penicillin x profile

penicillin X: RN given refers to (2S-(2alpha,5alpha,6beta))-isomer [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	120720
CHEBI ID	81065
SCHEMBL ID	5930569
MeSH ID	M0114211

Synonym
4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3,3-dimethyl-6-(2-(p-hydroxyphenyl)acetamido)-7-oxo-
p-hydroxybenzylpenicillin
penicillin x
penicillin iii
brn 0049686
C17404
525-91-7
unii-w097a2s1du
w097a2s1du ,
4-27-00-05890 (beilstein handbook reference)
benzylpenicillin (benzathine) tetrahydrate impurity g [ep impurity]
penicillin g sodium impurity c [ep impurity]
benzathine benzylpenicillin impurity g [ep impurity]
(2s,5r,6r)-6-(2-(4-hydroxyphenyl)acetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid
4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-((2-(4-hydroxyphenyl)acetyl)amino)-3,3-dimethyl-7-oxo-, (2s,5r,6r)-
SCHEMBL5930569
CHEBI:81065
DTXSID20200505
Q27155022

Excerpt	Relevance	Reference
" In both man and rabbit, penicillin X provided higher and more sustained blood levels than did penicillins F or G similarly administered in equal dosage (0."	( THE VARYING BLOOD LEVELS AFFORDED BY PENICILLINS F, G, K, AND X IN RABBITS AND MAN. Eagle, H, 1947)	0.53

Class	Description
penicillin	Any member of the group of substituted penams containing two methyl substituents at position 2, a carboxylate substituent at position 3 and a carboxamido group at position 6.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	23 (92.00)	18.7374
1990's	2 (8.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	26 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
aztreonam Aztreonam: A monocyclic beta-lactam antibiotic originally isolated from Chromobacterium violaceum. It is resistant to beta-lactamases and is used in gram-negative infections, especially of the meninges, bladder, and kidneys. It may cause a superinfection with gram-positive organisms.. aztreonam : A synthetic monocyclic beta-lactam antibiotic (monobactam), used primarily to treat infections caused by Gram-negative bacteria. It inhibits mucopeptide synthesis in the bacterial cell wall, thereby blocking peptidoglycan crosslinking.	1.97	1
cephaloridine Cephaloridine: A cephalosporin antibiotic.. cefaloridine : A cephalosporin compound having pyridinium-1-ylmethyl and 2-thienylacetamido side-groups. A first-generation semisynthetic derivative of cephalosporin C.	1.97	1	beta-lactam antibiotic allergen; cephalosporin; semisynthetic derivative	antibacterial drug
penicillin g Penicillin G: A penicillin derivative commonly used in the form of its sodium or potassium salts in the treatment of a variety of infections. It is effective against most gram-positive bacteria and against gram-negative cocci. It has also been used as an experimental convulsant because of its actions on GAMMA-AMINOBUTYRIC ACID mediated synaptic transmission.. benzylpenicillin : A penicillin in which the substituent at position 6 of the penam ring is a phenylacetamido group.	4.49	25	penicillin allergen; penicillin	antibacterial drug; drug allergen; epitope
methicillin Methicillin: One of the PENICILLINS which is resistant to PENICILLINASE but susceptible to a penicillin-binding protein. It is inactivated by gastric acid so administered by injection.. methicillin : A penicillin that is 6-aminopenicillanic acid in which one of the amino hydrogens is replaced by a 2,6-dimethoxybenzoyl group.	6.93	1	penicillin allergen; penicillin	antibacterial drug
streptomycin [no description available]	6.92	1	antibiotic antifungal drug; antibiotic fungicide; streptomycins	antibacterial drug; antifungal agrochemical; antimicrobial agent; antimicrobial drug; bacterial metabolite; protein synthesis inhibitor
laccase Laccase: A copper-containing oxidoreductase enzyme that catalyzes the oxidation of 4-benzenediol to 4-benzosemiquinone. It also has activity towards a variety of O-quinols and P-quinols. It primarily found in FUNGI and is involved in LIGNIN degradation, pigment biosynthesis and detoxification of lignin-derived products.	1.98	1
penicillin f penicillin F: RN given refers to (2S-(2alpha,5alpha,6beta))-isomer; RN for cpd without isomeric designation not avail 3/91	3.17	6	penicillin
penicillin k penicillin K: biosynthesized from glutathione S-derivatives; RN given refers to parent cpd	3.43	8	penicillin

Condition	Relationship Strength	Studies
Infection [description not available]	7.33	2
Infections, Pneumococcal [description not available]	1.92	1
Group A Strep Infection [description not available]	1.92	1
Infections Invasion of the host organism by microorganisms or their toxins or by parasites that can cause pathological conditions or diseases.	7.33	2
Pneumococcal Infections Infections with bacteria of the species STREPTOCOCCUS PNEUMONIAE.	1.92	1
Streptococcal Infections Infections with bacteria of the genus STREPTOCOCCUS.	1.92	1
Neisseria gonorrhoeae Infection [description not available]	2.33	2
Gonorrhea Acute infectious disease characterized by primary invasion of the urogenital tract. The etiologic agent, NEISSERIA GONORRHOEAE, was isolated by Neisser in 1879.	2.33	2
Enteric Fever [description not available]	1.92	1
Typhoid Fever An acute systemic febrile infection caused by SALMONELLA TYPHI, a serotype of SALMONELLA ENTERICA.	1.92	1
Grippe [description not available]	1.92	1
Influenza, Human An acute viral infection in humans involving the respiratory tract. It is marked by inflammation of the NASAL MUCOSA; the PHARYNX; and conjunctiva, and by headache and severe, often generalized, myalgia.	1.92	1
Scarlet Fever Infection with group A streptococci that is characterized by tonsillitis and pharyngitis. An erythematous rash is commonly present.	6.92	1
Great Pox [description not available]	2.62	3
Syphilis A contagious venereal disease caused by the spirochete TREPONEMA PALLIDUM.	2.62	3
Infections, Staphylococcal [description not available]	1.93	1
Staphylococcal Infections Infections with bacteria of the genus STAPHYLOCOCCUS.	1.93	1
Infective Endocarditis [description not available]	1.92	1
Bacterial Endocarditides [description not available]	1.92	1
Endocarditis Inflammation of the inner lining of the heart (ENDOCARDIUM), the continuous membrane lining the four chambers and HEART VALVES. It is often caused by microorganisms including bacteria, viruses, fungi, and rickettsiae. Left untreated, endocarditis can damage heart valves and become life-threatening.	1.92	1
Endocarditis, Bacterial Inflammation of the ENDOCARDIUM caused by BACTERIA that entered the bloodstream. The strains of bacteria vary with predisposing factors, such as CONGENITAL HEART DEFECTS; HEART VALVE DISEASES; HEART VALVE PROSTHESIS IMPLANTATION; or intravenous drug use.	1.92	1

penicillin x

Description

Cross-References

Synonyms (19)

Research Excerpts

Dosage Studied

Drug Classes (1)

Research

Studies (25)

Market Indicators

Research Demand Index: 32.01

Study Types

penicillin x

Description

Cross-References

Synonyms (19)

Research Excerpts

Dosage Studied

Drug Classes (1)

Research

Studies (25)

Market Indicators

Research Demand Index: 32.01

Study Types

Related Drugs (8)

Related Conditions (21)