,4as,6ar,6as,6br,8ar,10s,12ar,14bs)-10-acetyloxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1h-picene-4a-carboxylic acid
CHEBI:175831
(1s,2r,4as,6ar,6as,6br,8ar,10s,12ar,14bs)-10-acetoxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1h-picene-4a-carboxylic acid
ursolic acid acetate
MLS000728570
smr000445682
3-acetylursolic acid
3beta-o-acetylursolic acid
o-acetylursolic acid
CHEMBL410525 ,
NCGC00247636-01
bdbm50346610
AKOS016036256
SCHEMBL10951133
3-o-acetylursolic acid
mfcd09752431
3-(acetyloxy)urs-12-en-28-oic acid
DTXSID40994595
CS-0023373
HY-N2815
A1-34641
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
triterpenoidAny terpenoid derived from a triterpene. The term includes compounds in which the C30 skeleton of the parent triterpene has been rearranged or modified by the removal of one or more skeletal atoms (generally methyl groups).
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (8)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASEHomo sapiens (human)Potency19.95260.003245.467312,589.2998AID2517
Chain A, ATP-DEPENDENT DNA HELICASE Q1Homo sapiens (human)Potency0.56230.125919.1169125.8920AID2549
nonstructural protein 1Influenza A virus (A/WSN/1933(H1N1))Potency3.98110.28189.721235.4813AID2326
DNA polymerase betaHomo sapiens (human)Potency39.81070.022421.010289.1251AID485314
nuclear receptor ROR-gamma isoform 1Mus musculus (house mouse)Potency0.35480.00798.23321,122.0200AID2551
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Glycogen phosphorylase, muscle formOryctolagus cuniculus (rabbit)IC50 (µMol)131.41300.01405.93249.0000AID603224
Tyrosyl-DNA phosphodiesterase 1Homo sapiens (human)IC50 (µMol)100.00000.01203.32138.4300AID1662670
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Activation Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
streptokinase A precursorStreptococcus pyogenes M1 GASEC50 (µMol)2.82800.06008.9128130.5170AID1902
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (3)

Processvia Protein(s)Taxonomy
single strand break repairTyrosyl-DNA phosphodiesterase 1Homo sapiens (human)
DNA repairTyrosyl-DNA phosphodiesterase 1Homo sapiens (human)
double-strand break repairTyrosyl-DNA phosphodiesterase 1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (5)

Processvia Protein(s)Taxonomy
double-stranded DNA bindingTyrosyl-DNA phosphodiesterase 1Homo sapiens (human)
single-stranded DNA bindingTyrosyl-DNA phosphodiesterase 1Homo sapiens (human)
exonuclease activityTyrosyl-DNA phosphodiesterase 1Homo sapiens (human)
protein bindingTyrosyl-DNA phosphodiesterase 1Homo sapiens (human)
3'-tyrosyl-DNA phosphodiesterase activityTyrosyl-DNA phosphodiesterase 1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (5)

Processvia Protein(s)Taxonomy
nucleoplasmTyrosyl-DNA phosphodiesterase 1Homo sapiens (human)
cytoplasmTyrosyl-DNA phosphodiesterase 1Homo sapiens (human)
plasma membraneTyrosyl-DNA phosphodiesterase 1Homo sapiens (human)
intracellular membrane-bounded organelleTyrosyl-DNA phosphodiesterase 1Homo sapiens (human)
nucleusTyrosyl-DNA phosphodiesterase 1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (36)

Assay IDTitleYearJournalArticle
AID691857Cytotoxicity against human HT-29 cells incubated for 48 hrs by MTT assay2011Bioorganic & medicinal chemistry, Jul-01, Volume: 19, Issue:13
Synthesis of [3β-acetoxy-urs-12-en-28-oyl]-1-monoglyceride and investigation on its anti tumor effects against BGC-823.
AID346797Antiproliferative activity against human HeLa cells at 10 uM after 96 hrs by MTT assay2009Bioorganic & medicinal chemistry, Jan-15, Volume: 17, Issue:2
The synthesis of ursolic acid derivatives with cytotoxic activity and the investigation of their preliminary mechanism of action.
