Page last updated: 2024-12-06
2-aminobenzyl alcohol
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Description
2-Aminobenzyl alcohol, also known as o-aminobenzyl alcohol, is an organic compound with the formula C7H9NO. It is a colorless solid that is soluble in water and ethanol. The compound is used as a building block in the synthesis of various pharmaceuticals and agrochemicals. It is also a precursor to a variety of other organic compounds, such as dyes, resins, and polymers. 2-Aminobenzyl alcohol has been studied for its potential biological activity, including its antifungal and antibacterial properties. Its unique structure with both a primary amine and an alcohol functionality makes it a versatile compound for medicinal chemistry research. The compound can be synthesized through various methods, including reduction of 2-nitrobenzaldehyde or by the reaction of 2-aminobenzaldehyde with sodium borohydride. Its importance stems from its potential applications in various fields, including pharmaceuticals, agrochemicals, and materials science.'
2-aminobenzyl alcohol: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 21439 |
| CHEMBL ID | 1235999 |
| SCHEMBL ID | 16252 |
| MeSH ID | M0196010 |
Synonyms (64)
| Synonym |
|---|
| 2-aminobenzylalcohol |
| 2-(hydroxymethyl)aniline |
| CHEMBL1235999 |
| (2-aminophenyl)-methanol |
| AC-907/25014178 |
| (2-aminophenyl)methanol |
| einecs 226-293-7 |
| nsc 1173 |
| brn 1072211 |
| 5344-90-1 |
| wln: zr b1q |
| o-(hydroxymethyl)aniline |
| o-aminobenzyl alcohol |
| benzenemethanol, 2-amino- |
| 2-aminobenzyl alcohol |
| nsc-1173 |
| nsc1173 |
| benzyl alcohol, o-amino- |
| o-aminobenzylic alcohol |
| inchi=1/c7h9no/c8-7-4-2-1-3-6(7)5-9/h1-4,9h,5,8h |
| 1BIO |
| 2-aminobenzenemethanol |
| DB03058 |
| 2-aminobenzyl alcohol, 98% |
| OPREA1_783408 |
| STK077953 |
| AC-11377 |
| 2-hydroxymethylaniline |
| A1000 |
| AKOS000119677 |
| A829598 |
| ec 226-293-7 |
| 3-13-00-01615 (beilstein handbook reference) |
| unii-jk3ah3ng9c |
| jk3ah3ng9c , |
| o-amino-benzylalcohol |
| FT-0611234 |
| (2-amino-phenyl)-methanol |
| PS-3377 |
| BBL027657 |
| SCHEMBL16252 |
| DTXSID6063800 |
| 2-amino-benzyl alcohol |
| o-aminobenzylalcohol |
| 2-amino-benzylalcohol |
| o-amino-benzyl alcohol |
| 2-amino-benzenemethanol |
| 2-aminophenylmethanol |
| 0-aminobenzyl alcohol |
| W-105736 |
| STR03329 |
| (o-aminophenyl)methanol |
| o-aminophenylcarbinol |
| mfcd00007749 |
| F0001-1388 |
| CS-W004705 |
| mianserin hydrochloride imp. c (ep); mianserin imp. c (ep); (2-aminophenyl)methanol; benzocaine impurity b; mianserin hydrochloride impurity c; mianserin impurity c |
| SY006439 |
| Q27094019 |
| AMY4003 |
| PB47249 |
| EN300-21387 |
| HY-W004705 |
| Z104495736 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Protein Targets (1)
Inhibition Measurements
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Chain A, Complement Factor D | Homo sapiens (human) | IC50 (µMol) | 2.9000 | 2.9000 | 2.9000 | 2.9000 | AID977608 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
Bioassays (16)
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1449688 | Cytotoxicity against HEK293 cells harboring pendrin P123S mutant after 72 hrs by MTT assay | 2017 | Bioorganic & medicinal chemistry, 05-01, Volume: 25, Issue:9 | Discovery of (2-aminophenyl)methanol as a new molecular chaperone that rescues the localization of P123S mutant pendrin stably expressed in HEK293 cells. |
| AID1449700 | Chaperone activity at recombinant human C-terminal FLAG-tagged pendrin P123S mutant expressed in HEK293 cells assessed as translocation of mutant protein from cytoplasm to plasma membrane at 0.1 mM measured after 12 hrs by DAPI staining based immunofluore | 2017 | Bioorganic & medicinal chemistry, 05-01, Volume: 25, Issue:9 | Discovery of (2-aminophenyl)methanol as a new molecular chaperone that rescues the localization of P123S mutant pendrin stably expressed in HEK293 cells. |
| AID1449691 | Cytotoxicity against HEK293 cells harboring pendrin P123S mutant assessed as decrease in cell viability at 0.3 mM after 72 hrs by MTT assay | 2017 | Bioorganic & medicinal chemistry, 05-01, Volume: 25, Issue:9 | Discovery of (2-aminophenyl)methanol as a new molecular chaperone that rescues the localization of P123S mutant pendrin stably expressed in HEK293 cells. |
| AID1449702 | Chaperone activity at recombinant human C-terminal FLAG-tagged pendrin P123S mutant expressed in HEK293 cells assessed as increase in fluorescence intensity ratio of plasma membrane to cytoplasm measured after 12 hrs by DAPI staining based immunofluoresce | 2017 | Bioorganic & medicinal chemistry, 05-01, Volume: 25, Issue:9 | Discovery of (2-aminophenyl)methanol as a new molecular chaperone that rescues the localization of P123S mutant pendrin stably expressed in HEK293 cells. |
| AID1339468 | Inhibition of wild type PI3K p110alpha/p85alpha niSH2 (unknown origin) expressed in baculovirus infected sf9 cells assessed as reduction in PIP3 formation at 100 uM using PIP2 as substrate after 45 mins by fluorescence polarization assay relative to contr | 2017 | Bioorganic & medicinal chemistry, 02-15, Volume: 25, Issue:4 | Identification of allosteric binding sites for PI3Kα oncogenic mutant specific inhibitor design. |
