Page last updated: 2024-09-27

Bone Demineralization, Pathologic

Decrease, loss, or removal of the mineral constituents of bones. Temporary loss of bone mineral content is especially associated with space flight, weightlessness, and extended immobilization. OSTEOPOROSIS is permanent, includes reduction of total bone mass, and is associated with increased rate of fractures. CALCIFICATION, PHYSIOLOGIC is the process of bone remineralizing. (From Dorland, 27th ed; Stedman, 25th ed; Nicogossian, Space Physiology and Medicine, 2d ed, pp327-33)

Synonyms(2)

Synonym
Bone Demineralization, Pathologic
Pathologic Bone Demineralization

Research

Studies (161)

TimeframeStudies, This Condition (%)All Conditions %
pre-19908 (4.97)23.3326
1990's47 (29.19)12.5806
2000's57 (35.40)18.1394
2010's46 (28.57)28.8240
2020's3 (1.86)9.53
DrugIndicatedRelationship StrengthStudiesTrials
citric acid, anhydrous0low10
glycerol0low20
thioctic acid0medium11
alendronate0medium41
caffeine0low10
chloroquine0low10
etidronate0medium32
fluorouracil0medium11
metformin0low10
pamidronate0medium42
stearic acid0low10
corticosterone0low10
prednisolone0medium63
hydroxyproline0low50
thyroxine0medium21
aldosterone0low20
prednisone0low10
triiodothyronine0medium21
ethinyl estradiol0low10
carbostyril0low10
edetic acid0low10
cycloheximide0low10
norethindrone0medium11
medroxyprogesterone acetate0low30
tolonium chloride0low10
calcium gluconate0low10
nandrolone decanoate0low10
nandrolone0low10
levonorgestrel0low10
durapatite0low30
d-alpha tocopherol0low10
titanium0low10
magnesium sulfate0low20
calcium phosphate, dibasic, anhydrous0low10
calcium phosphate, monobasic, anhydrous0low10
tricalcium phosphate0low30
cadmium chloride0low10
trolamine salicylate0low20
clodronic acid0medium31
fluorides0low20
raloxifene hydrochloride0low10
ibandronic acid0low10
emtricitabine0medium11
fluorodeoxyglucose f180low10
zoledronic acid0low20
homocysteine0medium11
pyridinoline0low10
deoxypyridinoline0medium41
methotrexate0medium11
ym 5290low30
calcium pyrophosphate0low10
ritonavir0low10
retinol0low10
eicosapentaenoic acid0low10
enkephalin, leucine0low10
tenofovir0medium11
leuprolide0medium11
tamoxifen0low20
osteoprotegerin0low30
calcitriol0low70
vitamin k semiquinone radical0low30
cholecalciferol0low10
menaquinone 60low10
menaquinone 70low10
lead0low20
phosphorus0low130
1,25-dihydroxy-19-norvitamin d30low10
aluminum oxide0low10
pituitrin0low20
acid phosphatase0low30
calcitonin0medium11
vx-7700low10
technetium tc 99m sestamibi0low10
eliglustat0medium11
canagliflozin0low10
trelstar0medium11
tetracycline0low10
chlortetracycline0low10
epidermal growth factor0low10
transforming growth factor beta0low20
cyclosporine0low10
sapropterin0low10
preproenkephalin0low10

Protein Targets (793)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
AR protein260026
glucocorticoid receptor [Homo sapiens]240024
thyroid hormone receptor beta isoform a150015
nuclear factor erythroid 2-related factor 2 isoform 2110011
geminin210021
Sex hormone-binding globulin0066
Corticosteroid-binding globulin0404
Mineralocorticoid receptor 0448
Androgen receptor013013
Mineralocorticoid receptor0101
Solute carrier organic anion transporter family member 1A10102
Guanine nucleotide-binding protein G2002
Chain A, farnesyl pyrophosphate synthase0101
Geranylgeranyl pyrophosphate synthase0708
Farnesyl pyrophosphate synthase0909
Acetylcholinesterase0303
Hypoxanthine-guanine phosphoribosyltransferase0202
Farnesyl pyrophosphate synthase 0404
Farnesyl pyrophosphate synthase 0202
Chain A, Glycogen Phosphorylase0101
Chain A, Glycogen phosphorylase, liver form0011
Chain A, glycogen phosphorylase, liver form0011
Chain A, Glycogen phosphorylase, liver form0011
Chain A, Glycogen phosphorylase, liver form0011
Chain A, Chitinase0101
phosphopantetheinyl transferase6006
