Paralysis, Hyperkalemic Periodic

An autosomal dominant familial disorder which presents in infancy or childhood and is characterized by episodes of weakness associated with hyperkalemia. During attacks, muscles of the lower extremities are initially affected, followed by the lower trunk and arms. Episodes last from 15-60 minutes and typically occur after a period of rest following exercise. A defect in skeletal muscle sodium channels has been identified as the cause of this condition. Normokalemic periodic paralysis is a closely related disorder marked by a lack of alterations in potassium levels during attacks of weakness. (Adams et al., Principles of Neurology, 6th ed, p1481)

Synonym
Paralysis, Hyperkalemic Periodic

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	15 (28.85)	23.3326
1990's	2 (3.85)	12.5806
2000's	19 (36.54)	18.1394
2010's	11 (21.15)	28.8240
2020's	5 (9.62)	9.53

Drug	Relationship Strength	Studies	Trials
chlorine	low	1	0
hydrogen carbonate	low	2	0
iodine	low	1	0
phenytoin	low	1	0
acetazolamide	medium	11	1
albuterol	low	2	0
amiodarone	low	2	0
carbamazepine	low	1	0
chlorothiazide	low	1	0
amphetamine	low	1	0
hydrochlorothiazide	low	3	0
imipramine	low	2	0
isoflurane	low	1	0
mexiletine	low	2	0
pinacidil	low	1	0
potassium chloride	low	4	0
dextroamphetamine	low	1	0
spironolactone	low	1	0
aldosterone	low	2	0
glutamine	low	1	0
arginine	low	2	0
thiophenes	medium	1	1
calcium gluconate	low	2	0
copper gluconate	low	1	0
potassium citrate	low	1	0
n 0437, (-)-isomer	medium	1	1
monensin	low	1	0
capsaicin	low	1	0
17-ketosteroids	low	1	0
sulfur	low	1	0
cysteine	low	1	0
tetrodotoxin	low	1	0
vendex	low	1	0