AID333388Antitrypanosomal activity against Trypanosoma brucei S427 by microdilution method2004Journal of natural products, Oct, Volume: 67, Issue:10
Triterpenoids from Brazilian Ilex species and their in vitro antitrypanosomal activity.
AID1662672Cytotoxicity against human A549 cells assessed as growth inhibition after 72 hrs by MTT assay2020Bioorganic & medicinal chemistry, 06-01, Volume: 28, Issue:11
Secondary metabolites from Isodon ternifolius (D. Don) Kudo and their anticancer activity as DNA topoisomerase IB and Tyrosyl-DNA phosphodiesterase 1 inhibitors.
AID452564Cytotoxicity against human NTUB1 cells after 72 hrs by MTT assay2009Bioorganic & medicinal chemistry, Oct-15, Volume: 17, Issue:20
Ursolic acid derivatives induce cell cycle arrest and apoptosis in NTUB1 cells associated with reactive oxygen species.
AID346957Antiproliferative activity against human BGC823 cells after 96 hrs by MTT assay2009Bioorganic & medicinal chemistry, Jan-15, Volume: 17, Issue:2
The synthesis of ursolic acid derivatives with cytotoxic activity and the investigation of their preliminary mechanism of action.
AID364070Inhibition of aromatase2008European journal of medicinal chemistry, Sep, Volume: 43, Issue:9
Evaluation of ursolic acid isolated from Ilex paraguariensis and derivatives on aromatase inhibition.
AID689291Cytotoxicity against human AsPC1 cells after 72 hrs by MTT assay2012Bioorganic & medicinal chemistry, Oct-01, Volume: 20, Issue:19
Synthesis of novel ursolic acid heterocyclic derivatives with improved abilities of antiproliferation and induction of p53, p21waf1 and NOXA in pancreatic cancer cells.
AID691860Cytotoxicity against human GES-1 cells incubated for 48 hrs by MTT assay2011Bioorganic & medicinal chemistry, Jul-01, Volume: 19, Issue:13
Synthesis of [3β-acetoxy-urs-12-en-28-oyl]-1-monoglyceride and investigation on its anti tumor effects against BGC-823.
AID691859Cytotoxicity against human BGC823 cells by MTT assay2011Bioorganic & medicinal chemistry, Jul-01, Volume: 19, Issue:13
Synthesis of [3β-acetoxy-urs-12-en-28-oyl]-1-monoglyceride and investigation on its anti tumor effects against BGC-823.
AID333387Antitrypanosomal activity against Trypanosoma cruzi Tulahuen CL2 by microdilution method2004Journal of natural products, Oct, Volume: 67, Issue:10
Triterpenoids from Brazilian Ilex species and their in vitro antitrypanosomal activity.
AID1662671Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay2020Bioorganic & medicinal chemistry, 06-01, Volume: 28, Issue:11
Secondary metabolites from Isodon ternifolius (D. Don) Kudo and their anticancer activity as DNA topoisomerase IB and Tyrosyl-DNA phosphodiesterase 1 inhibitors.
AID1153780Inhibition of TPH-1-mediated serotonin biosynthesis in rat RBL2H3 cells at 10 uM after 48 hrs by RP-HPLC analysis relative to control2014Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11
Tryptophan hydroxylase 1 (Tph-1)-targeted bone anabolic agents for osteoporosis.
AID1153782Cytotoxicity against rat RBL2H3 cells by MTT assay2014Journal of medicinal chemistry, Jun-12, Volume: 57, Issue:11
Tryptophan hydroxylase 1 (Tph-1)-targeted bone anabolic agents for osteoporosis.
AID1888106Cytotoxicity against human HeLa cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay2022European journal of medicinal chemistry, Jan-05, Volume: 227Discovery and radiosensitization research of ursolic acid derivatives as SENP1 inhibitors.
AID1370899Selectivity index, ratio of CC50 for human HepG2 cells to IC50 for chloroquine-resistant Plasmodium falciparum W2
AID320719Inhibition of beta-hematin formation at 1 to 20 mM2008Bioorganic & medicinal chemistry, Jan-15, Volume: 16, Issue:2
Pharmacomodulation on the 3-acetylursolic acid skeleton: Design, synthesis, and biological evaluation of novel N-{3-[4-(3-aminopropyl)piperazinyl]propyl}-3-O-acetylursolamide derivatives as antimalarial agents.
