phenylthiourea and Goiter--Nodular

Taste sensitivity to phenylthiocarbamide is thought to reflect a genotype homozygous for a single recessive gene. European and North American populations show a mean non-taster frequency of about 30% whereas Mongoloid populations show a much lower frequency of non-tasters. In the present study of Nigerians, there were mean non-taster frequencies of 1.9-2.9% among healthy subjects and not a significantly different level, 3.5%, among goitrous ones. Among subjects with nodular goiter, however, the non-taster frequency was 18.7%, significantly higher. The results suggest that there is a rarity of non-tasters among Nigerians and that non-tasters are more susceptible to the development of nodular goiter than are tasters.

Topics: Adult; Ageusia; Female; Goiter, Nodular; Humans; Male; Middle Aged; Nigeria; Phenylthiourea; Taste

Topics: Adolescent; Adult; Age Factors; Aged; Black People; Brazil; Child; Child, Preschool; Ethnicity; Female; Germany; Goiter; Goiter, Nodular; Humans; Hypothyroidism; Infant; Italy; Male; Middle Aged; Phenylthiourea; Portugal; Sex Factors; Spain; Statistics as Topic; Taste; White People

Topics: ABO Blood-Group System; Child; Cholesterol; Deafness; Genetics, Medical; Goiter; Goiter, Nodular; Hearing Loss; Humans; Infant; Infant, Newborn; Iodine Isotopes; Perchlorates; Phenylthiourea; Radiography; Taste; Thyroid Function Tests