nitrous oxide has been researched along with Refractory Depression in 6 studies
Nitrous Oxide: Nitrogen oxide (N2O). A colorless, odorless gas that is used as an anesthetic and analgesic. High concentrations cause a narcotic effect and may replace oxygen, causing death by asphyxia. It is also used as a food aerosol in the preparation of whipping cream.
dinitrogen oxide : A nitrogen oxide consisting of linear unsymmetrical molecules with formula N2O. While it is the most used gaseous anaesthetic in the world, its major commercial use, due to its solubility under pressure in vegetable fats combined with its non-toxicity in low concentrations, is as an aerosol spray propellant and aerating agent for canisters of 'whipped' cream.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Nitrous oxide has rapid antidepressant effects in patients with treatment-resistant depression (TRD), but its underlying mechanisms of therapeutic actions are not well understood." | 9.69 | Brain function changes reveal rapid antidepressant effects of nitrous oxide for treatment-resistant depression:Evidence from task-state EEG. ( Hu, B; Kong, W; Li, L; Li, X; Liao, M; Ou, W; Shao, X; Sun, S; Yan, D; Zhang, Y; Zheng, F, 2023) |
| "In this double-blind randomized controlled trial, 25 adults with BD I/II and current treatment-refractory depression received either: (1) nitrous oxide (20 min at 25% concentration) plus intravenous saline (n = 12), or (2) medical air plus intravenous midazolam (2 mg total; n = 13)." | 5.69 | Proof-of-concept randomized controlled trial of single-session nitrous oxide treatment for refractory bipolar depression: Focus on cerebrovascular target engagement. ( Belo, S; Choi, M; Choi, S; Detzler, G; Dimick, MK; Goldstein, BI; Herrmann, N; Iazzetta, J; Kim, WSH; Levitt, A; MacIntosh, BJ; McIntyre, RS; Mitchell, RHB; Omrin, D; Orser, BA; Riegert, D; Schaffer, A, 2023) |
| "Nitrous oxide has rapid antidepressant effects in patients with treatment-resistant depression (TRD), but its underlying mechanisms of therapeutic actions are not well understood." | 5.69 | Brain function changes reveal rapid antidepressant effects of nitrous oxide for treatment-resistant depression:Evidence from task-state EEG. ( Hu, B; Kong, W; Li, L; Li, X; Liao, M; Ou, W; Shao, X; Sun, S; Yan, D; Zhang, Y; Zheng, F, 2023) |
| "Nitrous oxide has also shown antidepressant efficacy." | 2.58 | Emerging evidence for antidepressant actions of anesthetic agents. ( Mickey, BJ; Tadler, SC, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (50.00) | 24.3611 |
| 2020's | 3 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Quach, DF | 1 |
| de Leon, VC | 1 |
| Conway, CR | 2 |
| Kim, WSH | 1 |
| Dimick, MK | 1 |
| Omrin, D | 1 |
| Mitchell, RHB | 1 |
| Riegert, D | 1 |
| Levitt, A | 1 |
| Schaffer, A | 1 |
| Belo, S | 1 |
| Iazzetta, J | 1 |
| Detzler, G | 1 |
| Choi, M | 1 |
| Choi, S | 1 |
| Herrmann, N | 1 |
| McIntyre, RS | 1 |
| MacIntosh, BJ | 1 |
| Orser, BA | 1 |
| Goldstein, BI | 1 |
| Shao, X | 1 |
| Yan, D | 1 |
| Kong, W | 1 |
| Sun, S | 1 |
| Liao, M | 1 |
| Ou, W | 1 |
| Zhang, Y | 1 |
| Zheng, F | 1 |
| Li, X | 1 |
| Li, L | 1 |
| Hu, B | 1 |
| Tadler, SC | 1 |
| Mickey, BJ | 1 |
| Nagele, P | 1 |
| Duma, A | 1 |
| Kopec, M | 1 |
| Gebara, MA | 1 |
| Parsoei, A | 1 |
| Walker, M | 1 |
| Janski, A | 1 |
| Panagopoulos, VN | 1 |
| Cristancho, P | 1 |
| Miller, JP | 1 |
| Zorumski, CF | 1 |
| Zarate, CA | 1 |
| Machado-Vieira, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Nitrous Oxide as a Putative Novel Dual-Mechanism Treatment for Bipolar Disorder[NCT02351869] | Phase 2 | 25 participants (Actual) | Interventional | 2015-08-31 | Terminated (stopped due to This study was terminated due to COVID-19 pandemic-related halting of recruitment in the context of an upcoming replacement of the study MRI scanner.) | ||
| Evaluation of the Antidepressant Effects of Nitrous Oxide in People With Major Depressive Disorder[NCT05357040] | Phase 2 | 172 participants (Anticipated) | Interventional | 2021-06-30 | Recruiting | ||
