thromboplastin and Goiter--Nodular

Heparanase, galectin-3, and tissue factor (TF) are overexpressed in solid malignant thyroid tumors. We studied their expression in multinodular goiters (MNGs).. Thyroid tissue specimens from 15 MNGs were obtained during surgery. mRNA expression for galectin-3, heparanase, and TF was assessed by RT-PCR.. Isolated expressions of heparanase and galectin- 3 mRNA were expressed in 2 and 4 of the 15 MNGs, respectively; 8/15 MNGs were positive for both heparanase and galectin-3. TF mRNA was found in all MNG specimens.. Galectin-3, heparanase, and TF RNA expression is prevalent in MNGs. Further studies will be needed to determine the prognostic significance of these findings.

Topics: Biomarkers, Tumor; Female; Galectin 3; Glucuronidase; Goiter, Nodular; Humans; Male; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thromboplastin; Thyroid Neoplasms