Protein Targets (526)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	2	0	0	2
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Beta-lactamase	4	0	0	4
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Class Iii Chitinase Chia1	0	1	0	1
Chain A, Carbonic anhydrase 13	0	1	0	1
Chain A, Carbonic anhydrase II	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase	0	1	0	1
Chain B, Carbonic anhydrase	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	3	0	3
thioredoxin reductase	6	0	0	6
GALC protein	1	0	0	1
GLI family zinc finger 3	7	0	0	7
nuclear receptor subfamily 1, group I, member 3	6	0	0	6
cytochrome P450 family 3 subfamily A polypeptide 4	2	0	0	2
glucocorticoid receptor [Homo sapiens]	8	0	0	8
retinoic acid nuclear receptor alpha variant 1	12	0	0	12
retinoid X nuclear receptor alpha	5	0	0	5
estrogen-related nuclear receptor alpha	11	0	0	11
Carbonic anhydrase	0	3	0	3
Carbonic anhydrase	0	2	0	2
arylsulfatase A	6	0	0	6
Carbonic anhydrase	0	2	0	2
euchromatic histone-lysine N-methyltransferase 2	11	0	0	11
Bloom syndrome protein isoform 1	5	0	0	5
thyroid hormone receptor beta isoform a	7	0	0	7
nuclear factor erythroid 2-related factor 2 isoform 1	8	0	0	8
geminin	9	0	0	9
peripheral myelin protein 22	8	0	0	8
survival motor neuron protein isoform d	4	0	0	4
muscleblind-like protein 1 isoform 1	1	0	0	1
Gamma-aminobutyric acid receptor subunit pi	4	2	0	6
ATP-binding cassette sub-family C member 3	0	7	0	7
Multidrug resistance-associated protein 4	0	7	0	7
Carbonic anhydrase	0	2	0	2
Solute carrier family 22 member 6	0	2	0	2
Carbonic anhydrase 12	0	4	1	8
Prolyl endopeptidase	0	2	0	2
Carbonic anhydrase-related protein 11	0	1	0	2
Bile salt export pump	0	10	0	10
Glycogen phosphorylase, muscle form	0	2	0	2
Renin	0	2	0	2
Carbonic anhydrase 1	0	8	1	15
Carbonic anhydrase 2	0	9	1	15
Carbonic anhydrase 2	0	2	0	2
Cytochrome P450 1A2	0	2	0	3
Carbonic anhydrase 3	0	4	1	8
Cathepsin B	0	1	0	1
Cytochrome P450 3A4	0	2	0	4
Steryl-sulfatase	0	1	0	1
5-hydroxytryptamine receptor 2C	0	5	2	7
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	2
Cytochrome P450 2C8	0	2	0	2
Cytochrome P450 2D6	0	2	0	2
Cytochrome P450 2A6	0	2	0	2
Cytochrome P450 2C9	0	7	0	7
5-hydroxytryptamine receptor 2A	0	5	2	7
Androgen receptor	0	6	0	7
Gamma-aminobutyric acid receptor subunit beta-1	4	2	0	6
Translocator protein	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	4	2	0	6
Gamma-aminobutyric acid receptor subunit gamma-2	4	2	0	6
Gamma-aminobutyric acid receptor subunit alpha-5	4	2	0	6
Gamma-aminobutyric acid receptor subunit alpha-3	4	2	0	6
Cannabinoid receptor 1	0	2	0	2
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
Cytochrome P450 2B6	0	1	1	2
Carbonic anhydrase 4	0	7	1	10
Carbonic anhydrase 6	0	4	1	7
Gamma-aminobutyric acid receptor subunit gamma-1	4	2	0	6
Gamma-aminobutyric acid receptor subunit alpha-2	4	2	0	6
Carbonic anhydrase 5A, mitochondrial	0	2	0	2
Adenosine receptor A1	0	1	0	1
Serum paraoxonase/arylesterase 1	0	1	0	1
Dipeptidyl peptidase 4	0	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	4	2	0	6
Gamma-aminobutyric acid receptor subunit gamma-3	4	2	0	6
Endochitinase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	4	2	0	6
Adenosine receptor A2a	0	1	0	1
5-hydroxytryptamine receptor 2B	0	5	2	7
Sodium-dependent serotonin transporter	0	4	1	5
Delta-type opioid receptor	0	3	0	3
Cytochrome P450 2C19	0	3	0	4
Delta-type opioid receptor	0	3	1	4
Mu-type opioid receptor	0	3	0	3
Carbonic anhydrase 5A, mitochondrial	0	5	1	9
Carbonic anhydrase	0	4	0	4
Kappa-type opioid receptor	0	1	0	1
Carbonic anhydrase 7	0	4	1	7
Carbonic anhydrase	0	1	0	1
D(1A) dopamine receptor	2	1	0	3
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
Carbonic anhydrase	0	2	0	2
D(2) dopamine receptor	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-1	4	2	0	6
