bromochlorodifluoromethane profile

Bromochlorodifluoromethane (BCF) is a colorless gas with a slightly sweet odor. It is a synthetic compound that was once widely used as a refrigerant and propellant. BCF is highly stable and unreactive, which made it ideal for these applications. However, due to its contribution to ozone depletion, BCF has been phased out and is no longer produced. It can be synthesized by reacting chlorodifluoromethane with bromine under UV light or by reacting bromoform with chlorine and fluorine. BCF is highly toxic and can cause severe health effects, including respiratory problems, liver damage, and cancer. It is also a potent greenhouse gas and contributes to climate change. Research on BCF has focused on its environmental impact, particularly its role in ozone depletion, as well as its potential for remediation and replacement with safer alternatives. The study of BCF has been crucial for understanding the impact of human-made chemicals on the environment and for developing alternative technologies that minimize environmental damage.'
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bromochlorodifluoromethane : A one-carbon compound that is methane in which the hydrogens have been replaced by two fluorines, a bromine, and a chlorine. Widely used in 'vapourising liquid'-type fire extinguishers, its use is now generally banned under the Montreal Protocol (ozone-depleting substances), although it is still used in certain applications (e.g. aviation). [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

ID Source	ID
PubMed CID	9625
CHEBI ID	84698
SCHEMBL ID	288
MeSH ID	M0114589

Synonym
bromochlorodifluoromethane
methane, bromochlorodifluoro-
bromo(chloro)difluoromethane
353-59-3
daiflon 12b1
flugex 12b1
BCF ,
fluorocarbon 1211
einecs 206-537-9
hsdb 6784
un1974
halon-1211
dwufluorochlorobromometan [polish]
chlorodifluoromonobromomethane
brn 1732514
chlorodifluobromometano [spanish]
ccris 5663
halon 1211
freon 12b1
r 12b1
bromo-chloro-difluoromethane
AKOS006237189
chlorodifluorobromomethane or refrigerant gas r 12b1
unii-91i5x8ajxs
dwufluorochlorobromometan
chlorodifluorobromomethane or refrigerant gas r 12b1 [un1974] [nonflammable gas]
4-01-00-00075 (beilstein handbook reference)
chlorodifluobromometano
91i5x8ajxs ,
bromochlorodifluoromethane [mart.]
bromochlorodifluoromethane [hsdb]
difluorochlorobromomethane
SCHEMBL288
bromo-chloro-difluoro-methane
refrigerant gas r 12b1
monobromomonochlorodifluoromethane
CHEBI:84698
difluorobromochloromethane
cf2brcl
r 12 b1
chlorobromodifluoromethane
chlorodifluorobromomethane
un 1974
DTXSID0027147
mfcd00042122
bromochlorodifluoromethane 100 microg/ml in methanol
Q419723

Excerpt	Reference	Relevance
"Bromochlorodifluoromethane (Halon 1211) is a widely used fire extinguishing agent. "	( Fatal accidental inhalation of bromochlorodifluoromethane (Halon 1211). Almog, S; Danon, Y; Lerman, Y; Tirosh, MS; Winkler, E, 1991)	2.01

