Cross-Transfusion, Intrauterine

Passage of blood from one fetus to another via an arteriovenous communication or other shunt, in a monozygotic twin pregnancy. It results in anemia in one twin and polycythemia in the other. (Lee et al., Wintrobe's Clinical Hematology, 9th ed, p737-8)

Synonym
Fetofetal Transfusion
Twin Transfusion
Intrauterine Cross-Transfusion
Twin Transfusion Syndrome
Twin Twin Transfusion Syndrome
Fetofetal Transfusion Syndrome
Cross-Transfusion, Intrauterine
Twin-to-Twin Transfusion Syndrome
Fetal Transfusion Syndrome

Excerpt	Reference
"Twin transfusion syndrome is a serious complication of monozygotic twin pregnancy."	( Baldwin, VJ; Farquharson, DF; Thomas, WD; Wadsworth, LD; Wittmann, BK, 1986)
"The twin-twin transfusion syndrome is a rare but severe complication in monozygotic twins."	( Bernaschek, G; Deutinger, J; Frigo, P; Golaszewski, S; Golaszewski, T; Plöckinger, B, 1995)
"Twin-twin transfusion syndrome is a serious complication of monozygotic twin pregnancies and is associated with high rates of perinatal morbidity and mortality."	( Abramowicz, JS; Mahone, PR; Sherer, DM; Woods, JR, 1993)
"A case of twin-twin transfusion is presented with hydrops occurring twice in the recipient twin and resolving."	( Boogert, A; Hind, F; Scott, F, 1997)
"Twin-twin transfusion syndrome is a serious obstetric complication unique to monochorionic twin gestations."	( Cheng, PJ; Chueh, HY; Huang, SY; Shaw, SW; Soong, YK; Yang, TY, 2008)
"Twin-twin transfusion syndrome is a complication of monochorionic-diamniotic placentation."	( Cowles, T; Holland, M; Parrott, J; Schwartz, T; Weiner, CP, 2017)

Excerpt	Reference
"This was a case of twin-to-twin transfusion syndrome and the arrhythmia was caused by ritodrine therapy."	( Banzai, M; Chimura, T; Hiroi, M; Komiya, H; Sato, S; Tezuka, N, 1995)
"A case is reported of presumed twin-twin transfusion syndrome successfully treated with amniocentesis and also complicated by congenital cytomegalovirus infection and second trimester exposure to high-dose ibuprofen with temporally related ductal narrowing."	( Baker, ER; Brown, ZA; Eberhardt, H, 1993)
"Acute polyhydramnios due to twin to twin transfusion is a rare complication of twin pregnancies which, despite treatment, has a high perinatal mortality."	( Busby, G; Kuruvilla, A; Ramsewak, S, 2001)
"Despite advances in treatment, twin-to-twin transfusion syndrome (TTTS) still carries a high risk for perinatal mortality and morbidity."	( Delezoide, AL; Dommergues, M; Fisk, NM; Gubler, MC; Madelenat, P; Mahieu-Caputo, D; Martinovic, J; Meulemans, A; Muller, F, 2005)
"The underlying etiology of twin-twin transfusion syndrome (TTTS) is unknown, but our growing understanding of the cardiovascular features of TTTS suggests this may be a disease that could respond to transplacental medical therapy."	( Crombleholme, TM; Somme, S; Zaretsky, MV, 2014)
"The preferred treatment for twin-twin transfusion syndrome is fetoscopic laser coagulation of inter-twin vascular anastomoses on the monochorionic placenta."	( Balestriero, MA; Faiola, S; Introvini, P; Koopman, HM; Lopriore, E; Middeldorp, JM; Oepkes, D; Rijken, M; Rustico, M; Scelsa, B; Slaghekke, F; van Klink, JM, 2016)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	26 (14.29)	23.3326
1990's	36 (19.78)	12.5806
2000's	49 (26.92)	18.1394
2010's	54 (29.67)	28.8240
2020's	17 (9.34)	9.53