RAR-related orphan receptor gamma170017
GLS protein3003
GLI family zinc finger 3200020
nuclear receptor subfamily 1, group I, member 3160016
retinoic acid nuclear receptor alpha variant 1210021
retinoid X nuclear receptor alpha180018
estrogen-related nuclear receptor alpha210021
farnesoid X nuclear receptor170017
pregnane X nuclear receptor190019
estrogen nuclear receptor alpha290029
euchromatic histone-lysine N-methyltransferase 2170017
thyroid stimulating hormone receptor9009
v-jun sarcoma virus 17 oncogene homolog (avian)140014
atrial natriuretic peptide receptor 1 precursor1001
chromobox protein homolog 1100010
thyroid hormone receptor beta isoform 2200020
DNA polymerase beta4004
nuclear factor erythroid 2-related factor 2 isoform 1230023
nuclear receptor ROR-gamma isoform 1110011
DNA polymerase kappa isoform 18008
muscarinic acetylcholine receptor M11001
lethal factor (plasmid)4004
ATP-binding cassette sub-family C member 3015015
Multidrug resistance-associated protein 4015016
Voltage-dependent calcium channel gamma-2 subunit140014
Potassium channel subfamily K member 20011
Bile salt export pump019019
Glycogen phosphorylase, muscle form0101
Renin0101
Carbonic anhydrase 10404
Carbonic anhydrase 20415
Cholinesterase0202
Glycogen phosphorylase, liver form0101
Glycogen phosphorylase, muscle form0101
Replicase polyprotein 1ab0448
Adenosine receptor A30505
Replicase polyprotein 1ab06410
Glutamate receptor 2150015
Amine oxidase [flavin-containing] A0101
Adenosine receptor A10203
Amine oxidase [flavin-containing] B0202
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0202
Adenosine receptor A30101
Adenosine receptor A2a0618
Adenosine receptor A2b0102
Adenosine receptor A2b0203
Adenosine receptor A10518
Adenosine receptor A2a0204
Vasopressin V2 receptor0001
Serine/threonine-protein kinase mTOR0202
Adenosine receptor A2a0101
Adenosine receptor A10101
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 0101
DNA-dependent protein kinase catalytic subunit0101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B0101
Adenylate cyclase type 10001
Chitotriosidase-10101
Serine-protein kinase ATM0101
Serine/threonine-protein kinase ATR0101
Adenosine receptor A2b0102
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C0101
Palmitoleoyl-protein carboxylesterase NOTUM0123
Endochitinase B10101
Muscarinic acetylcholine receptor0001
Canalicular multispecific organic anion transporter 1015015
Phosphodiesterase 0101
Broad substrate specificity ATP-binding cassette transporter ABCG20203
Guanine deaminase0101
ATP-dependent phosphofructokinase5005
Chain A, Vitamin D Nuclear Receptor0011
Chain A, Beta-lactamase7007
Chain A, Ferritin light chain9009
Vitamin D3 receptor0011
USP1 protein, partial140014
PPM1D protein6006
Microtubule-associated protein tau110011
thioredoxin glutathione reductase3003
mitogen-activated protein kinase 14004
peripheral myelin protein 229009
Interferon beta170017
Vitamin D-binding protein0011
Cytochrome P450 1A20304
Cytochrome P450 3A409011
Androgen receptor0628
Cytochrome P450 2D60404
Vitamin D3 receptor0238
Cytochrome P450 2C9 0405
Vitamin D3 receptor0113
Retinoic acid receptor RXR-alpha0134
Cytochrome P450 2C190303
Kappa-type opioid receptor0112
Vitamin D3 receptor0022
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial0011
Vitamin D3 receptor0112
Transporter0101
Vitamin D3 receptor A0022
Sodium/glucose cotransporter 10112
Sodium/glucose cotransporter 20112
Spike glycoprotein81413
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
Chain A, serum paraoxonase0101
Carbonic anhydrase 120202
Carbonic anhydrase 30101
Neutrophil cytosol factor 10101
Carbonic anhydrase 40202
Carbonic anhydrase 60101
Carbonic anhydrase 5A, mitochondrial0101
Carbonic anhydrase 70101
Carbonic anhydrase 90202
Carbonic anhydrase 130101
