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azathioprine and Pyoderma Gangrenosum

azathioprine has been researched along with Pyoderma Gangrenosum in 22 studies

Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.

Pyoderma Gangrenosum: An idiopathic, rapidly evolving, and severely debilitating disease occurring most commonly in association with chronic ulcerative colitis. It is characterized by the presence of boggy, purplish ulcers with undermined borders, appearing mostly on the legs. The majority of cases are in people between 40 and 60 years old. Its etiology is unknown.

Research Excerpts

ExcerptRelevanceReference
"To report a patient with a rare clinical presentation of marginal keratitis and pyoderma gangrenosum (PG) that responded to the steroid-sparing agent azathioprine."3.71Effective steroid-sparing treatment for peripheral ulcerative keratitis and pyoderma gangrenosum. ( Bower, KS; Brown, BA; Parker, CT, 2001)
"High doses of orally administered prednisolone induced the healing of the pyoderma gangrenosum within 2 months."3.70[Extra-intestinal manifestations and complications in chronic active ulcerative colitis in childhood and adolescence]. ( Hüppe, D; Schenck, B; Tromm, A, 1999)
"A woman in her 30s was diagnosed with ulcerative colitis (UC) 4 years ago and treated with tacrolimus, azathioprine, and prednisolone 5mg (PSL)."1.72[Ulcerative colitis complicated by pyoderma gangrenosum and multiple aseptic abscesses]. ( Hashimoto, Y; Hosaka, H; Itoi, Y; Kasuga, K; Kita, A; Kuribayashi, S; Sato, K; Tanaka, H; Uraoka, T, 2022)
"Pyoderma gangrenosum is an unusual wounding disease that makes the diagnosis and manage- ment challenging."1.46Ulcerative Pyoderma Gangrenosum and Leukocytoclastic Vasculitis in a Hypothyroid Woman: A Case Report. ( Agarwal, P; Agarwal, US; Prakash, C; Sharma, P, 2017)
"Leg ulcerations can occur in systemic lupus erythematosus (SLE) patients with antiphospholipid (aPL) antibodies and/or vasculitis, and it has been suggested that aPL antibodies may play a pathogenetic role in skin manifestations of SLE."1.34Lupus and leg ulcers--a diagnostic quandary. ( Boyce, S; Dziadzio, M; Hamdulay, S; Keat, A; Prasad, N; Reddy, V, 2007)
"Collagenous colitis is one of the microscopic colitides, which are thought to be on the same spectrum of disease as Crohn's disease and ulcerative colitis."1.32Pyoderma gangrenosum in a patient with collagenous colitis. ( Batra, AK; Levey, JM; Patwardhan, R; Trister, J, 2003)
"Treatment with prednisolone and azathioprine was initiated."1.30[Pyoderma gangrenosum and portal vein thrombosis in a 33-year-old female patient]. ( Berr, F; Halm, U; Mössner, J; Paasch, U; Pönisch, W; Schiefke, I, 1999)
"We report a case of pyoderma gangrenosum affecting both hands simultaneously."1.29Pyoderma gangrenosum severely affecting both hands. ( Adam, DJ; Nawroz, I; Petrie, PW, 1996)

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's6 (27.27)18.2507
2000's7 (31.82)29.6817
2010's8 (36.36)24.3611
2020's1 (4.55)2.80

