clonidine has been researched along with Refractory Depression in 2 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Clonidine was co-administered to reduce psychotomimetic effects." | 1.62 | Prolonged ketamine infusion modulates limbic connectivity and induces sustained remission of treatment-resistant depression. ( Ances, BM; Farber, NB; Kharasch, ED; Lenze, EJ; Nicol, GE; Palanca, BJA; Schweiger, JA; Siegel, JS; Snyder, AZ; Yingling, MD, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 1 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Siegel, JS | 1 |
| Palanca, BJA | 1 |
| Ances, BM | 1 |
| Kharasch, ED | 1 |
| Schweiger, JA | 1 |
| Yingling, MD | 1 |
| Snyder, AZ | 1 |
| Nicol, GE | 1 |
| Lenze, EJ | 2 |
| Farber, NB | 2 |
| Kharasch, E | 1 |
| Schweiger, J | 1 |
| Yingling, M | 1 |
| Olney, J | 1 |
| Newcomer, JW | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Safe Ketamine-Based Therapy for Treatment Resistant Depression[NCT01179009] | 20 participants (Actual) | Interventional | 2012-04-30 | Completed | |||
| Evaluation of the Antidepressant Effects of Nitrous Oxide in People With Major Depressive Disorder[NCT05357040] | Phase 2 | 172 participants (Anticipated) | Interventional | 2021-06-30 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The Montgomery-Asberg Depression Rating Scale (MADRS) is a 10-item scale that measures the severity of depression, with a higher score indicating a higher level of depression. The range of scores is 0 to 60. (NCT01179009)
Timeframe: 8 weeks
| Intervention | Scores on a scale (Mean) |
|---|---|
| Ketamine 100-hour Infusion | -9.0 |
| Ketamine 40-minute Infusion | -6.4 |
1 trial available for clonidine and Refractory Depression
| Article | Year |
|---|---|
Ninety-six hour ketamine infusion with co-administered clonidine for treatment-resistant depression: A pilot randomised controlled trial.
Topics: Adult; Antidepressive Agents; Clonidine; Depressive Disorder, Treatment-Resistant; Double-Blind Meth | 2016 |
Ninety-six hour ketamine infusion with co-administered clonidine for treatment-resistant depression: A pilot randomised controlled trial.
Topics: Adult; Antidepressive Agents; Clonidine; Depressive Disorder, Treatment-Resistant; Double-Blind Meth | 2016 |
Ninety-six hour ketamine infusion with co-administered clonidine for treatment-resistant depression: A pilot randomised controlled trial.
Topics: Adult; Antidepressive Agents; Clonidine; Depressive Disorder, Treatment-Resistant; Double-Blind Meth | 2016 |
Ninety-six hour ketamine infusion with co-administered clonidine for treatment-resistant depression: A pilot randomised controlled trial.
Topics: Adult; Antidepressive Agents; Clonidine; Depressive Disorder, Treatment-Resistant; Double-Blind Meth | 2016 |
1 other study available for clonidine and Refractory Depression
| Article | Year |
|---|---|
Prolonged ketamine infusion modulates limbic connectivity and induces sustained remission of treatment-resistant depression.
Topics: Adolescent; Adult; Aged; Antidepressive Agents; Clonidine; Depressive Disorder, Treatment-Resistant; | 2021 |