Page last updated: 2024-12-06

alpha-carboline

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Alpha-carbolines are a class of heterocyclic compounds containing a fused indole and pyridine ring system. They are found naturally in various plants and are known for their diverse biological activities, including anti-inflammatory, anti-cancer, and neuroprotective effects. The synthesis of alpha-carbolines often involves the condensation of an indole derivative with a pyridine derivative. Research on alpha-carbolines is driven by their potential therapeutic applications, particularly in areas like neurodegenerative diseases, cancer, and inflammatory disorders. Studies explore their mechanisms of action, focusing on their interactions with various enzymes, receptors, and signaling pathways. The potential for alpha-carbolines as drug candidates is being investigated, although further research is needed to understand their safety and efficacy.'

alpha-carboline: RN given refers to unlabeled cpd; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID67486
CHEMBL ID259556
CHEBI ID182292
SCHEMBL ID9145
MeSH IDM0156404

Synonyms (49)

Synonym
STL301814
CHEBI:182292
9h-pyrido[2,3-b]indole
DIVK1C_006713
inchi=1/c11h8n2/c1-2-6-10-8(4-1)9-5-3-7-12-11(9)13-10/h1-7h,(h,12,13
alpha-carboline
nsc67064
244-76-8
nsc-67064
1h-pyrido[2,3-b]indole
KBIO1_001657
SPECPLUS_000617
CHEMBL259556
FT-0664263
1h-pyrido(2,3-b)indole
nsc 67064
einecs 205-960-6
unii-274z75i9bq
274z75i9bq ,
AKOS015918052
9h-1,9-diazafluorene
|a-carboline
SCHEMBL9145
3-carboline
9h-pyrido[2,3-b]indole #
n-.alpha.-carboline
.alpha.-carboline
1-azacarbazole
9h-pyrido(2,3-b)indole
1,9-diazafluorene
P2310
DTXSID40179148
9h-?pyrido[2,3-?b]?indole
alpha-carboline, 99%
J-015543
mfcd00473709
DS-4768
9h-pyrido[2,3-b]indole;(c) paragraph sign-carboline; 1,9-diazafluorene 1-azacarbazole; 9h-1,9-diazafluorene
BCP20997
azacarbazole
Q27254162
A853697
i+/--carboline
SY055484
SB66733
O11680
alpha -carboline
CS-0147267
Z3234909647
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
pyridoindole
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (2)

Assay IDTitleYearJournalArticle
AID318337Cytotoxicity against mock-infected MDBK cells by LDH method2008Bioorganic & medicinal chemistry, Apr-01, Volume: 16, Issue:7
Gamma-carboline derivatives with anti-bovine viral diarrhea virus (BVDV) activity.
AID318336Antiviral activity against BVDV infected in MDBK cells assessed as reduction in viral induced cell destruction by MTT assay2008Bioorganic & medicinal chemistry, Apr-01, Volume: 16, Issue:7
Gamma-carboline derivatives with anti-bovine viral diarrhea virus (BVDV) activity.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (29)

TimeframeStudies, This Drug (%)All Drugs %
pre-19908 (27.59)18.7374
1990's1 (3.45)18.2507
2000's3 (10.34)29.6817
2010's12 (41.38)24.3611
2020's5 (17.24)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 21.04

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index21.04 (24.57)
Research Supply Index3.43 (2.92)
Research Growth Index5.18 (4.65)
Search Engine Demand Index18.60 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (21.04)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (3.33%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other29 (96.67%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]