capromab pendetide

Description

Capromab Pendetide: an (111)Indium-labeled IgG antibody against a prostate specific membrane antigen (PSMA); used in the evaluation of metastatic involvement in prostate cancer [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	135509147
SCHEMBL ID	2315499
MeSH ID	M0265650

Synonyms (9)

Synonym
145464-28-4
guanosine-3',5'-diphosphate
capromab pendetide
[(2r,3s,4r,5r)-5-(2-amino-6-oxo-3h-purin-9-yl)-4-hydroxy-2-(phosphonooxymethyl)oxolan-3-yl] dihydrogen phosphate
SCHEMBL2315499
guanosine 3',5'-diphosphate
guanosine 3',5'-bis(dihydrogen phosphate)
Q27464412
[(2r,3s,4r,5r)-5-(2-amino-6-oxo-1h-purin-9-yl)-4-hydroxy-2-(phosphonooxymethyl)oxolan-3-yl] dihydrogen phosphate

Research Excerpts

Overview

Capromab pendetide (ProstaScint) is an indium In 111 ((111)In)-labeled monoclonal antibody to prostate-specific membrane antigen (PSMA) used to image prostate cancer.

Excerpt	Reference
"Capromab Pendetide is a technically demanding procedure best performed and interpreted at sites with experience and expertise."	( Capromab Pendetide imaging of prostate cancer. Haseman, MK; Polascik, TJ; Rosenthal, SA, 2000)
"Capromab pendetide (ProstaScint) is an indium In 111 ((111)In)-labeled monoclonal antibody to prostate-specific membrane antigen (PSMA) used to image prostate cancer. "	( Utility of capromab pendetide (ProstaScint) imaging in the management of prostate cancer. Haseman, MK; Polascik, TJ; Rosenthal, SA, 2001)

Effects

Excerpt	Reference
"The capromab pendetide scan has a low positive predictive value in patients with positive elsewhere uptake and the 4-year bRFS was similar to that for those who did not exhibit positive elsewhere uptake. "	( Long-term follow-up of 111In-capromab pendetide (ProstaScint) scan as pretreatment assessment in patients who undergo salvage radiotherapy for rising prostate-specific antigen after radical prostatectomy for prostate cancer. Campbell, S; Dillehay, G; Flanigan, R; Khan, U; Lo, SS; Mohideen, N; Nagda, SN; Wagner, R, 2007)

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (89)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	22 (24.72)	18.2507
2000's	55 (61.80)	29.6817
2010's	12 (13.48)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	13 (13.83%)	5.53%
Reviews	18 (19.15%)	6.00%
Case Studies	18 (19.15%)	4.05%
Observational	0 (0.00%)	0.25%
Other	45 (47.87%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
edetic acid Edetic Acid: A chelating agent that sequesters a variety of polyvalent cations such as CALCIUM. It is used in pharmaceutical manufacturing and as a food additive.	3.38	1	1	ethylenediamine derivative; polyamino carboxylic acid; tetracarboxylic acid	anticoagulant; antidote; chelator; copper chelator; geroprotector
lutetium Lutetium: An element of the rare earth family of metals. It has the atomic symbol Lu, atomic number 71, and atomic weight 175.	3.11	1	0	d-block element atom; lanthanoid atom
technetium Technetium: The first artificially produced element and a radioactive fission product of URANIUM. Technetium has the atomic symbol Tc, and atomic number 43. All technetium isotopes are radioactive. Technetium 99m (m=metastable) which is the decay product of Molybdenum 99, has a half-life of about 6 hours and is used diagnostically as a radioactive imaging agent. Technetium 99 which is a decay product of technetium 99m, has a half-life of 210,000 years.	2.02	1	0	manganese group element atom
yttrium radioisotopes Yttrium Radioisotopes: Unstable isotopes of yttrium that decay or disintegrate emitting radiation. Y atoms with atomic weights 82-88 and 90-96 are radioactive yttrium isotopes.	3.38	1	1
fluciclovine f-18 fluciclovine F-18: A radioactive diagnostic agent used for the detection of recurrent prostate cancer by POSITRON EMISSION TOMOGRAPHY; structure in first source.	8.2	6	4
strontium Strontium: An element of the alkaline earth family of metals. It has the atomic symbol Sr, atomic number 38, and atomic weight 87.62.	2.02	1	0	alkaline earth metal atom
losartan potassium Erythropoietin: Glycoprotein hormone, secreted chiefly by the KIDNEY in the adult and the LIVER in the FETUS, that acts on erythroid stem cells of the BONE MARROW to stimulate proliferation and differentiation.	3.14	1	0
sodium pertechnetate tc 99m Sodium Pertechnetate Tc 99m: A gamma-emitting radionuclide imaging agent used for the diagnosis of diseases in many tissues, particularly in the gastrointestinal system, cardiovascular and cerebral circulation, brain, thyroid, and joints.	1.99	1	0
technetium tc 99m medronate Technetium Tc 99m Medronate: A gamma-emitting radionuclide imaging agent used primarily in skeletal scintigraphy. Because of its absorption by a variety of tumors, it is useful for the detection of neoplasms.	2.41	2	0

