MEA 2b

Similar to MEN2A, it is also caused by mutations of the MEN2 gene, also known as the RET proto-oncogene. Its clinical symptoms include medullary carcinoma (CARCINOMA, MEDULLARY) of THYROID GLAND and PHEOCHROMOCYTOMA of ADRENAL MEDULLA (50%). Unlike MEN2a, MEN2b does not involve PARATHYROID NEOPLASMS. It can be distinguished from MEN2A by its neural abnormalities such as mucosal NEUROMAS on EYELIDS; LIP; and TONGUE, and ganglioneuromatosis of GASTROINTESTINAL TRACT leading to MEGACOLON. It is an autosomal dominant inherited disease.

Synonym
MEA 2b
Wagenmann-Froboese Syndrome
Multiple Endocrine Neoplasms Type 2b
Neuromata, Mucosal, With Endocrine Tumors
Neoplasia, Multiple Endocrine Type 2b
MEN 2b
Mucosal Neuroma Syndrome
Neoplasms, Multiple Endocrine Type 2b
MEN 3
MEN IIb
MEN2b
MEN III
Multiple Endocrine Neoplasia Type 2b
MEA IIb
Multiple Endocrine Neoplasia, Type 2b
Multiple Endocrine Neoplasia, Type IIb

Excerpt	Reference
"MEN 2B is associated with medullary thyroid carcinoma and pheochromocytoma with oral, ocular, and alimentary submucosal ganglioneuromas and Marfanoid body features."	( Cote, GJ; Gagel, RF; Kahn, MA, 1996)
"MEN2B is caused by the substitution of methionine 918 by a threonine in the tyrosine kinase (TK) domain of RET."	( Carlomagno, F; Cirafici, AM; Dathan, NA; De Vita, G; Fusco, A; Melillo, RM; Salvatore, G; Santoro, M; Visconti, R, 1997)
"MEN 2B is considered to have the most aggressive form of MTC."	( Andrew, SD; Dahia, PL; Eng, C; Frilling, A; Gimm, O; Marsh, DJ; Mulligan, LM; Robinson, BG; Zajac, JD, 1997)
"MEN 2B (multiple endocrine neoplasia type 2B) is an autosomal dominant cancer syndrome caused by an oncogenic form of the receptor tyrosine kinase REarranged during transfection (RET)."	( Runeberg-Roos, P; Saarma, M; Virtanen, H, 2007)

Excerpt	Reference
"Patients with MEN 2B have enlarged enteric ganglia and may be affected by gastrointestinal dysmotility."	( Hutson, JM; King, SK; Southwell, BR, 2006)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	3 (4.17)	23.3326
1990's	17 (23.61)	12.5806
2000's	28 (38.89)	18.1394
2010's	23 (31.94)	28.8240
2020's	1 (1.39)	9.53

Drug	Relationship Strength	Studies	Trials
indoleacetic acid	low	1	0
niacinamide	low	2	0
hydroxyindoleacetic acid	low	1	0
amitriptyline	low	1	0
cyclobenzaprine	low	1	0
amphetamine	low	1	0
fluorouracil	low	1	0
2-propanol	low	1	0
neostigmine	low	1	0
omeprazole	low	1	0
ag 1879	low	1	0
thyroxine	low	1	0
alanine	low	2	0
tyrosine	low	9	0
methionine	low	6	0
phenylalanine	low	2	0
valine	low	1	0
threonine	low	5	0
quinazolines	medium	5	1
calcium gluconate	low	1	0
d-alpha tocopherol	low	1	0
metanephrine	low	1	0
phosphotyrosine	low	1	0
substance p	low	2	0
3-iodobenzylguanidine	low	6	0
fluorodeoxyglucose f18	low	2	0
imatinib mesylate	low	2	0
gefitinib	low	1	0
lestaurtinib	low	1	0
sorafenib	low	2	0
inositol 3-phosphate	low	7	0
zd 6474	medium	4	1
calcitriol	low	1	0
brefeldin a	low	1	0
cysteine	low	2	0
pentagastrin	low	3	0
mart-1 antigen	low	1	0
losartan potassium	low	1	0
piperidines	medium	4	1
vasoactive intestinal peptide	low	1	0
tetracycline	low	1	0
epidermal growth factor	low	2	0
transforming growth factor beta	low	1	0
dacarbazine	low	1	0
eye	low	2	0