Poly [ADP-ribose] polymerase tankyrase-20101
Carbonic anhydrase 140202
Carbonic anhydrase 5B, mitochondrial0101
thioredoxin reductase9009
TDP1 protein220022
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase0101
Spike glycoprotein0145
Replicase polyprotein 1ab0145
glucose-6-phosphate 1-dehydrogenase isoform b0101
flap endonuclease 13003
Transmembrane protease serine 20145
Dihydrofolate reductase 0202
DNA ligase0101
Riboflavin-binding protein0011
Major prion protein0011
Amyloid-beta precursor protein1304
Histidine-rich protein PFHRP-II0102
Procathepsin L0145
Muscarinic acetylcholine receptor M20606
Muscarinic acetylcholine receptor M40404
Muscarinic acetylcholine receptor M50404
Alpha-2A adrenergic receptor0404
Replicase polyprotein 1a0145
Replicase polyprotein 1ab0145
Spike glycoprotein0101
Muscarinic acetylcholine receptor M10404
Ribosyldihydronicotinamide dehydrogenase [quinone]0101
Alpha-2B adrenergic receptor0404
Alpha-2C adrenergic receptor0202
DNA ligase 10101
Muscarinic acetylcholine receptor M30404
Nuclear receptor subfamily 4 group A member 20011
Beta-secretase 10101
Calcium-dependent protein kinase 10011
MO15-related protein kinase Pfmrk 0101
DNA ligase A0101
Potassium voltage-gated channel subfamily H member 20505
Sigma intracellular receptor 20202
Phosphoethanolamine N-methyltransferase0101
Ataxin-29009
Sigma non-opioid intracellular receptor 10505
Angiotensin-converting enzyme 2 0145
Cysteine proteinase falcipain 2a 0101
Cysteine proteinase falcipain 2a 0101
P2Y purinoceptor 120202
Protein-arginine deiminase type-40404
Chain A, HADH2 protein7007
Chain B, HADH2 protein7007
Chain A, Cruzipain4004
Luciferase5005
interleukin 86006
15-lipoxygenase, partial5005
aldehyde dehydrogenase 1 family, member A1140014
peroxisome proliferator-activated receptor delta150015
peroxisome proliferator activated receptor gamma160016
vitamin D (1,25- dihydroxyvitamin D3) receptor150015
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 12002
vitamin D3 receptor isoform VDRA8008
survival motor neuron protein isoform d5005
cytochrome P450 3A4 isoform 18008
Gamma-aminobutyric acid receptor subunit pi8019
Cellular tumor antigen p53200020
60 kDa chaperonin0101
60 kDa heat shock protein, mitochondrial0101
Gamma-aminobutyric acid receptor subunit beta-18019
Gamma-aminobutyric acid receptor subunit delta8019
Gamma-aminobutyric acid receptor subunit gamma-28019
Gamma-aminobutyric acid receptor subunit alpha-58019
Gamma-aminobutyric acid receptor subunit alpha-38019
Glycine receptor subunit alpha-10011
Gamma-aminobutyric acid receptor subunit gamma-18019
Gamma-aminobutyric acid receptor subunit alpha-28019
Gamma-aminobutyric acid receptor subunit alpha-48019
Gamma-aminobutyric acid receptor subunit gamma-38019
Gamma-aminobutyric acid receptor subunit alpha-68019
Nuclear receptor ROR-gamma8008
10 kDa heat shock protein, mitochondrial0101
Gamma-aminobutyric acid receptor subunit alpha-18019
Gamma-aminobutyric acid receptor subunit beta-38019
Gamma-aminobutyric acid receptor subunit beta-28019
Thiosulfate sulfurtransferase0101
60 kDa chaperonin 0101
10 kDa chaperonin 0101
GABA theta subunit8019
Gamma-aminobutyric acid receptor subunit epsilon8019
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, N5-carboxyaminoimidazole ribonucleotide mutase0011
Chain B, N5-carboxyaminoimidazole ribonucleotide mutase0011
Chain A, N5-carboxyaminoimidazole ribonucleotide mutase0011
Chain B, N5-carboxyaminoimidazole ribonucleotide mutase0011
Chain A, JmjC domain-containing histone demethylation protein 3A4004
hepatocyte nuclear factor 4-alpha isoform 20101
perilipin-50101
perilipin-10101
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a0101
Beta-lactamase0101
Proto-oncogene tyrosine-protein kinase Src0101
3-dehydroquinate dehydratase0011
ATP-citrate synthase 0001
