Camurati-Engelmann Disease

An autosomal dominant form of dysplasia that is characterized by progressive thickening of diaphyseal cortex of long bones. Mutations in the gene that encodes TRANSFORMING GROWTH FACTOR BETA1 are one cause of this disorder.

Synonyms(8)

Synonym
Progressive Diaphyseal Dysplasia
Diaphyseal Hyperostosis
Camurati-Engelmann Syndrome
Camurati-Engelmann Disease
Diaphyseal Dysplasia 1, Progressive
Engelmann's Disease
Engelmann Disease
Diaphyseal Dysplasia, Progressive

Research Excerpts

Overview

Excerpt	Reference
"Progressive diaphyseal dysplasia is characterized clinically by crippling leg pain, fatigue, headache, poor appetite, muscle weakness, and waddling gait."	( Alon, U; Berant, M; Kaftori, JK; Naveh, Y, 1985)
"It is argued that Engelmann's disease is not primarily a metabolic bone disease but may be a systemic disorder which might be included within the spectrum of the inflammatory connective tissue diseases."	( Brenton, DP; Crisp, AJ, 1982)
"Camurati-Engelmann disease is characterized by hyperostosis of the long bones and the skull, muscle atrophy, severe limb pain, and progressive joint contractures in some patients."	( Boduroglu, K; Bonafe, L; Campos-Xavier, B; Dikoglu, E; Simsek-Kiper, PO; Superti-Furga, A; Unger, S; Utine, GE, 2014)
"Camurati-Engelmann disease is an extremely rare disease characterized by hyperostosis of multiple long bones."	( Choi, JH; Kang, E; Kim, GH; Kim, YM; Lee, BH; Yoo, HW, 2018)

Treatment

Excerpt	Reference
"A 27-year-old woman with progressive diaphyseal dysplasia (Camurati-Engelmann disease) received pamidronate and corticosteroid therapy for bone pain."	( Aburano, T; Inaoka, T; Ishikawa, Y; Makita, Y; Sato, J; Shuke, N; Takahashi, K, 2001)

Research

Studies (91)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	21 (23.08)	23.3326
1990's	13 (14.29)	12.5806
2000's	28 (30.77)	18.1394
2010's	25 (27.47)	28.8240
2020's	4 (4.40)	9.53

Drug	Relationship Strength	Studies
carnitine	low	1
nitrous oxide	low	1
acetazolamide	low	2
alendronate	low	2
betahistine	low	1
celecoxib	low	1
losartan	low	8
activins	low	1
pamidronate	low	3
sevoflurane	low	1
prednisolone	low	9
prednisone	low	8
pilocarpine	low	1
serine	low	1
methylprednisolone	low	3
calcium gluconate	low	1
ethylnitrosourea	low	1
technetium	low	3
thallium chloride	low	1
transferrin	low	1
tramadol	low	1
vecuronium bromide	low	1
propiconazole	low	3
6-amino-1-hydroxyhexane-1,1-diphosphonate	low	1
arginyl-glycyl-aspartic acid	low	1
pyridinoline	low	1
technetium tc 99m hydroxymethylene diphosphonate	low	3
deflazacort	low	1
thallium	low	1
sulfur	low	1
cysteine	low	1
acid phosphatase	low	1
jaw	low	1
calcitonin	low	1
transforming growth factor beta	low	18
technetium tc 99m sulfur colloid	low	1
technetium tc 99m medronate	low	15