Protein Targets (1,076)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
hypoxia-inducible factor 1 alpha subunit	4	0	0	4
RAR-related orphan receptor gamma	6	0	0	6
GLI family zinc finger 3	7	0	0	7
AR protein	9	0	0	9
aldehyde dehydrogenase 1 family, member A1	5	0	0	5
retinoic acid nuclear receptor alpha variant 1	9	0	0	9
retinoid X nuclear receptor alpha	6	0	0	6
estrogen nuclear receptor alpha	13	0	0	13
peroxisome proliferator-activated receptor delta	5	0	0	5
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	6	0	0	6
activating transcription factor 6	6	0	0	6
v-jun sarcoma virus 17 oncogene homolog (avian)	4	0	0	4
Histone H2A.x	3	0	0	3
thyroid hormone receptor beta isoform a	4	0	0	4
heat shock protein beta-1	3	0	0	3
nuclear factor erythroid 2-related factor 2 isoform 1	8	0	0	8
lamin isoform A-delta10	8	0	0	8
Voltage-dependent calcium channel gamma-2 subunit	5	0	0	5
Glutamate receptor 2	5	0	0	5
dopamine D1 receptor	1	0	0	1
thioredoxin reductase	7	0	0	7
GLS protein	4	0	0	4
Thrombopoietin	3	0	0	3
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	1	0	0	1
cytochrome P450 2D6 isoform 1	3	0	0	3
cytochrome P450 2C19 precursor	2	0	0	2
ras-related protein Rab-9A	2	0	0	2
histone acetyltransferase KAT2A isoform 1	4	0	0	4
lethal factor (plasmid)	1	0	0	1
POU domain, class 2, transcription factor 1	0	0	0	1
Spike glycoprotein	4	0	0	4
ATP-dependent phosphofructokinase	3	0	0	3
Chain A, Lck Kinase	0	1	0	1
Chain A, BCL-2-RELATED PROTEIN A1	0	0	0	1
Chain A, Tyrosine-protein kinase Lyn	0	1	0	1
Chain A, Tyrosine-protein kinase Lyn	0	1	0	1
glp-1 receptor, partial	3	0	0	3
Skn7p	0	0	0	2
TDP1 protein	10	0	0	10
Smad3	5	0	0	5
regulator of G-protein signaling 4	4	0	0	4
nonstructural protein 1	2	0	0	2
67.9K protein	4	0	0	4
LAP4	0	0	1	1
RPL19A	0	0	1	1
nuclear factor erythroid 2-related factor 2 isoform 2	3	0	0	3
amino acid transporter AGP1	0	0	1	1
geminin	14	0	0	14
survival motor neuron protein isoform d	4	0	0	4
Receptor-interacting serine/threonine-protein kinase 2	0	2	4	6
Tyrosine-protein kinase JAK2	0	2	4	6
Tyrosine-protein kinase ABL1	0	6	5	11
Proto-oncogene tyrosine-protein kinase Src	0	1	1	2
Epidermal growth factor receptor	0	8	5	13
Tyrosine-protein kinase Lck	0	3	4	8
Proto-oncogene tyrosine-protein kinase LCK	0	1	0	1
Tyrosine-protein kinase Fyn	0	1	4	5
Tyrosine-protein kinase Lyn	0	1	4	5
Tyrosine-protein kinase HCK	0	3	4	7
Proto-oncogene tyrosine-protein kinase Src	0	5	4	10
Ephrin type-A receptor 3	0	0	5	5
Ephrin type-B receptor 2	0	1	5	6
Alpha-synuclein	2	1	0	3
Tyrosine-protein kinase CSK	0	1	4	5
Tyrosine-protein kinase ZAP-70	0	1	4	5
Casein kinase I isoform delta	0	1	4	5
TAR DNA-binding protein 43	1	0	0	1
Mitogen-activated protein kinase 14	0	2	4	6
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	2
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	4	0	0	4
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	1	0	0	1
Carbonic anhydrase 1	0	1	0	4
Carbonic anhydrase 2	0	1	0	4
Alanine racemase, biosynthetic	0	0	0	1
5-hydroxytryptamine receptor 1D	0	0	0	1
Glutamate receptor ionotropic, NMDA 1	0	1	0	3
Proton-coupled amino acid transporter 1	0	1	0	1
Adenosine deaminase	0	0	0	1
Carbonic anhydrase 4	0	0	0	1
Chain A, HADH2 protein	2	0	0	2
Chain B, HADH2 protein	2	0	0	2
USP1 protein, partial	10	0	0	10
NFKB1 protein, partial	2	0	0	2
cytochrome P450 family 3 subfamily A polypeptide 4	7	0	0	7
cytochrome P450 2D6	5	0	0	5
arylsulfatase A	3	0	0	3
D(1A) dopamine receptor	2	0	0	2
chromobox protein homolog 1	6	0	0	6
atrial natriuretic peptide receptor 2 precursor	2	0	0	2
serine/threonine-protein kinase mTOR isoform 1	6	0	0	6
muscarinic acetylcholine receptor M1	3	0	0	3
Solute carrier family 22 member 1	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	4	0	0	4
ATP-binding cassette sub-family C member 3	0	9	0	9
Multidrug resistance-associated protein 4	0	9	0	9
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
5-hydroxytryptamine receptor 4	0	2	0	2
Bile salt export pump	0	11	0	11
Albumin	0	0	1	1
High affinity nerve growth factor receptor	0	1	6	7
Aldo-keto reductase family 1 member B1	0	2	0	2
Muscarinic acetylcholine receptor M2	0	3	0	3
Muscarinic acetylcholine receptor M4	0	2	0	2
Muscarinic acetylcholine receptor M1	0	1	0	1
Muscarinic acetylcholine receptor M3	0	1	0	1
Muscarinic acetylcholine receptor M4	0	1	0	1
5-hydroxytryptamine receptor 2C	0	3	1	4
Muscarinic acetylcholine receptor M5	0	1	0	1
Muscarinic acetylcholine receptor M5	0	2	0	2
Alpha-2A adrenergic receptor	0	2	0	2
Muscarinic acetylcholine receptor M2	0	1	0	1
Muscarinic acetylcholine receptor M1	0	2	0	2
Angiotensin-converting enzyme	0	2	0	2
D(2) dopamine receptor	0	2	0	2
5-hydroxytryptamine receptor 2A	0	3	1	4
Alpha-2B adrenergic receptor	0	2	0	2
Alpha-2C adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 1A	0	3	1	4
Muscarinic acetylcholine receptor M3	0	2	0	2
D(1A) dopamine receptor	0	2	0	2
D(1B) dopamine receptor	0	1	0	1
UDP-glucuronosyltransferase 1A4	0	1	0	2
Sodium-dependent noradrenaline transporter	0	2	0	2
Histamine H2 receptor	0	2	0	2
Alpha-1D adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 2A	0	3	0	3
5-hydroxytryptamine receptor 2C	0	3	0	3
5-hydroxytryptamine receptor 1B	0	3	1	4
5-hydroxytryptamine receptor 1D	0	2	1	3
5-hydroxytryptamine receptor 1F	0	2	1	3
5-hydroxytryptamine receptor 2B	0	3	1	4
5-hydroxytryptamine receptor 6	0	1	1	2
Histamine H1 receptor	0	1	0	1
Sodium-dependent serotonin transporter	0	2	0	2
5-hydroxytryptamine receptor 7	0	1	1	2
5-hydroxytryptamine receptor 5A	0	1	1	2
5-hydroxytryptamine receptor 5B	0	1	1	2
Histamine H1 receptor	0	2	0	2
D(3) dopamine receptor	0	2	0	2
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 4 subunit alpha	0	1	0	1
UDP-glucuronosyltransferase 1A3	0	0	0	1
5-hydroxytryptamine receptor 3A	0	1	1	2
5-hydroxytryptamine receptor 2B	0	3	0	3
Alpha-1A adrenergic receptor	0	2	0	2
Histamine H2 receptor	5	1	0	7
D(1A) dopamine receptor	2	0	0	2
5-hydroxytryptamine receptor 6	0	3	0	3
5-hydroxytryptamine receptor 7	0	1	0	1
Voltage-dependent N-type calcium channel subunit alpha-1B	0	2	0	2
Sodium channel protein type 7 subunit alpha	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Sodium-dependent dopamine transporter	0	2	0	2
Potassium voltage-gated channel subfamily H member 2	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Sodium channel protein type 5 subunit alpha	0	1	0	1
Sodium channel protein type 9 subunit alpha	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	1	1	2
5-hydroxytryptamine receptor 4	0	1	1	2
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
