Page last updated: 2024-09-28

Familial Hyperpotassemia and Hypertension

Rare autosomal disorder of renal electrolyte transport dysfunctions. The Type I features HYPERKALEMIA with sodium wasting; Type II, HYPERKALEMIA without sodium wasting. Loss of function mutations in EPITHELIAL SODIUM CHANNELS subunits (autosomal dominant) or MINERALOCORTICOID RECEPTORS (autosomal recessive) cause the disorder. Different mutations in EPITHELIAL SODIUM CHANNELS subunits cause Liddle syndrome.

Synonyms(15)

Synonym
Pseudohypoaldosteronism Type 1, Autosomal Recessive
Pseudohypoaldosteronism, Type I, Autosomal Recessive
Pseudohypoaldosteronism, Type I, Autosomal Dominant
Pseudohypoaldosteronism, Type I
Pseudohypoaldosteronism Type II
Hyperpotassemia and Hypertension, Familial
Familial Hyperpotassemia and Hypertension
Pseudohypoaldosteronism Type I
Pseudohypoaldosteronism Type 1
Pseudohypoaldosteronism Type 1, Autosomal Dominant
Pseudohypoaldosteronism Type 2
Pseudohypoaldosteronism, Type II
Gordon Hyperkalemia-Hypertension Syndrome
Hypertensive Hyperkalemia, Familial
Familial Hypertensive Hyperkalemia

Research Excerpts

Overview

ExcerptReference
"Pseudohypoaldosteronism type II is a salt-sensitive form of hypertension with hyperkalemia in humans caused by mutations in the with-no-lysine kinase 4 (WNK4)."( Alessi, DR; Bobadilla, NA; Castañeda-Bueno, M; Cervantes-Pérez, LG; Doucet, A; Gamba, G; Kantesaria, S; Morla, L; Uribe, N; Vázquez, N, 2012)
"Pseudohypoaldosteronism type 1 is a rare disorder characterized by renal resistance to aldosterone which may present with a salt wasting crisis in infancy."( Choudhry, S; Najam, Y, 2012)
"Renal pseudohypoaldosteronism type 1 is a rare autosomal-dominant disease caused by NR3C2 loss-of-function mutations, which is characterized by renal salt loss and compensatory high renin and aldo secretion."( Chillon, S; Couffignal, C; Escoubet, B; Jeunemaitre, X; Laisy, JP; Laouénan, C; Mangin, L; Mentré, F; Serfaty, JM; Zennaro, MC, 2013)
"Pseudohypoaldosteronism type I is a rare genetic disease of mineralocorticoid resistance that typically manifests in neonatal age."( de Potzolli, B; Seeliger, S; Tropschuh, A, 2020)
"Pseudohypoaldosteronism type 1B is a rare autosomal recessive disorder caused by dysfunction of amiloride-sensitive epithelial sodium channels (ENaCs)."( Kelchtermans, J; Leonard, JMM; Mcgrath-Morrow, S; Pinney, SE, 2022)

Research

Studies (245)

TimeframeStudies, This Condition (%)All Conditions %
pre-199011 (4.49)23.3326
1990's64 (26.12)12.5806
2000's76 (31.02)18.1394
2010's77 (31.43)28.8240
2020's17 (6.94)9.53
DrugIndicatedRelationship StrengthStudiesTrials
phosphoserine0low10
ammonium hydroxide0low10
chlorine0low180
n(g),n(g')-dimethyl-l-arginine0low10
cytosine0low10
glycine0low10
hydrogen carbonate0low40
iodine0low50
thymine0low10
uric acid0low10
albuterol0low10
bendroflumethiazide0low10
flumazenil0low10
furosemide0low50
gentamicin0low10
hydrochlorothiazide0low60
indomethacin0low60
methylphenidate0low10
risperidone0low10
succinylcholine0low10
trichlormethiazide0low20
spironolactone0low30
aldosterone0medium1121
aspartic acid0low10
methionine0low10
cycloheximide0low10
sodium citrate, anhydrous0low10
17-alpha-hydroxyprogesterone0low20
histidine0low20
threonine0low20
arginine0low10
oxazoles0low10
calcium gluconate0low10
glycyrrhizic acid0low10
amiloride0low150
iodinated glycerol0low30