Drug	Relationship Strength	Studies	Trials
chlorine	low	1	0
creatine	low	1	0
lactic acid	low	1	0
urea	low	3	0
bupivacaine	low	1	0
chlorothiazide	low	1	0
fentanyl	medium	2	1
furosemide	low	1	0
ibuprofen	low	1	0
lidocaine	medium	4	1
indomethacin	low	9	0
ketoprofen	low	1	0
metoprolol	low	1	0
midazolam	medium	2	1
milrinone	low	1	0
nicardipine	low	1	0
nifedipine	low	4	0
potassium chloride	low	3	0
thyroxine	low	4	0
aldosterone	low	2	0
triiodothyronine	low	1	0
androstenedione	low	2	0
calcium gluconate	low	1	0
betamethasone	low	2	0
cdta	low	1	0
dehydroepiandrosterone sulfate	low	1	0
d-alpha tocopherol	low	1	0
enbucrilate	low	2	0
barium sulfate	low	2	0
du-21220	low	2	0
transferrin	low	1	0
esmolol	low	1	0
remifentanil	medium	3	1
3-iodobenzylguanidine	low	1	0
angiotensin ii	low	2	0
fibrin	low	1	0
pancuronium	low	1	0
ergonovine	low	1	0
y 27632	low	1	0
sulindac	low	1	0
enclomiphene	low	2	0
digoxin	low	5	0
bilirubin	low	1	0
amphotericin b	low	1	0
morphine	low	4	0
dexmedetomidine	medium	1	1
shu 508	low	1	0
losartan potassium	low	2	0
indocyanine green	low	2	0
pituitrin	low	3	0
atrial natriuretic factor	low	9	0
endothelin-1	low	3	0
sodium ethylxanthate	low	1	0
cardiovascular agents	low	1	0
piperidines	medium	3	1
interleukin-8	low	1	0
natriuretic peptide, brain	low	9	0
epidermal growth factor	low	1	0
muramidase	low	1	0
exudates	low	1	0
ganciclovir	low	1	0
leptin	medium	5	1

