Compounds > Mangiferonic acid
Page last updated: 2024-11-12

Mangiferonic acid

Cross-References

ID SourceID
PubMed CID14034474
CHEMBL ID490331
CHEBI ID172009

Synonyms (8)

Synonym
CHEBI:172009
mangiferonic acid
13878-90-5
(e,6r)-2-methyl-6-[(1s,3r,8r,11s,12s,15r,16r)-7,7,12,16-tetramethyl-6-oxo-15-pentacyclo[9.7.0.01,3.03,8.012,16]octadecanyl]hept-2-enoic acid
CHEMBL490331
(24e)-3-oxo-9,19-cyclolanost-24-en-26-oic acid
9,19-cyclolanost-24-en-26-oic acid, 3-oxo-, (24e)-
DTXSID901316348
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
triterpenoidAny terpenoid derived from a triterpene. The term includes compounds in which the C30 skeleton of the parent triterpene has been rearranged or modified by the removal of one or more skeletal atoms (generally methyl groups).
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (15)

Assay IDTitleYearJournalArticle
AID1616519Antibacterial activity against Klebsiella pneumoniae after 24 hrs by broth microdilution method2019Journal of natural products, 10-25, Volume: 82, Issue:10
Highly Oxygenated Triterpenoids and Rare Tetraterpenoids from
AID1328108Cytotoxicity against human PANC1 cells in Dulbecco's modified Eagle medium measured after 24 hrs by WST8 assay2016Journal of natural products, 08-26, Volume: 79, Issue:8
Chemical Constituents of Mangifera indica and Their Antiausterity Activity against the PANC-1 Human Pancreatic Cancer Cell Line.
AID1356584Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production measured after 24 hrs by Griess assay2018Journal of natural products, 08-24, Volume: 81, Issue:8
Structural Characterization of Terpenoids from Abies holophylla Using Computational and Statistical Methods and Their Biological Activities.
AID1616518Antibacterial activity against Escherichia coli after 24 hrs by broth microdilution method2019Journal of natural products, 10-25, Volume: 82, Issue:10
Highly Oxygenated Triterpenoids and Rare Tetraterpenoids from
AID1328102Antiausteritic activity against human PANC1 cells in nutrient-deprived medium measured after 24 hrs by WST8 assay2016Journal of natural products, 08-26, Volume: 79, Issue:8
Chemical Constituents of Mangifera indica and Their Antiausterity Activity against the PANC-1 Human Pancreatic Cancer Cell Line.
AID430984Cytotoxicity against human PANC1 cells in nutrient-deprived condition assessed as 100% cell death after 24 hrs by WST8 assay2009Journal of natural products, Jul, Volume: 72, Issue:7
Chemical constituents of propolis from Myanmar and their preferential cytotoxicity against a human pancreatic cancer cell line.
AID398516Antiviral activity against HIV1 3B infected in human HOG.R5 assessed as inhibition of viral replication by microtiter assay2003Journal of natural products, Feb, Volume: 66, Issue:2
Natural anti-HIV agents. Part IV. Anti-HIV constituents from Vatica cinerea.
AID398517Cytotoxicity against human HOG.R5 cells2003Journal of natural products, Feb, Volume: 66, Issue:2
Natural anti-HIV agents. Part IV. Anti-HIV constituents from Vatica cinerea.
AID1616521Antibacterial activity against Bacillus subtilis after 24 hrs by broth microdilution method2019Journal of natural products, 10-25, Volume: 82, Issue:10
Highly Oxygenated Triterpenoids and Rare Tetraterpenoids from
AID398518Cytotoxicity against human HOG.R5 cells at 20 ug/ml2003Journal of natural products, Feb, Volume: 66, Issue:2
Natural anti-HIV agents. Part IV. Anti-HIV constituents from Vatica cinerea.
AID430989Cytotoxicity against human PANC1 cells in nutrient-deprived condition assessed as 50% cell death after 24 hrs by WST8 assay2009Journal of natural products, Jul, Volume: 72, Issue:7
Chemical constituents of propolis from Myanmar and their preferential cytotoxicity against a human pancreatic cancer cell line.
AID1356585Cytotoxicity against mouse BV2 cells assessed as cell viability at 20 uM measured after 24 hrs by MTT assay relative to control2018Journal of natural products, 08-24, Volume: 81, Issue:8
Structural Characterization of Terpenoids from Abies holophylla Using Computational and Statistical Methods and Their Biological Activities.
AID1378835Antiausteritic activity against human PANC1 cells in nutrient-deprived medium assessed as decrease in cell viability measured after 24 hrs by WST-8 assay
AID1616520Antibacterial activity against Staphylococcus aureus after 24 hrs by broth microdilution method2019Journal of natural products, 10-25, Volume: 82, Issue:10
Highly Oxygenated Triterpenoids and Rare Tetraterpenoids from
AID398513Antiviral activity against HIV1 3B infected in human HOG.R5 assessed as inhibition of viral replication at 20 ug/ml by microtiter assay2003Journal of natural products, Feb, Volume: 66, Issue:2
Natural anti-HIV agents. Part IV. Anti-HIV constituents from Vatica cinerea.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (33.33)29.6817
2010's4 (66.67)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.68

