4-aminopyridine has been researched along with Botulism in 11 studies
Botulism: A disease caused by potent protein NEUROTOXINS produced by CLOSTRIDIUM BOTULINUM which interfere with the presynaptic release of ACETYLCHOLINE at the NEUROMUSCULAR JUNCTION. Clinical features include abdominal pain, vomiting, acute PARALYSIS (including respiratory paralysis), blurred vision, and DIPLOPIA. Botulism may be classified into several subtypes (e.g., food-borne, infant, wound, and others). (From Adams et al., Principles of Neurology, 6th ed, p1208)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Toosendanin is a triterpenoid derivative extracted from a digestive tract-parasiticide in Chinese traditional medicine." | 6.42 | Cure of experimental botulism and antibotulismic effect of toosendanin. ( Shi, YL; Wang, ZF, 2004) |
| "4-Aminopyridine and 3,4-diaminopyridine were evaluated for their abilities to delay the onset of paralysis due to botulinum neurotoxin types A, B, and E." | 3.67 | A preclinical evaluation of aminopyridines as putative therapeutic agents in the treatment of botulism. ( Simpson, LL, 1986) |
| "Toosendanin is a triterpenoid derivative extracted from a digestive tract-parasiticide in Chinese traditional medicine." | 2.42 | Cure of experimental botulism and antibotulismic effect of toosendanin. ( Shi, YL; Wang, ZF, 2004) |
| "The specific treatments of botulism with serotherapy and with guanidine are of debatable efficacy." | 1.31 | [Treatment of severe botulism with 3,4-diaminopyridine]]. ( Ben Ali, A; Carlet, J; Deletie, E; Dock, M; Garrouste-Orgeas, M; Goldstein, F; Karras, A; Misset, B, 2002) |
| "Aspects of the treatment of botulism in animals are discussed." | 1.27 | Diagnosis and treatment of botulism in lions. ( Greenwood, AG, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (72.73) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (18.18) | 29.6817 |
| 2010's | 1 (9.09) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Friggeri, A | 1 |
| Marçon, F | 1 |
| Marciniak, S | 1 |
| Lemaire-Hurtel, AS | 1 |
| Seydi, A | 1 |
| Ammenouche, N | 1 |
| Levrard, M | 1 |
| Mahjoub, Y | 1 |
| Airapetian, N | 1 |
| Tinturier, F | 1 |
| Petitjean, M | 1 |
| Dupont, H | 1 |
| Shi, YL | 1 |
| Wang, ZF | 1 |
| Sellin, LC | 2 |
| Soni, N | 1 |
| Kam, P | 1 |
| Dock, M | 1 |
| Ben Ali, A | 1 |
| Karras, A | 1 |
| Misset, B | 1 |
| Garrouste-Orgeas, M | 1 |
| Deletie, E | 1 |
| Goldstein, F | 1 |
| Carlet, J | 1 |
| Kryzhanovskiĭ, GN | 2 |
| Morrison, VV | 2 |
| Simpson, LL | 1 |
| Siegel, LS | 2 |
| Price, JI | 1 |
| Johnson-Winegar, AD | 1 |
| Greenwood, AG | 1 |
3 reviews available for 4-aminopyridine and Botulism
| Article | Year |
|---|---|
Cure of experimental botulism and antibotulismic effect of toosendanin.
Topics: 4-Aminopyridine; Amifampridine; Animals; Botulinum Toxins; Botulism; Drugs, Chinese Herbal; Melia; N | 2004 |
The action of batulinum toxin at the neuromuscular junction.
Topics: 4-Aminopyridine; Acetylcholine; Amifampridine; Aminopyridines; Botulinum Toxins; Botulism; Calcium; | 1981 |
4-aminopyridine-a review.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Botulism; Central Nervous System; Humans; Ion Channels; My | 1982 |
1 trial available for 4-aminopyridine and Botulism
| Article | Year |
|---|---|
3,4-Diaminopyridine may improve neuromuscular block during botulism.
Topics: 4-Aminopyridine; Action Potentials; Adult; Amifampridine; Botulism; Female; Humans; Neuromuscular Bl | 2013 |
7 other studies available for 4-aminopyridine and Botulism
| Article | Year |
|---|---|
[Treatment of severe botulism with 3,4-diaminopyridine]].
Topics: 4-Aminopyridine; Acetylcholine; Aged; Amifampridine; Botulinum Toxins; Botulinum Toxins, Type A; Bot | 2002 |
[Complex pathogenetic therapy of experimental botulism].
Topics: 4-Aminopyridine; Aminopyridines; Animals; Botulism; Drug Therapy, Combination; Guanylthiourea; Male; | 1987 |
[Effect of 4-aminopyridine on the development of experimental botulism].
Topics: 4-Aminopyridine; Aminopyridines; Animals; Botulinum Toxins; Botulism; Male; Mice; Rats | 1985 |
A preclinical evaluation of aminopyridines as putative therapeutic agents in the treatment of botulism.
Topics: 4-Aminopyridine; Amifampridine; Aminopyridines; Animals; Botulinum Toxins; Botulism; Dose-Response R | 1986 |
Ineffectiveness of 3,4-diaminopyridine as a therapy for type C botulism.
Topics: 4-Aminopyridine; Acetylcholine; Amifampridine; Aminopyridines; Animals; Botulism; Mice; Neuromuscula | 1987 |
Effect of 3,4-diaminopyridine on the survival of mice injected with botulinum neurotoxin type A, B, E, or F.
Topics: 4-Aminopyridine; Amifampridine; Aminopyridines; Animals; Botulinum Toxins; Botulism; Injections, Int | 1986 |
Diagnosis and treatment of botulism in lions.
Topics: 4-Aminopyridine; Amifampridine; Aminopyridines; Amoxicillin; Animals; Animals, Zoo; Botulinum Antito | 1985 |