Protein Targets (622)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
dopamine D1 receptor	2	0	0	2
thioredoxin reductase	8	0	0	8
GLS protein	10	0	0	10
Thrombopoietin	2	0	0	2
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	4	0	0	4
cytochrome P450 2D6 isoform 1	4	0	0	4
cytochrome P450 2C19 precursor	5	0	0	5
ras-related protein Rab-9A	4	0	0	4
histone acetyltransferase KAT2A isoform 1	4	0	0	4
lethal factor (plasmid)	3	0	0	3
POU domain, class 2, transcription factor 1	0	0	0	1
Spike glycoprotein	6	0	0	6
ATP-dependent phosphofructokinase	7	0	0	7
AR protein	20	0	0	20
glucocorticoid receptor [Homo sapiens]	11	0	0	11
thyroid hormone receptor beta isoform a	6	0	0	6
nuclear factor erythroid 2-related factor 2 isoform 2	3	0	0	3
geminin	16	0	0	16
Sex hormone-binding globulin	0	0	2	2
Corticosteroid-binding globulin	0	2	0	2
Mineralocorticoid receptor	0	1	2	3
Androgen receptor	0	2	0	2
Mineralocorticoid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	1	0	3
Guanine nucleotide-binding protein G	3	0	0	3
Chain A, HADH2 protein	5	0	0	5
Chain B, HADH2 protein	5	0	0	5
Chain A, Cruzipain	4	0	0	4
interleukin 8	4	0	0	4
phosphopantetheinyl transferase	5	0	0	5
farnesoid X nuclear receptor	10	0	0	10
peroxisome proliferator-activated receptor delta	12	0	0	12
vitamin D (1,25- dihydroxyvitamin D3) receptor	13	0	0	13
tumor necrosis factor	3	0	0	3
vitamin D3 receptor isoform VDRA	6	0	0	6
nuclear factor erythroid 2-related factor 2 isoform 1	15	0	0	15
peripheral myelin protein 22	8	0	0	8
lamin isoform A-delta10	18	0	0	18
Cytochrome P450 1A2	0	2	0	2
Cytochrome P450 3A4	0	6	1	7
Cytochrome P450 2D6	0	3	0	3
Cytochrome P450 2C9	0	9	0	9
Cytochrome P450 2C19	0	1	0	1
Nuclear receptor ROR-gamma	5	1	1	7
Potassium voltage-gated channel subfamily H member 2	0	7	0	7
Aurora kinase B	0	2	0	2
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	4	0	4
acetylcholinesterase	5	0	0	5
RAR-related orphan receptor gamma	13	0	0	13
SMAD family member 2	6	0	0	6
SMAD family member 3	6	0	0	6
TDP1 protein	15	0	0	15
GLI family zinc finger 3	10	0	0	10
Smad3	5	0	0	5
aldehyde dehydrogenase 1 family, member A1	9	0	0	9
estrogen receptor 2 (ER beta)	8	0	0	8
progesterone receptor	10	0	0	10
regulator of G-protein signaling 4	8	0	0	8
cytochrome P450 family 3 subfamily A polypeptide 4	14	0	0	14
nonstructural protein 1	4	0	0	4
retinoic acid nuclear receptor alpha variant 1	12	0	0	12
retinoid X nuclear receptor alpha	10	0	0	10
estrogen-related nuclear receptor alpha	17	0	0	17
pregnane X nuclear receptor	13	0	0	13
estrogen nuclear receptor alpha	18	0	0	18
peroxisome proliferator activated receptor gamma	12	0	0	12
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	9	0	0	9
Histone H2A.x	3	0	0	3
Caspase-7	2	0	0	2
Bloom syndrome protein isoform 1	6	0	0	6
peripheral myelin protein 22 isoform 1	5	0	0	5
potassium voltage-gated channel subfamily H member 2 isoform d	3	0	0	3
caspase-3	2	0	0	2
thyroid hormone receptor beta isoform 2	11	0	0	11
importin subunit beta-1 isoform 1	3	0	0	3
mitogen-activated protein kinase 1	5	0	0	5
nuclear factor NF-kappa-B p105 subunit isoform 1	1	0	0	1
snurportin-1	3	0	0	3
GTP-binding nuclear protein Ran isoform 1	2	0	0	2
DNA polymerase iota isoform a (long)	5	0	0	5
nuclear receptor ROR-gamma isoform 1	6	0	0	6
survival motor neuron protein isoform d	5	0	0	5
muscleblind-like protein 1 isoform 1	5	0	0	5
neuropeptide S receptor isoform A	4	0	0	4
Beta-glucuronidase	0	1	0	1
Cholinesterase	0	2	0	2
Aromatase	0	2	0	4
Gastrin/cholecystokinin type B receptor	0	0	0	1
Testosterone 17-beta-dehydrogenase 3	0	1	0	1
Alpha-synuclein	1	1	0	2
TAR DNA-binding protein 43	2	0	0	2
glucocerebrosidase	4	0	0	4
DNA polymerase kappa isoform 1	6	0	0	6
Atrial natriuretic peptide receptor 3	0	1	0	1
Type-1A angiotensin II receptor	0	3	1	4
Type-1 angiotensin II receptor	0	0	1	1
Type-1B angiotensin II receptor	0	4	0	4
Type-1 angiotensin II receptor	0	2	2	4
Type-2 angiotensin II receptor	0	3	0	3
Type-2 angiotensin II receptor	0	2	0	2
Atrial natriuretic peptide receptor 1	0	1	1	2
Atrial natriuretic peptide receptor 1	0	0	1	1
pregnane X receptor	2	0	0	2
IDH1	6	0	0	6
aryl hydrocarbon receptor	9	0	0	9
nuclear receptor subfamily 1, group I, member 2	1	0	0	1
galanin receptor type 3	0	1	0	1