Condition	Relationship Strength	Studies	Trials
Lymph Node Metastasis [description not available]	9.52	20	3
Cancer of Pelvis [description not available]	2.08	1	0
Cancer of Prostate [description not available]	17.07	99	27
Prostatic Neoplasms Tumors or cancer of the PROSTATE.	17.07	99	27
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	10.59	20	4
Carcinoma, Anaplastic [description not available]	11.44	18	16
Local Neoplasm Recurrence [description not available]	15.15	47	19
Carcinoma A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm and not a synonym for cancer.	11.44	18	16
Experimental Neoplasms [description not available]	2.1	1	0
Diffuse Mixed Small and Large Cell Lymphoma [description not available]	2.46	2	0
Lymphoma, Non-Hodgkin Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease.	2.46	2	0
Adenocarcinoma, Basal Cell [description not available]	8.36	17	5
Cancer of Lung [description not available]	2.05	1	0
Adenocarcinoma A malignant epithelial tumor with a glandular organization.	13.36	17	5
Lung Neoplasms Tumors or cancer of the LUNG.	2.05	1	0
Invasiveness, Neoplasm [description not available]	2.05	1	0
Injuries, Radiation [description not available]	4.73	2	1
Metastase [description not available]	5.88	6	0
Neoplasm Metastasis The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.	5.88	6	0
B-Cell Lymphoma [description not available]	2.01	1	0
Multiple Primary Neoplasms [description not available]	2.4	2	0
Lymphoma, B-Cell A group of heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes.	2.01	1	0
Disease Exacerbation [description not available]	5.7	4	1
Bone Cancer [description not available]	5.34	7	0
Bone Neoplasms Tumors or cancer located in bone tissue or specific BONES.	5.34	7	0
Kahler Disease [description not available]	2.02	1	0
Benign Neoplasms [description not available]	2.02	1	0
Multiple Myeloma A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.	2.02	1	0
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	2.02	1	0
Neuroendocrine Tumors Tumors whose cells possess secretory granules and originate from the neuroectoderm, i.e., the cells of the ectoblast or epiblast that program the neuroendocrine system. Common properties across most neuroendocrine tumors include ectopic hormone production (often via APUD CELLS), the presence of tumor-associated antigens, and isozyme composition.	2.02	1	0
Angioma A vascular anomaly due to proliferation of blood or lymphatic vessels that forms a tumor-like mass. Vessels in the angioma may or may not be dilated.	1.99	1	0
Cancer of Liver [description not available]	1.99	1	0
Hemangioma A vascular anomaly due to proliferation of BLOOD VESSELS that forms a tumor-like mass. The common types involve CAPILLARIES and VEINS. It can occur anywhere in the body but is most frequently noticed in the SKIN and SUBCUTANEOUS TISSUE. (from Stedman, 27th ed, 2000)	1.99	1	0
Liver Neoplasms Tumors or cancer of the LIVER.	1.99	1	0
Minimal Disease, Residual [description not available]	5.55	3	2
Abdominal Neoplasms New abnormal growth of tissue in the ABDOMEN.	2.4	2	0
Adenocarcinoma Of Kidney [description not available]	2	1	0
Cancer of Kidney [description not available]	2	1	0
Carcinoma, Renal Cell A heterogeneous group of sporadic or hereditary carcinoma derived from cells of the KIDNEYS. There are several subtypes including the clear cells, the papillary, the chromophobe, the collecting duct, the spindle cells (sarcomatoid), or mixed cell-type carcinoma.	2	1	0
