flecainide has been researched along with Myotonia in 2 studies
Flecainide: A potent anti-arrhythmia agent, effective in a wide range of ventricular and atrial ARRHYTHMIAS and TACHYCARDIAS.
flecainide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 2,5-bis(2,2,2-trifluoroethoxy)benzoic acid with the primary amino group of piperidin-2-ylmethylamine. An antiarrhythmic agent used (in the form of its acetate salt) to prevent and treat tachyarrhythmia (abnormal fast rhythm of the heart).
Myotonia: Prolonged failure of muscle relaxation after contraction. This may occur after voluntary contractions, muscle percussion, or electrical stimulation of the muscle. Myotonia is a characteristic feature of MYOTONIC DISORDERS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Flecainide, a class Ic antiarrhythmic drug, has been anecdotally reported to improve myotonia, but little is known about its kinetics on human skeletal muscle sodium channels applicable in vivo." | 3.73 | Class Ic antiarrhythmics block human skeletal muscle Na channel during myotonia-like stimulation. ( Aoike, F; Sakoda, S; Takahashi, MP, 2006) |
| "Flecainide, a class IC antiarrhythmic, was shown to improve myotonia caused by sodium channel mutations in situations where the class IB antiarrhythmic drug mexiletine was less efficient." | 3.72 | Different flecainide sensitivity of hNav1.4 channels and myotonic mutants explained by state-dependent block. ( Camerino Conte, D; De Luca, A; Desaphy, JF; Didonna, MP; George, AL; Luca, AD, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Desaphy, JF | 1 |
| De Luca, A | 1 |
| Didonna, MP | 1 |
| George, AL | 1 |
| Camerino Conte, D | 1 |
| Luca, AD | 1 |
| Aoike, F | 1 |
| Takahashi, MP | 1 |
| Sakoda, S | 1 |
2 other studies available for flecainide and Myotonia
| Article | Year |
|---|---|
Different flecainide sensitivity of hNav1.4 channels and myotonic mutants explained by state-dependent block.
Topics: Dose-Response Relationship, Drug; Flecainide; Humans; Ion Channel Gating; Muscle Proteins; Mutation; | 2004 |
Class Ic antiarrhythmics block human skeletal muscle Na channel during myotonia-like stimulation.
Topics: Anti-Arrhythmia Agents; Cell Line; Dose-Response Relationship, Drug; Flecainide; Humans; Ion Channel | 2006 |