ATP-binding cassette sub-family C member 3	0	10	0	10
Multidrug resistance-associated protein 4	0	11	0	12
Voltage-dependent calcium channel gamma-2 subunit	5	0	0	5
Bile salt export pump	0	15	0	15
Glucocorticoid receptor	0	2	0	2
Glycine receptor subunit alpha-1	0	2	0	2
Glutamate receptor 2	5	0	0	5
Glycine receptor subunit beta	0	2	0	2
Glycine receptor subunit alpha-2	0	2	0	2
Glycine receptor subunit alpha-3	0	2	0	2
Canalicular multispecific organic anion transporter 1	0	8	0	8
ORF73	0	0	2	2
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	4	0	0	4
Chain A, Putative fructose-1,6-bisphosphate aldolase	3	0	0	3
Chain A, 2-oxoglutarate Oxygenase	6	0	0	6
USP1 protein, partial	9	0	0	9
Microtubule-associated protein tau	7	0	0	7
caspase-1 isoform alpha precursor	1	0	0	1
Caspase-7	1	0	0	1
Inositol monophosphatase 1	3	0	0	3
Solute carrier organic anion transporter family member 1B3	0	5	0	8
Solute carrier organic anion transporter family member 1B1	0	5	0	9
Potassium channel subfamily K member 3	0	2	0	2
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 2	0	1	2	3
Potassium channel subfamily K member 9	0	1	0	1
Carbonic anhydrase 1	0	5	0	6
Carbonic anhydrase 2	0	5	0	6
Carbonic anhydrase 4	0	4	0	5
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase 15	0	2	0	2
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	8	0	0	8
Chain A, Beta-lactamase	7	0	0	7
NFKB1 protein, partial	4	0	0	4
thyroid stimulating hormone receptor	4	0	0	4
EWS/FLI fusion protein	8	0	0	8
arylsulfatase A	6	0	0	6
euchromatic histone-lysine N-methyltransferase 2	14	0	0	14
transcriptional regulator ERG isoform 3	2	0	0	2
cytochrome P450 3A4 isoform 1	7	0	0	7
muscarinic acetylcholine receptor M1	4	0	0	4
Gamma-aminobutyric acid receptor subunit pi	7	1	2	10
Gamma-aminobutyric acid receptor subunit beta-1	7	1	2	10
Gamma-aminobutyric acid receptor subunit delta	7	1	2	10
Gamma-aminobutyric acid receptor subunit gamma-2	7	1	2	10
Gamma-aminobutyric acid receptor subunit alpha-5	7	1	2	10
Gamma-aminobutyric acid receptor subunit alpha-3	7	1	2	10
Gamma-aminobutyric acid receptor subunit gamma-1	7	1	2	10
Gamma-aminobutyric acid receptor subunit alpha-2	7	1	2	10
Gamma-aminobutyric acid receptor subunit alpha-4	7	1	2	10
Gamma-aminobutyric acid receptor subunit gamma-3	7	1	2	10
Gamma-aminobutyric acid receptor subunit alpha-6	7	1	2	10
Gamma-aminobutyric acid receptor subunit alpha-1	7	1	2	10
Gamma-aminobutyric acid receptor subunit beta-3	7	1	2	10
Gamma-aminobutyric acid receptor subunit beta-2	7	1	2	10
GABA theta subunit	7	1	2	10
Gamma-aminobutyric acid receptor subunit epsilon	7	1	2	10
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Proton-coupled amino acid transporter 1	0	1	0	1
activating transcription factor 6	5	0	0	5
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	6	0	0	6
heat shock protein beta-1	5	0	0	5
Rap guanine nucleotide exchange factor 3	3	0	0	3
Cellular tumor antigen p53	9	0	0	9
Glutathione S-transferase P	0	1	0	1
Alpha-tocopherol transfer protein	0	0	1	1
Solute carrier organic anion transporter family member 1A4	0	3	0	7
Solute carrier organic anion transporter family member 1A5	0	0	0	3
Steryl-sulfatase	0	0	0	1
Multidrug resistance-associated protein 1	0	1	0	2
Solute carrier organic anion transporter family member 1A2	0	0	0	3
Solute carrier organic anion transporter family member 1A3	0	2	0	5
G-protein coupled bile acid receptor 1	0	0	1	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Solute carrier family 22 member 11	0	0	0	1
Solute carrier organic anion transporter family member 1A1	0	0	0	1
Solute carrier organic anion transporter family member 1B2	0	0	0	1
Alpha-1B adrenergic receptor	0	0	1	1
cellular tumor antigen p53 isoform a	4	0	0	4
cytochrome P450 2C9 precursor	4	0	0	4
Alpha-2A adrenergic receptor	0	5	2	7
Alpha-1B adrenergic receptor	0	5	0	5
Alpha-1A adrenergic receptor	0	0	1	1
Alpha-2C adrenergic receptor	0	3	1	4
Alpha-2B adrenergic receptor	0	1	0	1
Alpha-2C adrenergic receptor	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Alpha-1D adrenergic receptor	0	1	0	1
Alpha-1D adrenergic receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	5	0	5
Histamine H2 receptor	4	0	0	4
Chain A, ATP-DEPENDENT DNA HELICASE Q1	1	0	0	1
