Page last updated: 2024-11-12

migrastatin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

migrastatin: inhibits tumor cell migration; isolated from Streptomyces; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

migrastatin : A 14-membered macrolide which is isolated from Streptomyces sp.MK929-43F1 and inhibits cell migration of human esophageal cancer EC17 cells and mouse melanona B16 cells. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID11016431
CHEMBL ID474321
CHEBI ID66389
SCHEMBL ID41023
MeSH IDM0376507

Synonyms (14)

Synonym
CHEMBL474321
chebi:66389 ,
migrastatin
314245-65-3
4-{(5s)-5-[(2r,3z,5r,6s,7s,8e,12e)-6-hydroxy-7-methoxy-3,5-dimethyl-14-oxooxacyclotetradeca-3,8,12-trien-2-yl]-4-oxohexyl}piperidine-2,6-dione
(+)-migrastatin
OGYMUMAKGYYNHV-IJMHZYIBSA-N
SCHEMBL41023
IMC-10708
DTXSID70904046
4-[(5s)-5-[(2r,3z,5r,6s,7s,8e,12e)-6-hydroxy-7-methoxy-3,5-dimethyl-14-oxo-1-oxacyclotetradeca-3,8,12-trien-2-yl]-4-oxohexyl]piperidine-2,6-dione
Q6844317
HY-121452
CS-0082071

Research Excerpts

Overview

Migrastatin is a natural product secreted by Streptomyces. Synthesized migrastatin analogues are potent inhibitors of metastatic tumour cell migration, invasion and metastasis.

ExcerptReferenceRelevance
"Migrastatin is a natural product secreted by Streptomyces, and synthesized migrastatin analogues such as macroketone are potent inhibitors of metastatic tumour cell migration, invasion and metastasis."( Migrastatin analogues target fascin to block tumour metastasis.
Chen, L; Huang, XY; Jakoncic, J; Yang, S; Zhang, JJ, 2010
)
2.52
"Migrastatin is a biologically active natural product isolated from Streptomyces that has been shown to inhibit tumor cell migration. "( Emergence of potent inhibitors of metastasis in lung cancer via syntheses based on migrastatin.
Danishefsky, SJ; Downey, R; Lecomte, N; Moore, MA; Nagorny, P; Njardarson, JT; Ouerfelli, O; Yang, G, 2011
)
2.04
"Migrastatin (MGS) is a Streptomyces metabolite that inhibits cancer cell migration. "( Suppression of multidrug resistance by migrastatin.
Imoto, M; Takemoto, Y; Tashiro, E, 2006
)
2.05

Dosage Studied

ExcerptRelevanceReference
" In a human small-cell lung carcinoma (SCLC) primary xenograft model, ME and CME compounds were found to be highly potent in inhibiting overall metastasis even at the lowest dosage used (degree of inhibition: 96."( Emergence of potent inhibitors of metastasis in lung cancer via syntheses based on migrastatin.
Danishefsky, SJ; Downey, R; Lecomte, N; Moore, MA; Nagorny, P; Njardarson, JT; Ouerfelli, O; Yang, G, 2011
)
0.59
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (2)

RoleDescription
metaboliteAny intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
antineoplastic agentA substance that inhibits or prevents the proliferation of neoplasms.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (4)

ClassDescription
etherAn organooxygen compound with formula ROR, where R is not hydrogen.
secondary alcoholA secondary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has two other carbon atoms attached to it.
piperidones
macrolide antibioticA macrocyclic lactone with a ring of twelve or more members which exhibits antibiotic activity.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (9)

Assay IDTitleYearJournalArticle
AID409663Inhibition of cell migration of mouse 4T1 cells after 4 days by scratch wound healing assay2008Bioorganic & medicinal chemistry letters, Nov-15, Volume: 18, Issue:22
Evaluation of new migrastatin and dorrigocin congeners unveils cell migration inhibitors with dramatically improved potency.
AID409662Inhibition of human MDA-MB-231 cell migration after 4 days by scratch wound healing assay2008Bioorganic & medicinal chemistry letters, Nov-15, Volume: 18, Issue:22
Evaluation of new migrastatin and dorrigocin congeners unveils cell migration inhibitors with dramatically improved potency.
AID409666Metabolic stability in mouse plasma assessed as half life2008Bioorganic & medicinal chemistry letters, Nov-15, Volume: 18, Issue:22
Evaluation of new migrastatin and dorrigocin congeners unveils cell migration inhibitors with dramatically improved potency.
AID501212Antiproliferative activity against human MDA-MB-231 cells assessed as incorporation of [3H]thymidine in nuclear DNA at 2.5 uM after 24 hrs by scintillation counting2010Nature chemical biology, Mar, Volume: 6, Issue:3
Inhibition of eukaryotic translation elongation by cycloheximide and lactimidomycin.
AID501214Inhibition of protein synthesis in human HeLa cells assessed as [35S]cysteine/methionine utilization after 2 hrs by scintillation spectroscopy2010Nature chemical biology, Mar, Volume: 6, Issue:3
Inhibition of eukaryotic translation elongation by cycloheximide and lactimidomycin.
AID501211Antiproliferative activity against human HeLa cells assessed as incorporation of [3H]thymidine in nuclear DNA at 2.5 uM after 24 hrs by scintillation counting2010Nature chemical biology, Mar, Volume: 6, Issue:3
Inhibition of eukaryotic translation elongation by cycloheximide and lactimidomycin.
AID409664Cytotoxicity against human MDA-MB-231 cells2008Bioorganic & medicinal chemistry letters, Nov-15, Volume: 18, Issue:22
Evaluation of new migrastatin and dorrigocin congeners unveils cell migration inhibitors with dramatically improved potency.
AID409665Cytotoxicity against human mouse 4T1 cells2008Bioorganic & medicinal chemistry letters, Nov-15, Volume: 18, Issue:22
Evaluation of new migrastatin and dorrigocin congeners unveils cell migration inhibitors with dramatically improved potency.
AID501213Antiproliferative activity against human Jurkat cells assessed as incorporation of [3H]thymidine in nuclear DNA at 2.5 uM after 24 hrs by scintillation counting2010Nature chemical biology, Mar, Volume: 6, Issue:3
Inhibition of eukaryotic translation elongation by cycloheximide and lactimidomycin.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (31)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's17 (54.84)29.6817
2010's13 (41.94)24.3611
2020's1 (3.23)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 22.47

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index22.47 (24.57)
Research Supply Index3.47 (2.92)
Research Growth Index5.35 (4.65)
Search Engine Demand Index21.17 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (22.47)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews3 (9.68%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other28 (90.32%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]