sodium sulfate0low10
chlorine0low30
fludrocortisone0low120
4-methoxyamphetamine0low10
mifepristone0low10
fura-20low10
tetrahydroaldosterone0low10
ru-283620low10
n,n-dimethylarginine0low10
proline0low10
angiotensin ii0low30
cortisone0low10
tacrolimus0low20
cocaine0low10
sodium bicarbonate0low10
carbenoxolone sodium0medium41
benztropine0low10
phosphothreonine0low10
deamino arginine vasopressin0low10
calyculin a0low10
phosphorus0low10
nad0low10
9-fluorocortisone0low10
atrial natriuretic factor0low20
ru 283180low10
glycolipids0low10
18-hydroxycortisol0low10
cyclosporine0low40
technetium tc 99m dimercaptosuccinic acid0low10
eye0low10

Protein Targets (620)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
acetylcholinesterase6006
pregnane X receptor5005
SMAD family member 24004
SMAD family member 34004
TDP1 protein120012
GLI family zinc finger 38008
Microtubule-associated protein tau2002
AR protein140014
progesterone receptor9009
glucocorticoid receptor [Homo sapiens]120012
retinoic acid nuclear receptor alpha variant 19009
retinoid X nuclear receptor alpha9009
estrogen-related nuclear receptor alpha100010
farnesoid X nuclear receptor7007
pregnane X nuclear receptor5005
estrogen nuclear receptor alpha170017
G6006
vitamin D (1,25- dihydroxyvitamin D3) receptor8008
arylsulfatase A7007
euchromatic histone-lysine N-methyltransferase 2130013
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a8008
activating transcription factor 67007
nuclear receptor subfamily 1, group I, member 23003
chromobox protein homolog 17007
nuclear factor erythroid 2-related factor 2 isoform 1120012
geminin120012
survival motor neuron protein isoform d7007
histone acetyltransferase KAT2A isoform 14004
lamin isoform A-delta108008
Voltage-dependent calcium channel gamma-2 subunit8008
Interferon beta8008
HLA class I histocompatibility antigen, B alpha chain 6006
Glucocorticoid receptor18314
Sex hormone-binding globulin0033
Glycine receptor subunit alpha-10808
Corticosteroid-binding globulin0303
Adenosine receptor A30202
Replicase polyprotein 1ab0123
Androgen receptor0708
Alpha-1B adrenergic receptor0303
Glutamate receptor 28008
Glycine receptor subunit beta0808
Glycine receptor subunit alpha-20808
Glycine receptor subunit alpha-30808
Mitogen-activated protein kinase 3 0101
Alpha-1A adrenergic receptor0303
Sodium-dependent dopamine transporter 0808
TAR DNA-binding protein 436006
Inositol hexakisphosphate kinase 16006
cytochrome P450 2C9, partial6006
ATP-dependent phosphofructokinase5005
5-hydroxytryptamine receptor 2C0516
5-hydroxytryptamine receptor 2A0516
5-hydroxytryptamine receptor 1A0617
5-hydroxytryptamine receptor 1B0415
5-hydroxytryptamine receptor 1D0213
5-hydroxytryptamine receptor 1F0213
5-hydroxytryptamine receptor 2B0516
5-hydroxytryptamine receptor 60112
Sodium-dependent serotonin transporter0617
Sodium-dependent serotonin transporter0506
5-hydroxytryptamine receptor 7 0213
5-hydroxytryptamine receptor 5A0112
5-hydroxytryptamine receptor 5B0112
5-hydroxytryptamine receptor 3A0112
5-hydroxytryptamine receptor 4 0112
5-hydroxytryptamine receptor 3B0112
glp-1 receptor, partial5005
thioredoxin reductase9009
GLS protein4004
regulator of G-protein signaling 45005
NPYLR7B0011
thyroid stimulating hormone receptor2002
flap endonuclease 16006
peripheral myelin protein 224004
ATP-binding cassette sub-family C member 30808
