9-anthroic acid has been researched along with Myotonia in 13 studies
9-anthroic acid: RN given refers to unlabeled parent cpd; chloride channel blocker; do not confuse with c-ANCA (anti-neutrophil cytoplasmic antibodies) which is frequently abbreviated as ANCA
9-anthroic acid : An anthroic acid carrying the carboxy substituent at position 9.
Myotonia: Prolonged failure of muscle relaxation after contraction. This may occur after voluntary contractions, muscle percussion, or electrical stimulation of the muscle. Myotonia is a characteristic feature of MYOTONIC DISORDERS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "These findings suggest that lamotrigine and rufinamide could be considered for anti-myotonic treatment in myotonia congenita." | 7.85 | The anti-convulsants lacosamide, lamotrigine, and rufinamide reduce myotonia in isolated human and rat skeletal muscle. ( de Paoli, FV; Nielsen, OB; Pedersen, TH; Skov, M, 2017) |
| "The authors' in vitro data imply that propofol administration for general anesthesia may be better suited for patients with chloride channel myotonia versus volatile anesthetics." | 7.75 | In vitro effects of propofol and volatile agents on pharmacologically induced chloride channel myotonia. ( Bandschapp, O; Ginz, HF; Girard, T; Iaizzo, PA; Soule, CL; Urwyler, A, 2009) |
| "These findings suggest that lamotrigine and rufinamide could be considered for anti-myotonic treatment in myotonia congenita." | 3.85 | The anti-convulsants lacosamide, lamotrigine, and rufinamide reduce myotonia in isolated human and rat skeletal muscle. ( de Paoli, FV; Nielsen, OB; Pedersen, TH; Skov, M, 2017) |
| "The authors' in vitro data imply that propofol administration for general anesthesia may be better suited for patients with chloride channel myotonia versus volatile anesthetics." | 3.75 | In vitro effects of propofol and volatile agents on pharmacologically induced chloride channel myotonia. ( Bandschapp, O; Ginz, HF; Girard, T; Iaizzo, PA; Soule, CL; Urwyler, A, 2009) |
| "The myotonia-inducing effects of furosemide and clofibrate, two widely used pharmaceutical agents, were investigated in excised human external intercostal muscle." | 3.67 | Drug-induced myotonia in human intercostal muscle. ( Kwieciński, H; Lehmann-Horn, F; Rüdel, R, 1988) |
| "Myotonia was induced by ClC-1 inhibition using 9-anthracene carboxylic acid (9-AC) and was assessed from integrals of force induced by 5-Hz stimulation for 2 seconds." | 1.42 | Extracellular magnesium and calcium reduce myotonia in isolated ClC-1 chloride channel-inhibited human muscle. ( De Paoli, FV; Lausten, J; Nielsen, OB; Pedersen, TH; Skov, M, 2015) |
| "Slowed muscle relaxation is the contractile hallmark of myotonia congenita, a disease caused by genetic CLC-1 chloride channel deficiency, which improves with antecedent brief contractions ("warm-up phenomenon")." | 1.37 | Fatigue-inducing stimulation resolves myotonia in a drug-induced model. ( Moyer, M; Spiegler, SE; van Lunteren, E, 2011) |
| "A model myotonia was induced in the muscles in vitro, using either the chloride channel blocker anthracene-9-carboxylic acid or chloride-free Krebs solution." | 1.30 | Effect of temperature reduction on myotonia in rat skeletal muscles in vitro. ( Fanning, L; MacDermott, M, 1997) |
| " Other pharmacokinetic parameters are: t1/2 alpha = 2." | 1.27 | Pharmacokinetics of anthracene-9-carboxylic acid, a potent myotonia-inducer. ( Martinez-Morales, M; Morales-Aguilera, A; Villegas-Navarro, A, 1986) |
| "Hitherto, myotonia has been considered peculiar to homeotherms where it is associated with several hereditable diseases and can be induced by specific treatments, most of which seem to act by decreasing membrane chloride conductance." | 1.26 | Chemically induced myotonia in amphibia. ( Bretag, AH; Dawe, SR; Moskwa, AG, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (30.77) | 18.7374 |
| 1990's | 4 (30.77) | 18.2507 |
| 2000's | 1 (7.69) | 29.6817 |
| 2010's | 4 (30.77) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Skov, M | 2 |
| De Paoli, FV | 2 |
| Lausten, J | 1 |
| Nielsen, OB | 2 |
| Pedersen, TH | 2 |
| Bandschapp, O | 2 |
| Ginz, HF | 1 |
| Soule, CL | 2 |
| Girard, T | 1 |
| Urwyler, A | 1 |
| Iaizzo, PA | 3 |
| van Lunteren, E | 1 |
| Spiegler, SE | 1 |
| Moyer, M | 1 |
| Bretag, AH | 1 |
| Dawe, SR | 1 |
| Moskwa, AG | 1 |
| Fanning, L | 1 |
| MacDermott, M | 1 |
| Coonan, JR | 1 |
| Lamb, GD | 1 |
| Villegas-Navarro, A | 2 |
| Bustos, E | 1 |
| González, A | 1 |
| Salazar, S | 1 |
| Jiménez, Z | 1 |
| Solis, JG | 1 |
| Mercado, R | 1 |
| González, G | 1 |
| Reyes, JL | 1 |
| Dieck, TA | 1 |
| Lehmann-Horn, F | 3 |
| Kwieciński, H | 1 |
| Rüdel, R | 2 |
| Martinez-Morales, M | 1 |
| Morales-Aguilera, A | 1 |
1 review available for 9-anthroic acid and Myotonia
| Article | Year |
|---|---|
Membrane changes in cells from myotonia patients.
