3-hydroxypalmitic acid

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

3-hydroxypalmitic acid : A long-chain fatty acid that is the 3-hydroxy derivative of palmitic acid. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID Source	ID
PubMed CID	15569776
CHEMBL ID	2207728
CHEBI ID	38247
SCHEMBL ID	1358867
MeSH ID	M0281239

Synonyms (14)

Synonym
(r)-beta-hydroxypalmitic acid
(r)-3-hydroxypalmitic acid
CHEBI:38247 ,
(3r)-3-hydroxyhexadecanoic acid
3-hydroxypalmitic acid
3r-hydroxyhexadecanoic acid
3r-hydroxypalmitic acid
LMFA01050366
CHEMBL2207728
SCHEMBL1358867
(r)-3-hydroxyhexadecanoic acid
(r)-3-hydroxy-hexadecanoic acid
Q27117428
DTXSID401344857

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (2)

Class	Description
3-hydroxypalmitic acid	A long-chain fatty acid that is the 3-hydroxy derivative of palmitic acid.
(3R)-3-hydroxy fatty acid	A 3-hydroxy fatty acid in which the carbon at position 3 has R configuration.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathways (1)

Pathway	Proteins	Compounds
Fatty Acid Biosynthesis	2	33

Bioassays (4)

Assay ID	Title	Year	Journal	Article
AID718446	Antibacterial activity against Bacillus cereus by broth dilution method	2012	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24	Heterologously expressed β-hydroxyl fatty acids from a metagenomic library of a marine sponge.
AID718445	Antibacterial activity against methicillin-resistant Staphylococcus aureus by broth dilution method	2012	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24	Heterologously expressed β-hydroxyl fatty acids from a metagenomic library of a marine sponge.
AID718444	Antifungal activity against Candida albicans by broth dilution	2012	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24	Heterologously expressed β-hydroxyl fatty acids from a metagenomic library of a marine sponge.
AID718443	Antibacterial activity against Escherichia coli by broth dilution method	2012	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24	Heterologously expressed β-hydroxyl fatty acids from a metagenomic library of a marine sponge.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (17)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	2 (11.76)	18.2507
2000's	4 (23.53)	29.6817
2010's	11 (64.71)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	17 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
palmitic acid Palmitic Acid: A common saturated fatty acid found in fats and waxes including olive oil, palm oil, and body lipids.. hexadecanoic acid : A straight-chain, sixteen-carbon, saturated long-chain fatty acid.	2.1	1	long-chain fatty acid; straight-chain saturated fatty acid	algal metabolite; Daphnia magna metabolite; EC 1.1.1.189 (prostaglandin-E2 9-reductase) inhibitor; plant metabolite
mercaptoethanol Mercaptoethanol: A water-soluble thiol derived from hydrogen sulfide and ethanol. It is used as a reducing agent for disulfide bonds and to protect sulfhydryl groups from oxidation.	1.99	1	alkanethiol; primary alcohol	geroprotector
methyl palmitate [no description available]	2.11	1	fatty acid methyl ester	metabolite
16-hydroxypalmitic acid 16-hydroxyhexadecanoic acid : An omega-hydroxy-long-chain fatty acid that is hexadecanoic acid (also known as palmitic acid) which is substituted at position 16 by a hydroxy group. It is a key monomer of cutin in the plant cuticle.	2.1	1	hydroxypalmitic acid; omega-hydroxy-long-chain fatty acid	plant metabolite
beta-hydroxymyristic acid beta-hydroxymyristic acid: RN given refers to cpd without isomeric designation. 3-hydroxytetradecanoic acid : A 3-hydroxy fatty acid that is tetradecanoic (myristic) acid substituted at position 3 by a hydroxy group	3.21	5	3-hydroxy fatty acid; 3-hydroxy monocarboxylic acid; long-chain fatty acid	bacterial metabolite; human metabolite
myrmicacin myrmicacin: found in secretions of South American leaf-cutting ant; inhibitor for mitotic progression after metaphase. 3-hydroxydecanoic acid : A medium-chain fatty acid that is decanoic acid substituted at position 3 by a hydroxy group.	2.05	1	3-hydroxy fatty acid; medium-chain fatty acid	antimitotic; Escherichia coli metabolite
glycidyl nitrate glycidyl nitrate: a nitric oxide donor; structure in first source. peptidoglycan : A peptidoglycosaminoglycan formed by alternating residues of beta-(1->4)-linked N-acetylglucosamine and N-acetylmuramic acid {2-amino-3-O-[(S)-1-carboxyethyl]-2-deoxy-D-glucose} residues. Attached to the carboxy group of the muramic acid is a peptide chain of three to five amino acids.	1.99	1
3-hydroxydodecanoic acid 3-hydroxydodecanoic acid: RN given refers to cpd without isomeric designation. 3-hydroxylauric acid : A medium-chain fatty acid that is the 3-hydroxylated derivative of lauric acid; associated with fatty acid metabolic disorders.	2.1	1	3-hydroxy fatty acid; medium-chain fatty acid
nadp [no description available]	2.8	3
cytochrome c-t Cytochromes c: Cytochromes of the c type that are found in eukaryotic MITOCHONDRIA. They serve as redox intermediates that accept electrons from MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX III and transfer them to MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX IV.	2.1	1

Condition	Relationship Strength	Studies
Luft Disease [description not available]	2.8	3
Lipid Metabolism, Inborn Error [description not available]	2.8	3
Cardiomyopathies, Primary [description not available]	2.8	3
Nervous System Disorders [description not available]	2.8	3
Cardiomyopathies A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classified according to their predominant pathophysiological features (DILATED CARDIOMYOPATHY; HYPERTROPHIC CARDIOMYOPATHY; RESTRICTIVE CARDIOMYOPATHY) or their etiological/pathological factors (CARDIOMYOPATHY, ALCOHOLIC; ENDOCARDIAL FIBROELASTOSIS).	2.8	3
Nervous System Diseases Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, peripheral nerves, nerve roots, autonomic nervous system, neuromuscular junction, and muscle.	2.8	3
Rhabdomyolysis Necrosis or disintegration of skeletal muscle often followed by myoglobinuria.	2.8	3
Mitochondrial Myopathies A group of muscle diseases associated with abnormal mitochondria function.	2.8	3
Acquired Metabolic Diseases, Brain [description not available]	2.05	1
Lipid Metabolism Disorders Pathological conditions resulting from abnormal anabolism or catabolism of lipids in the body.	2.05	1
Inborn Errors of Metabolism [description not available]	2.01	1
Metabolism, Inborn Errors Errors in metabolic processes resulting from inborn genetic mutations that are inherited or acquired in utero.	2.01	1
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	2.01	1

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