PAX8	0	0	0	1
ATAD5 protein, partial	5	0	0	5
PPM1D protein	1	0	0	1
STAT3, partial	0	1	0	1
thioredoxin glutathione reductase	1	0	0	1
nuclear receptor subfamily 1, group I, member 3	8	0	0	8
67.9K protein	4	0	0	4
alpha-galactosidase	1	0	0	1
thyroid stimulating hormone receptor	6	0	0	6
v-jun sarcoma virus 17 oncogene homolog (avian)	6	0	0	6
NPC intracellular cholesterol transporter 1 precursor	2	0	0	2
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
signal transducer and activator of transcription 1-alpha/beta isoform alpha	0	1	0	1
Interferon beta	8	0	0	8
Sodium/potassium-transporting ATPase subunit alpha-1	0	2	0	2
Sodium/potassium-transporting ATPase subunit beta-1	0	2	0	2
Integrin beta-3	3	0	0	3
Sodium/potassium-transporting ATPase subunit alpha-2	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-3	0	1	0	1
ATP-dependent translocase ABCB1	0	5	0	5
Sodium/potassium-transporting ATPase subunit beta-1	0	1	0	1
ATP-dependent translocase ABCB1	0	10	0	13
Integrin alpha-IIb	3	0	0	3
Replicase polyprotein 1ab	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-2	0	1	0	1
ATP-dependent translocase ABCB1	0	5	0	5
Sodium/potassium-transporting ATPase subunit alpha-2	0	2	0	2
Sodium/potassium-transporting ATPase subunit alpha-1	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit gamma	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-4	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-4	0	1	0	1
Solute carrier organic anion transporter family member 4C1	0	1	0	3
Solute carrier organic anion transporter family member 4C1	0	0	0	2
ATPase family AAA domain-containing protein 5	4	0	0	4
Ataxin-2	4	0	0	4
Solute carrier organic anion transporter family member 1A4	0	0	0	1
Beta-2 adrenergic receptor	0	1	0	1
Beta-3 adrenergic receptor	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	2	0	0	2
glp-1 receptor, partial	3	0	0	3
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
bromodomain adjacent to zinc finger domain 2B	3	0	0	3
ubiquitin-conjugating enzyme E2 N	0	1	0	1
protein AF-9 isoform a	0	0	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	2	0	0	2
5-hydroxytryptamine receptor 4	0	6	0	6
Epidermal growth factor receptor	0	5	0	5
Estrogen receptor	0	2	0	2
Receptor tyrosine-protein kinase erbB-2	0	1	0	1
Tyrosine-protein kinase Fyn	0	1	0	1
Aldo-keto reductase family 1 member B1	0	2	0	2
Muscarinic acetylcholine receptor M2	0	2	0	3
Muscarinic acetylcholine receptor M4	0	2	0	3
Muscarinic acetylcholine receptor M5	0	2	0	3
Adenosine receptor A3	0	5	0	5
Muscarinic acetylcholine receptor M1	0	2	0	3
Beta-3 adrenergic receptor	0	2	1	3
Alpha-2B adrenergic receptor	0	4	0	4
Muscarinic acetylcholine receptor M3	0	2	0	3
Substance-K receptor	0	2	0	2
Prostaglandin G/H synthase 1	0	5	0	5
Sodium-dependent noradrenaline transporter	0	2	0	2
5-hydroxytryptamine receptor 2A	0	4	0	4
5-hydroxytryptamine receptor 2C	0	6	0	6
Sodium-dependent serotonin transporter	0	2	0	2
C-8 sterol isomerase	0	1	0	1
D(3) dopamine receptor	0	5	0	5
5-hydroxytryptamine receptor 2B	0	4	0	4
5-hydroxytryptamine receptor 6	0	4	0	4
Sodium-dependent dopamine transporter	0	2	0	2
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	5	1	6
Endothelin-1 receptor	0	1	0	1
D(2) dopamine receptor	0	3	0	3
5-hydroxytryptamine receptor 1A	0	4	1	5
D(1A) dopamine receptor	0	2	0	2
5-hydroxytryptamine receptor 1B	0	2	0	2
Beta-1 adrenergic receptor	0	0	2	2
Beta-1 adrenergic receptor	0	4	1	5
Luciferase	6	0	0	6
Solute carrier family 22 member 1	0	3	0	4
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
Amine oxidase [flavin-containing] A	0	1	0	1
D(4) dopamine receptor	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
Delta-type opioid receptor	0	3	0	4
Delta-type opioid receptor	0	4	1	6
Mu-type opioid receptor	0	5	2	10
Kappa-type opioid receptor	0	3	1	5
Histamine H1 receptor	0	1	0	1
Mu-type opioid receptor	0	4	2	7
Delta-type opioid receptor	0	4	1	6
Kappa-type opioid receptor	0	4	0	4
Kappa-type opioid receptor	0	4	1	6
Mu-type opioid receptor	0	3	1	6
Mu-type opioid receptor	0	5	0	5
Sigma non-opioid intracellular receptor 1	0	3	1	4
Sigma non-opioid intracellular receptor 1	0	1	1	2
thyrotropin-releasing hormone receptor	1	0	0	1
Solute carrier family 22 member 6	0	4	0	4
