propofol has been researched along with Refractory Depression in 7 studies
Propofol: An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.
propofol : A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Ketamine in electroconvulsive therapy (ECT) anesthesia has been reported to be associated with better seizure quality and longer duration compared with methohexital anesthesia." | 5.17 | Effects of S-ketamine as an anesthetic adjuvant to propofol on treatment response to electroconvulsive therapy in treatment-resistant depression: a randomized pilot study. ( Björkqvist, M; Chrapek, W; Häkkinen, H; Järventausta, K; Kampman, O; Leinonen, E; Tuohimaa, K; Yli-Hankala, A, 2013) |
| "Propofol treatments were well tolerated by all subjects." | 2.87 | Propofol for Treatment-Resistant Depression: A Pilot Study. ( Arp, AM; Beck, MM; Bushnell, LA; Jessop, JE; Kendrick, EJ; Larson, AL; Leonardi, K; Light, AR; Light, KC; Mickey, BJ; Odell, DH; Pierson, MD; Sakata, DJ; Solzbacher, D; Tadler, SC; Torres, MM; Weeks, HR; White, AT; Whittingham, SA, 2018) |
| "Nitrous oxide has also shown antidepressant efficacy." | 2.58 | Emerging evidence for antidepressant actions of anesthetic agents. ( Mickey, BJ; Tadler, SC, 2018) |
| " Despite adequate dosing of both intravenous and inhalation anesthetics, our patient was resistant to induction of the state of general anesthesia." | 1.43 | Hyperlipidemia sink for anesthetic agents. ( Eldesouki, E; Hobika, GG; Johnson, TJ; Nader, ND; Porhomayon, J; Smith, K, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (71.43) | 24.3611 |
| 2020's | 2 (28.57) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, Q | 1 |
| Dong, J | 1 |
| Luo, J | 1 |
| Ren, L | 1 |
| Min, S | 1 |
| Hao, X | 1 |
| Luo, Q | 1 |
| Chen, J | 1 |
| Li, X | 1 |
| Zhang, J | 1 |
| Tian, H | 1 |
| Li, J | 1 |
| Ji, S | 1 |
| Chen, S | 1 |
| Zhu, J | 1 |
| Jiang, D | 1 |
| Wang, L | 1 |
| Li, G | 1 |
| Chen, M | 1 |
| Wang, W | 1 |
| Lin, X | 1 |
| Zhuo, C | 1 |
| Tadler, SC | 2 |
| Mickey, BJ | 2 |
| White, AT | 1 |
| Arp, AM | 1 |
| Leonardi, K | 1 |
| Torres, MM | 1 |
| Larson, AL | 1 |
| Odell, DH | 1 |
| Whittingham, SA | 1 |
| Beck, MM | 1 |
| Jessop, JE | 1 |
| Sakata, DJ | 1 |
| Bushnell, LA | 1 |
| Pierson, MD | 1 |
| Solzbacher, D | 1 |
| Kendrick, EJ | 1 |
| Weeks, HR | 1 |
| Light, AR | 1 |
| Light, KC | 1 |
| Järventausta, K | 1 |
| Chrapek, W | 1 |
| Kampman, O | 1 |
| Tuohimaa, K | 1 |
| Björkqvist, M | 1 |
| Häkkinen, H | 1 |
| Yli-Hankala, A | 1 |
| Leinonen, E | 1 |
| Zhong, X | 1 |
| He, H | 1 |
| Zhang, C | 1 |
| Wang, Z | 1 |
| Jiang, M | 1 |
| Li, Q | 1 |
| Zhang, M | 1 |
| Huang, X | 1 |
| Johnson, TJ | 1 |
| Porhomayon, J | 1 |
| Nader, ND | 1 |
| Eldesouki, E | 1 |
| Smith, K | 1 |
| Hobika, GG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Burst Suppression Anesthesia for Treatment of Severe Depression[NCT02935647] | Phase 1 | 11 participants (Actual) | Interventional | 2016-10-01 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for propofol and Refractory Depression
| Article | Year |
|---|---|
Emerging evidence for antidepressant actions of anesthetic agents.
Topics: Anesthesiologists; Anesthetics; Antidepressive Agents; Cerebral Cortex; Depressive Disorder, Treatme | 2018 |
3 trials available for propofol and Refractory Depression
| Article | Year |
|---|---|
Propofol for Treatment-Resistant Depression: A Pilot Study.
Topics: Adolescent; Adult; Anesthetics, Intravenous; Depressive Disorder, Treatment-Resistant; Electroenceph | 2018 |
Effects of S-ketamine as an anesthetic adjuvant to propofol on treatment response to electroconvulsive therapy in treatment-resistant depression: a randomized pilot study.
Topics: Adjuvants, Anesthesia; Adult; Aged; Aged, 80 and over; Anesthesia; Anesthesia Recovery Period; Anest | 2013 |
Mood and neuropsychological effects of different doses of ketamine in electroconvulsive therapy for treatment-resistant depression.
Topics: Adolescent; Adult; Affect; Aged; Anesthetics, Intravenous; Cognition Disorders; Combined Modality Th | 2016 |
3 other studies available for propofol and Refractory Depression
| Article | Year |
|---|---|
Effects of Low-Dose Ketamine on the Antidepressant Efficacy and Suicidal Ideations in Patients Undergoing Electroconvulsive Therapy.
Topics: Adult; Anesthetics, Dissociative; Anesthetics, Intravenous; Antidepressive Agents; Combined Modality | 2020 |
Ketamine plus propofol-electroconvulsive therapy (ECT) transiently improves the antidepressant effects and the associated brain functional alterations in patients with propofol-ECT-resistant depression.
Topics: Adult; Anesthetics, Intravenous; Antidepressive Agents; Brain; Combined Modality Therapy; Depressive | 2020 |
Hyperlipidemia sink for anesthetic agents.
Topics: Adult; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, Inhalation; Anesthetics, Intrav | 2016 |