Gamma-aminobutyric acid receptor subunit beta-3	4	2	0	6
Gamma-aminobutyric acid receptor subunit beta-2	4	2	0	6
Cholinesterase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Mu-type opioid receptor	0	3	0	3
Fatty-acid amide hydrolase 1	0	1	0	1
Beta-carbonic anhydrase 1	0	2	0	2
Carbonic anhydrase 2	0	2	0	2
Glutamate receptor ionotropic, NMDA 2B	0	2	0	2
Squalene synthase	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Carbonic anhydrase 9	0	6	1	10
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase, alpha family	0	3	0	3
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase 3	0	1	0	1
Carbonic anhydrase	0	2	0	3
Carbonic anhydrase	0	2	0	3
Carbonic anhydrase	0	3	0	3
Sigma intracellular receptor 2	0	2	0	2
Delta carbonic anhydrase	0	3	0	3
Sigma non-opioid intracellular receptor 1	0	2	0	2
Renin	0	1	0	1
Carbonic anhydrase	0	2	0	2
Endochitinase A1	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	1
Carbonic anhydrase 13	0	3	1	5
GABA theta subunit	4	2	0	6
Canalicular multispecific organic anion transporter 1	0	7	0	7
Carbonic anhydrase 4	0	4	0	4
Carbonic anhydrase 15	0	4	0	5
Acidic mammalian chitinase	0	1	0	1
Carbonic anhydrase 13	0	4	0	6
Carbonic anhydrase 7	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	4	2	0	6
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 14	0	4	1	8
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 2, isoform A	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	4	1	8
glp-1 receptor, partial	3	0	0	3
GLS protein	7	0	0	7
regulator of G-protein signaling 4	4	0	0	4
estrogen nuclear receptor alpha	12	0	0	12
NPYLR7B	0	0	1	1
thyroid stimulating hormone receptor	3	0	0	3
flap endonuclease 1	5	0	0	5
Beta-2 adrenergic receptor	0	2	2	4
Beta-1 adrenergic receptor	0	2	2	4
60 kDa chaperonin	0	1	0	1
60 kDa heat shock protein, mitochondrial	0	1	0	1
Beta-3 adrenergic receptor	0	2	1	3
10 kDa heat shock protein, mitochondrial	0	1	0	1
Thiosulfate sulfurtransferase	0	1	0	1
Beta-2 adrenergic receptor	0	0	1	3
60 kDa chaperonin	0	1	0	1
10 kDa chaperonin	0	1	0	1
Beta-2 adrenergic receptor	0	2	2	4
ATP-dependent phosphofructokinase	9	0	0	9
AR protein	10	0	0	10
nuclear factor erythroid 2-related factor 2 isoform 2	3	0	0	3
Sex hormone-binding globulin	0	0	1	1
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	3	2	6
Mineralocorticoid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	0	0	1
Guanine nucleotide-binding protein G	2	0	0	2
acetylcholinesterase	6	0	0	6
phosphopantetheinyl transferase	4	0	0	4
hypoxia-inducible factor 1 alpha subunit	3	0	0	3
RAR-related orphan receptor gamma	7	0	0	7
SMAD family member 2	2	0	0	2
ATAD5 protein, partial	2	0	0	2
Fumarate hydratase	1	0	0	1
USP1 protein, partial	6	0	0	6
NFKB1 protein, partial	3	0	0	3
PPM1D protein	1	0	0	1
SMAD family member 3	2	0	0	2
TDP1 protein	8	0	0	8
Thrombopoietin	1	0	0	1
caspase 7, apoptosis-related cysteine protease	1	0	0	1
aldehyde dehydrogenase 1 family, member A1	5	0	0	5
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	1	0	0	1
thyroid stimulating hormone receptor	4	0	0	4
estrogen receptor 2 (ER beta)	4	0	0	4
progesterone receptor	5	0	0	5
EWS/FLI fusion protein	3	0	0	3
farnesoid X nuclear receptor	2	0	0	2
pregnane X nuclear receptor	6	0	0	6
G	5	0	0	5
cytochrome P450 2D6	4	0	0	4
polyprotein	1	0	0	1
peroxisome proliferator-activated receptor delta	3	0	0	3
peroxisome proliferator activated receptor gamma	6	0	0	6
caspase-3	1	0	0	1
v-jun sarcoma virus 17 oncogene homolog (avian)	5	0	0	5
Histone H2A.x	2	0	0	2
cytochrome P450 2D6 isoform 1	2	0	0	2
cellular tumor antigen p53 isoform a	1	0	0	1
cytochrome P450 2C9 precursor	4	0	0	4
D(1A) dopamine receptor	3	0	0	3
chromobox protein homolog 1	7	0	0	7
potassium voltage-gated channel subfamily H member 2 isoform d	3	0	0	3
thyroid hormone receptor beta isoform 2	5	0	0	5
