alanine has been researched along with Luft Disease in 6 studies
Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.
alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Furthermore, in a mouse model of mitochondrial myopathy, we show that increased oxidative αKG flux in muscle arises from enhanced alanine synthesis and release into blood, concomitant with accelerated amino acid catabolism from protein breakdown." | 1.48 | Rewiring of Glutamine Metabolism Is a Bioenergetic Adaptation of Human Cells with Mitochondrial DNA Mutations. ( Arreguin, AJ; Beal, MF; Calder, EL; Carelli, V; Chen, Q; D'Aurelio, M; Denton, TT; Gross, SS; Kirk, K; Manfredi, G; Primiano, G; Shahi, I; Shurubor, YI; Valsecchi, F; Zhao, D, 2018) |
| "Five patients with McArdle's disease and five patients with mitochondrial myopathies performed the same incremental maximal exercise test." | 1.28 | Exercise intolerance in patients with McArdle's disease or mitochondrial myopathies. ( Camus, F; Chaussain, M; Defoligny, C; Eymard, B; Fardeau, M, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, Q | 1 |
| Kirk, K | 1 |
| Shurubor, YI | 1 |
| Zhao, D | 1 |
| Arreguin, AJ | 1 |
| Shahi, I | 1 |
| Valsecchi, F | 1 |
| Primiano, G | 1 |
| Calder, EL | 1 |
| Carelli, V | 1 |
| Denton, TT | 1 |
| Beal, MF | 1 |
| Gross, SS | 1 |
| Manfredi, G | 1 |
| D'Aurelio, M | 1 |
| Taylor, RW | 2 |
| Schaefer, AM | 1 |
| McFarland, R | 2 |
| Maddison, P | 1 |
| Turnbull, DM | 2 |
| Müller, T | 1 |
| Deschauer, M | 1 |
| Neudecker, S | 1 |
| Zierz, S | 1 |
| Swalwell, H | 1 |
| Blakely, EL | 1 |
| He, L | 1 |
| Groen, EJ | 1 |
| Bushby, KM | 1 |
| De Stefano, N | 1 |
| Matthews, PM | 1 |
| Ford, B | 1 |
| Genge, A | 1 |
| Karpati, G | 1 |
| Arnold, DL | 1 |
| Chaussain, M | 1 |
| Camus, F | 1 |
| Defoligny, C | 1 |
| Eymard, B | 1 |
| Fardeau, M | 1 |
1 trial available for alanine and Luft Disease
| Article | Year |
|---|---|
Short-term dichloroacetate treatment improves indices of cerebral metabolism in patients with mitochondrial disorders.
Topics: Acetylcysteine; Adenosine Diphosphate; Adolescent; Adult; Aged; Alanine; Brain; Child; Creatine; Cro | 1995 |
5 other studies available for alanine and Luft Disease
| Article | Year |
|---|---|
Rewiring of Glutamine Metabolism Is a Bioenergetic Adaptation of Human Cells with Mitochondrial DNA Mutations.
Topics: Adaptation, Physiological; Alanine; Animals; Disease Models, Animal; DNA, Mitochondrial; Energy Meta | 2018 |
A novel mitochondrial DNA tRNA(Ile) (A4267G) mutation in a sporadic patient with mitochondrial myopathy.
Topics: Adult; Alanine; Biopsy; DNA, Mitochondrial; Electron Transport Complex IV; Female; Germ-Line Mutatio | 2002 |
Late-onset mitochondrial myopathy with dystrophic changes due to a G7497A mutation in the mitochondrial tRNA(Ser(UCN)) gene.
Topics: Adult; Alanine; Disease Progression; DNA Mutational Analysis; DNA, Mitochondrial; Family Health; Fem | 2005 |
The m.5650G>A mitochondrial tRNAAla mutation is pathogenic and causes a phenotype of pure myopathy.
Topics: Adult; Alanine; Base Sequence; Child; DNA Mutational Analysis; Female; Genetic Markers; Genetic Pred | 2008 |
Exercise intolerance in patients with McArdle's disease or mitochondrial myopathies.
Topics: Adult; Alanine; Ammonia; Energy Metabolism; Exercise Test; Exercise Tolerance; Female; Glycogen Stor | 1992 |