Canalicular multispecific organic anion transporter 1	0	8	0	8
Sodium channel protein type 2 subunit alpha	0	1	0	1
Ataxin-2	6	0	0	6
Sigma non-opioid intracellular receptor 1	0	2	0	2
5-hydroxytryptamine receptor 3B	0	1	1	2
Sodium channel protein type 3 subunit alpha	0	1	0	1
Sodium channel protein type 11 subunit alpha	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	1	0	1
Histamine H3 receptor	0	1	0	1
Sodium channel protein type 10 subunit alpha	0	1	0	1
Solute carrier family 22 member 3	0	1	0	1
Phenylethanolamine N-methyltransferase	0	2	0	2
Cytochrome P450 2A6	0	1	0	1
Substance-P receptor	0	3	0	3
Cytochrome P450 2A5	0	1	0	1
Sodium-dependent dopamine transporter	0	2	0	2
Beta-2 adrenergic receptor	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	1	0	1
PAX8	0	0	0	1
ATAD5 protein, partial	3	0	0	3
thioredoxin glutathione reductase	2	0	0	2
IDH1	4	0	0	4
euchromatic histone-lysine N-methyltransferase 2	9	0	0	9
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
major prion protein preproprotein Prp precursor	0	1	0	1
nuclear receptor subfamily 0 group B member 1	0	1	0	1
steroidogenic factor 1	0	1	0	1
urokinase-type plasminogen activator precursor	3	0	0	3
plasminogen precursor	3	0	0	3
urokinase plasminogen activator surface receptor precursor	3	0	0	3
Chain A, Vitamin D Nuclear Receptor	0	0	1	1
Chain A, Beta-lactamase	1	0	0	1
Chain A, Ferritin light chain	1	0	0	1
Vitamin D3 receptor	0	0	1	1
PPM1D protein	4	0	0	4
Microtubule-associated protein tau	5	0	0	5
mitogen-activated protein kinase 1	1	0	0	1
nuclear receptor ROR-gamma isoform 1	5	0	0	5
peripheral myelin protein 22	8	0	0	8
Interferon beta	6	0	0	6
Vitamin D-binding protein	0	0	1	1
Cytochrome P450 1A2	0	1	0	2
Cytochrome P450 3A4	0	4	0	6
Androgen receptor	0	1	0	1
Cytochrome P450 2D6	0	1	0	1
Vitamin D3 receptor	0	1	2	4
Cytochrome P450 2C9	0	3	0	4
Vitamin D3 receptor	0	1	1	3
Retinoic acid receptor RXR-alpha	0	0	3	3
Cytochrome P450 2C19	0	3	0	4
Kappa-type opioid receptor	0	0	1	1
Vitamin D3 receptor	0	0	1	1
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	0	0	1	1
Vitamin D3 receptor	0	1	1	2
Transporter	0	1	0	1
Vitamin D3 receptor A	0	0	2	2
15-lipoxygenase, partial	1	0	0	1
Fumarate hydratase	5	0	0	5
thyroid stimulating hormone receptor	4	0	0	4
EWS/FLI fusion protein	8	0	0	8
polyprotein	5	0	0	5
cellular tumor antigen p53 isoform a	1	0	0	1
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
Inositol monophosphatase 1	2	0	0	2
estrogen-related nuclear receptor alpha	8	0	0	8
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	2	0	0	2
importin subunit beta-1 isoform 1	1	0	0	1
snurportin-1	1	0	0	1
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
Rap guanine nucleotide exchange factor 3	2	0	0	2
Cellular tumor antigen p53	7	0	0	7
Glutathione S-transferase P	0	1	0	1
Alpha-tocopherol transfer protein	0	0	1	1
Chain A, 2-oxoglutarate Oxygenase	2	0	0	2
interleukin 8	2	0	0	2
glucocorticoid receptor [Homo sapiens]	9	0	0	9
peroxisome proliferator activated receptor gamma	7	0	0	7
thyroid stimulating hormone receptor	2	0	0	2
Matrix metalloproteinase-9	0	1	0	1
Isocitrate lyase	0	1	0	1
Chain A, Uracil Phosphoribosyltransferase	0	1	0	1
Luciferase	5	0	0	5
endonuclease IV	2	0	0	2
acetylcholinesterase	5	0	0	5
pregnane X receptor	1	0	0	1
estrogen receptor 2 (ER beta)	4	0	0	4
nuclear receptor subfamily 1, group I, member 3	5	0	0	5
progesterone receptor	4	0	0	4
farnesoid X nuclear receptor	5	0	0	5
pregnane X nuclear receptor	6	0	0	6
peripheral myelin protein 22 isoform 1	2	0	0	2
hemoglobin subunit beta	1	0	0	1
thyroid hormone receptor beta isoform 2	6	0	0	6
huntingtin isoform 2	4	0	0	4
flap endonuclease 1	1	0	0	1
Vpr	1	0	0	1
muscleblind-like protein 1 isoform 1	1	0	0	1
Solute carrier family 22 member 8	0	0	0	1
Amyloid-beta precursor protein	1	0	0	1
Thymidylate synthase	0	1	0	1
Aromatase	0	2	0	2
ATPase family AAA domain-containing protein 5	4	0	0	4
Leukotriene C4 synthase	0	0	4	4
caspase 7, apoptosis-related cysteine protease	1	0	0	1
caspase-3	1	0	0	1
aryl hydrocarbon receptor	8	0	0	8
Caspase-7	2	0	0	2
vitamin D3 receptor isoform VDRA	3	0	0	3
potassium voltage-gated channel subfamily H member 2 isoform d	2	0	0	2
caspase-3	2	0	0	2
epidermal growth factor receptor isoform a precursor	1	1	0	2
tyrosine-protein kinase Yes	3	0	0	3
Bone morphogenetic protein receptor type-1B	0	0	4	4
Cell division cycle 7-related protein kinase	0	0	4	4
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	0	2	4	6
Serine/threonine-protein kinase PLK4	0	1	4	5
Serine/threonine-protein kinase 25	0	0	4	4
ATP-dependent RNA helicase DDX3X	0	0	4	4
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta	0	0	4	4
Pyridoxal kinase	0	0	4	4
Citron Rho-interacting kinase	0	0	4	4
Serine/threonine-protein kinase RIO3	0	0	4	4
Dual specificity mitogen-activated protein kinase kinase 7	0	0	4	4
Serine/threonine-protein kinase Chk1	0	0	4	4
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	4	4
Peripheral plasma membrane protein CASK	0	0	4	4
Aurora kinase A	0	1	4	5
Cyclin-G-associated kinase	0	1	4	5
Serine/threonine-protein kinase DCLK1	0	0	4	4
Inhibitor of nuclear factor kappa-B kinase subunit alpha	0	0	4	4
Muscle, skeletal receptor tyrosine-protein kinase	0	0	4	4
Ephrin type-B receptor 6	0	0	4	4
Peroxisomal acyl-coenzyme A oxidase 3	0	0	4	4
Mitogen-activated protein kinase 13	0	0	4	4
3-phosphoinositide-dependent protein kinase 1	0	0	4	4
Mitogen-activated protein kinase kinase kinase 13	0	0	4	4
Death-associated protein kinase 3	0	0	4	4
Mitogen-activated protein kinase kinase kinase 7	0	0	4	4
Mitotic checkpoint serine/threonine-protein kinase BUB1	0	0	4	4
NUAK family SNF1-like kinase 1	0	0	4	4
Dynamin-like 120 kDa protein, mitochondrial	0	0	4	4
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma	0	0	4	4
Rho-associated protein kinase 2	0	0	4	4
Serine/threonine-protein kinase ULK1	0	0	4	4
Serine/threonine-protein kinase/endoribonuclease IRE1	0	0	4	4
Ribosomal protein S6 kinase alpha-5	0	0	4	4
U5 small nuclear ribonucleoprotein 200 kDa helicase	0	0	4	4
Ribosomal protein S6 kinase alpha-4	0	0	4	4
Serine/threonine-protein kinase 16	0	0	4	4
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	0	0	4	4
Serine/threonine-protein kinase PAK 3	0	0	4	4
Cyclin-dependent kinase-like 5	0	0	4	4
Serine/threonine-protein kinase 17B	0	0	4	4
Serine/threonine-protein kinase 10	0	0	4	4
Serine/threonine-protein kinase D3	0	0	4	4
Cyclin-dependent kinase 14	0	0	4	4
Structural maintenance of chromosomes protein 2	0	0	4	4
Mitogen-activated protein kinase kinase kinase 6	0	0	4	4