| AID1449706 | Chaperone activity at recombinant human C-terminal FLAG-tagged pendrin P123S mutant expressed in HEK293 cells assessed as intracellular localization of mutant protein in plasma membrane at 0.1 mM incubated for 12 hrs followed by compound washout measured | 2017 | Bioorganic & medicinal chemistry, 05-01, Volume: 25, Issue:9 | Discovery of (2-aminophenyl)methanol as a new molecular chaperone that rescues the localization of P123S mutant pendrin stably expressed in HEK293 cells. |
| AID1449705 | Chaperone activity at recombinant human C-terminal FLAG-tagged pendrin P123S mutant expressed in HEK293 cells assessed as fluorescence intensity ratio of plasma membrane to cytoplasm at 0.1 mM measured after 12 hrs by DAPI staining based immunofluorescenc | 2017 | Bioorganic & medicinal chemistry, 05-01, Volume: 25, Issue:9 | Discovery of (2-aminophenyl)methanol as a new molecular chaperone that rescues the localization of P123S mutant pendrin stably expressed in HEK293 cells. |
| AID1449692 | Cytotoxicity against HEK293 cells harboring pendrin P123S mutant assessed as decrease in cell viability at 0.1 mM after 72 hrs by MTT assay | 2017 | Bioorganic & medicinal chemistry, 05-01, Volume: 25, Issue:9 | Discovery of (2-aminophenyl)methanol as a new molecular chaperone that rescues the localization of P123S mutant pendrin stably expressed in HEK293 cells. |
| AID1449695 | Chaperone activity at recombinant human C-terminal FLAG-tagged pendrin P123S mutant expressed in HEK293 cells assessed as intracellular localization of mutant protein in plasma membrane at 0.1 mM incubated for 12 hrs followed by compound washout measured | 2017 | Bioorganic & medicinal chemistry, 05-01, Volume: 25, Issue:9 | Discovery of (2-aminophenyl)methanol as a new molecular chaperone that rescues the localization of P123S mutant pendrin stably expressed in HEK293 cells. |
| AID1339469 | Inhibition of full length PI3Kalpha (unknown origin) assessed as reduction in PIP3 formation at 100 uM using PIP2 as substrate after 45 mins by fluorescence polarization assay relative to control | 2017 | Bioorganic & medicinal chemistry, 02-15, Volume: 25, Issue:4 | Identification of allosteric binding sites for PI3Kα oncogenic mutant specific inhibitor design. |
| AID1449704 | Chaperone activity at recombinant human C-terminal FLAG-tagged pendrin P123S mutant expressed in HEK293 cells assessed as fluorescence intensity ratio of plasma membrane to cytoplasm at 0.3 mM measured after 12 hrs by DAPI staining based immunofluorescenc | 2017 | Bioorganic & medicinal chemistry, 05-01, Volume: 25, Issue:9 | Discovery of (2-aminophenyl)methanol as a new molecular chaperone that rescues the localization of P123S mutant pendrin stably expressed in HEK293 cells. |
| AID1449690 | Cytotoxicity against HEK293 cells harboring pendrin P123S mutant assessed as decrease in cell viability at 1 mM after 72 hrs by MTT assay | 2017 | Bioorganic & medicinal chemistry, 05-01, Volume: 25, Issue:9 | Discovery of (2-aminophenyl)methanol as a new molecular chaperone that rescues the localization of P123S mutant pendrin stably expressed in HEK293 cells. |
| AID1449697 | Chaperone activity at recombinant human C-terminal FLAG-tagged pendrin P123S mutant expressed in HEK293 cells assessed as increase in localization of protein mutant in plasma membrane at 0.03 to 1 mM after 12 hrs by DAPI staining based immunofluorescence | 2017 | Bioorganic & medicinal chemistry, 05-01, Volume: 25, Issue:9 | Discovery of (2-aminophenyl)methanol as a new molecular chaperone that rescues the localization of P123S mutant pendrin stably expressed in HEK293 cells. |
| AID1449701 | Potency index, ratio of compound effect to salicylate effect for chaperone activity at recombinant human C-terminal FLAG-tagged pendrin P123S mutant expressed in HEK293 cells assessed as translocation of mutant protein from cytoplasm to plasma membrane | 2017 | Bioorganic & medicinal chemistry, 05-01, Volume: 25, Issue:9 | Discovery of (2-aminophenyl)methanol as a new molecular chaperone that rescues the localization of P123S mutant pendrin stably expressed in HEK293 cells. |
| AID977608 | Experimentally measured binding affinity data (IC50) for protein-ligand complexes derived from PDB | 1998 | Journal of molecular biology, Oct-09, Volume: 282, Issue:5 | Structures of native and complexed complement factor D: implications of the atypical His57 conformation and self-inhibitory loop in the regulation of specific serine protease activity. |
| AID1811 | Experimentally measured binding affinity data derived from PDB | 1998 | Journal of molecular biology, Oct-09, Volume: 282, Issue:5 | Structures of native and complexed complement factor D: implications of the atypical His57 conformation and self-inhibitory loop in the regulation of specific serine protease activity. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
Research
Studies (9)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 5 (55.56) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Market Indicators
Research Demand Index: 33.34
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (33.34) All Compounds (24.57) |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 10 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||