Authors

AuthorsStudies
Kita, A1
Hashimoto, Y1
Sato, K1
Itoi, Y1
Kasuga, K1
Tanaka, H1
Hosaka, H1
Kuribayashi, S1
Uraoka, T1
Agarwal, US1
Agarwal, P1
Prakash, C1
Sharma, P1
Gisondi, P1
Pizzolato, M1
Galvan, A1
Girolomoni, G1
Chua, EP1
Mallett, RB1
Dahiya, S1
Nordstrom, E1
Fischer, M1
Fernández, ML1
Ramírez, F1
García, E1
Chatzinasiou, F1
Polymeros, D1
Panagiotou, M1
Theodoropoulos, K1
Rigopoulos, D1
Gelber, AC1
Zaidan, M1
Lidove, O1
Sacré, K1
Klein, I1
Papo, T1
Tsanadis, GD1
Chouliara, ST1
Voulgari, PV1
Makrydimas, GV1
Drosos, AA1
Rogalski, C1
Paasch, U2
Glander, HJ1
Haustein, UF1
Batra, AK1
Levey, JM1
Trister, J1
Patwardhan, R1
Reddy, V1
Dziadzio, M1
Hamdulay, S1
Boyce, S1
Prasad, N1
Keat, A1
Castro-Fernández, M1
Sánchez-Muñoz, D1
Ruíz-Granados, E1
Merchante, N1
Corzo, J1
Duffill, MB1
Aoki, M1
Miura, A1
Sato, I1
Suzuki, C1
Adam, DJ1
Nawroz, I1
Petrie, PW1
Anstey, AV1
Schiefke, I1
Halm, U1
Pönisch, W1
Berr, F1
Mössner, J1
Hüppe, D1
Schenck, B1
Tromm, A1
Coors, EA1
von den Driesch, P1
Brown, BA1
Parker, CT1
Bower, KS1

Other Studies

22 other studies available for azathioprine and Pyoderma Gangrenosum

ArticleYear
[Ulcerative colitis complicated by pyoderma gangrenosum and multiple aseptic abscesses].
    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 2022, Volume: 119, Issue:11

    Topics: Abscess; Azathioprine; Colitis, Ulcerative; Female; Humans; Infliximab; Prednisolone; Pyoderma Gangr

2022
Ulcerative Pyoderma Gangrenosum and Leukocytoclastic Vasculitis in a Hypothyroid Woman: A Case Report.
    Wounds : a compendium of clinical research and practice, 2017, Volume: 29, Issue:6

    Topics: Azathioprine; Drug Therapy, Combination; Female; Humans; Hypothyroidism; Immunosuppressive Agents; M

2017
Image Gallery: Pyoderma gangrenosum of the penis.
    The British journal of dermatology, 2018, Volume: 178, Issue:1

    Topics: Acute Disease; Adrenal Cortex Hormones; Aged; Azathioprine; Dermatologic Agents; Drug Therapy, Combi

2018
Cogan's syndrome with pyoderma gangrenosum: management of two uncommon disorders with aggressive presentation in a patient.
    BMJ case reports, 2018, Jun-19, Volume: 2018

    Topics: Administration, Intravenous; Azathioprine; Biopsy; Cogan Syndrome; Cyclophosphamide; Cyclosporine; D

2018
The great masquerader: Behcet's disease.
    BMJ case reports, 2014, Apr-19, Volume: 2014

    Topics: Abdominal Pain; Adrenal Cortex Hormones; Adult; Azathioprine; Behcet Syndrome; Crohn Disease; Cyclop

2014
[Cutaneous leishmaniasis in a patient with ulcerative colitis under treatment with infliximab].
    Gastroenterologia y hepatologia, 2015, Volume: 38, Issue:9

    Topics: Antiprotozoal Agents; Azathioprine; Colitis, Ulcerative; Diagnosis, Differential; Humans; Immunocomp

2015
Generalized Pyoderma Gangrenosum Associated with Ulcerative Colitis: Successful Treatment with Infliximab and Azathioprine.
    Acta dermatovenerologica Croatica : ADC, 2016, Volume: 24, Issue:1

    Topics: Adult; Azathioprine; Colitis, Ulcerative; Dermatologic Agents; Humans; Immunosuppressive Agents; Inf

2016
Infliximab, azathioprine, or combination therapy for Crohn's disease.
    The New England journal of medicine, 2010, 09-09, Volume: 363, Issue:11

    Topics: Anti-Inflammatory Agents; Antibodies, Monoclonal; Arthritis; Azathioprine; Crohn Disease; Drug Thera

2010
"Fulminant" Behçet disease.
    Presse medicale (Paris, France : 1983), 2011, Volume: 40, Issue:11

    Topics: Administration, Oral; Adolescent; Anti-Inflammatory Agents; Antibodies, Monoclonal; Atrophy; Azathio