Serine/threonine-protein kinase OSR1	0	0	4	4
Mitogen-activated protein kinase kinase kinase kinase 4	0	0	4	4
Serine/threonine-protein kinase LATS1	0	0	4	4
Serine/threonine-protein kinase PAK 4	0	0	4	4
Serine/threonine-protein kinase Chk2	0	0	4	4
RAF proto-oncogene serine/threonine-protein kinase	0	2	4	6
Receptor tyrosine-protein kinase erbB-2	0	2	4	6
Guanine nucleotide-binding protein G(i) subunit alpha-2	0	0	3	3
ADP/ATP translocase 2	0	0	4	4
Cytochrome P450 2E1	0	1	0	1
Protein kinase C beta type	0	0	4	4
Insulin receptor	0	2	4	6
Cyclin-dependent kinase 1	0	1	4	5
Glycogen phosphorylase, liver form	0	0	4	4
Tyrosine-protein kinase Fes/Fps	0	0	4	4
Macrophage colony-stimulating factor 1 receptor	0	3	4	7
Adenine phosphoribosyltransferase	0	0	4	4
Tyrosine-protein kinase Yes	0	0	4	4
Proto-oncogene tyrosine-protein kinase receptor Ret	0	4	4	8
Insulin-like growth factor 1 receptor	0	1	4	5
ATP-dependent translocase ABCB1	0	2	1	3
Signal recognition particle receptor subunit alpha	0	0	3	3
Cytochrome c1, heme protein, mitochondrial	0	0	4	4
Hepatocyte growth factor receptor	0	1	4	5
Proto-oncogene tyrosine-protein kinase ROS	0	0	4	4
Platelet-derived growth factor receptor beta	0	2	4	6
Tyrosine-protein kinase Fgr	0	0	4	4
Quinolone resistance protein NorA	0	1	0	1
Wee1-like protein kinase 2	0	0	4	4
Uncharacterized serine/threonine-protein kinase SBK3	0	0	4	4
Serine/threonine-protein kinase A-Raf	0	1	4	5
Cytochrome P450 2C8	0	1	0	2
Mast/stem cell growth factor receptor Kit	0	3	5	8
Glycogen phosphorylase, brain form	0	0	4	4
Breakpoint cluster region protein	0	1	5	6
Serine/threonine-protein kinase pim-1	0	0	4	4
Fibroblast growth factor receptor 1	0	2	4	7
DNA topoisomerase 2-alpha	0	0	4	4
Myosin light chain kinase, smooth muscle	0	0	3	3
Cyclin-dependent kinase 4	0	1	4	5
ADP/ATP translocase 3	0	0	4	4
Inosine-5'-monophosphate dehydrogenase 2	0	0	4	4
cAMP-dependent protein kinase type II-alpha regulatory subunit	0	0	4	4
Insulin receptor-related protein	0	0	4	4
Serine/threonine-protein kinase B-raf	0	4	5	9
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	0	0	4	4
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	0	4	4
Platelet-derived growth factor receptor alpha	0	2	5	7
Tyrosine-protein kinase Fer	0	0	4	4
Protein kinase C alpha type	0	0	4	4
cAMP-dependent protein kinase catalytic subunit alpha	0	0	4	4
Vascular endothelial growth factor receptor 1	0	2	4	6
General transcription and DNA repair factor IIH helicase subunit XPD	0	0	4	4
Interferon-induced, double-stranded RNA-activated protein kinase	0	0	4	4
Casein kinase II subunit alpha'	0	0	4	4
Ras-related protein Rab-6A	0	0	4	4
Serine/threonine-protein kinase MAK	0	0	4	4
Cyclin-dependent kinase 11B	0	0	4	4
Ephrin type-A receptor 1	0	0	4	4
Fibroblast growth factor receptor 2	0	0	4	4
Receptor tyrosine-protein kinase erbB-3	0	1	4	5
Multifunctional protein ADE2	0	0	4	4
Fibroblast growth factor receptor 4	0	0	4	4
Fibroblast growth factor receptor 3	0	0	4	4
cAMP-dependent protein kinase catalytic subunit gamma	0	0	3	3
cAMP-dependent protein kinase catalytic subunit beta	0	0	4	4
Ferrochelatase, mitochondrial	0	0	4	4
Ribosomal protein S6 kinase beta-1	0	0	4	4
Tyrosine-protein kinase JAK1	0	0	4	4
Protein kinase C eta type	0	0	4	4
Cyclin-dependent kinase 2	0	1	4	5
Beta-adrenergic receptor kinase 1	0	0	4	4
Cruzipain	0	1	0	1
Probable ATP-dependent RNA helicase DDX6	0	0	4	4
Activin receptor type-2A	0	0	4	4
Mitogen-activated protein kinase 3	0	1	4	5
MAP/microtubule affinity-regulating kinase 3	0	0	4	4
Deoxycytidine kinase	0	0	4	4
Mitogen-activated protein kinase 1	0	1	4	5
Ephrin type-A receptor 2	0	0	4	4
Ephrin type-A receptor 8	0	0	4	4
Leukocyte tyrosine kinase receptor	0	0	4	4
Non-receptor tyrosine-protein kinase TYK2	0	0	4	4
UMP-CMP kinase	0	0	3	3
Phosphatidylethanolamine-binding protein 1	0	0	3	3
Wee1-like protein kinase	0	0	4	4
Heme oxygenase 2	0	0	4	4
Tyrosine-protein kinase receptor UFO	0	0	4	4
Mitogen-activated protein kinase 4	0	0	4	4
S-adenosylmethionine synthase isoform type-2	0	0	4	4
DnaJ homolog subfamily A member 1	0	0	4	4
RAC-alpha serine/threonine-protein kinase	0	0	4	4
RAC-beta serine/threonine-protein kinase	0	0	4	4
G protein-coupled receptor kinase 4	0	0	4	4
Dual specificity protein kinase TTK	0	0	4	4
DNA replication licensing factor MCM4	0	0	4	4
Type-1 angiotensin II receptor	0	1	0	1
Prostaglandin G/H synthase 2	0	0	4	4
Tyrosine-protein kinase receptor Tie-1	0	0	4	4
Vascular endothelial growth factor receptor 3	0	2	4	6
Vascular endothelial growth factor receptor 2	0	4	5	10
Dual specificity mitogen-activated protein kinase kinase 2	0	0	4	4
Receptor-type tyrosine-protein kinase FLT3	0	3	4	7
Bone morphogenetic protein receptor type-1A	0	0	4	4
Activin receptor type-1B	0	0	4	4
TGF-beta receptor type-1	0	0	4	4
Serine/threonine-protein kinase receptor R3	0	0	4	4
TGF-beta receptor type-2	0	0	4	4
Electron transfer flavoprotein subunit beta	0	0	4	4
Glycine--tRNA ligase	0	0	4	4
Mitogen-activated protein kinase kinase kinase 8	0	1	0	1
Protein kinase C iota type	0	0	4	4
Exosome RNA helicase MTR4	0	0	4	4
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	0	2	4	6
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0	2	4	6
Serine/threonine-protein kinase mTOR	0	2	4	6
Megakaryocyte-associated tyrosine-protein kinase	0	0	4	4
Tyrosine-protein kinase Tec	0	0	4	4
Tyrosine-protein kinase TXK	0	0	4	4
Tyrosine-protein kinase ABL2	0	0	4	4
Tyrosine-protein kinase FRK	0	0	4	4
G protein-coupled receptor kinase 6	0	0	4	4
Tyrosine-protein kinase SYK	0	0	4	4
26S proteasome regulatory subunit 6B	0	0	4	4
Mitogen-activated protein kinase 8	0	0	4	4
Mitogen-activated protein kinase 9	0	0	4	4
Dual specificity mitogen-activated protein kinase kinase 4	0	0	4	4
Dual specificity mitogen-activated protein kinase kinase 3	0	0	4	4
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	0	0	4	4
Casein kinase I isoform alpha	0	2	4	6
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	2	4	6
MAP kinase-activated protein kinase 2	0	0	4	4
Cyclin-dependent kinase 8	0	1	4	5
Elongation factor Tu, mitochondrial	0	0	4	4
Cysteine--tRNA ligase, cytoplasmic	0	0	3	3
Casein kinase I isoform epsilon	0	0	4	4
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	0	0	4	4
Dual specificity protein kinase CLK1	0	0	4	4
Dual specificity protein kinase CLK2	0	0	4	4
Dual specificity protein kinase CLK3	0	0	4	4
Glycogen synthase kinase-3 alpha	0	0	4	4
Glycogen synthase kinase-3 beta	0	1	4	5
Cyclin-dependent kinase 7	0	0	4	4
Cyclin-dependent kinase 9	0	0	4	4
