metyrapone has been researched along with Refractory Depression in 2 studies
Metyrapone: An inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.
metyrapone : An aromatic ketone that is 3,3-dimethylbutan-2-one in which the methyl groups at positions 1 and 4 are replaced by pyridin-3-yl groups. A steroid 11beta-monooxygenase (EC 1.14.15.4) inhibitor, it is used in the diagnosis of adrenal insufficiency.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Many patients with major depressive disorder have treatment-resistant depression, defined as no adequate response to two consecutive courses of antidepressants." | 2.82 | Antidepressant augmentation with metyrapone for treatment-resistant depression (the ADD study): a double-blind, randomised, placebo-controlled trial. ( Anderson, IM; Ferrier, IN; Finkelmeyer, A; Gallagher, P; Grunze, HC; Haddad, PM; Hughes, T; Lloyd, AJ; Mamasoula, C; McAllister-Williams, RH; McColl, E; Pearce, S; Siddiqi, N; Sinha, BN; Steen, N; Wainwright, J; Watson, S; Winter, FH, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| McAllister-Williams, RH | 2 |
| Smith, E | 1 |
| Anderson, IM | 2 |
| Barnes, J | 1 |
| Gallagher, P | 2 |
| Grunze, HC | 2 |
| Haddad, PM | 2 |
| House, AO | 1 |
| Hughes, T | 2 |
| Lloyd, AJ | 2 |
| McColl, EM | 1 |
| Pearce, SH | 1 |
| Siddiqi, N | 2 |
| Sinha, B | 1 |
| Speed, C | 1 |
| Steen, IN | 1 |
| Wainright, J | 1 |
| Watson, S | 2 |
| Winter, FH | 2 |
| Ferrier, IN | 2 |
| Finkelmeyer, A | 1 |
| Mamasoula, C | 1 |
| McColl, E | 1 |
| Pearce, S | 1 |
| Sinha, BN | 1 |
| Steen, N | 1 |
| Wainwright, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects of the Addition of Metyrapone to Antidepressant Therapy in Depression With Dexamethasone Suppression Test Non-suppression.[NCT03491696] | Phase 4 | 14 participants (Anticipated) | Interventional | 2018-12-22 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for metyrapone and Refractory Depression
| Article | Year |
|---|---|
Study protocol for the randomised controlled trial: antiglucocorticoid augmentation of anti-Depressants in Depression (The ADD Study).
Topics: Adolescent; Adult; Aged; Antidepressive Agents; Clinical Protocols; Depressive Disorder, Major; Depr | 2013 |
Antidepressant augmentation with metyrapone for treatment-resistant depression (the ADD study): a double-blind, randomised, placebo-controlled trial.
Topics: Adolescent; Adult; Aged; Antidepressive Agents; Depressive Disorder, Major; Depressive Disorder, Tre | 2016 |