amitriptyline has been researched along with Myotonia in 2 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
Myotonia: Prolonged failure of muscle relaxation after contraction. This may occur after voluntary contractions, muscle percussion, or electrical stimulation of the muscle. Myotonia is a characteristic feature of MYOTONIC DISORDERS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Amitriptyline, a tricyclic antidepressant, has been reported to diminish signs of human myotonic muscular dystrophy, but has not been examined in other myotonias." | 7.68 | Lack of effect of amitriptyline in murine myotonia. ( Carter, GT; Entrikin, RK; Longley, KJ; Walsh, SA, 1992) |
| "Amitriptyline, a tricyclic antidepressant, has been reported to diminish signs of human myotonic muscular dystrophy, but has not been examined in other myotonias." | 3.68 | Lack of effect of amitriptyline in murine myotonia. ( Carter, GT; Entrikin, RK; Longley, KJ; Walsh, SA, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bissay, V | 1 |
| Keymolen, K | 1 |
| Lissens, W | 1 |
| Laureys, G | 1 |
| Schmedding, E | 1 |
| De Keyser, J | 1 |
| Carter, GT | 1 |
| Longley, KJ | 1 |
| Walsh, SA | 1 |
| Entrikin, RK | 1 |
2 other studies available for amitriptyline and Myotonia
| Article | Year |
|---|---|
Late onset painful cold-aggravated myotonia: three families with SCN4A L1436P mutation.
Topics: Acetazolamide; Adult; Age of Onset; Aged; Aged, 80 and over; Amitriptyline; Anticonvulsants; Belgium | 2011 |
Lack of effect of amitriptyline in murine myotonia.
Topics: Amitriptyline; Animals; Behavior, Animal; Electromyography; Mice; Mice, Inbred Strains; Muscle Contr | 1992 |