Ras-related protein Rab-27A	0	0	4	4
Tyrosine-protein kinase Blk	0	0	4	4
Interleukin-1 receptor-associated kinase 1	0	0	4	4
Ribosomal protein S6 kinase alpha-3	0	0	4	4
Cytoplasmic tyrosine-protein kinase BMX	0	0	4	4
cAMP-dependent protein kinase catalytic subunit PRKX	0	0	4	4
Serine/threonine-protein kinase Nek2	0	0	4	4
Serine/threonine-protein kinase Nek3	0	0	4	4
Serine/threonine-protein kinase Nek4	0	0	4	4
Tyrosine-protein kinase JAK3	0	1	4	5
Dual specificity mitogen-activated protein kinase kinase 6	0	0	4	4
Serine/threonine-protein kinase PLK1	0	1	4	5
Death-associated protein kinase 1	0	0	4	4
LIM domain kinase 1	0	0	4	4
LIM domain kinase 2	0	0	4	4
Mitogen-activated protein kinase 12	0	0	4	4
Mitogen-activated protein kinase 10	0	0	4	4
Tyrosine--tRNA ligase, cytoplasmic	0	0	4	4
5'-AMP-activated protein kinase subunit gamma-1	0	0	4	4
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	4	4
Ephrin type-B receptor 3	0	0	4	4
Ephrin type-A receptor 5	0	0	4	4
Ephrin type-B receptor 4	0	2	4	6
Ephrin type-B receptor 1	0	0	4	4
Ephrin type-A receptor 4	0	0	4	4
Adenylate kinase 2, mitochondrial	0	0	4	4
Adenosine kinase	0	0	4	4
Beta-secretase 1	0	1	0	1
Hormonally up-regulated neu tumor-associated kinase	0	0	4	4
Serine/threonine-protein kinase SIK1	0	0	4	4
Receptor-interacting serine/threonine-protein kinase 4	0	0	4	4
Ras-related protein Rab-10	0	0	4	4
Cell division control protein 2 homolog	0	0	4	4
Actin-related protein 3	0	0	4	4
Actin-related protein 2	0	0	4	4
Calcium-dependent protein kinase 1	0	0	4	4
GTP-binding nuclear protein Ran	0	0	4	4
Tubulin alpha-1A chain	0	0	3	3
Casein kinase II subunit alpha	0	0	4	4
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	0	0	4	4
SRSF protein kinase 2	0	0	4	4
Casein kinase I isoform gamma-2	0	0	4	4
DNA-dependent protein kinase catalytic subunit	0	2	0	2
Mitogen-activated protein kinase kinase kinase 9	0	0	4	4
Serine/threonine-protein kinase PknB	0	0	4	4
Cyclin-dependent kinase 3	0	0	4	4
Cyclin-dependent kinase-like 1	0	0	4	4
Cyclin-dependent kinase 6	0	1	4	5
Cyclin-dependent-like kinase 5	0	0	4	4
Cyclin-dependent kinase 16	0	0	4	4
Cyclin-dependent kinase 17	0	0	4	4
ATP-dependent 6-phosphofructokinase, platelet type	0	0	3	3
Synaptic vesicular amine transporter	0	1	0	1
Protein kinase C epsilon type	0	0	4	4
Dual specificity mitogen-activated protein kinase kinase 1	0	1	4	5
Angiopoietin-1 receptor	0	2	4	6
Mitogen-activated protein kinase kinase kinase 10	0	0	4	4
DNA topoisomerase 2-beta	0	0	4	4
Transcription factor p65	0	1	0	1
Protein kinase C theta type	0	0	4	4
Activin receptor type-1	0	0	4	4
Macrophage-stimulating protein receptor	0	1	4	5
Focal adhesion kinase 1	0	0	4	4
Protein kinase C zeta type	0	0	4	4
Protein kinase C delta type	0	0	4	4
Tyrosine-protein kinase BTK	0	0	4	4
Tyrosine-protein kinase receptor TYRO3	0	0	4	4
Cyclin-dependent kinase 18	0	0	4	4
Activated CDC42 kinase 1	0	0	4	4
Epithelial discoidin domain-containing receptor 1	0	0	4	4
Tyrosine-protein kinase ITK/TSK	0	0	4	4
Myotonin-protein kinase	0	0	4	4
Mitogen-activated protein kinase kinase kinase kinase 2	0	0	4	4
Mitogen-activated protein kinase kinase kinase 12	0	0	4	4
Tyrosine-protein kinase Mer	0	1	4	5
Serine/threonine-protein kinase 4	0	0	4	4
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	4	4
Serine/threonine-protein kinase PAK 1	0	0	4	4
Dual specificity mitogen-activated protein kinase kinase 5	0	0	4	4
Mitogen-activated protein kinase 7	0	0	4	4
Serine/threonine-protein kinase PAK 2	0	0	4	4
Serine/threonine-protein kinase 3	0	0	4	4
Mitogen-activated protein kinase kinase kinase 1	0	0	4	4
cGMP-dependent protein kinase 2	0	0	4	4
Integrin-linked protein kinase	0	0	4	4
Rho-associated protein kinase 1	0	0	4	4
Non-receptor tyrosine-protein kinase TNK1	0	0	4	4
Serine/threonine-protein kinase PRP4 homolog	0	0	4	4
Receptor-interacting serine/threonine-protein kinase 1	0	1	4	5
Calcium/calmodulin-dependent protein kinase type II subunit beta	0	0	4	4
Calcium/calmodulin-dependent protein kinase type II subunit gamma	0	0	4	4
Calcium/calmodulin-dependent protein kinase type II subunit delta	0	0	4	4
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	1	4	5
Activin receptor type-2B	0	0	4	4
Bone morphogenetic protein receptor type-2	0	0	4	4
Protein-tyrosine kinase 6	0	0	4	4
cGMP-dependent protein kinase 1	0	0	4	4
Cyclin-dependent kinase 13	0	0	4	4
Calcium/calmodulin-dependent protein kinase type 1	0	0	4	4
Inhibitor of nuclear factor kappa-B kinase subunit epsilon	0	0	4	4
Protein-tyrosine kinase 2-beta	0	0	4	4
Maternal embryonic leucine zipper kinase	0	0	4	4
Structural maintenance of chromosomes protein 1A	0	0	4	4
Chromodomain-helicase-DNA-binding protein 4	0	0	4	4
Peroxisomal acyl-coenzyme A oxidase 1	0	0	3	3
Serine/threonine-protein kinase D1	0	0	4	4
Serine/threonine-protein kinase 38	0	0	4	4
Receptor tyrosine-protein kinase erbB-4	0	1	4	5
Ribosomal protein S6 kinase alpha-2	0	0	4	4
Ephrin type-A receptor 7	0	0	4	4
Delta(24)-sterol reductase	0	0	4	4
Ribosomal protein S6 kinase alpha-1	0	0	4	4
Dual specificity testis-specific protein kinase 1	0	0	4	4
Myosin light chain kinase, smooth muscle	0	0	4	4
Mitogen-activated protein kinase 11	0	0	4	4
Serine/threonine-protein kinase STK11	0	0	4	4
Rhodopsin kinase GRK1	0	0	4	4
NT-3 growth factor receptor	0	0	4	4
Serine/threonine-protein kinase N1	0	0	4	4
Serine/threonine-protein kinase N2	0	0	4	4
Calcium/calmodulin-dependent protein kinase type IV	0	0	4	4
Mitogen-activated protein kinase kinase kinase 11	0	0	4	4
BDNF/NT-3 growth factors receptor	0	0	4	4
Mitogen-activated protein kinase 6	0	0	4	4
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform	0	0	4	4
Discoidin domain-containing receptor 2	0	1	4	5
AP2-associated protein kinase 1	0	0	4	4
Myosin light chain kinase 3	0	0	4	4
Uncharacterized aarF domain-containing protein kinase 5	0	0	3	3
Serine/threonine-protein kinase ULK3	0	0	1	1
Serine/threonine-protein kinase SBK1	0	0	4	4
Mitogen-activated protein kinase kinase kinase 19	0	0	4	4
Putative heat shock protein HSP 90-beta 2	0	0	3	3
Serine/threonine-protein kinase TNNI3K	0	1	4	5
Leucine-rich repeat serine/threonine-protein kinase 2	0	0	4	4
Serine/threonine-protein kinase MRCK alpha	0	0	4	4
Serine/threonine-protein kinase MRCK gamma	0	0	4	4
Acyl-CoA dehydrogenase family member 10	0	0	4	4
Serine/threonine-protein kinase Nek5	0	0	4	4
Serine/threonine-protein kinase N3	0	0	4	4
Serine/threonine-protein kinase ULK3	0	0	4	4
Dual serine/threonine and tyrosine protein kinase	0	0	4	4
Mitogen-activated protein kinase kinase kinase 15	0	0	4	4
