Page last updated: 2024-11-08

alanine and Luft Disease

alanine has been researched along with Luft Disease in 6 studies

Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.
alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.

Research Excerpts

ExcerptRelevanceReference
"Furthermore, in a mouse model of mitochondrial myopathy, we show that increased oxidative αKG flux in muscle arises from enhanced alanine synthesis and release into blood, concomitant with accelerated amino acid catabolism from protein breakdown."1.48Rewiring of Glutamine Metabolism Is a Bioenergetic Adaptation of Human Cells with Mitochondrial DNA Mutations. ( Arreguin, AJ; Beal, MF; Calder, EL; Carelli, V; Chen, Q; D'Aurelio, M; Denton, TT; Gross, SS; Kirk, K; Manfredi, G; Primiano, G; Shahi, I; Shurubor, YI; Valsecchi, F; Zhao, D, 2018)
"Five patients with McArdle's disease and five patients with mitochondrial myopathies performed the same incremental maximal exercise test."1.28Exercise intolerance in patients with McArdle's disease or mitochondrial myopathies. ( Camus, F; Chaussain, M; Defoligny, C; Eymard, B; Fardeau, M, 1992)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (33.33)18.2507
2000's3 (50.00)29.6817
2010's1 (16.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Chen, Q1
Kirk, K1
Shurubor, YI1
Zhao, D1
Arreguin, AJ1
Shahi, I1
Valsecchi, F1
Primiano, G1
Calder, EL1
Carelli, V1
Denton, TT1
Beal, MF1
Gross, SS1
Manfredi, G1
D'Aurelio, M1
Taylor, RW2
Schaefer, AM1
McFarland, R2
Maddison, P1
Turnbull, DM2
Müller, T1
Deschauer, M1
Neudecker, S1
Zierz, S1
Swalwell, H1
Blakely, EL1
He, L1
Groen, EJ1
Bushby, KM1
De Stefano, N1
Matthews, PM1
Ford, B1
Genge, A1
Karpati, G1
Arnold, DL1
Chaussain, M1
Camus, F1
Defoligny, C1
Eymard, B1
Fardeau, M1

Trials

1 trial available for alanine and Luft Disease

ArticleYear
Short-term dichloroacetate treatment improves indices of cerebral metabolism in patients with mitochondrial disorders.
    Neurology, 1995, Volume: 45, Issue:6

    Topics: Acetylcysteine; Adenosine Diphosphate; Adolescent; Adult; Aged; Alanine; Brain; Child; Creatine; Cro

1995

Other Studies

5 other studies available for alanine and Luft Disease

ArticleYear
Rewiring of Glutamine Metabolism Is a Bioenergetic Adaptation of Human Cells with Mitochondrial DNA Mutations.
    Cell metabolism, 2018, May-01, Volume: 27, Issue:5

    Topics: Adaptation, Physiological; Alanine; Animals; Disease Models, Animal; DNA, Mitochondrial; Energy Meta

2018
A novel mitochondrial DNA tRNA(Ile) (A4267G) mutation in a sporadic patient with mitochondrial myopathy.
    Neuromuscular disorders : NMD, 2002, Volume: 12, Issue:7-8

    Topics: Adult; Alanine; Biopsy; DNA, Mitochondrial; Electron Transport Complex IV; Female; Germ-Line Mutatio

2002
Late-onset mitochondrial myopathy with dystrophic changes due to a G7497A mutation in the mitochondrial tRNA(Ser(UCN)) gene.
    Acta neuropathologica, 2005, Volume: 110, Issue:4

    Topics: Adult; Alanine; Disease Progression; DNA Mutational Analysis; DNA, Mitochondrial; Family Health; Fem

2005
The m.5650G>A mitochondrial tRNAAla mutation is pathogenic and causes a phenotype of pure myopathy.
    Neuromuscular disorders : NMD, 2008, Volume: 18, Issue:1

    Topics: Adult; Alanine; Base Sequence; Child; DNA Mutational Analysis; Female; Genetic Markers; Genetic Pred

2008
Exercise intolerance in patients with McArdle's disease or mitochondrial myopathies.
    The European journal of medicine, 1992, Volume: 1, Issue:8

    Topics: Adult; Alanine; Ammonia; Energy Metabolism; Exercise Test; Exercise Tolerance; Female; Glycogen Stor

1992