heat shock protein beta-1	1	0	0	1
huntingtin isoform 2	1	0	0	1
mitogen-activated protein kinase 1	3	0	0	3
serine/threonine-protein kinase mTOR isoform 1	2	0	0	2
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	3	0	0	3
urokinase-type plasminogen activator precursor	1	0	0	1
plasminogen precursor	1	0	0	1
urokinase plasminogen activator surface receptor precursor	1	0	0	1
nuclear receptor ROR-gamma isoform 1	3	0	0	3
cytochrome P450 3A4 isoform 1	4	0	0	4
muscarinic acetylcholine receptor M1	5	0	0	5
lethal factor (plasmid)	2	0	0	2
lamin isoform A-delta10	9	0	0	9
Polyunsaturated fatty acid lipoxygenase ALOX15B	2	0	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	3	0	3
Solute carrier organic anion transporter family member 1A4	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	4	0	4
5-hydroxytryptamine receptor 4	0	2	0	2
Lysine-specific demethylase PHF2	0	1	0	1
Interferon beta	5	0	0	5
HLA class I histocompatibility antigen, B alpha chain	5	0	0	5
Thyroid hormone receptor alpha	0	1	0	1
Receptor tyrosine-protein kinase erbB-2	0	1	0	1
Cellular tumor antigen p53	6	0	0	6
Integrin beta-3	1	0	0	1
Tyrosine-protein kinase Fyn	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
Aldo-keto reductase family 1 member B1	0	2	0	2
Muscarinic acetylcholine receptor M2	0	2	0	2
Muscarinic acetylcholine receptor M4	0	2	0	2
ATP-dependent translocase ABCB1	0	3	1	4
Integrin alpha-IIb	1	0	0	1
Muscarinic acetylcholine receptor M5	0	2	0	2
Alpha-2A adrenergic receptor	0	2	0	2
Adenosine receptor A3	0	2	0	2
Thyroid hormone receptor alpha	0	1	0	1
Thyroid hormone receptor beta	0	1	0	1
Muscarinic acetylcholine receptor M1	0	2	0	2
D(2) dopamine receptor	0	5	1	6
Alpha-1B adrenergic receptor	0	4	0	4
Lethal factor	0	1	0	1
Alpha-2B adrenergic receptor	0	2	0	2
Thyroid hormone receptor beta	0	1	0	1
Muscarinic acetylcholine receptor M3	0	2	0	2
ATP-dependent translocase ABCB1	0	1	0	1
Substance-K receptor	0	2	0	2
D(1A) dopamine receptor	0	2	1	3
D(4) dopamine receptor	0	3	0	3
Carnitine O-palmitoyltransferase 2, mitochondrial	0	1	0	1
Sodium-dependent noradrenaline transporter	0	6	1	7
Histamine H2 receptor	0	2	0	2
Endothelin-1 receptor	0	2	0	2
5-hydroxytryptamine receptor 2A	0	4	0	4
5-hydroxytryptamine receptor 2C	0	3	0	3
Lysine-specific demethylase 5A	0	1	0	1
B2 bradykinin receptor	0	2	0	2
Sodium-dependent serotonin transporter	0	6	1	7
Melanocortin receptor 4	0	2	0	2
C-8 sterol isomerase	0	1	0	1
Melanocortin receptor 5	0	2	0	2
Mu-type opioid receptor	0	2	0	2
D(3) dopamine receptor	0	3	0	3
Sodium channel protein type 1 subunit alpha	0	4	0	4
Sodium channel protein type 4 subunit alpha	0	5	0	7
Squalene synthase	0	1	0	1
Delta-type opioid receptor	0	2	0	2
Kappa-type opioid receptor	0	2	0	2
5-hydroxytryptamine receptor 2B	0	4	0	4
C-C chemokine receptor type 2	0	2	0	2
Melanocortin receptor 3	0	2	0	2
Alpha-1A adrenergic receptor	0	4	0	4
Histamine H2 receptor	5	1	0	6
5-hydroxytryptamine receptor 6	0	3	0	3
Carnitine O-palmitoyltransferase 1, liver isoform	0	1	0	1
C-C chemokine receptor type 4	0	2	0	2
Spike glycoprotein	8	0	0	8
Sodium channel protein type 7 subunit alpha	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1D	0	4	0	4
Sodium-dependent dopamine transporter	0	5	1	6
Potassium voltage-gated channel subfamily H member 2	0	5	0	5
Voltage-dependent L-type calcium channel subunit alpha-1S	0	4	0	4
Voltage-dependent L-type calcium channel subunit alpha-1C	0	4	0	4
Sodium channel protein type 5 subunit alpha	0	4	0	4
Squalene monooxygenase	0	1	0	1
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	1	0	1
Sodium channel protein type 9 subunit alpha	0	8	0	8
Lysine-specific demethylase 7A	0	1	0	1
Carnitine O-palmitoyltransferase 1, muscle isoform	0	1	0	1
Inositol hexakisphosphate kinase 1	5	0	0	5
Sodium channel protein type 2 subunit alpha	0	4	0	4