Multidrug resistance-associated protein 40808
Bile salt export pump012012
Beta-2 adrenergic receptor0224
Beta-1 adrenergic receptor0022
60 kDa chaperonin0101
60 kDa heat shock protein, mitochondrial0101
Beta-3 adrenergic receptor0011
Delta-type opioid receptor0112
10 kDa heat shock protein, mitochondrial0101
Thiosulfate sulfurtransferase0101
Beta-2 adrenergic receptor 0013
60 kDa chaperonin 0101
10 kDa chaperonin 0101
Beta-2 adrenergic receptor0123
Canalicular multispecific organic anion transporter 10808
thyroid hormone receptor beta isoform a5005
nuclear factor erythroid 2-related factor 2 isoform 24004
Mineralocorticoid receptor 15311
Mineralocorticoid receptor0101
Solute carrier organic anion transporter family member 1A10001
Guanine nucleotide-binding protein G4004
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE7007
Chain U, UROKINASE-TYPE PLASMINOGEN ACTIVATOR0101
Chain A, UROKINASE-TYPE PLASMINOGEN ACTIVATOR0101
Chain A, UROKINASE-TYPE PLASMINOGEN ACTIVATOR0101
Chain A, HADH2 protein2002
Chain B, HADH2 protein2002
Chain A, 2-oxoglutarate Oxygenase3003
acid sphingomyelinase1001
aldehyde dehydrogenase 1 family, member A17007
thyroid stimulating hormone receptor5005
glucocerebrosidase3003
alpha-galactosidase2002
Bloom syndrome protein isoform 13003
cytochrome P450 2D6 isoform 14004
lysosomal alpha-glucosidase preproprotein1001
cytochrome P450 2C19 precursor6006
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 11001
thyroid hormone receptor beta isoform 28008
huntingtin isoform 22002
Membrane primary amine oxidase 0101
Solute carrier family 22 member 1 0101
Prothrombin0101
Coagulation factor X0101
Plasminogen0101
Urokinase-type plasminogen activator0202
Tissue-type plasminogen activator0202
Cationic trypsin0101
Coagulation factor XI0101
Plasma kallikrein0102
Vitamin K-dependent protein C0101
Cellular tumor antigen p538008
Urokinase-type plasminogen activator0202
Trypsin-10101
Trypsin-20101
Sodium/hydrogen exchanger 10101
Amine oxidase [flavin-containing] A0101
Sodium/hydrogen exchanger 10202
Sodium/hydrogen exchanger 30202
Adenosine receptor A2a0101
Trypsin-30101
Amiloride-sensitive sodium channel subunit alpha0101
5-hydroxytryptamine receptor 70101
Sodium/hydrogen exchanger 20202
Acid-sensing ion channel 10101
Potassium voltage-gated channel subfamily H member 20505
Sodium channel protein type 5 subunit alpha0202
Sodium/hydrogen exchanger 50202
Solute carrier family 22 member 10101
Solute carrier family 22 member 20101
Acid-sensing ion channel 30101
Sodium/hydrogen exchanger0101
DNA polymerase kappa isoform 14004
Atrial natriuretic peptide receptor 30101
Type-1A angiotensin II receptor 0213
Type-1 angiotensin II receptor0011
Type-1B angiotensin II receptor0202
Type-1 angiotensin II receptor0224
Type-2 angiotensin II receptor0202
Type-2 angiotensin II receptor0202
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0022
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0022
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0022
phosphopantetheinyl transferase3003
NFKB1 protein, partial2002
DNA polymerase iota isoform a (long)3003
muscarinic acetylcholine receptor M14004
lethal factor (plasmid)4004
Cytochrome P450 3A40405
Nitric oxide synthase, endothelial0002
Nitric oxide synthase, brain0102
Nitric oxide synthase, brain 0102
Nitric oxide synthase, inducible0102
Nitric oxide synthase, inducible0013