Carbonic anhydrase 12	0	1	0	2
Bile salt export pump	0	4	0	4
Albumin	0	5	2	7
Carbonic anhydrase 3	0	1	0	1
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Carbonic anhydrase 6	0	1	0	2
Serum paraoxonase/arylesterase 1	0	3	0	3
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	2	0	3
Carbonic anhydrase 7	0	1	0	2
Adenosine receptor A1	0	1	0	1
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
Cytochrome P450 2J2	0	6	0	6
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Holo-[acyl-carrier-protein] synthase	0	1	0	1
Solute carrier organic anion transporter family member 2A1	0	1	0	1
Sodium/bile acid cotransporter	0	1	0	1
Carbonic anhydrase 9	0	2	0	3
Multidrug and toxin extrusion protein 1	0	3	0	3
Carbonic anhydrase 13	0	1	0	2
G-protein coupled receptor 35	0	1	1	2
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
Carbonic anhydrase 14	0	1	0	2
Carbonic anhydrase 5B, mitochondrial	0	1	0	2
Thymidine kinase	0	1	0	1
endonuclease IV	1	0	0	1
ClpP	1	0	0	1
Fumarate hydratase	3	0	0	3
polyprotein	3	0	0	3
POU domain, class 2, transcription factor 2	0	0	0	1
Transitional endoplasmic reticulum ATPase	0	1	0	1
Purine nucleoside phosphorylase	0	0	1	1
Solute carrier family 22 member 6	0	3	0	4
chromobox protein homolog 1	8	0	0	8
Acid-sensing ion channel 3	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	3
Prostaglandin G/H synthase 2	0	2	0	3
Dihydrofolate reductase	0	1	0	1
Fatty acid-binding protein, liver	0	1	0	1
Albumin	0	1	0	1
Albumin	0	0	1	1
Prostaglandin G/H synthase 1	0	6	0	7
Fatty acid-binding protein, intestinal	0	2	0	2
Polyunsaturated fatty acid 5-lipoxygenase	0	3	0	5
UDP-glucuronosyltransferase 2B7	0	1	0	3
Acetylcholinesterase	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Adenosine receptor A1	0	2	0	2
Caspase-1	0	2	0	3
Adenosine receptor A2a	0	4	0	4
Substance-P receptor	0	2	0	2
Prostaglandin G/H synthase 2	0	5	1	6
Prostaglandin G/H synthase 2	0	2	0	3
UDP-glucuronosyltransferase 1A3	0	0	0	3
Aldo-keto reductase family 1 member C3	0	3	0	3
Caspase-3	0	2	0	2
Caspase-4	0	2	0	2
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Caspase-5	0	2	0	2
Caspase-9	0	2	0	2
Acid-sensing ion channel 1	0	1	0	1
Prostaglandin G/H synthase 2	0	5	0	5
Fatty-acid amide hydrolase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	2	0	3
Prostaglandin G/H synthase 1	0	2	0	3
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 8	0	3	0	3
Solute carrier family 22 member 6	0	1	0	1
Dehydrogenase/reductase SDR family member 9	0	1	0	1
Chain A, membrane-associated prostaglandin E synthase-2	0	1	0	1
hypoxia-inducible factor 1 alpha subunit	5	0	0	5
G	7	0	0	7
Parkin	3	0	0	3
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	2	0	0	2
serine/threonine-protein kinase mTOR isoform 1	4	0	0	4
M-phase phosphoprotein 8	3	0	0	3
Prostaglandin-H2 D-isomerase	0	1	0	1
Prostaglandin E synthase	0	2	0	2
3',5'-cyclic-AMP phosphodiesterase	0	2	0	2
Solute carrier organic anion transporter family member 2B1	0	2	0	2
Cytochrome c oxidase subunit 2	0	1	0	1
Phospholipase A2, major isoenzyme	0	1	0	1
HLA class I histocompatibility antigen, B alpha chain	7	0	0	7
Procathepsin L	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	0	1	0	1
Interleukin-8	0	1	0	1
Androgen receptor	0	1	1	2
Neuronal acetylcholine receptor subunit beta-2	0	1	0	1
Aldo-keto reductase family 1 member B1	0	3	0	3
Aldo-keto reductase family 1 member B1	0	2	0	2
Aldo-keto reductase family 1 member C4	0	1	0	1
Sodium-dependent dopamine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Thromboxane-A synthase	0	2	0	2
Indoleamine 2,3-dioxygenase 1	0	2	0	2
Nitric oxide synthase, inducible	0	1	0	1
Prostaglandin E2 receptor EP3 subtype	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Prostaglandin E2 receptor EP4 subtype	0	1	0	1
Bifunctional epoxide hydrolase 2	0	1	0	1
Prostaglandin E2 receptor EP1 subtype	0	1	0	1
Peroxisome proliferator-activated receptor gamma	0	0	7	7
Sodium- and chloride-dependent betaine transporter	0	1	0	1
C-X-C chemokine receptor type 3	0	1	0	1
Aldo-keto reductase family 1 member C2	0	1	0	1
Prostaglandin D2 receptor	0	2	0	2
Lactoylglutathione lyase	0	3	0	3
Aldo-keto reductase family 1 member C1	0	1	0	1
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Solute carrier family 22 member 7	0	1	0	2