Ataxin-2	3	0	0	3
Sigma non-opioid intracellular receptor 1	0	2	0	2
NAD-dependent protein deacetylase sirtuin-3, mitochondrial	0	0	1	1
Sodium channel protein type 3 subunit alpha	0	4	0	4
Sodium channel protein type 11 subunit alpha	0	3	0	3
Histone lysine demethylase PHF8	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	3	0	3
Sodium channel protein type 10 subunit alpha	0	3	0	3
cytochrome P450 2C9, partial	5	0	0	5
Solute carrier family 22 member 3	0	1	0	1
Phenylethanolamine N-methyltransferase	0	3	0	3
Substance-P receptor	0	1	0	1
5-hydroxytryptamine receptor 1A	0	3	2	5
Cytochrome P450 2A5	0	1	0	1
Sodium-dependent dopamine transporter	0	2	1	3
5-hydroxytryptamine receptor 1B	0	2	2	4
5-hydroxytryptamine receptor 1D	0	2	2	4
5-hydroxytryptamine receptor 1F	0	2	2	4
5-hydroxytryptamine receptor 6	0	1	2	3
5-hydroxytryptamine receptor 7	0	1	2	3
5-hydroxytryptamine receptor 5A	0	1	2	3
5-hydroxytryptamine receptor 5B	0	1	2	3
5-hydroxytryptamine receptor 3A	0	1	2	3
5-hydroxytryptamine receptor 4	0	1	2	3
5-hydroxytryptamine receptor 3B	0	1	2	3
Sigma non-opioid intracellular receptor 1	0	2	1	3
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	5	0	0	5
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
alpha-galactosidase	2	0	0	2
cytochrome P450 2C19 precursor	1	0	0	1
DNA polymerase iota isoform a (long)	2	0	0	2
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	0	0	1
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	1	0	1
Chain A, HADH2 protein	1	0	0	1
Chain B, HADH2 protein	1	0	0	1
15-lipoxygenase, partial	2	0	0	2
Microtubule-associated protein tau	3	0	0	3
67.9K protein	2	0	0	2
glucocerebrosidase	1	0	0	1
vitamin D (1,25- dihydroxyvitamin D3) receptor	4	0	0	4
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	7	0	0	7
transient receptor potential cation channel subfamily V member 1	1	0	0	1
Transient receptor potential cation channel subfamily V member 1	0	2	1	3
Lysine-specific histone demethylase 1A	0	1	0	1
Voltage-dependent calcium channel gamma-2 subunit	5	0	0	5
NADH-ubiquinone oxidoreductase chain 1	0	1	0	1
Glutamate receptor 2	5	0	0	5
Cannabinoid receptor 1	0	1	0	1
Acetylcholinesterase	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Cannabinoid receptor 2	0	1	0	1
Nuclear receptor ROR-gamma	1	0	0	1
Inositol monophosphatase 1	2	0	0	2
Potassium voltage-gated channel subfamily A member 1	0	1	0	1
Corticotropin-releasing factor receptor 2	0	1	0	1
Transient receptor potential cation channel subfamily V member 1	0	2	1	4
Transient receptor potential cation channel subfamily V member 4	0	0	1	1
Transient receptor potential cation channel subfamily V member 2	0	0	1	1
IDH1	2	0	0	2
Vpr	3	0	0	3
Bile salt export pump	0	2	0	2
Albumin	0	0	1	1
Major prion protein	0	0	2	2
Sodium channel protein type 1 subunit alpha	0	2	0	2
Sodium channel protein type 2 subunit alpha	0	3	0	3
Sodium channel protein type 3 subunit alpha	0	2	0	2
UDP-glucuronosyltransferase 2B7	0	0	0	1
Cytochrome P450 2J2	0	4	0	4
Frizzled-8	0	0	1	1
P2X purinoceptor 4	0	1	0	1
nonstructural protein 1	1	0	0	1
transcriptional regulator ERG isoform 3	2	0	0	2
ORF73	0	0	1	1
Amine oxidase [flavin-containing] B	0	1	0	1
Amine oxidase [flavin-containing] A	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
Trace amine-associated receptor 1	0	0	1	1
Trace amine-associated receptor 1	0	0	1	1
Trace amine-associated receptor 1	0	0	1	1
Trace amine-associated receptor 1	0	0	1	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
cystic fibrosis transmembrane conductance regulator ATP-binding cassette sub-family C member 7	0	0	0	1
Chain A, Glutamine Binding Protein	0	0	1	1
peripheral myelin protein 22 isoform 1	4	0	0	4
histone-lysine N-methyltransferase 2A isoform 2 precursor	1	0	0	1
Neutral amino acid transporter A	0	1	0	1
