amphotericin-b and Pyoderma-Gangrenosum
amphotericin-b has been researched along with Pyoderma-Gangrenosum* in 2 studies
Other Studies
2 other study(ies) available for amphotericin-b and Pyoderma-Gangrenosum
Article | Year |
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Abdominal wall mucormycosis successfully treated with amphotericin and itraconazole.
The routine management of cutaneous mucormycosis consists of combined surgical and medical therapy. We present a case of successful medical therapy with sequential liposomal amphotericin B and itraconazole for a peri-ostomal cutaneous Rhizopus infection in a 59-year-old woman following treatment for pyoderma gangrenosum in the setting of inflammatory bowel disease. Topics: Abdominal Muscles; Amphotericin B; Antifungal Agents; Drug Combinations; Female; Humans; Inflammatory Bowel Diseases; Itraconazole; Middle Aged; Mucormycosis; Phosphatidylcholines; Phosphatidylglycerols; Pyoderma Gangrenosum; Rhizopus | 2002 |
Disseminated histoplasmosis presenting as pyoderma gangrenosum-like lesions in a patient with acquired immunodeficiency syndrome.
A 33-year-old Hispanic woman with newly diagnosed human immunodeficiency virus (HIV) infection, a CD4 T-lymphocyte count of 2, viral load of 730,000 copies/mL, candidal esophagitis, seizure disorder, a history of bacterial pneumonia, and recent weight loss was admitted with tonic clonic seizure. On admission, her vital signs were: pulse of 88, respiration rate of 18, temperature of 37.7 degrees C, and blood pressure of 126/76. Her only medication was phenytoin. On examination, the patient was found to have multiple umbilicated papules on her face, as well as painful, erythematous, large, punched-out ulcers on the nose, face, trunk, and extremities of 3 months' duration (Fig. 1). The borders of the ulcers were irregular, raised, boggy, and undermined, while the base contained hemorrhagic exudate partially covered with necrotic eschar. The largest ulcer on the left mandible was 4 cm in diameter. The oral cavity was clear. Because of her subtherapeutic phenytoin level, the medication dose was adjusted, and she was empirically treated with Unasyn for presumptive bacterial infection. Chest radiograph and head computed tomography (CT) scan were within normal limits. Sputum for acid-fast bacilli (AFB) smear was negative. Serologic studies, including Histoplasma antibodies, toxoplasmosis immunoglobulin M (IgM), rapid plasma reagin (RPR), hepatitis C virus (HCV), and hepatitis B virus (HBV) antibodies were all negative. Examination of the cerebrospinal fluid was within normal limits without the presence of cryptococcal antigen. Blood and cerebrospinal cultures for bacteria, mycobacteria, and fungi were all negative. Viral culture from one of the lesions was also negative. The analysis of her complete blood count showed: white blood count, 2300/microl; hemoglobin, 8.5 g/dL; hematocrit, 25.7%; and platelets, 114,000/microl. Two days after admission, the dermatology service was asked to evaluate the patient. Although the umbilicated papules on the patient's face resembled lesions of molluscum contagiosum, other infectious processes considered in the differential diagnosis included histoplasmosis, cryptococcosis, and Penicillium marnefei. In addition, the morphology of the ulcers, particularly that on the left mandible, resembled lesions of pyoderma gangrenosum. A skin biopsy was performed on an ulcer on the chest. Histopathologic examination revealed granulomatous dermatitis with multiple budding yeast forms, predominantly within histiocytes, with few organisms resid Topics: Adult; Amphotericin B; Antifungal Agents; Biopsy; Dermatomycoses; Female; Histoplasma; Histoplasmosis; HIV Infections; Humans; Pyoderma Gangrenosum | 2001 |