Uncharacterized protein FLJ45252	0	0	4	4
Acyl-CoA dehydrogenase family member 11	0	0	4	4
Serine/threonine-protein kinase/endoribonuclease IRE2	0	0	3	3
Serine/threonine-protein kinase MARK2	0	0	4	4
Serine/threonine-protein kinase TAO1	0	0	4	4
STE20-related kinase adapter protein alpha	0	0	4	4
Myosin-14	0	0	4	4
AarF domain-containing protein kinase 1	0	0	4	4
Serine/threonine-protein kinase tousled-like 2	0	0	4	4
Serine/threonine-protein kinase 32C	0	0	4	4
Serine/threonine-protein kinase pim-3	0	0	4	4
ATP-dependent RNA helicase DDX42	0	0	3	3
Serine/threonine-protein kinase VRK2	0	0	4	4
Myosin light chain kinase family member 4	0	0	4	4
Homeodomain-interacting protein kinase 1	0	1	4	5
Calcium/calmodulin-dependent protein kinase type 1D	0	0	4	4
Mitogen-activated protein kinase kinase kinase kinase 3	0	0	4	4
Cyclin-dependent kinase-like 3	0	0	4	4
MAP kinase-activated protein kinase 5	0	0	4	4
Serine/threonine-protein kinase BRSK2	0	0	4	4
Serine/threonine-protein kinase NIM1	0	0	4	4
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B	0	0	1	1
Serine/threonine-protein kinase ULK2	0	0	4	4
Misshapen-like kinase 1	0	0	4	4
Serine/threonine-protein kinase DCLK2	0	0	4	4
Calcium/calmodulin-dependent protein kinase kinase 1	0	0	4	4
Casein kinase I isoform alpha-like	0	0	4	4
Homeodomain-interacting protein kinase 4	0	1	4	5
Myosin-IIIa	0	0	4	4
Ankyrin repeat and protein kinase domain-containing protein 1	0	0	4	4
Serine/threonine-protein kinase Nek11	0	0	4	4
Atypical kinase COQ8A, mitochondrial	0	0	4	4
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	0	0	4	4
Mitogen-activated protein kinase 15	0	0	4	4
Serine/threonine-protein kinase Nek9	0	0	4	4
Serine/threonine-protein kinase BRSK1	0	0	4	4
Serine/threonine-protein kinase 35	0	0	4	4
Serine/threonine-protein kinase Nek7	0	0	4	4
Rhodopsin kinase GRK7	0	0	4	4
Serine/threonine-protein kinase 32A	0	0	4	4
Myosin-IIIb	0	0	4	4
ATP-dependent RNA helicase DDX1	0	0	4	4
Dual specificity tyrosine-phosphorylation-regulated kinase 2	0	0	4	4
Cyclin-dependent kinase-like 2	0	0	4	4
Mitogen-activated protein kinase kinase kinase kinase 1	0	0	4	4
Serine/threonine-protein kinase Sgk3	0	0	4	4
Atypical kinase COQ8B, mitochondrial	0	0	4	4
Aurora kinase B	0	0	4	4
MAP/microtubule affinity-regulating kinase 4	0	0	4	4
Calcium/calmodulin-dependent protein kinase type 1G	0	0	4	4
Serine/threonine-protein kinase Nek1	0	0	4	4
Cyclin-dependent kinase 15	0	0	4	4
PAS domain-containing serine/threonine-protein kinase	0	0	4	4
Calcium/calmodulin-dependent protein kinase kinase 2	0	0	4	4
EKC/KEOPS complex subunit TP53RK	0	0	4	4
SRSF protein kinase 1	0	0	4	4
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	0	0	4	4
Mitogen-activated protein kinase kinase kinase 5	0	0	4	4
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha	0	0	4	4
Mitogen-activated protein kinase kinase kinase 3	0	0	4	4
Eukaryotic translation initiation factor 2-alpha kinase 1	0	0	4	4
Serine/threonine-protein kinase RIO1	0	0	4	4
MAP kinase-interacting serine/threonine-protein kinase 1	0	0	4	4
Serine/threonine-protein kinase RIO2	0	0	4	4
Cyclin-dependent kinase 19	0	1	4	5
Transient receptor potential cation channel subfamily M member 6	0	0	4	4
Testis-specific serine/threonine-protein kinase 1	0	0	4	4
Serine/threonine-protein kinase 33	0	0	4	4
Nucleolar GTP-binding protein 1	0	0	4	4
Serine/threonine-protein kinase D2	0	0	4	4
Serine/threonine-protein kinase DCLK3	0	0	4	4
NUAK family SNF1-like kinase 2	0	0	4	4
RNA cytidine acetyltransferase	0	0	4	4
Serine/threonine-protein kinase SIK2	0	0	4	4
Myosin light chain kinase 2, skeletal/cardiac muscle	0	0	4	4
STE20-like serine/threonine-protein kinase	0	0	4	4
Serine/threonine-protein kinase TAO3	0	0	4	4
Homeodomain-interacting protein kinase 2	0	1	4	5
Tyrosine-protein kinase Srms	0	0	4	4
Homeodomain-interacting protein kinase 3	0	1	4	5
Serine/threonine-protein kinase PLK3	0	1	4	5
dCTP pyrophosphatase 1	0	0	4	4
Dual specificity protein kinase CLK4	0	0	4	4
MAP kinase-interacting serine/threonine-protein kinase 2	0	1	4	5
Serine/threonine-protein kinase Nek6	0	0	4	4
Casein kinase I isoform gamma-1	0	0	4	4
Serine/threonine-protein kinase PAK 6	0	0	4	4
SNF-related serine/threonine-protein kinase	0	0	4	4
Serine/threonine-protein kinase LATS2	0	0	4	4
Serine/threonine-protein kinase 36	0	0	4	4
Phenylalanine--tRNA ligase beta subunit	0	0	4	4
Isoleucine--tRNA ligase, mitochondrial	0	0	3	3
BMP-2-inducible protein kinase	0	0	4	4
Obg-like ATPase 1	0	0	4	4
Midasin	0	0	4	4
Interleukin-1 receptor-associated kinase 4	0	0	4	4
Serine/threonine-protein kinase 32B	0	0	4	4
Mitogen-activated protein kinase kinase kinase 20	0	0	4	4
Cyclin-dependent kinase 12	0	0	4	4
Serine/threonine-protein kinase PLK2	0	1	4	5
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	0	0	4	4
Serine/threonine-protein kinase MARK1	0	0	4	4
Serine/threonine-protein kinase pim-2	0	0	4	4
Serine/threonine-protein kinase PAK 5	0	0	4	4
Serine/threonine-protein kinase 26	0	0	4	4
eIF-2-alpha kinase GCN2	0	0	4	4
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	0	0	4	4
Serine/threonine-protein kinase NLK	0	0	4	4
Phosphatidylinositol 4-kinase beta	0	0	4	4
Serine/threonine-protein kinase 17A	0	0	4	4
STE20/SPS1-related proline-alanine-rich protein kinase	0	0	4	4
Ephrin type-A receptor 6	0	0	4	4
5'-AMP-activated protein kinase subunit gamma-2	0	0	4	4
Serine/threonine-protein kinase TBK1	0	0	4	4
Septin-9	0	0	4	4
Death-associated protein kinase 2	0	0	4	4
Ribosomal protein S6 kinase alpha-6	0	0	4	4
TRAF2 and NCK-interacting protein kinase	0	0	4	4
Serine/threonine-protein kinase tousled-like 1	0	0	4	4
Serine/threonine-protein kinase TAO2	0	0	4	4
Long-chain-fatty-acid--CoA ligase 5	0	0	4	4
ALK tyrosine kinase receptor	0	0	4	4
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	4	1	5
SRSF protein kinase 3	0	0	4	4
Serine/threonine-protein kinase ICK	0	0	4	4
Cyclin-dependent kinase 11A	0	0	4	4
Aurora kinase C	0	0	4	4
Calcium/calmodulin-dependent protein kinase type II subunit alpha	0	0	4	4
RAC-gamma serine/threonine-protein kinase	0	0	4	4
Serine/threonine-protein kinase 38-like	0	0	4	4
Microtubule-associated serine/threonine-protein kinase 1	0	0	4	4
Serine/threonine-protein kinase SIK3	0	0	4	4
Mitogen-activated protein kinase kinase kinase 2	0	0	4	4
Thyroid hormone receptor-associated protein 3	0	0	4	4
Dual specificity tyrosine-phosphorylation-regulated kinase 1B	0	0	4	4
Mitogen-activated protein kinase kinase kinase kinase 5	0	0	4	4
Receptor-interacting serine/threonine-protein kinase 3	0	1	4	5