Asc-type amino acid transporter 1	0	1	0	1
Neutral amino acid transporter B(0)	0	1	0	1
Carbonic anhydrase-like protein, putative	0	0	0	1
Amino acid transporter	0	1	0	1
Hsf1 protein	0	0	1	1
Albumin	0	1	0	1
Snq2p	0	0	0	1
activating transcription factor 6	3	0	0	3
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	4	0	0	4
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
Solute carrier family 22 member 2	0	1	0	1
Solute carrier family 22 member 1	0	1	0	1
Sodium-dependent noradrenaline transporter	0	1	0	1
Solute carrier family 22 member 3	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
Muscarinic acetylcholine receptor M5	0	1	0	1
Sphingomyelin phosphodiesterase	0	1	0	1
D	0	1	0	1
D(3) dopamine receptor	0	1	0	1
Alpha-2B adrenergic receptor	0	2	0	2
Alpha-2C adrenergic receptor	0	2	0	2
UDP-glucuronosyltransferase 1A4	0	0	0	1
Alpha-2A adrenergic receptor	0	2	0	2
Alpha-1D adrenergic receptor	0	2	0	2
D(1B) dopamine receptor	0	1	0	1
D(4) dopamine receptor	0	1	0	1
Histamine H1 receptor	0	1	0	1
Pleiotropic ABC efflux transporter of multiple drugs	0	1	0	2
5-hydroxytryptamine receptor 2C	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
Histamine H1 receptor	0	2	0	2
Glutamate receptor ionotropic, NMDA 1	0	1	0	1
UDP-glucuronosyltransferase 1A3	0	0	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
D(2) dopamine receptor	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	1	0	1
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Voltage-dependent N-type calcium channel subunit alpha-1B	0	1	0	1
Envelope glycoprotein	0	0	1	1
Sodium-dependent serotonin transporter	0	1	0	1
Sodium-dependent dopamine transporter	0	1	0	1
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Solute carrier family 22 member 1	0	1	0	1
Multidrug and toxin extrusion protein 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Multidrug and toxin extrusion protein 1	0	2	0	2
Solute carrier family 22 member 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Transporter	0	2	0	2
Luciferase	1	0	0	1
aryl hydrocarbon receptor	2	0	0	2
histone deacetylase 9 isoform 3	1	0	0	1
Neuronal acetylcholine receptor subunit beta-2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 2	0	1	0	1
D(2) dopamine receptor	0	1	0	1
D	0	1	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	1	0	0	1
Gamma-aminobutyric acid	0	1	0	1
endonuclease IV	1	0	0	1
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	2	0	0	2
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
M-phase phosphoprotein 8	1	0	0	1
neuropeptide S receptor isoform A	1	0	0	1
ATP-binding cassette sub-family C member 9	0	0	1	1
Rap guanine nucleotide exchange factor 4	1	0	0	1
Taste receptor type 2 member 31	0	0	1	1
Taste receptor type 2 member 60	0	0	1	1
Sodium/potassium/calcium exchanger 4	0	1	1	2
Taste receptor type 2 member 14	0	0	1	1
Taste receptor type 2 member 13	0	0	1	1
Taste receptor type 2 member 9	0	0	1	1
Taste receptor type 2 member 4	0	0	1	1
Sodium/potassium/calcium exchanger 2	0	1	1	2
Chain A, Mineralocorticoid receptor	0	1	0	1
Chain A, Mineralocorticoid receptor	0	1	0	1
pregnane X receptor	1	0	0	1
Smad3	1	0	0	1
Estrogen receptor	0	2	1	3
Glucocorticoid receptor	0	2	1	3
Progesterone receptor	0	2	1	3
Glycine receptor subunit alpha-1	0	2	0	2
Androgen receptor	0	2	1	3
Glycine receptor subunit beta	0	2	0	2
Glycine receptor subunit alpha-2	0	2	0	2
Glycine receptor subunit alpha-3	0	2	0	2
Estrogen receptor beta	0	1	1	2
ATPase family AAA domain-containing protein 5	1	0	0	1
vitamin D3 receptor isoform VDRA	1	0	0	1
DNA polymerase kappa isoform 1	1	0	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Paralysis, Hyperkalemic Periodic

Synonyms(1)

Research

Studies (52)

Protein Targets (526)

Paralysis, Hyperkalemic Periodic

Synonyms(1)

Research

Studies (52)

Drugs Studied (43)

Protein Targets (526)