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.68 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.63 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.68)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
fluorouracil
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.. 5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.		2.4820nucleobase analogue;
organofluorine compound		antimetabolite;
antineoplastic agent;
environmental contaminant;
immunosuppressive agent;
radiosensitizing agent;
xenobiotic
chloramphenicol
Amphenicol: Chloramphenicol and its derivatives.		2.2110C-nitro compound;
carboxamide;
diol;
organochlorine compound		antibacterial drug;
antimicrobial agent;
Escherichia coli metabolite;
geroprotector;
Mycoplasma genitalium metabolite;
protein synthesis inhibitor
ampicillin
Ampicillin: Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.. ampicillin : A penicillin in which the substituent at position 6 of the penam ring is a 2-amino-2-phenylacetamido group.		2.2110beta-lactam antibiotic;
penicillin allergen;
penicillin		antibacterial drug
streptomycin
[no description available]		2.2110antibiotic antifungal drug;
antibiotic fungicide;
streptomycins		antibacterial drug;
antifungal agrochemical;
antimicrobial agent;
antimicrobial drug;
bacterial metabolite;
protein synthesis inhibitor
paclitaxel
Taxus: Genus of coniferous yew trees or shrubs, several species of which have medicinal uses. Notable is the Pacific yew, Taxus brevifolia, which is used to make the anti-neoplastic drug taxol (PACLITAXEL).		2.4820taxane diterpenoid;
tetracyclic diterpenoid		antineoplastic agent;
human metabolite;
metabolite;
microtubule-stabilising agent
gemcitabine
gemcitabine : A 2'-deoxycytidine having geminal fluoro substituents in the 2'-position. An inhibitor of ribonucleotide reductase, gemcitabine is used in the treatment of various carcinomas, particularly non-small cell lung cancer, pancreatic cancer, bladder cancer and breast cancer.		2.1310organofluorine compound;
pyrimidine 2'-deoxyribonucleoside		antimetabolite;
antineoplastic agent;
antiviral drug;
DNA synthesis inhibitor;
EC 1.17.4.1 (ribonucleoside-diphosphate reductase) inhibitor;
environmental contaminant;
immunosuppressive agent;
photosensitizing agent;
prodrug;
radiosensitizing agent;
xenobiotic
ursolic acid
[no description available]		2.0110hydroxy monocarboxylic acid;
pentacyclic triterpenoid		geroprotector;
plant metabolite
betulinic acid
[no description available]		2.0110hydroxy monocarboxylic acid;
pentacyclic triterpenoid		anti-HIV agent;
anti-inflammatory agent;
antimalarial;
antineoplastic agent;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
plant metabolite
arctigenin
arctigenin: precursor to catechols; in many plants		2.4820lignan
betulin
betulin: isolated from various white birch bark (BETULA). betulin : A pentacyclic triterpenoid that is lupane having a double bond at position 20(29) as well as 3beta-hydroxy and 28-hydroxymethyl substituents.		2.0110diol;
pentacyclic triterpenoid		analgesic;
anti-inflammatory agent;
antineoplastic agent;
antiviral agent;
metabolite
erythrodiol
[no description available]		2.0110diol;
pentacyclic triterpenoid;
primary alcohol;
secondary alcohol		plant metabolite
betulonic acid
betulonic acid: isolated from Rush javanica; strucure in first source		2.0110triterpenoidanticoronaviral agent
omega-n-methylarginine
omega-N-Methylarginine: A competitive inhibitor of nitric oxide synthetase.. N(omega)-methyl-L-arginine : A L-arginine derivative with a N(omega)-methyl substituent.		2.1710amino acid zwitterion;
arginine derivative;
guanidines;
L-arginine derivative;
non-proteinogenic L-alpha-amino acid
pimaric acid
pimaric acid: RN given refers to (D)-isomer; structure		2.1710diterpenoid
pheophorbide a
pheophorbide a: split product of chlorophyll obtained by saponification of pheophytin		2.0110
Euchrestaflavanone A
[no description available]		2.0510flavanones
8-isopentenylnaringenin
8-isopentenylnaringenin: a non-steroidal phytoestrogen from Anaxagorea luzonensis; structure in first source		2.0510flavanones
sclareolide
[no description available]		2.1710naphthofuran
mangiferin
shamimin: isolated from the leaves of Bombax ceiba; structure in first source		2.1310C-glycosyl compound;
xanthones		anti-inflammatory agent;
antioxidant;
hypoglycemic agent;
plant metabolite
shogaol
shogaol: from ginger, ZINGIBER OFFICINALE; less mutagenic than GINGEROL; structure given in first source		2.1710enone;
monomethoxybenzene;
phenols
ConditionIndicatedRelationship StrengthStudiesTrials
Osteogenic Sarcoma
[description not available]		02.0110
Osteosarcoma
A sarcoma originating in bone-forming cells, affecting the ends of long bones. It is the most common and most malignant of sarcomas of the bones, and occurs chiefly among 10- to 25-year-old youths. (From Stedman, 25th ed)		02.0110
Cancer of Pancreas
[description not available]		02.4820
Pancreatic Neoplasms
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).		02.4820
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