Serine/threonine-protein kinase MRCK beta	0	0	4	4
Interleukin-1 receptor-associated kinase 3	0	0	4	4
Serine/threonine-protein kinase 24	0	0	4	4
Casein kinase I isoform gamma-3	0	0	4	4
Mitogen-activated protein kinase kinase kinase 4	0	0	4	4
hypothetical protein, conserved	1	0	0	1
alpha-galactosidase	1	0	0	1
cytochrome P450 2C9 precursor	1	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	2	0	0	2
M-phase phosphoprotein 8	1	0	0	1
neuropeptide S receptor isoform A	1	0	0	1
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
SMAD family member 2	2	0	0	2
SMAD family member 3	2	0	0	2
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
DNA polymerase iota isoform a (long)	2	0	0	2
DNA repair protein RAD52 homolog isoform a	0	0	0	1
Cytochrome P450 3A5	0	1	0	2
Peptide deformylase 1A, chloroplastic/mitochondrial	0	1	0	1
Peptide deformylase	0	1	0	1
nuclear receptor subfamily 1, group I, member 2	2	0	0	2
Eukaryotic translation initiation factor 5B	0	0	2	2
Myosin-10	0	0	3	3
Choline-phosphate cytidylyltransferase A	0	0	2	2
Protein delta homolog 1	0	0	2	2
Serine/threonine-protein kinase ATR	0	0	3	3
Cyclin-dependent kinase 10	0	0	1	1
MAP kinase-activated protein kinase 3	0	0	2	2
ATP-dependent RNA helicase DHX30	0	0	3	3
Dual specificity testis-specific protein kinase 2	0	0	2	2
Poly [ADP-ribose] polymerase tankyrase-2	0	0	2	2
Type-1A angiotensin II receptor	0	1	0	1
Type-1B angiotensin II receptor	0	2	0	2
Type-2 angiotensin II receptor	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	1	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
Type-1 angiotensin II receptor	0	1	0	1
HLA class I histocompatibility antigen, A alpha chain	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	2	1	3
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Aminopeptidase	0	1	0	1
Chain A, Methionine aminopeptidase	0	1	0	1
S-ribosylhomocysteine lyase	0	1	0	1
Adenylate cyclase type 5	0	0	0	1
S-adenosylmethionine synthase isoform type-1	0	0	0	1
S-adenosylmethionine synthase isoform type-2	0	0	0	1
Fatty acid synthase	0	3	0	3
Large neutral amino acids transporter small subunit 1	0	4	0	5
Acetylcholinesterase	0	1	0	1
Cholinesterase	0	2	0	2
Acetylcholinesterase	0	2	0	2
Cholinesterase	0	1	0	1
Chain A, NAD-dependent deacetylase	0	1	0	1
Poly [ADP-ribose] polymerase 2	0	1	0	1
NAD-dependent histone deacetylase SIR2	0	1	0	1
Coagulation factor VII	0	1	0	1
Poly [ADP-ribose] polymerase 1	0	1	0	1
Tissue factor	0	1	0	1
NAD-dependent protein deacetylase HST2	0	1	0	1
Fatty-acid amide hydrolase 1	0	2	0	2
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
NAD(+) hydrolase SARM1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-2	0	1	0	1
NAD-dependent protein deacetylase sirtuin-6	0	1	0	1
NAD-dependent protein deacetylase sirtuin-1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-3, mitochondrial	0	1	0	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
NAD-dependent protein deacetylase	0	1	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	1	0	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	1	0	0	1
ClpP	1	0	0	1
Mcl-1	0	1	0	1
phosphopantetheinyl transferase	1	0	0	1
apical membrane antigen 1, AMA1	2	0	0	2
G	2	0	0	2
bromodomain adjacent to zinc finger domain 2B	1	0	0	1
vitamin D (1,25- dihydroxyvitamin D3) receptor	1	0	0	1
pyruvate kinase PKM isoform a	1	0	0	1
serine/threonine-protein kinase PLK1	2	0	0	2
cytochrome P450 3A4 isoform 1	1	0	0	1
Gamma-aminobutyric acid receptor subunit pi	1	0	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	1	0	1
HLA class I histocompatibility antigen, B alpha chain	2	0	0	2
Sodium/potassium-transporting ATPase subunit alpha-1	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-1	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-2	0	1	0	1
Bifunctional cytochrome P450/NADPH--P450 reductase	0	0	1	1
Gamma-aminobutyric acid receptor subunit beta-1	1	0	0	1
UDP-glucuronosyltransferase 2B7	0	1	0	1
Potassium-transporting ATPase subunit beta	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	1	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	1	0	0	1
Potassium-transporting ATPase alpha chain 1	0	1	0	1
UDP-glucuronosyltransferase 1-6	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	1	0	0	1
Potassium-transporting ATPase alpha chain 1	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-1	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	1	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	1	0	0	1
Bombesin receptor subtype-3	0	0	1	1
UDP-glucuronosyltransferase 2B10	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-2	0	1	0	1
Potassium-transporting ATPase subunit beta	0	1	0	1
Cytochrome P450 2J2	0	1	0	1
Potassium-transporting ATPase alpha chain 2	0	0	0	1
Sodium/potassium-transporting ATPase subunit beta-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit gamma	0	1	0	1
WD repeat-containing protein 5	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	1	0	0	1
Gamma-aminobutyric acid receptor subunit beta-3	1	0	0	1
Gamma-aminobutyric acid receptor subunit beta-2	1	0	0	1
Glutathione S-transferase omega-1	0	1	0	1
Histone-lysine N-methyltransferase 2A	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-4	0	1	0	1
Cytosolic endo-beta-N-acetylglucosaminidase	0	1	0	1
Muscarinic acetylcholine receptor	0	1	0	1
GABA theta subunit	1	0	0	1
Inositol hexakisphosphate kinase 1	2	0	0	2
Gamma-aminobutyric acid receptor subunit epsilon	1	0	0	1
cytochrome P450 2C9, partial	2	0	0	2
Cholecystokinin receptor type A	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	0	1	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Carbonic anhydrase 12	0	0	0	2
Plasma kallikrein	0	0	0	2
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Carbonic anhydrase 3	0	0	0	2
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
5'-nucleotidase	0	1	0	1
Carbonic anhydrase 4	0	0	0	2
Carbonic anhydrase 6	0	0	0	2
Adenosine receptor A1	0	0	0	2
Adenosine receptor A2a	0	0	0	2
Carbonic anhydrase 5A, mitochondrial	0	0	0	2
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase 7	0	1	0	3
Carbonic anhydrase	0	0	0	2
E3 ubiquitin-protein ligase XIAP	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	0	0	2
Glutamate receptor ionotropic, NMDA 2B	0	0	0	2
Glutamate receptor ionotropic, NMDA 2C	0	0	0	2
SLC16A10 protein	0	0	0	2
Carbonic anhydrase 9	0	1	0	3
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase-like protein, putative	0	0	0	2
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	0	0	2
Glutamate receptor ionotropic, NMDA 2D	0	0	0	2