Protein Targets (408)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Geranylgeranyl pyrophosphate synthase	0	3	0	3
Farnesyl pyrophosphate synthase	0	6	0	6
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	2	0	0	2
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Beta-lactamase	2	0	0	2
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Class Iii Chitinase Chia1	0	1	0	1
Chain A, Carbonic anhydrase 13	0	1	0	1
Chain A, Carbonic anhydrase II	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase	0	1	0	1
Chain B, Carbonic anhydrase	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	2	0	2
thioredoxin reductase	3	0	0	3
GALC protein	1	0	0	1
GLI family zinc finger 3	8	0	0	8
nuclear receptor subfamily 1, group I, member 3	3	0	0	3
cytochrome P450 family 3 subfamily A polypeptide 4	6	0	0	6
glucocorticoid receptor [Homo sapiens]	11	0	0	11
retinoic acid nuclear receptor alpha variant 1	8	0	0	8
retinoid X nuclear receptor alpha	6	0	0	6
estrogen-related nuclear receptor alpha	8	0	0	8
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase	0	2	0	2
arylsulfatase A	3	0	0	3
Carbonic anhydrase	0	2	0	2
euchromatic histone-lysine N-methyltransferase 2	4	0	0	4
Bloom syndrome protein isoform 1	2	0	0	2
thyroid hormone receptor beta isoform a	4	0	0	4
nuclear factor erythroid 2-related factor 2 isoform 1	7	0	0	7
geminin	5	0	0	5
peripheral myelin protein 22	3	0	0	3
survival motor neuron protein isoform d	2	0	0	2
muscleblind-like protein 1 isoform 1	2	0	0	2
Gamma-aminobutyric acid receptor subunit pi	3	1	0	4
ATP-binding cassette sub-family C member 3	0	5	0	5
Multidrug resistance-associated protein 4	0	5	0	5
Carbonic anhydrase	0	1	0	1
Solute carrier family 22 member 6	0	2	0	2
Carbonic anhydrase 12	0	3	1	6
Prolyl endopeptidase	0	1	0	1
Carbonic anhydrase-related protein 11	0	1	0	2
Bile salt export pump	0	7	0	7
Glycogen phosphorylase, muscle form	0	1	0	1
Renin	0	2	0	2
Carbonic anhydrase 1	0	4	1	9
Carbonic anhydrase 2	0	4	1	8
Carbonic anhydrase 2	0	2	0	2
Cytochrome P450 1A2	0	1	0	1
Carbonic anhydrase 3	0	3	1	6
Cathepsin B	0	1	0	1
Cytochrome P450 3A4	0	2	0	2
Steryl-sulfatase	0	1	0	1
5-hydroxytryptamine receptor 2C	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	2
Cytochrome P450 2C8	0	1	0	1
Cytochrome P450 2D6	0	2	0	2
Cytochrome P450 2A6	0	2	1	3
Cytochrome P450 2C9	0	4	0	4
5-hydroxytryptamine receptor 2A	0	1	0	1
Androgen receptor	0	4	0	4
Gamma-aminobutyric acid receptor subunit beta-1	3	1	0	4
Translocator protein	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	3	1	0	4
Gamma-aminobutyric acid receptor subunit gamma-2	3	1	0	4
Gamma-aminobutyric acid receptor subunit alpha-5	3	1	0	4
Gamma-aminobutyric acid receptor subunit alpha-3	3	1	0	4
Cannabinoid receptor 1	0	1	0	1
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
Cytochrome P450 2B6	0	1	0	1
Carbonic anhydrase 4	0	3	1	5
Carbonic anhydrase 6	0	3	1	5
Gamma-aminobutyric acid receptor subunit gamma-1	3	1	0	4
Gamma-aminobutyric acid receptor subunit alpha-2	3	1	0	4
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Adenosine receptor A1	0	2	0	2
Serum paraoxonase/arylesterase 1	0	1	0	1
Dipeptidyl peptidase 4	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	3	1	0	4
Gamma-aminobutyric acid receptor subunit gamma-3	3	1	0	4
Endochitinase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	3	1	0	4
Adenosine receptor A2a	0	2	0	2
5-hydroxytryptamine receptor 2B	0	1	0	1
Sodium-dependent serotonin transporter	0	1	1	2
Delta-type opioid receptor	0	2	0	2
Cytochrome P450 2C19	0	1	0	1
Delta-type opioid receptor	0	2	0	2
Mu-type opioid receptor	0	2	0	2
Carbonic anhydrase 5A, mitochondrial	0	3	1	6
Carbonic anhydrase	0	2	0	2