Sigma intracellular receptor 2	0	1	0	1
Prostaglandin E2 receptor EP2 subtype	0	1	0	1
Rho-associated protein kinase 2	0	2	0	2
Nicotinate phosphoribosyltransferase	0	1	0	1
Inositol hexakisphosphate kinase 1	7	0	0	7
Dehydrogenase/reductase SDR family member 9	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
Cytosolic phospholipase A2 gamma	0	1	0	1
Prostaglandin D2 receptor 2	0	1	1	2
cytochrome P450 2C9, partial	7	0	0	7
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
cytochrome P450 2D6	5	0	0	5
Rac1 protein	0	0	1	1
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	3	0	0	3
flap endonuclease 1	3	0	0	3
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Ras-related protein Rab-2A	0	0	1	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily A member 5	0	2	0	2
Sodium channel protein type 4 subunit alpha	0	2	0	2
Sodium channel protein type 5 subunit alpha	0	2	0	2
Sodium channel protein type 9 subunit alpha	0	2	0	2
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Potassium channel subfamily K member 18	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	2	0	2
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	3	0	3
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	3	0	3
5-hydroxytryptamine receptor 1A	0	1	0	1
Type-1 angiotensin II receptor	0	1	0	1
Beta-2 adrenergic receptor	0	2	1	3
Beta-1 adrenergic receptor	0	1	1	2
Beta-1 adrenergic receptor	0	1	0	1
Beta-2 adrenergic receptor	0	1	1	3
Translocator protein	0	1	1	2
UDP-glucuronosyltransferase 1-6	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	2	0	2
UDP-glucuronosyltransferase 1A4	0	1	0	1
UDP-glucuronosyltransferase 2B10	0	1	0	1
Phosphodiesterase	0	1	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	3	0	0	3
Vpr	1	0	0	1
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	1	0	1
Aurora kinase A	0	1	0	1
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	0	1	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Dual specificity protein kinase TTK	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	2	0	2
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
Inner centromere protein	0	1	0	1
Phosphodiesterase	0	1	0	1
Opioid receptor, delta 1b	0	1	0	1
Acetylcholinesterase	0	1	0	1
Opioid receptor homologue	0	1	0	1
Acyl-CoA desaturase 1	0	1	0	1
Muscarinic acetylcholine receptor M1	0	1	0	1
Muscarinic acetylcholine receptor M3	0	1	0	1
Muscarinic acetylcholine receptor M4	0	1	0	1
Muscarinic acetylcholine receptor M5	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
Histidine decarboxylase	0	0	1	1
Proteinase-activated receptor 1	0	1	1	2
Sodium-dependent serotonin transporter	0	1	0	1
Kappa-type opioid receptor	0	2	1	4
Nociceptin receptor	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Mas-related G-protein coupled receptor member X2	0	0	1	1
Mu-type opioid receptor	0	1	0	1
D(1A) dopamine receptor	2	0	0	2
atrial natriuretic peptide receptor 1 precursor	2	0	0	2
atrial natriuretic peptide receptor 2 precursor	2	0	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Equilibrative nucleoside transporter 1	0	1	0	1
B2 bradykinin receptor	0	1	0	1
Chymotrypsinogen A	0	1	0	1
Beta-lactamase	0	1	0	1
Quinolone resistance protein NorA	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	4	0	4
Voltage-dependent L-type calcium channel subunit alpha-1D	0	2	0	2
Adenosine receptor A3	0	1	0	1
Malate dehydrogenase, cytoplasmic	0	1	0	1
D(1A) dopamine receptor	1	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	3	0	4
Transient receptor potential cation channel subfamily A member 1	0	0	2	2
hypothetical protein, conserved	1	0	0	1
beta-2 adrenergic receptor	1	0	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
perilipin-5	0	1	0	1
perilipin-1	0	1	0	1
serine/threonine-protein kinase PLK1	3	0	0	3
eyes absent homolog 2 isoform a	1	0	0	1
urokinase-type plasminogen activator precursor	1	0	0	1
plasminogen precursor	1	0	0	1
urokinase plasminogen activator surface receptor precursor	1	0	0	1
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	2	0	2
Glutathione reductase, mitochondrial	0	2	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Phospholipase A2, membrane associated	0	0	0	1
5-hydroxytryptamine receptor 2A	0	2	0	2