Class	Description
one-carbon compound	An organic molecular entity containing a single carbon atom (C1).
organobromine compound	A compound containing at least one carbon-bromine bond.
organochlorine compound	An organochlorine compound is a compound containing at least one carbon-chlorine bond.
organofluorine compound	An organofluorine compound is a compound containing at least one carbon-fluorine bond.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	10 (52.63)	18.7374
1990's	5 (26.32)	18.2507
2000's	4 (21.05)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	1 (5.00%)	5.53%
Reviews	1 (5.00%)	6.00%
Case Studies	8 (40.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	10 (50.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
hydrogen Hydrogen: The first chemical element in the periodic table with atomic symbol H, and atomic number 1. Protium (atomic weight 1) is by far the most common hydrogen isotope. Hydrogen also exists as the stable isotope DEUTERIUM (atomic weight 2) and the radioactive isotope TRITIUM (atomic weight 3). Hydrogen forms into a diatomic molecule at room temperature and appears as a highly flammable colorless and odorless gas.. dihydrogen : An elemental molecule consisting of two hydrogens joined by a single bond.	2.02	1	elemental hydrogen; elemental molecule; gas molecular entity	antioxidant; electron donor; food packaging gas; fuel; human metabolite
bromotrifluoromethane [no description available]	3.79	3
dichlorodifluoromethane dichlorodifluoromethane: refrigerant,aerosol propellant	2.03	1
2,2-dichloro-1,1,1-trifluoroethane 2,2-dichloro-1,1,1-trifluoroethane: structure given in first source. hydrochlorofluorocarbon : An organochlorine compound derived from methane, ethane or propane that contains atoms of hydrogen, chlorine, fluorine, and carbon only.	1.98	1
perflexane perfluorohexane : A fluoroalkane that is hexane in which all of the hydrogens have been replaced by fluorines.	1.98	1	fluoroalkane; fluorocarbon; volatile organic compound	non-polar solvent; radioopaque medium
trifluoroiodomethane [no description available]	1.99	1
1,1,1,2-tetrafluoro-2-chloroethane 1,1,1,2-tetrafluoro-2-chloroethane: refrigerant	1.98	1
ozone Ozone: The unstable triatomic form of oxygen, O3. It is a powerful oxidant that is produced for various chemical and industrial uses. Its production is also catalyzed in the ATMOSPHERE by ULTRAVIOLET RAY irradiation of oxygen or other ozone precursors such as VOLATILE ORGANIC COMPOUNDS and NITROGEN OXIDES. About 90% of the ozone in the atmosphere exists in the stratosphere (STRATOSPHERIC OZONE).. ozone : An elemental molecule with formula O3. An explosive, pale blue gas (b.p. -112degreeC) that has a characteristic, pungent odour, it is continuously produced in the upper atmosphere by the action of solar ultraviolet radiation on atmospheric oxygen. It is an antimicrobial agent used in the production of bottled water, as well as in the treatment of meat, poultry and other foodstuffs.	1.97	1	elemental molecule; gas molecular entity; reactive oxygen species; triatomic oxygen	antiseptic drug; disinfectant; electrophilic reagent; greenhouse gas; mutagen; oxidising agent; tracer

Condition	Relationship Strength	Studies	Trials
Asthma, Bronchial [description not available]	2.02	1	0
Diseases, Occupational [description not available]	2.39	2	0
Symptom Cluster [description not available]	2.02	1	0
Asthma A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).	2.02	1	0
Syndrome A characteristic symptom complex.	7.02	1	0
Bronchial Hyperreactivity Tendency of the smooth muscle of the tracheobronchial tree to contract more intensely in response to a given stimulus than it does in the response seen in normal individuals. This condition is present in virtually all symptomatic patients with asthma. The most prominent manifestation of this smooth muscle contraction is a decrease in airway caliber that can be readily measured in the pulmonary function laboratory.	2.02	1	0
Chemical Dependence [description not available]	2.66	3	0
Cerebral Ischemia [description not available]	1.96	1	0
Death, Sudden The abrupt cessation of all vital bodily functions, manifested by the permanent loss of total cerebral, respiratory, and cardiovascular functions.	2.37	2	0
Brain Ischemia Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.	1.96	1	0
Ventricular Fibrillation A potentially lethal cardiac arrhythmia that is characterized by uncoordinated extremely rapid firing of electrical impulses (400-600/min) in HEART VENTRICLES. Such asynchronous ventricular quivering or fibrillation prevents any effective cardiac output and results in unconsciousness (SYNCOPE). It is one of the major electrocardiographic patterns seen with CARDIAC ARREST.	2.38	2	0
Substance-Related Disorders Disorders related to substance use or abuse.	2.66	3	0
Atrial Ectopic Tachycardia [description not available]	1.99	1	0
Arrhythmia [description not available]	3.77	2	1
Frostbite Damage to tissues as the result of low environmental temperatures.	1.99	1	0
Arrhythmias, Cardiac Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.	3.77	2	1
Poisoning Used with drugs, chemicals, and industrial materials for human or animal poisoning, acute or chronic, whether the poisoning is accidental, occupational, suicidal, by medication error, or by environmental exposure.	1.99	1	0
Blood Pressure, High [description not available]	3.36	1	1
Hypertension Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.	3.36	1	1
Carcinoma, Epidermoid [description not available]	1.97	1	0
Malignant Melanoma [description not available]	1.97	1	0
Cancer, Radiation-Induced [description not available]	1.97	1	0
Cancer of Skin [description not available]	1.97	1	0
Carcinoma, Squamous Cell A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)	1.97	1	0
Melanoma A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)	1.97	1	0
Skin Neoplasms Tumors or cancer of the SKIN.	1.97	1	0
Diathesis [description not available]	1.97	1	0
Anesthesia Related Hyperthermia [description not available]	1.97	1	0
Rhabdomyolysis Necrosis or disintegration of skeletal muscle often followed by myoglobinuria.	1.97	1	0
Abnormalities, Drug-Induced Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment.	1.97	1	0
Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	1.97	1	0
Leukemia L5178 An experimental lymphocytic leukemia of mice.	1.96	1	0

bromochlorodifluoromethane

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