Kidney Neoplasms Tumors or cancers of the KIDNEY.	2	1	0
Soft Tissue Neoplasms Neoplasms of whatever cell type or origin, occurring in the extraskeletal connective tissue framework of the body including the organs of locomotion and their various component structures, such as nerves, blood vessels, lymphatics, etc.	3.79	2	1
Leukocytopenia [description not available]	3.38	1	1
Thrombopenia [description not available]	3.38	1	1
Leukopenia A decrease in the number of LEUKOCYTES in a blood sample below the normal range (LEUKOCYTE COUNT less than 4000).	3.38	1	1
Thrombocytopenia A subnormal level of BLOOD PLATELETS.	3.38	1	1
Multiple Neurofibromas [description not available]	2	1	0
Neurofibromatoses A group of disorders characterized by an autosomal dominant pattern of inheritance with high rates of spontaneous mutation and multiple neurofibromas or neurilemmomas. NEUROFIBROMATOSIS 1 (generalized neurofibromatosis) accounts for approximately 95% of cases, although multiple additional subtypes (e.g., NEUROFIBROMATOSIS 2, neurofibromatosis 3, etc.) have been described. (From Neurochirurgie 1998 Nov;44(4):267-72)	2	1	0
Urination Disorders Abnormalities in the process of URINE voiding, including bladder control, frequency of URINATION, as well as the volume and composition of URINE.	2	1	0
Myelolipoma A rare benign tumor of the adrenal gland, several centimeters in diameter, composed in varying proportions of adipose tissue, lymphocytes, and primitive myeloid cells, probably a developmental abnormality. (Dorland, 27th ed)	7	1	0
Benign Neoplasms, Brain [description not available]	2	1	0
Angioblastic Meningioma [description not available]	2	1	0
Brain Neoplasms Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.	2	1	0
Meningioma A relatively common neoplasm of the CENTRAL NERVOUS SYSTEM that arises from arachnoidal cells. The majority are well differentiated vascular tumors which grow slowly and have a low potential to be invasive, although malignant subtypes occur. Meningiomas have a predilection to arise from the parasagittal region, cerebral convexity, sphenoidal ridge, olfactory groove, and SPINAL CANAL. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2056-7)	7	1	0
Argentaffinoma [description not available]	2	1	0
Cancer of Colon [description not available]	2	1	0
Cancer of the Thyroid [description not available]	2	1	0
Nodular Goiter [description not available]	2	1	0
Carcinoid Tumor A usually small, slow-growing neoplasm composed of islands of rounded, oxyphilic, or spindle-shaped cells of medium size, with moderately small vesicular nuclei, and covered by intact mucosa with a yellow cut surface. The tumor can occur anywhere in the gastrointestinal tract (and in the lungs and other sites); approximately 90% arise in the appendix. It is now established that these tumors are of neuroendocrine origin and derive from a primitive stem cell. (From Stedman, 25th ed & Holland et al., Cancer Medicine, 3d ed, p1182)	2	1	0
Colonic Neoplasms Tumors or cancer of the COLON.	2	1	0
Goiter, Nodular An enlarged THYROID GLAND containing multiple nodules (THYROID NODULE), usually resulting from recurrent thyroid HYPERPLASIA and involution over many years to produce the irregular enlargement. Multinodular goiters may be nontoxic or may induce THYROTOXICOSIS.	2	1	0
Thyroid Neoplasms Tumors or cancer of the THYROID GLAND.	2	1	0

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