imipramine has been researched along with Refractory Depression in 7 studies
Imipramine: The prototypical tricyclic antidepressant. It has been used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. It has less sedative effect than some other members of this therapeutic group.
imipramine : A dibenzoazepine that is 5H-dibenzo[b,f]azepine substituted by a 3-(dimethylamino)propyl group at the nitrogen atom.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A recent review proposed four criteria for an animal model of treatment-resistant depression (TRD): a phenotypic resemblance to a risk factor for depression; enhanced response to stress; nonresponse to antidepressant drugs and response to treatments effective in TRD, such as deep brain stimulation (DBS) of the prefrontal cortex or ketamine." | 3.91 | Validation of chronic mild stress in the Wistar-Kyoto rat as an animal model of treatment-resistant depression. ( Gruca, P; Lason, M; Litwa, E; Niemczyk, M; Papp, M; Tota-Glowczyk, K; Willner, P, 2019) |
| "Post-traumatic stress disorder (PTSD) displays high co-morbidity with major depression and treatment-resistant depression (TRD)." | 1.46 | Exploring a post-traumatic stress disorder paradigm in Flinders sensitive line rats to model treatment-resistant depression II: response to antidepressant augmentation strategies. ( Brand, SJ; Harvey, BH, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 7 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Papp, M | 2 |
| Gruca, P | 2 |
| Lason, M | 2 |
| Tota-Glowczyk, K | 2 |
| Niemczyk, M | 2 |
| Litwa, E | 2 |
| Willner, P | 2 |
| Pereira, VS | 1 |
| Joca, SRL | 1 |
| Harvey, BH | 3 |
| Elfving, B | 1 |
| Wegener, G | 1 |
| Brand, SJ | 2 |
| Hayashi, H | 1 |
| Doi, M | 1 |
| Onoue, Y | 1 |
| Kuwatsuka, K | 1 |
| Miyake, A | 1 |
| Koyama, T | 1 |
| Shinomiya, K | 1 |
| Miyazaki, I | 1 |
| Aasanuma, M | 1 |
| Kitamura, Y | 1 |
| Iwai, T | 1 |
| Ohnuki, T | 1 |
| Sasaki-Hamada, S | 1 |
| Saitoh, A | 1 |
| Sugiyama, A | 1 |
| Oka, J | 1 |
1 review available for imipramine and Refractory Depression
| Article | Year |
|---|---|
[Investigation on the mechanisms for the suppression of cell proliferation in the dentate gyrus of the hippocampus in ACTH treated rats].
Topics: Adrenocorticotropic Hormone; Animals; Brain-Derived Neurotrophic Factor; Cell Proliferation; Dentate | 2012 |
6 other studies available for imipramine and Refractory Depression
| Article | Year |
|---|---|
Rapid antidepressant effects of deep brain stimulation of the pre-frontal cortex in an animal model of treatment-resistant depression.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Citalopram; Deep Brain Stimulation; Depressive Dis | 2018 |
Validation of chronic mild stress in the Wistar-Kyoto rat as an animal model of treatment-resistant depression.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Citalopram; Depression; Depressive Disorder; Depre | 2019 |
Esketamine and rapastinel, but not imipramine, have antidepressant-like effect in a treatment-resistant animal model of depression.
Topics: Adrenocorticotropic Hormone; Animals; Antidepressive Agents; Behavior, Animal; Corticosterone; Depre | 2019 |
Exploring a post-traumatic stress disorder paradigm in Flinders sensitive line rats to model treatment-resistant depression I: bio-behavioural validation and response to imipramine.
Topics: Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Cerebral Cortex; Comorbidity; Depressiv | 2017 |
Exploring a post-traumatic stress disorder paradigm in Flinders sensitive line rats to model treatment-resistant depression II: response to antidepressant augmentation strategies.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Cerebral Cortex; Depressive Disorder, Treatment-Re | 2017 |
Glucagon-like peptide-2 but not imipramine exhibits antidepressant-like effects in ACTH-treated mice.
Topics: Adrenocorticotropic Hormone; Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Depressive | 2013 |