2011
Outcome of pregnancy in a patient with relapsing polychondritis and pyoderma gangrenosum.
    Clinical rheumatology, 2002, Volume: 21, Issue:6

    Topics: Adult; Azathioprine; Female; Humans; Immunosuppressive Agents; Methylprednisolone; Necrosis; Polycho

2002
Bullous pyoderma gangrenosum complicated by disseminated intravascular coagulation with subsequent myelodysplastic syndrome (chronic myelomonocytic leukemia).
    The Journal of dermatology, 2003, Volume: 30, Issue:1

    Topics: Administration, Oral; Adult; Azathioprine; Bandages, Hydrocolloid; Colloids; Diagnosis, Differential

2003
Pyoderma gangrenosum in a patient with collagenous colitis.
    Journal of the American Academy of Dermatology, 2003, Volume: 49, Issue:5 Suppl

    Topics: Administration, Oral; Aged; Azathioprine; Colitis; Diagnosis, Differential; Diarrhea; Female; Humans

2003
Lupus and leg ulcers--a diagnostic quandary.
    Clinical rheumatology, 2007, Volume: 26, Issue:7

    Topics: Adult; Azathioprine; Drug Therapy, Combination; Glucocorticoids; Humans; Immunosuppressive Agents; L

2007
Coexistence of pyoderma gangrenosum and Sweet's syndrome in a patient with ulcerative colitis.
    The American journal of gastroenterology, 2007, Volume: 102, Issue:12

    Topics: Antibodies, Monoclonal; Azathioprine; Colitis, Ulcerative; Dermatologic Agents; Glucocorticoids; Hum

2007
Cyclosporine, azathioprine and local therapy for pyoderma gangrenosum.
    The Australasian journal of dermatology, 1994, Volume: 35, Issue:1

    Topics: Administration, Topical; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Azathioprin

1994
[A case of repeated pyoderma gangrenosum with myelodysplastic syndrome].
    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 1993, Jan-10, Volume: 82, Issue:1

    Topics: Adult; Azathioprine; Humans; Male; Myelodysplastic Syndromes; Prednisolone; Pyoderma Gangrenosum; Re

1993
Pyoderma gangrenosum severely affecting both hands.
    Journal of hand surgery (Edinburgh, Scotland), 1996, Volume: 21, Issue:6

    Topics: Amputation, Surgical; Arthritis, Rheumatoid; Azathioprine; Biopsy; Colitis, Ulcerative; Debridement;

1996
Treatment of pyoderma gangrenosum.
    Journal of the American Academy of Dermatology, 1997, Volume: 36, Issue:5 Pt 1

    Topics: Azathioprine; Humans; Immunosuppressive Agents; Pyoderma Gangrenosum

1997
[Pyoderma gangrenosum and portal vein thrombosis in a 33-year-old female patient].
    Deutsche medizinische Wochenschrift (1946), 1999, Feb-12, Volume: 124, Issue:6

    Topics: Adult; Anti-Inflammatory Agents; Anticoagulants; Antineoplastic Agents; Ascites; Azathioprine; Bone

1999
[Extra-intestinal manifestations and complications in chronic active ulcerative colitis in childhood and adolescence].
    Deutsche medizinische Wochenschrift (1946), 1999, Jul-09, Volume: 124, Issue:27

    Topics: Adolescent; Azathioprine; Budesonide; Child; Colitis, Ulcerative; Diagnosis, Differential; Drug Ther

1999
Pyoderma gangrenosum in a patient with autoimmune haemolytic anaemia and complement deficiency.
    The British journal of dermatology, 2000, Volume: 143, Issue:1

    Topics: Adult; Anemia, Hemolytic, Autoimmune; Anti-Inflammatory Agents; Azathioprine; Complement C2; Complem

2000
Effective steroid-sparing treatment for peripheral ulcerative keratitis and pyoderma gangrenosum.
    Cornea, 2001, Volume: 20, Issue:1

    Topics: Administration, Oral; Azathioprine; Biopsy; Cornea; Corneal Ulcer; Drug Therapy, Combination; Glucoc

2001