Large neutral amino acids transporter small subunit 1	0	1	0	1
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase 13	0	0	0	1
Glutamate receptor ionotropic, NMDA 3B	0	0	0	2
Monocarboxylate transporter 10	0	0	0	2
Carbonic anhydrase 15	0	0	0	2
Carbonic anhydrase 13	0	0	0	1
Glutamate receptor ionotropic, NMDA 3A	0	0	0	2
Carbonic anhydrase 14	0	0	0	2
Phospholipase A-2-activating protein	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	0	0	2
Growth factor receptor-bound protein 2	0	0	0	1
Tyrosine-protein phosphatase non-receptor type 11	0	0	0	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2	0	1	0	1
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2	0	1	0	1
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2	0	1	0	1
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2	0	1	0	1
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2	0	1	0	1
melanocortin receptor 4	0	1	1	2
Membrane-associated progesterone receptor component 1	0	0	2	2
Tyrosine-protein kinase ABL1	0	1	0	1
Platelet-derived growth factor receptor beta	0	1	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
G1/S-specific cyclin-D1	0	1	0	1
Cyclin-C	0	1	1	2
Serine/threonine-protein kinase B-raf	0	1	0	1
Sodium-dependent serotonin transporter	0	1	0	1
Delta-type opioid receptor	0	0	1	1
Bifunctional epoxide hydrolase 2	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
Vascular endothelial growth factor receptor 3	0	1	0	1
Vascular endothelial growth factor receptor 2	0	1	0	1
5-hydroxytryptamine receptor 5A	0	1	0	1
Vascular endothelial growth factor receptor 2	0	1	0	1
Rab-like protein 3	0	0	2	2
RuvB-like 2	0	1	1	2
RuvB-like 1	0	1	0	1
DNA polymerase kappa isoform 1	2	0	0	2
Neuromedin-K receptor	0	0	1	1
Substance-K receptor	0	1	1	2
Substance-K receptor	0	2	0	2
Substance-P receptor	0	2	1	3
Neuromedin-K receptor	0	1	1	2
Substance-P receptor	0	1	0	1
Substance-K receptor	0	1	0	1
D(2) dopamine receptor	0	0	1	1
Substance-K receptor	0	1	0	1
Growth hormone secretagogue receptor type 1	0	0	1	1
Mas-related G-protein coupled receptor member X2	0	0	1	1
90-kda heat shock protein beta HSP90 beta, partial	0	1	0	1
estrogen receptor beta isoform 1	0	1	0	1
heat shock protein HSP 90-alpha isoform 2	0	1	0	1
tyrosine-protein phosphatase non-receptor type 7 isoform 2	0	1	0	1
Dihydroxyacetone phosphate acyltransferase	0	0	0	1
30S ribosomal protein S6	0	1	0	1
30S ribosomal protein S7	0	1	0	1
50S ribosomal protein L15	0	1	0	1
Tetracycline resistance protein, class B	0	0	0	1
72 kDa type IV collagenase	0	1	0	1
Stromelysin-1	0	1	0	1
50S ribosomal protein L10	0	1	0	1
50S ribosomal protein L11	0	1	0	1
50S ribosomal protein L7/L12	0	1	0	1
50S ribosomal protein L19	0	1	0	1
50S ribosomal protein L1	0	1	0	1
50S ribosomal protein L20	0	1	0	1
50S ribosomal protein L27	0	1	0	1
50S ribosomal protein L28	0	1	0	1
50S ribosomal protein L29	0	1	0	1
50S ribosomal protein L31	0	1	0	1
50S ribosomal protein L31 type B	0	1	0	1
50S ribosomal protein L32	0	1	0	1
50S ribosomal protein L33	0	1	0	1
50S ribosomal protein L34	0	1	0	1
50S ribosomal protein L35	0	1	0	1
50S ribosomal protein L36	0	1	0	1
30S ribosomal protein S10	0	1	0	1
30S ribosomal protein S11	0	1	0	1
30S ribosomal protein S12	0	1	0	1
30S ribosomal protein S13	0	1	0	1
30S ribosomal protein S16	0	1	0	1
30S ribosomal protein S18	0	1	0	1
30S ribosomal protein S19	0	1	0	1
30S ribosomal protein S20	0	1	0	1
30S ribosomal protein S2	0	1	0	1
30S ribosomal protein S3	0	1	0	1
30S ribosomal protein S4	0	1	0	1
30S ribosomal protein S5	0	1	0	1
30S ribosomal protein S8	0	1	0	1
30S ribosomal protein S9	0	1	0	1
50S ribosomal protein L13	0	1	0	1
50S ribosomal protein L14	0	1	0	1
50S ribosomal protein L16	0	1	0	1
50S ribosomal protein L23	0	1	0	1
30S ribosomal protein S15	0	1	0	1
Multidrug transporter MdfA	0	1	0	1
50S ribosomal protein L17	0	1	0	1
50S ribosomal protein L21	0	1	0	1
50S ribosomal protein L30	0	1	0	1
50S ribosomal protein L6	0	1	0	1
30S ribosomal protein S14	0	1	0	1
30S ribosomal protein S17	0	1	0	1
30S ribosomal protein S1	0	1	0	1
50S ribosomal protein L18	0	1	0	1
Alpha-1B adrenergic receptor	0	1	0	1
Neutrophil collagenase	0	1	0	1
Alpha-1D adrenergic receptor	0	1	0	1
Collagenase 3	0	1	0	1
Cannabinoid receptor 1	0	1	0	1
50S ribosomal protein L2	0	1	0	1
50S ribosomal protein L3	0	1	0	1
50S ribosomal protein L24	0	1	0	1
50S ribosomal protein L4	0	1	0	1
50S ribosomal protein L22	0	1	0	1
50S ribosomal protein L5	0	1	0	1
30S ribosomal protein S21	0	1	0	1
50S ribosomal protein L25	0	1	0	1
50S ribosomal protein L36 2	0	1	0	1
Integrase	0	1	0	1
Solute carrier family 22 member 8	0	0	0	1
P2Y purinoceptor 12	0	1	0	1
Solute carrier family 22 member 11	0	0	0	1
Protein-arginine deiminase type-4	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	1	0	0	1
DNA polymerase eta isoform 1	1	0	0	1
Solute carrier organic anion transporter family member 1A4	0	0	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Solute carrier organic anion transporter family member 1A5	0	0	0	1
Transthyretin	0	1	0	2
Thyroid hormone receptor alpha	0	0	1	1
Thyroid hormone receptor beta	0	0	1	1
Proliferating cell nuclear antigen	0	1	0	1
Peroxisome proliferator-activated receptor gamma	0	0	2	2
Malate dehydrogenase, mitochondrial	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	0	0	1
Solute carrier organic anion transporter family member 1A3	0	0	0	1
Solute carrier organic anion transporter family member 4C1	0	1	0	1
Monocarboxylate transporter 8	0	0	0	1
Bile acid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1C1	0	0	0	1
Solute carrier organic anion transporter family member 1B1	0	0	0	1
Chain A, CHORISMATE MUTASE	0	1	0	1
Chain A, TYROSYL-tRNA SYNTHETASE	0	0	1	1
Polyphenol oxidase 2	0	0	0	1
Tubulin--tyrosine ligase	0	1	0	1
Taste receptor type 2 member 14	0	0	0	1
Chain A, Arginase 1	0	1	0	1
Histone deacetylase 3	0	1	0	1
Kinesin-1 heavy chain	0	1	0	1
Histone deacetylase 4	0	1	0	1
Histone deacetylase 1	0	1	0	1
Coiled-coil domain-containing protein 6	0	1	0	1
Tubulin beta-2B chain	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
Histone deacetylase 7	0	1	0	1
Histone deacetylase 2	0	1	0	1
Polyamine deacetylase HDAC10	0	1	0	1
Histone deacetylase 11	0	1	0	1
Histone deacetylase 8	0	1	0	1
Histone deacetylase 6	0	1	0	1
Histone deacetylase 9	0	1	0	1
Histone deacetylase 5	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(16)

Research Excerpts

Overview

Context

Research

Studies (72)

Protein Targets (1,076)

MEA 2b

Synonyms(16)

Research Excerpts

Overview

Context

Research

Studies (72)

Drugs Studied (56)

Protein Targets (1,076)