Cationic amino acid transporter 30101
Chain A, TYROSYL-DNA PHOSPHODIESTERASE2002
Chain A, Ferritin light chain3003
Metabotropic glutamate receptor 60011
Excitatory amino acid transporter 40101
Glutamate transporter homolog0011
Carbonic anhydrase 107012
Carbonic anhydrase 209014
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase0101
5-hydroxytryptamine receptor 1D0002
Glutamate receptor ionotropic, NMDA 1 0517
Excitatory amino acid transporter 10101
Excitatory amino acid transporter 20101
Excitatory amino acid transporter 30101
Glutamate receptor ionotropic, NMDA 2A 0416
Glutamate receptor ionotropic, NMDA 2B0416
Glutamate receptor ionotropic, NMDA 2C0416
Metabotropic glutamate receptor 10011
Metabotropic glutamate receptor 20011
Carbonic anhydrase-like protein, putative0002
Glutamate receptor ionotropic, NMDA 2D0416
Glutamate receptor ionotropic, NMDA 3B0416
Carbonic anhydrase 40002
Glutamate receptor ionotropic, NMDA 3A0416
Atrial natriuretic peptide receptor 10011
Atrial natriuretic peptide receptor 1 0011
RAR-related orphan receptor gamma110011
peroxisome proliferator-activated receptor delta8008
potassium voltage-gated channel subfamily H member 2 isoform d3003
cytochrome P450 3A4 isoform 14004
Gamma-aminobutyric acid receptor subunit pi4206
Gamma-aminobutyric acid receptor subunit beta-14206
Gamma-aminobutyric acid receptor subunit delta4206
Gamma-aminobutyric acid receptor subunit gamma-24206
Gamma-aminobutyric acid receptor subunit alpha-54206
Gamma-aminobutyric acid receptor subunit alpha-34206
Gamma-aminobutyric acid receptor subunit gamma-14206
Gamma-aminobutyric acid receptor subunit alpha-24206
Gamma-aminobutyric acid receptor subunit alpha-44206
Gamma-aminobutyric acid receptor subunit gamma-34206
Gamma-aminobutyric acid receptor subunit alpha-64206
Gamma-aminobutyric acid receptor subunit alpha-14206
Gamma-aminobutyric acid receptor subunit beta-34206
Gamma-aminobutyric acid receptor subunit beta-24206
GABA theta subunit4206
Gamma-aminobutyric acid receptor subunit epsilon4206
cytochrome P450 family 3 subfamily A polypeptide 45005
Spike glycoprotein0022
Replicase polyprotein 1ab0022
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Transmembrane protease serine 20022
5-hydroxytryptamine receptor 40404
Procathepsin L0123
Aldo-keto reductase family 1 member B10202
Muscarinic acetylcholine receptor M20303
Muscarinic acetylcholine receptor M40303
Muscarinic acetylcholine receptor M10202
Muscarinic acetylcholine receptor M50303
Alpha-2A adrenergic receptor0404
Replicase polyprotein 1a0022
Replicase polyprotein 1ab0022
Replicase polyprotein 1ab0022
Muscarinic acetylcholine receptor M20101
Muscarinic acetylcholine receptor M10303
Alpha-2B adrenergic receptor0606
Alpha-2C adrenergic receptor0404
Muscarinic acetylcholine receptor M30404
Sodium-dependent noradrenaline transporter 0606
Sodium-dependent dopamine transporter0606
Histamine H2 receptor0404
Alpha-1D adrenergic receptor0404
5-hydroxytryptamine receptor 2A0404
5-hydroxytryptamine receptor 2C0404
Histamine H1 receptor0404
D(3) dopamine receptor0404
5-hydroxytryptamine receptor 2B0404
Histamine H2 receptor3003
5-hydroxytryptamine receptor 60303
Spike glycoprotein80210
Sigma non-opioid intracellular receptor 10606
Angiotensin-converting enzyme 2 0022
Tyrosine-protein phosphatase non-receptor type 10202
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit0101