Kappa-type opioid receptor	0	1	0	1
Carbonic anhydrase 7	0	3	1	5
Carbonic anhydrase	0	1	0	1
D(1A) dopamine receptor	0	1	0	1
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
Carbonic anhydrase	0	2	0	2
D(2) dopamine receptor	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	3	2	0	5
Gamma-aminobutyric acid receptor subunit beta-3	3	1	0	4
Gamma-aminobutyric acid receptor subunit beta-2	3	1	0	4
Cholinesterase	0	2	0	2
Carbonic anhydrase	0	2	0	2
Mu-type opioid receptor	0	3	0	3
Fatty-acid amide hydrolase 1	0	1	0	1
Beta-carbonic anhydrase 1	0	2	0	2
Carbonic anhydrase 2	0	2	0	2
Glutamate receptor ionotropic, NMDA 2B	0	1	0	1
Squalene synthase	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Carbonic anhydrase 9	0	4	1	7
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase, alpha family	0	2	0	2
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase 3	0	1	0	1
Carbonic anhydrase	0	2	0	3
Carbonic anhydrase	0	2	0	3
Carbonic anhydrase	0	2	0	2
Sigma intracellular receptor 2	0	2	0	2
Delta carbonic anhydrase	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	1	0	1
Renin	0	1	0	1
Carbonic anhydrase	0	2	0	2
Endochitinase A1	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	1
Carbonic anhydrase 13	0	3	1	5
GABA theta subunit	3	1	0	4
Canalicular multispecific organic anion transporter 1	0	5	0	5
Carbonic anhydrase 4	0	4	0	4
Carbonic anhydrase 15	0	2	0	3
Acidic mammalian chitinase	0	1	0	1
Carbonic anhydrase 13	0	2	0	3
Carbonic anhydrase 7	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	3	1	0	4
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 14	0	3	1	6
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 2, isoform A	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	3	1	6
Chain A, JmjC domain-containing histone demethylation protein 3A	1	0	0	1
Chain A, 2-oxoglutarate Oxygenase	2	0	0	2
Chain A, ATP-DEPENDENT DNA HELICASE Q1	1	0	0	1
acetylcholinesterase	3	0	0	3
dopamine D1 receptor	1	0	0	1
15-lipoxygenase, partial	1	0	0	1
pregnane X receptor	5	0	0	5
phosphopantetheinyl transferase	3	0	0	3
RAR-related orphan receptor gamma	4	0	0	4
USP1 protein, partial	2	0	0	2
NFKB1 protein, partial	1	0	0	1
Microtubule-associated protein tau	1	0	0	1
Thrombopoietin	2	0	0	2
AR protein	8	0	0	8
regulator of G-protein signaling 4	3	0	0	3
farnesoid X nuclear receptor	3	0	0	3
estrogen nuclear receptor alpha	10	0	0	10
vitamin D (1,25- dihydroxyvitamin D3) receptor	4	0	0	4
D(1A) dopamine receptor	1	0	0	1
thyroid hormone receptor beta isoform 2	4	0	0	4
heat shock protein beta-1	2	0	0	2
flap endonuclease 1	1	0	0	1
muscarinic acetylcholine receptor M1	3	0	0	3
Histone deacetylase 3	0	2	0	2
Histone deacetylase 4	0	2	0	2
Guanine nucleotide-binding protein G	2	0	0	2
Histone deacetylase 1	0	2	0	2
Histone deacetylase 7	0	2	0	2
Histone deacetylase 2	0	2	0	2
Polyamine deacetylase HDAC10	0	2	0	2
Histone deacetylase 11	0	2	0	2
Ataxin-2	6	0	0	6
Histone deacetylase 8	0	2	0	2
Histone deacetylase 6	0	2	0	2
Histone deacetylase 9	0	2	0	2
Histone deacetylase 5	0	2	0	2
ATP-dependent phosphofructokinase	4	0	0	4
Chain A, farnesyl pyrophosphate synthase	0	1	0	1
Acetylcholinesterase	0	1	0	1
Hypoxanthine-guanine phosphoribosyltransferase	0	2	0	2
Farnesyl pyrophosphate synthase	0	2	0	2
Farnesyl pyrophosphate synthase	0	1	0	1
DNA polymerase kappa isoform 1	2	0	0	2
Integrin beta-3	0	1	0	1
Integrin beta-1	0	1	0	1
Integrin alpha-V	0	1	0	1
Integrin alpha-IIb	0	1	0	1
Integrin alpha-5	0	1	0	1
Integrin beta-5	0	1	0	1
Histamine H3 receptor	0	1	0	1
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 2	0	0	1	1
Potassium channel subfamily K member 9	0	1	0	1
Solute carrier family 22 member 5	0	0	0	1
Solute carrier family 22 member 5	0	0	0	1
