rifampin and Scleritis

A 35-year-old man presented a case of recurrent episcleritis revealing brucellosis. No concurrent diagnosis other than brucellosis could account for the episcleritis. Moreover his status was dramatically improved by specific antibiotherapy. A review of the literature showed that uveitis and optic neuropathies are the most common ocular manifestations of brucellosis. To the best of our knowledge, this is the first case of episcleritis associated with brucellosis.

Topics: Adult; Anti-Bacterial Agents; Brucellosis; Enzyme Inhibitors; Follow-Up Studies; Humans; Male; Minocycline; Recurrence; Rifampin; Scleritis

Topics: Alcoholism; Antitubercular Agents; Conjunctival Diseases; Ethambutol; Eye Pain; Glucocorticoids; Humans; Hyperemia; Interferon-gamma; Isoniazid; Male; Middle Aged; Pyrazinamide; Rifampin; Scleritis; Tobacco Use Disorder; Tuberculosis, Pulmonary

Topics: Aged; Antitubercular Agents; Choroid Diseases; Drug Therapy, Combination; Ethambutol; Eye Infections, Bacterial; Eye Pain; Female; Humans; Interferon-gamma Release Tests; Isoniazid; Mycobacterium tuberculosis; Pyrazinamide; Radiography, Thoracic; Rifampin; Scleritis; Skin Tests; Tuberculoma; Tuberculosis, Ocular

Topics: Adult; Aged; Antigens, Bacterial; Antitubercular Agents; Bacterial Proteins; Drug Therapy, Combination; Ethambutol; Female; Humans; Immunoassay; Interferon-gamma; Isoniazid; Leukocytes; Male; Rifampin; Scleritis; Tuberculosis, Ocular

To document the clinical course and the treatment of episcleritis associated with brucellosis.. Three consecutive cases of patients with recurrent episcleritis associated with brucellosis were evaluated through clinical and laboratory data including serology (tube agglutination), blood culture, and synovial fluid culture.. All the patients had ingested contaminated milk and/or fresh cheese. The diagnosis of brucellosis was confirmed by high antibody titer, positive blood culture, negative synovial fluid culture and unresponsive condition to the previous nonspecific therapy for episcleritis and reactive arthritis. The patients responded well to the therapy with doxycycline and rifampicin.. We proposed that recurrent episcleritis had a co-occurence with reactive arthritis in the course of the brucellosis, and that it responded well to the antibrucellar antibiotics rather than to steroids. This also implies that brucellosis as a rule is an underlying triggering infection associated with reactive arthritis.

Topics: Aged; Antibodies, Bacterial; Arthritis, Reactive; Brucella; Brucellosis; Doxycycline; Drug Therapy, Combination; Eye Infections, Bacterial; Female; Humans; Middle Aged; Recurrence; Rifampin; Scleritis; Synovial Fluid