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B 0101
peroxisome proliferator activated receptor gamma8008
v-jun sarcoma virus 17 oncogene homolog (avian)5005
Solute carrier organic anion transporter family member 1B30505
Solute carrier organic anion transporter family member 1B10606
Carbonic anhydrase 408011
Carbonic anhydrase0405
Carbonic anhydrase 150203
Chain A, CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION0011
Chain B, CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION0011
Chain H, Fab M82G2, Heavy chain0011
Chain L, Fab M82G2, Light chain0011
Chain H, Fab M82g2, Heavy Chain0011
Chain L, Fab M82g2, Light Chain0011
Gamma-aminobutyric acid receptor subunit pi0202
Gamma-aminobutyric acid receptor subunit delta0202
Amyloid-beta precursor protein0101
Fatty acid-binding protein, heart0101
Muscarinic acetylcholine receptor M20101
Tryptophan 5-hydroxylase 10101
Gamma-aminobutyric acid receptor subunit alpha-10213
Gamma-aminobutyric acid receptor subunit beta-10202
Gamma-aminobutyric acid receptor subunit gamma-20213
D0202
Alpha-2B adrenergic receptor0202
Alpha-2C adrenergic receptor0202
Alpha-2A adrenergic receptor0202
Liver carboxylesterase 10001
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0101
Gamma-aminobutyric acid receptor subunit beta-30213
Gamma-aminobutyric acid receptor subunit alpha-50213
Gamma-aminobutyric acid receptor subunit alpha-30213
Lysosomal Pro-X carboxypeptidase0101
Gamma-aminobutyric acid receptor subunit alpha-20202
Gamma-aminobutyric acid receptor subunit beta-20202
Gamma-aminobutyric acid receptor subunit alpha-40202
D(2) dopamine receptor0303
Gamma-aminobutyric acid receptor subunit epsilon0202
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
Leukotriene B4 receptor 10101
Gamma-aminobutyric acid receptor subunit alpha-60202
Sodium-dependent dopamine transporter0202
Gamma-aminobutyric acid receptor subunit gamma-10202
Gamma-aminobutyric acid receptor subunit gamma-30202
Leukotriene B4 receptor 20101
Gamma-aminobutyric acid receptor subunit theta0202
Transporter0303
endonuclease IV2002
dopamine D1 receptor2002
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a3003
peripheral myelin protein 22 isoform 14004
atrial natriuretic peptide receptor 1 precursor1001
heat shock protein beta-13003
M-phase phosphoprotein 83003
Potassium voltage-gated channel subfamily A member 10011
Multidrug and toxin extrusion protein 10505
interleukin 82002
ATAD5 protein, partial4004
Fumarate hydratase2002
USP1 protein, partial3003
PPM1D protein1001
Smad33003
estrogen receptor 2 (ER beta)5005
nuclear receptor subfamily 1, group I, member 35005
EWS/FLI fusion protein6006
polyprotein2002
67.9K protein3003
P531001
RPL19A0011
IDH13003
aryl hydrocarbon receptor5005
Histone H2A.x3003
NPC intracellular cholesterol transporter 1 precursor1001
cellular tumor antigen p53 isoform a1001
nuclear factor NF-kappa-B p105 subunit isoform 11001
ras-related protein Rab-9A2002
heat shock protein HSP 90-alpha isoform 20001
urokinase-type plasminogen activator precursor2002
plasminogen precursor2002
urokinase plasminogen activator surface receptor precursor2002
nuclear receptor ROR-gamma isoform 15005
transactivating tegument protein VP16 [Human herpesvirus 1]0101
COUP transcription factor 2 isoform a0101
Glucose transporter0101
Hexose transporter 1 0101