Ribonuclease T0001
Cell death-related nuclease 40001
3-dehydroquinate dehydratase0011
Prolyl 4-hydroxylase0101
Alpha-ketoglutarate-dependent dioxygenase FTO0101
Type IV secretion-like conjugative transfer relaxase protein TraI 0202
72 kDa type IV collagenase0303
Stromelysin-10202
Matrix metalloproteinase-90202
Macrophage metalloelastase0101
pregnane X receptor8008
NFKB1 protein, partial1001
GALC protein1001
Thrombopoietin2002
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)2002
progesterone receptor170017
nonstructural protein 14004
G100010
IDH19009
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a170017
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a100010
heat shock protein beta-17007
serine/threonine-protein kinase mTOR isoform 13003
Solute carrier family 22 member 20404
Solute carrier family 22 member 1 0505
Solute carrier family 22 member 30202
Solute carrier family 22 member 30101
HLA class I histocompatibility antigen, B alpha chain 100010
C-8 sterol isomerase0202
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase0314
Solute carrier family 22 member 10203
Inositol hexakisphosphate kinase 1100010
Solute carrier family 22 member 20202
cytochrome P450 2C9, partial100010
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE5005
glp-1 receptor, partial4004
ATAD5 protein, partial5005
Fumarate hydratase7007
Smad32002
estrogen receptor 2 (ER beta)140014
EWS/FLI fusion protein100010
polyprotein7007
67.9K protein5005
P531001
RPL19A0011
aryl hydrocarbon receptor7007
activating transcription factor 67007
Histone H2A.x100010
NPC intracellular cholesterol transporter 1 precursor2002
cellular tumor antigen p53 isoform a4004
nuclear factor NF-kappa-B p105 subunit isoform 13003
ras-related protein Rab-9A2002
heat shock protein HSP 90-alpha isoform 20102
urokinase-type plasminogen activator precursor3003
plasminogen precursor3003
urokinase plasminogen activator surface receptor precursor3003
transactivating tegument protein VP16 [Human herpesvirus 1]0202
COUP transcription factor 2 isoform a0101
Glucose transporter0101
Hexose transporter 1 0101
Polyunsaturated fatty acid 5-lipoxygenase0202
Solute carrier family 2, facilitated glucose transporter member 10101
Alpha-synuclein3205
Eukaryotic initiation factor 4A-I0101
Peptidyl-prolyl cis-trans isomerase FKBP1A0202
Peptidyl-prolyl cis-trans isomerase FKBP30101
Peptidyl-prolyl cis-trans isomerase FKBP40101
TAR DNA-binding protein 434004
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 10101
Hypoxia-inducible factor 1-alpha0101
ATPase family AAA domain-containing protein 58008
Endothelial PAS domain-containing protein 10101
Peptidyl-prolyl cis-trans isomerase FKBP140101
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 40101
heat shock protein 90, putative0001
cytochrome P450 family 3 subfamily A polypeptide 4120012
importin subunit beta-1 isoform 12002
snurportin-12002
GTP-binding nuclear protein Ran isoform 11001
lamin isoform A-delta10170017
Rap guanine nucleotide exchange factor 34004
Glutathione S-transferase P0101
Alpha-tocopherol transfer protein0011
Chain A, TYROSYL-DNA PHOSPHODIESTERASE5005
hypoxia-inducible factor 1 alpha subunit8008
Eyes absent homolog 20101
Polyunsaturated fatty acid lipoxygenase ALOX15B3003
Angiotensin-converting enzyme 0101
Histamine H2 receptor3003
Metallo-beta-lactamase VIM-130101
Beta-lactamase 0101
Beta-lactamase 0101
Beta-lactamase VIM-1 0101
Chain A, Protein (peroxisome Proliferator Activated Receptor (ppar-delta))0101
regulator of G-protein signaling 42002
histone-lysine N-methyltransferase 2A isoform 2 precursor2002
Prostaglandin G/H synthase 1 0202
Trypsin0101
Coagulation factor VII0101
Aromatase0202
Tissue factor0101
Peroxisome proliferator-activated receptor gamma0055
Prostaglandin G/H synthase 20202
Oxoeicosanoid receptor 10101
Albumin0013
