Page last updated: 2024-12-05

4-toluenesulfonyl fluoride

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

4-toluenesulfonyl fluoride, also known as tosyl fluoride, is a white crystalline solid that is a versatile reagent in organic synthesis. It is commonly used as a strong electrophile in reactions such as aromatic electrophilic substitution and nucleophilic aromatic substitution. Tosyl fluoride can be synthesized by reacting p-toluenesulfonyl chloride with potassium fluoride in acetonitrile. It is a valuable reagent in the preparation of various functional groups, including ethers, esters, and amides. The compound's reactivity and selectivity make it a key tool in the development of new synthetic methods and the production of fine chemicals. It is also used in the synthesis of pharmaceuticals, agrochemicals, and other speciality chemicals.'

4-toluenesulfonyl fluoride: inhibitor of peptide hydrolases; structure in second source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID9965
SCHEMBL ID81712
MeSH IDM0044647

Synonyms (41)

Synonym
AKOS015840472
455-16-3
(4-methylphenyl)sulfonyl fluoride
4-tolylsulfonyl fluoride
wln: wsfr d1
nsc2749
4-methylbenzenesulfonyl fluoride
p-methylbenzenesulfonyl fluoride
toluene-4-sulfonyl fluoride
p-toluenesulfonyl fluoride
tosyl fluoride
benzenesulfonyl fluoride, 4-methyl-
nsc-2749
p-toluenesulfonyl fluoride, 98%
p-toluenesulphonyl fluoride
alpha-tolylsulfonyl fluoride
4-toluenesulfonyl fluoride
phenylmethane sulfonyl fluoride
brn 2208423
nsc 2749
toluene-p-sulphonyl fluoride
para-toluenesulfonyl fluoride
p-methylphenylsulfonyl fluoride
einecs 207-238-6
izzyabadqvqhlc-uhfffaoysa-
inchi=1/c7h7fo2s/c1-6-2-4-7(5-3-6)11(8,9)10/h2-5h,1h3
4-11-00-00375 (beilstein handbook reference)
FT-0619533
SCHEMBL81712
DTXSID0060014
J-640211
mfcd00007421
J-800213
Z1255372425
4-methylbenzene-1-sulfonyl fluoride
VS-0060
p-toluenesulfonylfluoride
E78238
4-methyl-benzenesulfonyl fluoride
EN300-153170
CS-0159325

Research Excerpts

Toxicity

ExcerptReferenceRelevance
" Elevated cytotoxicity of the supernatant is not related to the quantity of high-potassium-sensitive toxin, as was reported previously, since desalted supernatant still exerted its strong toxic effect."( Determination of the cytotoxic effect of Clostridium histolyticum culture supernatant on HeLa cells in the presence of protease inhibitors.
Jankowska, E; Jóźwiak, J; Komar, A; Martirosian, G, 2005
)
0.33
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (80)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (2.50)18.7374
1990's35 (43.75)18.2507
2000's33 (41.25)29.6817
2010's9 (11.25)24.3611
2020's1 (1.25)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.50

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.50 (24.57)
Research Supply Index4.44 (2.92)
Research Growth Index5.94 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.50)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (1.19%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other83 (98.81%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]