Polyunsaturated fatty acid 5-lipoxygenase0101
Solute carrier family 2, facilitated glucose transporter member 10101
Alpha-synuclein1001
Nuclear receptor ROR-gamma2002
Eukaryotic initiation factor 4A-I0101
Peptidyl-prolyl cis-trans isomerase FKBP1A0415
Peptidyl-prolyl cis-trans isomerase FKBP30101
Peptidyl-prolyl cis-trans isomerase FKBP40101
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 10101
Hypoxia-inducible factor 1-alpha0101
ATPase family AAA domain-containing protein 54004
Ataxin-24004
Endothelial PAS domain-containing protein 10101
Peptidyl-prolyl cis-trans isomerase FKBP140101
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 40101
heat shock protein 90, putative0001
Deoxycytidine kinase0001
Vasopressin V2 receptor0112
Oxytocin receptor0011
Vasopressin V1a receptor0112
Vasopressin V1b receptor0112
Translocator protein0101
Vasopressin V2 receptor 0112
GALC protein1001
muscleblind-like protein 1 isoform 11001
Bile salt export pump0202
Gamma-aminobutyric acid receptor subunit alpha-10202
Gamma-aminobutyric acid receptor subunit beta-10202
Neuronal acetylcholine receptor subunit alpha-40202
Gamma-aminobutyric acid receptor subunit alpha-20202
Gamma-aminobutyric acid receptor subunit alpha-30202
Neuronal acetylcholine receptor subunit beta-20202
Gamma-aminobutyric acid receptor subunit alpha-40202
Gamma-aminobutyric acid receptor subunit gamma-20202
Neuronal acetylcholine receptor subunit alpha-70101
thyrotropin-releasing hormone receptor1001
Solute carrier family 22 member 60303
Carbonic anhydrase 120306
Albumin0314
Carbonic anhydrase 30304
Glucose-6-phosphate 1-dehydrogenase0101
Cytochrome P450 2C9 0303
Carbonic anhydrase 60306
Serum paraoxonase/arylesterase 10202
Corticosteroid 11-beta-dehydrogenase isozyme 10213
Carbonic anhydrase 5A, mitochondrial0609
Carbonic anhydrase 70306
Adenosine receptor A10101
Corticosteroid 11-beta-dehydrogenase isozyme 10213
Cytochrome P450 2J20202
6-phosphogluconate dehydrogenase, decarboxylating0101
Holo-[acyl-carrier-protein] synthase0101
Solute carrier organic anion transporter family member 2A10101
Sodium/bile acid cotransporter0101
Carbonic anhydrase 90508
Carbonic anhydrase 130306
G-protein coupled receptor 350112
CDGSH iron-sulfur domain-containing protein 10202
Carbonic anhydrase 140306
Broad substrate specificity ATP-binding cassette transporter ABCG20202
Carbonic anhydrase 5B, mitochondrial0407
Glycine receptor subunit alpha-10022
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Sodium- and chloride-dependent glycine transporter 10101
Large neutral amino acids transporter small subunit 10303
Proton-coupled amino acid transporter 10202
Serine racemase0101
Olfactory receptor 51E20011
Sodium- and chloride-dependent glycine transporter 20101
Glycogen phosphorylase, muscle form0101
Pancreatic alpha-amylase0101
Beta-glucuronidase0101
Beta-glucuronidase0101
High mobility group protein B10011
High mobility group protein B10001
Corticosteroid 11-beta-dehydrogenase isozyme 20112
Canalicular multispecific organic anion transporter 10101
Solute carrier organic anion transporter family member 1B20101
Chain A, HISTIDINE-BINDING PROTEIN0011
Histidine-binding periplasmic protein0011
Adenosine receptor A10113
Adenosine receptor A2a0113
Carbonic anhydrase0001
Glutaminyl-peptide cyclotransferase0101
Carbonic anhydrase 0001
Carbonic anhydrase0001
Carbonic anhydrase0102
Carbonic anhydrase 0001