Solute carrier family 22 member 16	0	0	0	1
Solute carrier family 22 member 21	0	0	0	1
Solute carrier family 22 member 5	0	0	0	1
Chain A, Carbonic anhydrase II	0	1	0	1
Chain A, Cruzipain	2	0	0	2
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
glp-1 receptor, partial	3	0	0	3
hypoxia-inducible factor 1 alpha subunit	4	0	0	4
SMAD family member 2	2	0	0	2
PPM1D protein	2	0	0	2
SMAD family member 3	2	0	0	2
TDP1 protein	6	0	0	6
Smad3	1	0	0	1
caspase 7, apoptosis-related cysteine protease	1	0	0	1
thyroid stimulating hormone receptor	2	0	0	2
estrogen receptor 2 (ER beta)	3	0	0	3
progesterone receptor	7	0	0	7
EWS/FLI fusion protein	1	0	0	1
pregnane X nuclear receptor	6	0	0	6
G	3	0	0	3
cytochrome P450 2D6	2	0	0	2
67.9K protein	1	0	0	1
peroxisome proliferator-activated receptor delta	2	0	0	2
peroxisome proliferator activated receptor gamma	3	0	0	3
Rac1 protein	0	0	1	1
caspase-3	1	0	0	1
IDH1	2	0	0	2
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	6	0	0	6
thyroid stimulating hormone receptor	1	0	0	1
activating transcription factor 6	2	0	0	2
thyrotropin-releasing hormone receptor	1	0	0	1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	1	0	0	1
v-jun sarcoma virus 17 oncogene homolog (avian)	4	0	0	4
Histone H2A.x	1	0	0	1
Caspase-7	1	0	0	1
interferon gamma precursor	0	0	0	1
prostaglandin E2 receptor EP2 subtype	0	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 2	4	0	0	4
potassium voltage-gated channel subfamily H member 2 isoform d	1	0	0	1
caspase-3	1	0	0	1
cytochrome P450 3A4 isoform 1	3	0	0	3
lamin isoform A-delta10	3	0	0	3
Prostaglandin E synthase	0	1	0	1
3-phosphoinositide-dependent protein kinase 1	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
Cytochrome c oxidase subunit 1	0	1	0	1
Cytochrome c oxidase subunit 2	0	1	0	1
Catechol O-methyltransferase	0	1	0	1
Voltage-dependent calcium channel gamma-2 subunit	3	0	0	3
Cytochrome c oxidase subunit 2	0	1	0	1
Interferon beta	5	0	0	5
HLA class I histocompatibility antigen, B alpha chain	3	0	0	3
Cellular tumor antigen p53	4	0	0	4
Prostaglandin G/H synthase 1	0	1	0	1
Procathepsin L	0	1	0	1
Aldo-keto reductase family 1 member B1	0	2	0	2
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	0	1	0	1
Quinolone resistance protein NorA	0	1	0	1
Adenosine receptor A3	0	2	0	2
Neuronal acetylcholine receptor subunit beta-2	0	1	0	1
Beta-3 adrenergic receptor	0	2	0	2
Alpha-1B adrenergic receptor	0	2	0	2
Calpain-2 catalytic subunit	0	1	0	1
Alpha-2B adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 1A	0	2	0	2
Glutamate receptor 2	3	0	0	3
D(1A) dopamine receptor	0	2	0	2
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	2
Sodium-dependent noradrenaline transporter	0	2	0	2
Cruzipain	0	1	0	1
Sodium/hydrogen exchanger 1	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Sodium-dependent serotonin transporter	0	2	0	2
Bifunctional epoxide hydrolase 2	0	1	0	1
Prostaglandin G/H synthase 2	0	3	1	5
Prostaglandin G/H synthase 2	0	1	0	1
Alpha-1A adrenergic receptor	0	2	0	2
Urotensin-2 receptor	0	1	0	1
Nuclear receptor ROR-gamma	2	0	0	2
Ras-related protein Rab-2A	0	0	1	1
Prostaglandin G/H synthase 2	0	2	0	2
Sodium-dependent dopamine transporter	0	2	0	2
Prostaglandin G/H synthase 2	0	1	0	1
Mitogen-activated protein kinase 14	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Cyclooxygenase-2	0	1	0	1
Rap guanine nucleotide exchange factor 4	1	0	0	1
Inositol hexakisphosphate kinase 1	3	0	0	3
ATPase family AAA domain-containing protein 5	5	0	0	5
P2Y purinoceptor 12	0	1	0	1
cytochrome P450 2C9, partial	3	0	0	3
GLS protein	2	0	0	2
vitamin D3 receptor isoform VDRA	3	0	0	3
chromobox protein homolog 1	3	0	0	3