3-oxo-5-alpha-steroid 4-dehydrogenase 1	0	1	0	1
Platelet-activating factor receptor	0	0	0	1
Adenosine receptor A2a	0	1	0	1
Adenosine receptor A1	0	4	0	4
3-oxo-5-alpha-steroid 4-dehydrogenase 2	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
C-C chemokine receptor type 2	0	2	0	2
Sodium channel protein type 7 subunit alpha	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Potassium voltage-gated channel subfamily A member 1	0	1	0	1
C-terminal-binding protein 1	1	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	2	0	2
Leukotriene B4 receptor 1	0	0	0	1
Myosin light chain kinase, smooth muscle	0	1	0	1
Potassium channel subfamily K member 2	0	1	0	1
Indoleamine 2,3-dioxygenase 2	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
Leukotriene B4 receptor 2	0	0	0	1
Sodium channel protein type 11 subunit alpha	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	1	0	1
Sodium channel protein type 10 subunit alpha	0	1	0	1
Taste receptor type 2 member 31	0	0	1	1
Taste receptor type 2 member 60	0	0	1	1
Sodium/potassium/calcium exchanger 4	0	1	1	2
Taste receptor type 2 member 14	0	0	1	1
Taste receptor type 2 member 13	0	0	1	1
Taste receptor type 2 member 9	0	0	1	1
Taste receptor type 2 member 4	0	0	1	1
Sodium/potassium/calcium exchanger 2	0	1	1	2
Aldo-keto reductase family 1 member B10	0	1	0	1
Complement C5	0	0	1	1
Retinoic acid receptor RXR-alpha	0	1	2	3
Glycine receptor subunit alpha-1	0	0	1	1
Chain X, Thyroid hormone receptor beta-1	0	0	2	2
Chain X, Thyroid hormone receptor beta-1	0	0	2	2
apical membrane antigen 1, AMA1	2	0	0	2
DNA polymerase eta isoform 1	1	0	0	1
Transthyretin	0	1	0	3
Thyroid hormone receptor alpha	0	2	3	5
Thyroid hormone receptor beta	0	2	3	5
Proliferating cell nuclear antigen	0	2	0	2
Malate dehydrogenase, mitochondrial	0	1	0	1
Monocarboxylate transporter 8	0	0	0	1
Bile acid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1C1	0	0	0	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Prothrombin	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Thyroid hormone receptor beta	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Solute carrier organic anion transporter family member 4A1	0	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Solute carrier organic anion transporter family member 1C1	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
caspase 7, apoptosis-related cysteine protease	1	0	0	1
caspase-3	1	0	0	1
Urease subunit alpha	0	1	0	1
Urease subunit beta	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
Chain E, cAMP-dependent protein kinase, alpha-catalytic subunit	0	1	0	1
Chain I, cAMP-dependent protein kinase inhibitor, alpha form	0	1	0	1
Chain B, Rho-associated protein kinase 1	0	1	0	1
Chain A, Rho-associated protein kinase 1	0	1	0	1
Chain A, Rho-associated protein kinase 1	0	1	0	1
Chain A, cAMP-dependent protein kinase, alpha-catalytic subunit	0	1	0	1
Chain A, cAMP-dependent protein kinase, alpha-catalytic subunit	0	1	0	1
Chain A, cAMP-dependent protein kinase, alpha-catalytic subunit	0	1	0	1
Chain I, cAMP-dependent protein kinase inhibitor alpha	0	1	0	1
Chain A, cAMP-dependent protein kinase, alpha-catalytic subunit	0	1	0	1
Chain A, cAMP-dependent protein kinase, alpha-catalytic subunit	0	1	0	1
Chain I, cAMP-dependent protein kinase inhibitor alpha	0	1	0	1
Chain A, Rho-associated protein kinase 1	0	1	0	1
Rho-associated protein kinase 2	0	2	0	2
Ribosomal protein S6 kinase alpha-5	0	1	0	1
cAMP-dependent protein kinase catalytic subunit alpha	0	1	0	1
cAMP-dependent protein kinase catalytic subunit alpha	0	1	0	1
C-C motif chemokine 2	0	1	0	1
cAMP-dependent protein kinase catalytic subunit alpha	0	1	0	1
cAMP-dependent protein kinase catalytic subunit gamma	0	1	0	1
cAMP-dependent protein kinase catalytic subunit beta	0	1	0	1
Rho-associated protein kinase 1	0	2	0	2
Serine/threonine-protein kinase N2	0	1	0	1
Rho-associated protein kinase 2	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Cross-Transfusion, Intrauterine

Synonyms(9)

Research Excerpts

Overview

Treatment

Research

Studies (182)

Protein Targets (622)

Cross-Transfusion, Intrauterine

Synonyms(9)

Research Excerpts

Overview

Treatment

Research

Studies (182)

Drugs Studied (87)

Protein Targets (622)