| Nitrous Oxide as Treatment for Tinnitus: A Randomized Crossover Trial[NCT03365011] | Phase 4 | 40 participants (Actual) | Interventional | 2016-10-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Change of participant-reported tinnitus symptoms 1 week after each intervention.~The Tinnitus Functional Index (TFI) is a 25-question survey assessing tinnitus impact on quality of life. Participants were asked to rate on a scale from 0-10 the degree of unpleasantness, cognitive interference, sleep disturbance, auditory difficulties, interference with relaxation, and emotional distress associated with their tinnitus. Subscores are summed and scaled to a score of 0-100. A score less than 25 indicates mild problems due to tinnitus and little need for intervention, while a score between 25-50 indicates significant problems due to tinnitus with potential need for intervention.~A decrease in TFI score indicates decreased bother due to tinnitus over time, a better outcome. An increase in TFI score indicates increased bother due to tinnitus over time, a worse outcome." (NCT03365011)
Timeframe: Pre-intervention and 1 week post-intervention
| Intervention | score on a scale (Mean) |
|---|---|
| Placebo | -1.8 |
| Nitrous Oxide | -2.5 |
"Change in participant-reported tinnitus bother after each intervention.~Global Bothersome Scale (GBS) measured participant's self-assessment of tinnitus bother on a 5-point scale ranging from Not bothered, 0 to Extremely bothered, 5.~A change of 0 indicates no change in tinnitus bother over time. A change of -1 indicates somewhat improved tinnitus bother, and a change of positive 1 indicates somewhat worsened tinnitus bother. A change of positive 2 indicates significantly worsened tinnitus bother." (NCT03365011)
Timeframe: Pre-intervention and 1 week post-intervention
| Intervention | participants (Number) | |||
|---|---|---|---|---|
| Somewhat improved, -1 | No change, 0 | Somewhat worsened, 1 | Significantly worsened, 2 | |
| Nitrous Oxide | 2 | 34 | 2 | 0 |
| Placebo | 5 | 28 | 5 | 1 |
2 reviews available for nitrous oxide and Refractory Depression
| Article | Year |
|---|---|
Nitrous Oxide: an emerging novel treatment for treatment-resistant depression.
Topics: Antidepressive Agents; Depression; Depressive Disorder, Major; Depressive Disorder, Treatment-Resist | 2022 |
Emerging evidence for antidepressant actions of anesthetic agents.
Topics: Anesthesiologists; Anesthetics; Antidepressive Agents; Cerebral Cortex; Depressive Disorder, Treatme | 2018 |
3 trials available for nitrous oxide and Refractory Depression
| Article | Year |
|---|---|
Proof-of-concept randomized controlled trial of single-session nitrous oxide treatment for refractory bipolar depression: Focus on cerebrovascular target engagement.
Topics: Adult; Antidepressive Agents; Bipolar Disorder; Depressive Disorder, Treatment-Resistant; Double-Bli | 2023 |
Brain function changes reveal rapid antidepressant effects of nitrous oxide for treatment-resistant depression:Evidence from task-state EEG.
Topics: Antidepressive Agents; Brain; Depression; Depressive Disorder, Treatment-Resistant; Electroencephalo | 2023 |
Nitrous Oxide for Treatment-Resistant Major Depression: A Proof-of-Concept Trial.
Topics: Adult; Antidepressive Agents; Cross-Over Studies; Depression; Depressive Disorder, Major; Depressive | 2015 |
Nitrous Oxide for Treatment-Resistant Major Depression: A Proof-of-Concept Trial.
Topics: Adult; Antidepressive Agents; Cross-Over Studies; Depression; Depressive Disorder, Major; Depressive | 2015 |
Nitrous Oxide for Treatment-Resistant Major Depression: A Proof-of-Concept Trial.
Topics: Adult; Antidepressive Agents; Cross-Over Studies; Depression; Depressive Disorder, Major; Depressive | 2015 |
Nitrous Oxide for Treatment-Resistant Major Depression: A Proof-of-Concept Trial.
Topics: Adult; Antidepressive Agents; Cross-Over Studies; Depression; Depressive Disorder, Major; Depressive | 2015 |
1 other study available for nitrous oxide and Refractory Depression
| Article | Year |
|---|---|
Potential Pathways Involved in the Rapid Antidepressant Effects of Nitrous Oxide.
Topics: Antidepressive Agents; Depressive Disorder, Major; Depressive Disorder, Treatment-Resistant; Female; | 2015 |