Opioid receptor, delta 1b 0101
Opioid receptor homologue0101
Proenkephalin-B0011
Delta-type opioid receptor0214
Delta-type opioid receptor0202
Kappa-type opioid receptor0101
Mu-type opioid receptor0202
Kappa-type opioid receptor0202
Mu-type opioid receptor0819
Delta-type opioid receptor0314
Kappa-type opioid receptor0718
Mu-type opioid receptor0101
Mu-type opioid receptor0202
Mu-type opioid receptor0101
caspase 7, apoptosis-related cysteine protease3003
thyroid stimulating hormone receptor5005
caspase-33003
lysosomal alpha-glucosidase preproprotein1001
Vpr2002
Cytochrome P450 2B10101
Estrogen receptor010314
Glucocorticoid receptor010318
Glycine receptor subunit alpha-1010010
Aldo-keto reductase family 1 member B10404
Neuronal acetylcholine receptor subunit alpha-41001
Neuronal acetylcholine receptor subunit beta-21001
Polyunsaturated fatty acid lipoxygenase ALOX150101
Alpha-1B adrenergic receptor0606
Glycine receptor subunit beta010010
Cytochrome P450 2B60202
UDP-glucuronosyltransferase 1A1 0304
Glycine receptor subunit alpha-2010010
Sodium-dependent noradrenaline transporter 0404
3-oxo-5-alpha-steroid 4-dehydrogenase 1 0101
Glycine receptor subunit alpha-3010010
Sodium-dependent serotonin transporter0606
Alpha-1A adrenergic receptor0606
Sulfotransferase 1A10214
Sodium-dependent dopamine transporter 0404
Aldehyde oxidase0101
Nuclear receptor subfamily 1 group I member 3 0101
Multidrug and toxin extrusion protein 20202
Estrogen receptor beta07310
Multidrug and toxin extrusion protein 10303
acid sphingomyelinase2002
apical membrane antigen 1, AMA14004
DNA polymerase iota isoform a (long)8008
histone acetyltransferase KAT2A isoform 17007
Carbonic anhydrase0101
Carbonic anhydrase 150101
Chain A, Uracil Phosphoribosyltransferase0101
endonuclease IV2002
acetylcholinesterase6006
Skn7p0001
arylsulfatase A2002
peripheral myelin protein 22 isoform 12002
hemoglobin subunit beta1001
huntingtin isoform 22002
muscleblind-like protein 1 isoform 13003
Solute carrier family 22 member 80001
Epidermal growth factor receptor0202
Thymidylate synthase0303
HSP40, subfamily A [Plasmodium falciparum 3D7]0001
Chain B, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E0011
N(G),N(G)-dimethylarginine dimethylaminohydrolase 10101
Genome polyprotein 0101
Alpha-1D adrenergic receptor0404
Cyclic GMP-AMP synthase0101
Toll-like receptor 90101
Toll-like receptor 70101
Neutral amino acid transporter A0101
Asc-type amino acid transporter 10101
Neutral amino acid transporter B(0)0101
Proton-coupled amino acid transporter 10101
Amino acid transporter0101
Gonadotropin-releasing hormone receptor0101
Gonadotropin-releasing hormone receptor0202
SMAD family member 29009
SMAD family member 39009
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)2002
parathyroid hormone/parathyroid hormone-related peptide receptor precursor2002
transcriptional regulator ERG isoform 34004
Progesterone receptor07412
PINK11001
Parkin1001
nuclear receptor subfamily 1, group I, member 22002
neuropeptide S receptor isoform A4004
Androgen receptor0011
Histamine H2 receptor0404
5-hydroxytryptamine receptor 1B0303
Aldo-keto reductase family 1 member C30101
Aldo-keto reductase family 1 member C2 0101
Aldo-keto reductase family 1 member C10101
Dihydrofolate reductase0304
Dipeptidyl peptidase 40101
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain A, 2-oxoglutarate Oxygenase1001
dopamine D1 receptor1001
ClpP1001
Thymidylate synthase 0101
alpha-galactosidase2002
Thymidylate synthase 0101
Bloom syndrome protein isoform 13003
polyunsaturated fatty acid lipoxygenase ALOX121001
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]0101
peptidyl-prolyl cis-trans isomerase NIMA-interacting 13003
DNA polymerase eta isoform 12002
M-phase phosphoprotein 83003
caspase-1 isoform alpha precursor1001