aryl hydrocarbon receptor	3	0	0	3
nuclear receptor subfamily 1, group I, member 2	3	0	0	3
interleukin 8	1	0	0	1
lethal factor (plasmid)	2	0	0	2
Neutral amino acid transporter A	0	2	0	2
Asc-type amino acid transporter 1	0	1	0	1
Neutral amino acid transporter B(0)	0	2	0	2
Proton-coupled amino acid transporter 1	0	2	0	2
Amino acid transporter	0	2	0	2
ATAD5 protein, partial	1	0	0	1
Chymotrypsinogen A	0	1	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	2	0	0	2
histone acetyltransferase KAT2A isoform 1	2	0	0	2
ATP-dependent translocase ABCB1	0	0	0	1
Neprilysin	0	1	0	1
Angiotensin-converting enzyme	0	1	0	1
Atrial natriuretic peptide receptor 3	0	1	0	1
Thromboxane A2 receptor	0	1	0	2
Type-1A angiotensin II receptor	0	2	1	3
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Type-1B angiotensin II receptor	0	2	0	2
Type-1 angiotensin II receptor	0	2	1	5
Type-1 angiotensin II receptor	0	1	1	2
Type-2 angiotensin II receptor	0	2	0	2
Type-2 angiotensin II receptor	0	1	0	1
Spike glycoprotein	3	0	0	3
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	1	0	1
Multidrug and toxin extrusion protein 1	0	2	0	2
Platelet glycoprotein VI	0	1	1	3
Solute carrier organic anion transporter family member 1B3	0	2	0	2
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	1	0	1
Type-1 angiotensin II receptor	0	1	1	2
Solute carrier organic anion transporter family member 1B1	0	2	0	2
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	2	0	0	2
nonstructural protein 1	2	0	0	2
bromodomain adjacent to zinc finger domain 2B	1	0	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Glucocorticoid receptor	0	6	2	13
Glycine receptor subunit alpha-1	0	6	0	6
Glycine receptor subunit beta	0	6	0	6
Glycine receptor subunit alpha-2	0	6	0	6
Glycine receptor subunit alpha-3	0	6	0	6
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
cytochrome P450 2C19 precursor	1	0	0	1
cytochrome P450 2C9 precursor	1	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	1	0	0	1
Muscarinic acetylcholine receptor M2	0	1	1	2
Muscarinic acetylcholine receptor M1	0	2	0	3
Muscarinic acetylcholine receptor M3	0	2	0	3
Muscarinic acetylcholine receptor M4	0	2	0	3
Muscarinic acetylcholine receptor M5	0	2	0	3
Muscarinic acetylcholine receptor M5	0	1	0	1
Muscarinic acetylcholine receptor M2	0	2	0	3
Muscarinic acetylcholine receptor M1	0	1	2	3
Muscarinic acetylcholine receptor M1	0	0	1	1
Muscarinic acetylcholine receptor DM1	0	1	0	1
Histamine H2 receptor	2	0	0	2
Cytochrome P450 2A13	0	1	1	2
luciferase	0	0	0	1
Fatty acid-binding protein, liver	0	1	0	1
Estrogen receptor	0	2	0	2
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	2	1	3
Androgen receptor	0	2	0	2
Glutamine synthetase	0	0	1	1
Histamine H1 receptor	0	0	1	1
Nociceptin receptor	0	0	1	1
Cytochrome P450 2J2	0	1	0	1
Estrogen receptor beta	0	2	0	2
Chain A, HADH2 protein	1	0	0	1
Chain B, HADH2 protein	1	0	0	1
thioredoxin glutathione reductase	1	0	0	1
aldehyde dehydrogenase 1 family, member A1	1	0	0	1
nuclear receptor ROR-gamma isoform 1	2	0	0	2
Chain A, Ferritin light chain	1	0	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
DNA polymerase iota isoform a (long)	1	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
TAR DNA-binding protein 43	1	0	0	1
heat shock protein 90, putative	0	0	0	1
Acetylcholinesterase	0	1	0	1
Pyruvate kinase PKM	0	0	1	1
Solute carrier family 22 member 1	0	1	0	1
Mu-type opioid receptor	0	1	1	2
Delta-type opioid receptor	0	1	0	1
Kappa-type opioid receptor	0	1	0	1
Solute carrier family 22 member 2	0	1	0	1
Multidrug and toxin extrusion protein 2	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

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