Carbonic anhydrase 130001
Carbonic anhydrase 0303
Hsf1 protein0011
Carbonic anhydrase 0101
cytochrome P450 2C9 precursor2002
Delta-type opioid receptor0101
Mu-type opioid receptor0303
Mu-type opioid receptor0101
Carbonic anhydrase, alpha family 0101
Carbonic anhydrase 0101
Delta carbonic anhydrase0101
Chain A, membrane-associated prostaglandin E synthase-20101
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
Chain A, Cruzipain2002
Luciferase2002
hypoxia-inducible factor 1 alpha subunit2002
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)1001
Parkin1001
bromodomain adjacent to zinc finger domain 2B2002
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
vitamin D3 receptor isoform VDRA2002
serine/threonine-protein kinase mTOR isoform 12002
neuropeptide S receptor isoform A2002
Prostaglandin-H2 D-isomerase0101
Prostaglandin E synthase0101
Prostaglandin G/H synthase 1 0102
Prostaglandin G/H synthase 2 0102
3',5'-cyclic-AMP phosphodiesterase 0101
Solute carrier organic anion transporter family member 2B1 0202
Cytochrome c oxidase subunit 20101
Epidermal growth factor receptor0101
Phospholipase A2, major isoenzyme0101
Prostaglandin G/H synthase 10304
ATP-dependent translocase ABCB10203
Interleukin-80101
Androgen receptor1438
Polyunsaturated fatty acid 5-lipoxygenase0102
Aldo-keto reductase family 1 member B10101
Aldo-keto reductase family 1 member B10101
Aldo-keto reductase family 1 member C40101
Prostaglandin G/H synthase 10101
Prostaglandin G/H synthase 10202
Sodium- and chloride-dependent GABA transporter 10101
Thromboxane-A synthase 0101
Indoleamine 2,3-dioxygenase 10101
Caspase-10001
Substance-P receptor0202
Prostaglandin E2 receptor EP3 subtype0101
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Prostaglandin E2 receptor EP4 subtype0101
Multidrug resistance-associated protein 1 0101
Bifunctional epoxide hydrolase 20101
Prostaglandin G/H synthase 20213
Prostaglandin G/H synthase 2 0101
Prostaglandin E2 receptor EP1 subtype0101
Peroxisome proliferator-activated receptor gamma0011
Aldo-keto reductase family 1 member C30202
Sodium- and chloride-dependent betaine transporter0101
C-X-C chemokine receptor type 30101
Aldo-keto reductase family 1 member C2 0101
Prostaglandin D2 receptor 0202
Solute carrier organic anion transporter family member 1A30101
Prostaglandin G/H synthase 20202
Lactoylglutathione lyase0101
Aldo-keto reductase family 1 member C10101
Prostaglandin G/H synthase 20102
Uracil nucleotide/cysteinyl leukotriene receptor0101
Solute carrier family 22 member 60102
Solute carrier family 22 member 70001
Sigma intracellular receptor 20101
Prostaglandin E2 receptor EP2 subtype0101
Rho-associated protein kinase 20101
Prostaglandin G/H synthase 1 0101
Nicotinate phosphoribosyltransferase0101
Solute carrier family 22 member 80202
Dehydrogenase/reductase SDR family member 90101
P2Y purinoceptor 120101
Cytosolic phospholipase A2 gamma0101
Prostaglandin D2 receptor 20112
histone deacetylase 9 isoform 31001
Chain A, Methionyl-tRNA synthetase0011
Chain A, Methionyl-tRNA synthetase0011
Chain A, Aminopeptidase0101
Chain A, Methionine aminopeptidase0101
S-ribosylhomocysteine lyase0101
Adenylate cyclase type 50001
S-adenosylmethionine synthase isoform type-10001
S-adenosylmethionine synthase isoform type-20001
Fatty acid synthase0101
Chain A, Beta-lactamase2002
Chain A, JmjC domain-containing histone demethylation protein 3A2002