nuclear receptor coactivator 3 isoform a0101
Toll-like receptor 40101
Fatty-acid amide hydrolase 10101
Bile salt export pump0101
ATP-binding cassette sub-family C member 30102
Dihydrofolate reductase0203
Dihydrofolate reductase0101
Dihydrofolate reductase0101
Dihydrofolate reductase0203
Thymidylate synthase0101
Tyrosine-protein kinase ABL10011
Thymidylate synthase0202
Integrin beta-33003
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Integrin alpha-IIb3003
5-hydroxytryptamine receptor 2C0102
High mobility group protein B10011
Dihydrofolate reductase0101
Thymidylate synthase0101
Dihydrofolate reductase0224
Glucose-6-phosphate 1-dehydrogenase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Folate receptor beta0101
5-hydroxytryptamine receptor 2A0101
Cytochrome P450 11B1, mitochondrial 0101
Folate receptor alpha0101
Dihydrofolate reductase0202
Histidine decarboxylase0101
Trifunctional purine biosynthetic protein adenosine-30101
Cyclin-dependent kinase 20011
Bifunctional purine biosynthesis protein ATIC0202
Multidrug resistance-associated protein 1 0001
Reduced folate transporter0202
Folylpolyglutamate synthase, mitochondrial0103
6-phosphogluconate dehydrogenase, decarboxylating0101
Caspase-71001
Solute carrier organic anion transporter family member 1A30003
Dihydrofolate reductase0101
Pteridine reductase 10101
Folylpolyglutamate synthase, mitochondrial0103
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Solute carrier family 22 member 60002
Canalicular multispecific organic anion transporter 10102
Trifunctional purine biosynthetic protein adenosine-30101
Solute carrier family 22 member 200101
Dihydrofolate reductase 0101
Solute carrier family 22 member 80003
Solute carrier family 22 member 60101
Dihydrofolate reductase0101
ATP-binding cassette sub-family C member 110001
Proton-coupled folate transporter0101
Multidrug resistance associated protein0102
Solute carrier organic anion transporter family member 1B30204
Solute carrier family 22 member 110002
glucocerebrosidase4004
5-hydroxytryptamine receptor 70101
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial0101
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial0101
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial0101
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial0101
cytochrome P450 2D65005
Estrogen receptor0124
Estrogen receptor beta0124
luciferase0001
Fatty acid-binding protein, liver0101
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Glutamine synthetase0011
Histamine H1 receptor0011
Prostaglandin G/H synthase 20101
Nociceptin receptor0011
Cytochrome P450 2J20101
Prolyl 4-hydroxylase, beta polypeptide0001
Caspase-72002
potassium voltage-gated channel subfamily H member 2 isoform d2002
caspase-32002
DNA dC->dU-editing enzyme APOBEC-3G isoform 11102
HLA class I histocompatibility antigen, A alpha chain 0011
Gastric inhibitory polypeptide receptor0101
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR0011
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
Retinol-binding protein 40011
Beta-lactoglobulin0011
Disintegrin and metalloproteinase domain-containing protein 171001
Chain A, HIV-1 PROTEASE0101
Chain B, HIV-1 PROTEASE0101
Chain A, POL polyprotein0101
Chain B, POL polyprotein0101
Chain A, POL polyprotein0101
Chain B, POL polyprotein0101
Chain A, Endothiapepsin0101
Chain A, Endothiapepsin0101
Nuclear receptor subfamily 1 group I member 20022
Solute carrier organic anion transporter family member 2B1 0202
Gag-Pol polyprotein0101
Gag-Pol polyprotein0101
Gag-Pol polyprotein0101
Gag-Pol polyprotein0101
ATP-dependent translocase ABCB10101
ATP-dependent translocase ABCB10314
Gag-Pol polyprotein0101
Cytochrome P450 3A50101
ATP-dependent translocase ABCB10101
Substance-K receptor0404
Alpha-1D adrenergic receptor0202
Thromboxane-A synthase 0202