AID691858Cytotoxicity against human HepG2 cells incubated for 48 hrs by MTT assay2011Bioorganic & medicinal chemistry, Jul-01, Volume: 19, Issue:13
Synthesis of [3β-acetoxy-urs-12-en-28-oyl]-1-monoglyceride and investigation on its anti tumor effects against BGC-823.
AID1888104Inhibition of recombinant human SENP1 catalytic domain at 2 uM using RanGAP1 as substrate preincubated for 10 mins followed by substrate addition and measured after 30 mins by Western blot analysis relative to control2022European journal of medicinal chemistry, Jan-05, Volume: 227Discovery and radiosensitization research of ursolic acid derivatives as SENP1 inhibitors.
AID1662670Inhibition of TDP1 (unknown origin) expressed in Escherichia coli BL21 (DE3) using 5'-FAM-AGGATCTAAAAGACTT-BHQ-3' as substrate preincubated for 30 mins followed by substrate addition by fluorescence assay2020Bioorganic & medicinal chemistry, 06-01, Volume: 28, Issue:11
Secondary metabolites from Isodon ternifolius (D. Don) Kudo and their anticancer activity as DNA topoisomerase IB and Tyrosyl-DNA phosphodiesterase 1 inhibitors.
AID1662669Inhibition of calf thymus Top1 assessed as reduction in supercoiled pBR322 DNA relaxation at 100 uM measured after 30 mins by agarose gel electrophoresis relative to camptothecin2020Bioorganic & medicinal chemistry, 06-01, Volume: 28, Issue:11
Secondary metabolites from Isodon ternifolius (D. Don) Kudo and their anticancer activity as DNA topoisomerase IB and Tyrosyl-DNA phosphodiesterase 1 inhibitors.
AID1370897Cytotoxicity against African green monkey Vero cells after 72 hrs by MTT assay
AID346800Antiproliferative activity against human HeLa cells after 96 hrs by MTT assay2009Bioorganic & medicinal chemistry, Jan-15, Volume: 17, Issue:2
The synthesis of ursolic acid derivatives with cytotoxic activity and the investigation of their preliminary mechanism of action.
AID1604321Antiparasitic activity against Toxoplasma gondii2019European journal of medicinal chemistry, Dec-01, Volume: 183Recent progress on anti-Toxoplasma drugs discovery: Design, synthesis and screening.
AID320712Antimalarial activity against chloroquine-resistant Plasmodium falciparum FcB1 after 24 hrs2008Bioorganic & medicinal chemistry, Jan-15, Volume: 16, Issue:2
Pharmacomodulation on the 3-acetylursolic acid skeleton: Design, synthesis, and biological evaluation of novel N-{3-[4-(3-aminopropyl)piperazinyl]propyl}-3-O-acetylursolamide derivatives as antimalarial agents.
AID603224Inhibition of rabbit muscle glycogen phosphorylase A assessed as release of phosphate from glucose-1-phosphate after 25 mins by microplate reader based method2011European journal of medicinal chemistry, Jun, Volume: 46, Issue:6
Identification of pentacyclic triterpenes derivatives as potent inhibitors against glycogen phosphorylase based on 3D-QSAR studies.
AID1662673Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by MTT assay2020Bioorganic & medicinal chemistry, 06-01, Volume: 28, Issue:11
Secondary metabolites from Isodon ternifolius (D. Don) Kudo and their anticancer activity as DNA topoisomerase IB and Tyrosyl-DNA phosphodiesterase 1 inhibitors.
AID346799Antiproliferative activity against human BGC823 cells at 10 uM after 96 hrs by MTT assay2009Bioorganic & medicinal chemistry, Jan-15, Volume: 17, Issue:2
The synthesis of ursolic acid derivatives with cytotoxic activity and the investigation of their preliminary mechanism of action.