Chain A, PROGESTERONE RECEPTOR0101
Glucocorticoid receptor 0101
apical membrane antigen 1, AMA11001
hypothetical protein, conserved1001
nonstructural protein 11001
cytochrome P450 2D62002
D(1A) dopamine receptor2002
atrial natriuretic peptide receptor 2 precursor1001
Estrogen receptor1427
Tyrosine-protein kinase Fyn0101
Progesterone receptor0428
Tegument protein VP160011
Glucocorticoid receptor0113
Glucocorticoid receptor0101
Coagulation factor VII0101
Cytochrome P450 2C80101
Thyroid hormone receptor alpha0101
Thyroid hormone receptor beta0101
Steroid 17-alpha-hydroxylase/17,20 lyase 0101
Polyunsaturated fatty acid lipoxygenase ALOX150101
Tissue factor0101
ATP-dependent translocase ABCB10011
Mu-type opioid receptor0202
Kappa-type opioid receptor0202
D(1A) dopamine receptor1001
Mitogen-activated protein kinase 140101
Progesterone receptor0011
Estrogen receptor beta1326
Glucocorticoid receptor0101
N(G),N(G)-dimethylarginine dimethylaminohydrolase 10001
N(G),N(G)-dimethylarginine dimethylaminohydrolase 10102
N(G),N(G)-dimethylarginine dimethylaminohydrolase 10001
Chain B, Exotoxin A0011
Chain B, Exotoxin A0011
Chain B, Exotoxin A0011
Glutamate 5-kinase0001
Angiotensin-converting enzyme 0101
Neutral amino acid transporter A0101
Neutral amino acid transporter B(0)0101
Amino acid transporter0101
transcriptional regulator ERG isoform 31001
Solute carrier family 22 member 20101
Voltage-dependent L-type calcium channel subunit alpha-1F0101
Albumin0011
5-hydroxytryptamine receptor 1A0123
Cytochrome P450 2D60101
Angiotensin-converting enzyme0202
D(2) dopamine receptor0202
Beta-1 adrenergic receptor0101
D(3) dopamine receptor0101
D(1A) dopamine receptor0202
D(4) dopamine receptor0101
Alpha-1D adrenergic receptor0101
Histamine H1 receptor0101
5-hydroxytryptamine receptor 2C 0101
5-hydroxytryptamine receptor 70101
Alpha-1A adrenergic receptor0202
5-hydroxytryptamine receptor 2A0101
Alpha-1B adrenergic receptor0101
3-hydroxy-3-methylglutaryl-coenzyme A reductase 0101
D(2) dopamine receptor0101
Voltage-dependent L-type calcium channel subunit alpha-1D 0101
5-hydroxytryptamine receptor 2B0101
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Transporter0101
5-hydroxytryptamine receptor 1A0101
Nuclear receptor subfamily 3 group C member 3 0202
Multidrug and toxin extrusion protein 20101
Histamine H3 receptor0101
Carbonic anhydrase 0202
Chain A, Mineralocorticoid receptor0101
Chain A, Mineralocorticoid receptor0101
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
Vpr1001
Cytochrome P450 2C190101
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Acetylcholinesterase0101
Nuclear receptor subfamily 1 group I member 20011
UDP-glucuronosyltransferase 2B70001
Cytochrome P450 3A50101
UDP-glucuronosyltransferase 1A40001
Serine/threonine-protein kinase mTOR0101
Peptidyl-prolyl cis-trans isomerase FKBP1B0011
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform0101
Peptidyl-prolyl cis-trans isomerase FKBP50101
Splicing factor 3B subunit 30101
Thymidine phosphorylase0101
Chain A, Glycogen phosphorylase, liver form0011
Chain A, glycogen phosphorylase, liver form0011
Chain A, Glycogen phosphorylase, liver form0011
Chain A, Glycogen phosphorylase, liver form0011
Solute carrier family 2, facilitated glucose transporter member 90112
Guanine deaminase0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]