Gag-Pol polyprotein0101
Vasopressin V1a receptor0202
Thromboxane-A synthase0001
Sodium/bile acid cotransporter0101
Protease 0114
Plasmepsin V 0101
Solute carrier organic anion transporter family member 1B10204
Protease 0213
Nitric oxide synthase, brain0011
Chain A, MUSCLE FATTY ACID BINDING PROTEIN0011
Chain A, MUSCLE FATTY ACID BINDING PROTEIN0011
Chain A, MUSCLE FATTY ACID BINDING PROTEIN0011
Acetylcholinesterase0202
Fatty acid-binding protein, adipocyte0011
Tyrosine-protein phosphatase non-receptor type 10101
Peroxisome proliferator-activated receptor alpha0011
Chain A, CES1 protein0101
DNA polymerase III, partial1001
bromodomain adjacent to zinc finger domain 2B2002
thyrotropin-releasing hormone receptor1001
cytochrome P450 2D6 isoform 11001
interferon gamma precursor0001
D(1A) dopamine receptor1001
ubiquitin-conjugating enzyme E2 N0101
streptokinase A precursor0011
5-hydroxytryptamine receptor 40202
Serine/threonine-protein kinase D30101
Lysosomal acid glucosylceramidase0011
Receptor tyrosine-protein kinase erbB-20101
Protein kinase C gamma type0101
Protein kinase C alpha type0101
Protein kinase C beta type0101
Tyrosine-protein kinase Lck0101
Tyrosine-protein kinase Fyn0101
Beta-1 adrenergic receptor0202
Protein kinase C delta type0101
Protein kinase C epsilon type0101
Protein kinase C zeta type0101
Steroid hormone receptor ERR10101
Transcriptional activator protein LuxR0101
Angiotensin-converting enzyme0202
Beta-3 adrenergic receptor0202
D(2) dopamine receptor0202
Protein kinase C alpha type0101
5-hydroxytryptamine receptor 1A0202
D(1A) dopamine receptor0202
D(4) dopamine receptor0202
UDP-glucuronosyltransferase 1A40001
Prostaglandin G/H synthase 10101
Protein kinase C eta type0101
Substance-P receptor0202
5-hydroxytryptamine receptor 2A0202
5-hydroxytryptamine receptor 2C0202
B2 bradykinin receptor0202
Melanocortin receptor 40202
Melanocortin receptor 50202
D(3) dopamine receptor0202
5-hydroxytryptamine receptor 2B0202
Protein kinase C iota type0101
Melanocortin receptor 30202
D(1A) dopamine receptor1001
5-hydroxytryptamine receptor 60202
Estrogen-related receptor gamma0101
Protein kinase C gamma type0101
Protein kinase C beta type0101
Phospholipase D1 0101
Protein kinase C epsilon type0101
Protein kinase C theta type0101
Protein kinase C zeta type0101
Protein kinase C delta type0101
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform0101
Platelet-activating factor acetylhydrolase0101
Phospholipase D10101
Serine/threonine-protein kinase D10101
Protein kinase C eta type0101
Nuclear receptor subfamily 3 group C member 3 0202
Emopamil-binding protein-like0101
7-dehydrocholesterol reductase0112
Protein kinase C theta type0101
Adenylate kinase isoenzyme 10001
Adenylate kinase 2, mitochondrial0001
Capsid protein 0011
Reverse transcriptase/RNaseH 0114
90-kda heat shock protein beta HSP90 beta, partial0101
estrogen receptor beta isoform 10101
tyrosine-protein phosphatase non-receptor type 7 isoform 20101
Dihydroxyacetone phosphate acyltransferase0001
30S ribosomal protein S60101
30S ribosomal protein S70101
50S ribosomal protein L150101
Tetracycline resistance protein, class B0001
50S ribosomal protein L100101
50S ribosomal protein L110101
50S ribosomal protein L7/L120101
50S ribosomal protein L190101
50S ribosomal protein L10101
50S ribosomal protein L200101
50S ribosomal protein L270101
50S ribosomal protein L280101
50S ribosomal protein L290101
50S ribosomal protein L310101
50S ribosomal protein L31 type B0101
50S ribosomal protein L320101
50S ribosomal protein L330101
50S ribosomal protein L340101
50S ribosomal protein L350101
50S ribosomal protein L360101
30S ribosomal protein S100101
30S ribosomal protein S110101
30S ribosomal protein S120101
30S ribosomal protein S130101
30S ribosomal protein S160101
30S ribosomal protein S180101