AID1370896Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human erythrocytes
AID1662676Inhibition of TDP1 (unknown origin) expressed in Escherichia coli BL21 (DE3) at 100 uM using 5'-FAM-AGGATCTAAAAGACTT-BHQ-3' as substrate preincubated for 30 mins followed by substrate addition by fluorescence assay relative to control2020Bioorganic & medicinal chemistry, 06-01, Volume: 28, Issue:11
Secondary metabolites from Isodon ternifolius (D. Don) Kudo and their anticancer activity as DNA topoisomerase IB and Tyrosyl-DNA phosphodiesterase 1 inhibitors.
AID1370898Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay
AID346801Antiproliferative activity against human SKOV3 cells after 96 hrs by MTT assay2009Bioorganic & medicinal chemistry, Jan-15, Volume: 17, Issue:2
The synthesis of ursolic acid derivatives with cytotoxic activity and the investigation of their preliminary mechanism of action.
AID346798Antiproliferative activity against human SKOV3 cells at 10 uM after 96 hrs by MTT assay2009Bioorganic & medicinal chemistry, Jan-15, Volume: 17, Issue:2
The synthesis of ursolic acid derivatives with cytotoxic activity and the investigation of their preliminary mechanism of action.
AID1295390Antiplasmodial activity against Plasmodium falciparum Dd2 incubated under low oxygen conditions after 72 hrs by SYBR green assay2016Bioorganic & medicinal chemistry, 06-01, Volume: 24, Issue:11
Antiplasmodial phloroglucinol derivatives from Syncarpia glomulifera.
AID504810Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID504812Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (15)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (33.33)29.6817
2010's8 (53.33)24.3611
2020's2 (13.33)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.82

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.82 (24.57)
Research Supply Index2.77 (2.92)
Research Growth Index4.59 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.82)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (6.67%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other14 (93.33%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
chloroquine
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.. chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.		2.0410aminoquinoline;
organochlorine compound;
secondary amino compound;
tertiary amino compound		anticoronaviral agent;
antimalarial;
antirheumatic drug;
autophagy inhibitor;
dermatologic drug
hydroxyzine
Hydroxyzine: A histamine H1 receptor antagonist that is effective in the treatment of chronic urticaria, dermatitis, and histamine-mediated pruritus. Unlike its major metabolite CETIRIZINE, it does cause drowsiness. It is also effective as an antiemetic, for relief of anxiety and tension, and as a sedative.. hydroxyzine : A N-alkylpiperazine that is piperzine in which the nitrogens atoms are substituted by 2-(2-hydroxyethoxy)ethyl and (4-chlorophenyl)(phenyl)methyl groups respectively.		3.3110hydroxyether;
monochlorobenzenes;
N-alkylpiperazine		anticoronaviral agent;
antipruritic drug;
anxiolytic drug;
dermatologic drug;
H1-receptor antagonist
niclosamide
Niclosamide: An antihelmintic that is active against most tapeworms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p48). niclosamide : A secondary carboxamide resulting from the formal condensation of the carboxy group of 5-chlorosalicylic acid with the amino group of 2-chloro-4-nitroaniline. It is an oral anthelmintic drug approved for use against tapeworm infections.		3.3110benzamides;
C-nitro compound;
monochlorobenzenes;
salicylanilides;
secondary carboxamide		anthelminthic drug;
anticoronaviral agent;
antiparasitic agent;
apoptosis inducer;
molluscicide;
piscicide;
STAT3 inhibitor
oleanolic acid
[no description available]		4.1240hydroxy monocarboxylic acid;
pentacyclic triterpenoid		plant metabolite
formestane
[no description available]		2.041017-oxo steroid;
3-oxo-Delta(4) steroid;
enol;
hydroxy steroid		antineoplastic agent;
EC 1.14.14.14 (aromatase) inhibitor
