thymidine has been researched along with Luft Disease in 8 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "Telbivudine has also been reported to be associated with myopathy and neuropathy, particularly when used in combination with pegylated interferon." | 2.45 | Myopathy and neuropathy associated with nucleos(t)ide analog therapy for hepatitis B. ( Fleischer, RD; Lok, AS, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (37.50) | 29.6817 |
| 2010's | 2 (25.00) | 24.3611 |
| 2020's | 3 (37.50) | 2.80 |
| Authors | Studies |
|---|---|
| Harada, N | 1 |
| Nagasaki, H | 1 |
| Yamamoto, H | 1 |
| Matsubara, K | 1 |
| Suzuki, T | 1 |
| Gomori, A | 1 |
| Yokogawa, T | 1 |
| Matsuo, K | 1 |
| Miyadera, K | 1 |
| Hernandez-Voth, A | 1 |
| Sayas Catalan, J | 1 |
| Corral Blanco, M | 1 |
| Castaño Mendez, A | 1 |
| Martin, MA | 2 |
| De Fuenmayor Fernandez de la Hoz, C | 1 |
| Villena Garrido, V | 1 |
| Dominguez-Gonzalez, C | 2 |
| Lopez-Gomez, C | 1 |
| Sanchez-Quintero, MJ | 1 |
| Lee, EJ | 1 |
| Kleiner, G | 1 |
| Tadesse, S | 2 |
| Xie, J | 1 |
| Akman, HO | 1 |
| Gao, G | 1 |
| Hirano, M | 2 |
| Hernández-Laín, A | 1 |
| Guerrero, AM | 1 |
| Fernández-Vázquez, I | 1 |
| Maya, DG | 1 |
| Delmiro, A | 1 |
| Arenas, J | 1 |
| Morales, JR | 1 |
| Blázquez, A | 1 |
| Moran, M | 1 |
| Fleischer, RD | 1 |
| Lok, AS | 1 |
| El-Hattab, AW | 1 |
| Scaglia, F | 1 |
| Hayashi, N | 1 |
| Geraghty, MT | 1 |
| Green, WR | 1 |
| Spinazzola, A | 1 |
| Marti, R | 1 |
| Nishino, I | 1 |
| Andreu, AL | 1 |
| Naini, A | 1 |
| Pela, I | 1 |
| Zammarchi, E | 1 |
| Donati, MA | 1 |
| Oliver, JA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase 2 Open-Label Study of Continuation Treatment With Combination Pyrimidine Nucleosides in Patients With Thymidine Kinase 2 Deficiency (TK2)[NCT03845712] | Phase 2 | 47 participants (Actual) | Interventional | 2019-07-05 | Active, not recruiting | ||
| A Phase II, Monocenter, Single Arm Study To Assess The Safety and Efficacy Of Combination Deoxycytidine and Deoxythymidine For Mitochondrial Depletion Disorders[NCT04802707] | Phase 2 | 50 participants (Anticipated) | Interventional | 2021-10-18 | Recruiting | ||
| A Phase 1 Double-Blinded Study for Safety, Tolerability, Pharmacokinetics, and Antiviral Activity of ATI-2173 in Healthy Subjects and Subjects With Chronic Hepatitis B Virus Infection[NCT04248426] | Phase 1 | 88 participants (Actual) | Interventional | 2020-02-05 | Completed | ||
| Nutritional Assessment in Patients Affected by Mitochondrial Cytopathy[NCT02375438] | 26 participants (Actual) | Observational | 2014-12-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for thymidine and Luft Disease
| Article | Year |
|---|---|
Myopathy and neuropathy associated with nucleos(t)ide analog therapy for hepatitis B.
Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; Creatine Kinase; Drug Discovery; Early Terminatio | 2009 |
Mitochondrial DNA depletion syndromes: review and updates of genetic basis, manifestations, and therapeutic options.
Topics: DNA Replication; DNA, Mitochondrial; Humans; Liver Transplantation; Mitochondrial Diseases; Mitochon | 2013 |
Mitochondrial DNA depletion syndromes: review and updates of genetic basis, manifestations, and therapeutic options.
Topics: DNA Replication; DNA, Mitochondrial; Humans; Liver Transplantation; Mitochondrial Diseases; Mitochon | 2013 |
Mitochondrial DNA depletion syndromes: review and updates of genetic basis, manifestations, and therapeutic options.
Topics: DNA Replication; DNA, Mitochondrial; Humans; Liver Transplantation; Mitochondrial Diseases; Mitochon | 2013 |
Mitochondrial DNA depletion syndromes: review and updates of genetic basis, manifestations, and therapeutic options.
Topics: DNA Replication; DNA, Mitochondrial; Humans; Liver Transplantation; Mitochondrial Diseases; Mitochon | 2013 |
6 other studies available for thymidine and Luft Disease
| Article | Year |
|---|---|
Depletion of plasma thymidine results in growth retardation and mitochondrial myopathy in mice overexpressing human thymidine phosphorylase.
Topics: Animals; DNA, Mitochondrial; Growth Disorders; Humans; Mammals; Mice; Mitochondrial Encephalomyopath | 2023 |
Deoxynucleoside therapy for respiratory involvement in adult patients with thymidine kinase 2-deficient myopathy.
Topics: Adolescent; Adult; Child; Child, Preschool; Deoxycytidine; Female; Humans; Middle Aged; Mitochondria | 2020 |
Deoxynucleoside therapy for respiratory involvement in adult patients with thymidine kinase 2-deficient myopathy.
Topics: Adolescent; Adult; Child; Child, Preschool; Deoxycytidine; Female; Humans; Middle Aged; Mitochondria | 2020 |
Deoxynucleoside therapy for respiratory involvement in adult patients with thymidine kinase 2-deficient myopathy.
Topics: Adolescent; Adult; Child; Child, Preschool; Deoxycytidine; Female; Humans; Middle Aged; Mitochondria | 2020 |
Deoxynucleoside therapy for respiratory involvement in adult patients with thymidine kinase 2-deficient myopathy.
Topics: Adolescent; Adult; Child; Child, Preschool; Deoxycytidine; Female; Humans; Middle Aged; Mitochondria | 2020 |
Synergistic Deoxynucleoside and Gene Therapies for Thymidine Kinase 2 Deficiency.
Topics: Animals; Compassionate Use Trials; DNA, Mitochondrial; Genetic Therapy; Humans; Mice; Mitochondria; | 2021 |
A novel RRM2B gene variant associated with Telbivudine-induced mitochondrial myopathy.
Topics: Aged; Antiviral Agents; Cell Cycle Proteins; Female; Hepatitis B, Chronic; Humans; Liver Transplanta | 2015 |
Ocular histopathologic study of a patient with the T 8993-G point mutation in Leigh's syndrome.
Topics: Ciliary Body; DNA Mutational Analysis; DNA, Mitochondrial; Endothelium, Corneal; Epithelium; Eye Dis | 2000 |
Altered thymidine metabolism due to defects of thymidine phosphorylase.
Topics: Cells, Cultured; Chromosomes, Human, Pair 22; Humans; Mitochondrial Myopathies; Mutation; Thymidine; | 2002 |