30S ribosomal protein S190101
30S ribosomal protein S200101
30S ribosomal protein S20101
30S ribosomal protein S30101
30S ribosomal protein S40101
30S ribosomal protein S50101
30S ribosomal protein S80101
30S ribosomal protein S90101
50S ribosomal protein L130101
50S ribosomal protein L140101
50S ribosomal protein L160101
50S ribosomal protein L230101
30S ribosomal protein S150101
Multidrug transporter MdfA0101
50S ribosomal protein L170101
50S ribosomal protein L210101
50S ribosomal protein L300101
50S ribosomal protein L60101
30S ribosomal protein S140101
30S ribosomal protein S170101
30S ribosomal protein S10101
50S ribosomal protein L180101
Neutrophil collagenase0202
Collagenase 30101
Cannabinoid receptor 10101
50S ribosomal protein L20101
50S ribosomal protein L30101
50S ribosomal protein L240101
50S ribosomal protein L40101
50S ribosomal protein L220101
50S ribosomal protein L50101
30S ribosomal protein S210101
50S ribosomal protein L250101
50S ribosomal protein L36 20101
Integrase 0101
Solute carrier family 22 member 70001
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
Ubiquitin-like modifier activating enzyme 20101
SUMO1 activating enzyme subunit 10101
hexokinase0101
SUMO-conjugating enzyme UBC90101
eukaryotic translation initiation factor 4 gamma 1 isoform 40101
eukaryotic translation initiation factor 4E isoform 10101
lethal(3)malignant brain tumor-like protein 1 isoform I1001
Vif0101
Tat0101
bifunctional UDP-N-acetylglucosamine pyrophosphorylase/glucosamine-1-phosphate N-acetyltransferase0101
Aldo-keto reductase family 1 member B10101
Glutamate receptor 11001
Glutamate receptor 31001
Glutamate receptor 41001
Chain X, Thyroid hormone receptor beta-10022
Chain X, Thyroid hormone receptor beta-10022
serine/threonine-protein kinase PLK11001
Solute carrier organic anion transporter family member 1A40103
Solute carrier organic anion transporter family member 1A50002
Transthyretin0103
Thyroid hormone receptor alpha0235
Thyroid hormone receptor beta0235
Proliferating cell nuclear antigen0202
Malate dehydrogenase, mitochondrial0101
Solute carrier organic anion transporter family member 1A20002
Solute carrier organic anion transporter family member 4C10102
Monocarboxylate transporter 80001
Bile acid receptor0101
Solute carrier organic anion transporter family member 1C10001
histone deacetylase 9 isoform 31001
Microtubule-associated protein tau0202
Gamma-aminobutyric acid receptor subunit pi0101
Gamma-aminobutyric acid receptor subunit delta0101
Prothrombin0011
Gamma-aminobutyric acid receptor subunit alpha-10101
Thyroid hormone receptor beta0101
Gamma-aminobutyric acid receptor subunit beta-10101
Gamma-aminobutyric acid receptor subunit gamma-20101
Gamma-aminobutyric acid receptor subunit beta-30101
Gamma-aminobutyric acid receptor subunit alpha-50101
Gamma-aminobutyric acid receptor subunit alpha-30101
Gamma-aminobutyric acid receptor subunit alpha-20101
Gamma-aminobutyric acid receptor subunit beta-20101
Gamma-aminobutyric acid receptor subunit alpha-40101
Gamma-aminobutyric acid receptor subunit epsilon0101
Gamma-aminobutyric acid receptor subunit alpha-60101
Sigma non-opioid intracellular receptor 10011
Solute carrier organic anion transporter family member 4C10001
Gamma-aminobutyric acid receptor subunit gamma-10101
Solute carrier organic anion transporter family member 4A10001
Gamma-aminobutyric acid receptor subunit gamma-30101
Solute carrier organic anion transporter family member 1C10101
Gamma-aminobutyric acid receptor subunit theta0101
Cytochrome P450 2E10101
Cystic fibrosis transmembrane conductance regulator0011
Farnesyl diphosphate synthase0202
Geranylgeranyl pyrophosphate synthase0404
Butyrophilin subfamily 3 member A10012
Matrix metalloproteinase-140101
H0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]