camptothecin
NSC 100880: carboxylate (opened lactone) form of camptothecin; RN refers to (S)-isomer; structure given in first source		2.2510delta-lactone;
pyranoindolizinoquinoline;
quinoline alkaloid;
tertiary alcohol		antineoplastic agent;
EC 5.99.1.2 (DNA topoisomerase) inhibitor;
genotoxin;
plant metabolite
paclitaxel
Taxus: Genus of coniferous yew trees or shrubs, several species of which have medicinal uses. Notable is the Pacific yew, Taxus brevifolia, which is used to make the anti-neoplastic drug taxol (PACLITAXEL).		2.7430taxane diterpenoid;
tetracyclic diterpenoid		antineoplastic agent;
human metabolite;
metabolite;
microtubule-stabilising agent
ursolic acid
[no description available]		5.04120hydroxy monocarboxylic acid;
pentacyclic triterpenoid		geroprotector;
plant metabolite
betulinic acid
[no description available]		2.4920hydroxy monocarboxylic acid;
pentacyclic triterpenoid		anti-HIV agent;
anti-inflammatory agent;
antimalarial;
antineoplastic agent;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
plant metabolite
artemisinin
(+)-artemisinin : A sesquiterpene lactone obtained from sweet wormwood, Artemisia annua, which is used as an antimalarial for the treatment of multi-drug resistant strains of falciparum malaria.		2.1310organic peroxide;
sesquiterpene lactone		antimalarial;
plant metabolite
buparvaquone
buparvaquone: used in therapy of theileriasis; structure given in first source		3.3110
betulin
betulin: isolated from various white birch bark (BETULA). betulin : A pentacyclic triterpenoid that is lupane having a double bond at position 20(29) as well as 3beta-hydroxy and 28-hydroxymethyl substituents.		2.0610diol;
pentacyclic triterpenoid		analgesic;
anti-inflammatory agent;
antineoplastic agent;
antiviral agent;
metabolite
arjunolic acid
arjunolic acid: oleanane type; isol from Cochlospermum tinctorium (Bixaceae); structure given in first source; RN given refers to (2alpha,3beta,4alpha)-isomer; RN for cpd without isomeric designation not avail 12/89. arjunolic acid : A pentacyclic triterpenoid that is olean-12-en-28-oic acid substituted by hydroxy groups at positions 2, 3 and 23 (the 2alpha,3beta stereoisomer). Isolated from Symplocos lancifolia and Juglans sinensis, it exhibits antioxidant and antimicrobial activities.		2.0610hydroxy monocarboxylic acid;
pentacyclic triterpenoid		antibacterial agent;
antifungal agent;
antioxidant;
metabolite
maslinic acid
(2Alpha,3beta)-2,3-dihydroxyolean-12-en-28-oic acid: from Luehea divaricata and Agrimonia eupatoria		2.0610dihydroxy monocarboxylic acid;
pentacyclic triterpenoid		anti-inflammatory agent;
antineoplastic agent;
antioxidant;
plant metabolite
chloroquine diphosphate
[no description available]		2.0410
uvaol
uvaol: from Vauquelinia corymbosa (Rosaceae)		2.4820triterpenoidmetabolite
asiatic acid
[no description available]		2.0610monocarboxylic acid;
pentacyclic triterpenoid;
triol		angiogenesis modulating agent;
metabolite
oleanolic acid 3-acetate
oleanolic acid 3-acetate: from Gardenia jasminoides; RN given for (3beta)-isomer		3.3110
tanshinone ii a
tashinone IIA: a cardiovascular agent with antineoplastic activity; isolated from Salvia miltiorrhiza; structure in first source		3.3110abietane diterpenoid
scoparianoside b
scoparianoside B: isolated from the fruit of Japanese Kochia scoparia; structure given in first source		2.4110triterpenoid saponin
halofuginone
[no description available]		3.3110
euscaphic acid
euscaphic acid: isolated from medicinal plant, Euscaphis japonica Pax.; structure; RN given refers to 2alpha,3alpha-isomer. euscaphic acid : A pentacyclic triterpenoid that is urs-12-en-28-oic acid substituted by hydroxy groups at positions 2, 3 and 19 respectively (the 2alpha,3alpha-stereoisomer). It has been isolated from the leaves of Rosa laevigata.		2.2510hydroxy monocarboxylic acid;
pentacyclic triterpenoid;
triol		plant metabolite
methyl ursolate
methyl ursolate: structure in first source		2.7930
isoliquiritigenin
[no description available]		2.2510chalconesantineoplastic agent;