Topics: Action Potentials; Adenosine Triphosphatases; Anthracenes; Chlorides; Electromyography; Environment; | 1985 |
12 other studies available for 9-anthroic acid and Myotonia
| Article | Year |
|---|---|
Extracellular magnesium and calcium reduce myotonia in isolated ClC-1 chloride channel-inhibited human muscle.
Topics: Adult; Aged; Aged, 80 and over; Anthracenes; Area Under Curve; Biophysics; Calcium; Chloride Channel | 2015 |
The anti-convulsants lacosamide, lamotrigine, and rufinamide reduce myotonia in isolated human and rat skeletal muscle.
Topics: Acetamides; Animals; Anthracenes; Anticonvulsants; Area Under Curve; Dose-Response Relationship, Dru | 2017 |
In vitro effects of propofol and volatile agents on pharmacologically induced chloride channel myotonia.
Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Anthracenes; Chloride Channels; Dose-Res | 2009 |
Fatigue-inducing stimulation resolves myotonia in a drug-induced model.
Topics: Animals; Anthracenes; Chloride Channels; Diaphragm; Electric Stimulation; Male; Muscle Contraction; | 2011 |
Lactic acid restores skeletal muscle force in an in vitro fatigue model: are voltage-gated chloride channels involved?
Topics: Animals; Anthracenes; Chloride Channels; Epinephrine; Humans; Lactic Acid; Male; Muscle Contraction; | 2012 |
Chemically induced myotonia in amphibia.
Topics: Amphibians; Animals; Anthracenes; Anura; Bufo marinus; Carboxylic Acids; Chlorides; Electric Conduct | 1980 |
Effect of temperature reduction on myotonia in rat skeletal muscles in vitro.
Topics: Animals; Anthracenes; Chloride Channels; Cryotherapy; Electromyography; In Vitro Techniques; Isotoni | 1997 |
Effect of transverse-tubular chloride conductance on excitability in skinned skeletal muscle fibres of rat and toad.
Topics: Animals; Anthracenes; Bufo marinus; Chloride Channels; Chlorides; In Vitro Techniques; Membrane Pote | 1998 |
Effect of myotonia induced by anthracene-9-carboxylic acid on mitochondrial calcium, plasma creatinine-phosphokinase and aldolase activity in the rat.
Topics: Animals; Anthracenes; Calcium; Creatine Kinase; Diet; Fructose-Bisphosphate Aldolase; Male; Mitochon | 1992 |
The correlation between electrical after-activity and slowed relaxation in myotonia.
Topics: Anthracenes; Biopsy; Electromyography; Electrophysiology; Humans; In Vitro Techniques; Male; Muscle | 1990 |
Drug-induced myotonia in human intercostal muscle.
Topics: Anthracenes; Chlorides; Clofibrate; Furosemide; Humans; In Vitro Techniques; Intercostal Muscles; Io | 1988 |
Pharmacokinetics of anthracene-9-carboxylic acid, a potent myotonia-inducer.
Topics: Animals; Anthracenes; Blood Proteins; Erythrocytes; Hematocrit; Kinetics; Male; Models, Biological; | 1986 |