Page last updated: 2024-12-06

4-methylaminobenzoic acid

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

4-methylaminobenzoic acid, also known as 4-amino-benzoic acid, is an organic compound with the formula C7H8NO2. It is a white crystalline solid that is soluble in water. 4-methylaminobenzoic acid is used as an intermediate in the synthesis of various pharmaceuticals and dyes. It is also used as a food additive and a photographic developer. Research on 4-methylaminobenzoic acid focuses on its potential use in the treatment of various diseases, including cancer, diabetes, and Alzheimer's disease. It has been shown to have antioxidant and anti-inflammatory properties.'
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Cross-References

ID SourceID
PubMed CID66345
CHEMBL ID3098156
CHEBI ID7308
SCHEMBL ID98312
SCHEMBL ID10643579
SCHEMBL ID18881012
MeSH IDM0071095

Synonyms (58)

Synonym
AC-18777
4-(methylamino)benzoic
BIDD:GT0254
IDI1_014737
OPREA1_065286
p-methylaminobenzoic acid
benzoic acid, p-(methylamino)-
n-methyl-4-aminobenzoic acid
nsc102506
p-(methylamino)benzoic acid
benzoic acid, 4-(methylamino)-
4-(methylamino)benzoic acid
4-(n-methylamino)benzoic acid
10541-83-0
nsc-102506
4-methylaminobenzoic acid
n-methyl-4-aminobenzoate
C03522
4-(methylamino)benzoic acid, 97%
MAYBRIDGE3_003350
inchi=1/c8h9no2/c1-9-7-4-2-6(3-5-7)8(10)11/h2-5,9h,1h3,(h,10,11
535DA2AE-A158-46F5-AFD0-CA8F157E14D4
HMS1440I06
M0267
A801236
4-methylamino-benzoic acid
unii-aru98z0ozy
aru98z0ozy ,
nsc 102506
ai3-62242
einecs 234-121-7
AKOS005202998
FT-0619057
FT-0619056
SCHEMBL98312
p-methylamino-benzoic acid
4-(methylamino) benzoic acid
4-(methylamino)-benzoic acid
4-methylamino benzoic acid
p-(n-methylamino)benzoic acid
chebi:7308 ,
CHEMBL3098156
p-carboxy-n-methylaniline
DTXSID8065117
SCHEMBL10643579
W-200739
STR03499
mfcd00002535
81P ,
SCHEMBL18881012
F16175
4-(methylamino)benzoicacid
SY011239
CS-0029513
Q27107471
AMY23261
EN300-51519
Z727574068
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
aminobenzoic acid
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (4)

Assay IDTitleYearJournalArticle
AID1234441Drug level in phosphate buffer treated with (Z)-1-(2-cyano-5-(4-(methylamino)benzoyloxy)-4-nitrophenoxy)-3,3-dimethyltriaz-1-ene 2-oxide at 1 uM at pH 7.4 at 37 degC after 30 secs by LC-MS analysis in presence of GSH2015Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15
PABA/NO lead optimization: Improved targeting of cytotoxicity to glutathione S-transferase P1-overexpressing cancer cells.
AID1060463Inhibition of Sir2p in yeast DMY2844 assessed as growth inhibition after 48 hrs2014Bioorganic & medicinal chemistry letters, Jan-01, Volume: 24, Issue:1
Evaluation of benzoic acid derivatives as sirtuin inhibitors.
AID1234453Drug level in phosphate buffer treated with (Z)-3,3-dimethyl-1-(5-(4-(methylamino)benzoyloxy)-2,4-dinitrophenoxy)triaz-1-ene 2-oxide at 1 uM at pH 7.4 at 37 degC after 1 to 30 mins by LC/MS-MS analysis2015Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15
PABA/NO lead optimization: Improved targeting of cytotoxicity to glutathione S-transferase P1-overexpressing cancer cells.
AID1234430Drug level in phosphate buffer treated with (Z)-3,3-dimethyl-1-(5-(4-(methylamino)benzoyloxy)-2,4-dinitrophenoxy)triaz-1-ene 2-oxide at 1 uM at pH 7.4 at 25 degC by HPLC trapping method2015Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15
PABA/NO lead optimization: Improved targeting of cytotoxicity to glutathione S-transferase P1-overexpressing cancer cells.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (20.00)29.6817
2010's4 (80.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 13.28

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index13.28 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index5.08 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (13.28)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]