biological pigment;
EC 1.14.18.1 (tyrosinase) inhibitor;
GABA modulator;
geroprotector;
metabolite;
NMDA receptor antagonist
tamoxifen
[no description available]		3.3110stilbenoid;
tertiary amino compound		angiogenesis inhibitor;
antineoplastic agent;
bone density conservation agent;
EC 1.2.3.1 (aldehyde oxidase) inhibitor;
EC 2.7.11.13 (protein kinase C) inhibitor;
estrogen antagonist;
estrogen receptor antagonist;
estrogen receptor modulator
apigenin
Chamomile: Common name for several daisy-like plants (MATRICARIA; TRIPLEUROSPERMUM; ANTHEMIS; CHAMAEMELUM) native to Europe and Western Asia, now naturalized in the United States and Australia.		2.0410trihydroxyflavoneantineoplastic agent;
metabolite
licochalcone a
licochalcone A: has both anti-inflammatory and antineoplastic activities; structure given in first source; isolated from root of Glycyrrhiza inflata; RN given refers to (E)-isomer		3.3110chalcones
guttiferone e
guttiferone E: isolated from the fruits of Garcinia pyrifera collected in Malaysia; structure in first source		3.3110
nifurtimox
Nifurtimox: A nitrofuran thiazine that has been used against TRYPANOSOMIASIS.		2.0210nitrofuran antibiotic
corosolic acid
[no description available]		2.5220triterpenoidmetabolite
jasplakinolide
jasplakinolide: cyclodepsipeptide isolated from marine sponge Jaspis; active against Candida; RN refers to 2S-(2R*,4E,6S*,8R*)-isomer; structure in first source. jaspamide : A cyclodepsipeptide isolated from Jaspis splendens and has been shown to exhibit antineoplastic activity. It is an actin polymerization and stabilization inducer.		3.3110cyclodepsipeptide;
phenols		actin polymerisation inducer;
animal metabolite;
antifungal agent;
antineoplastic agent;
apoptosis inducer;
marine metabolite;
neuroprotective agent
3-oxo-12-ursen-28-oic acid
3-oxo-12-ursen-28-oic acid: from Potentilla chinensis		3.1750triterpenoid
3-epioleanolic acid
[no description available]		2.0610triterpenoidmetabolite
11-deoxy glycyrrhetinic acid
[no description available]		2.0610triterpenoid
oleanonic acid
oleanonic acid: structure in first source		2.0610
pedunculoside
pedunculoside: from leaves of Ilex chinensis; structure given in first source		2.0210
augustic acid
[no description available]		2.0610
23-hydroxybetulinic acid
23-hydroxybetulinic acid: structure in first source		2.0610triterpenoidmetabolite
3mb-pp1
[no description available]		3.3110
epi-maslinic acid
epi-maslinic acid : A pentacyclic triterpenoid that is 3alpha-hydroxy epimer of maslinic acid. Isolated from Prunella vulgaris and Isodon japonicus, it exhibits anti-inflammatory activity.		2.5220dihydroxy monocarboxylic acid;
pentacyclic triterpenoid		anti-inflammatory agent;
metabolite
nitd 609
NITD 609: an antimalarial and coccidiostat; structure in first source		3.3110
lp533401
LP533401: Serotonin Agents; Tryptophan Hydroxylase inhibitor; structure in first source		2.110
zaprinast
zaprinast: anaphylaxis inhibitor; structure		3.3110triazolopyrimidines
ConditionIndicatedRelationship StrengthStudiesTrials
Cancer of Stomach
[description not available]		02.0610
Stomach Neoplasms
Tumors or cancer of the STOMACH.		02.0610
Cancer of Pancreas
[description not available]		02.0710
Pancreatic Neoplasms
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).		02.0710
Age-Related Osteoporosis
[description not available]		02.110
Osteoporosis
Reduction of bone mass without alteration in the composition of bone, leading to fractures. Primary osteoporosis can be of two major types: postmenopausal osteoporosis (OSTEOPOROSIS, POSTMENOPAUSAL) and age-related or senile osteoporosis.		02.110
Infections, Plasmodium
[description not available]		02.1310
Malaria
A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia.		02.1310
Infection, Toxoplasma gondii
[description not available]		03.1210
Pregnancy
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.		03.1210
Toxoplasmosis
The acquired form of infection by Toxoplasma gondii in animals and man.		03.1210