pterostilbene has been researched along with Breast-Neoplasms* in 2 studies
2 other study(ies) available for pterostilbene and Breast-Neoplasms
| Article | Year |
|---|---|
Discovery of STAT3 and Histone Deacetylase (HDAC) Dual-Pathway Inhibitors for the Treatment of Solid Cancer.
Nowadays, simultaneous inhibition of multiple targets through drug combination is an important anticancer strategy owing to the complex mechanism behind tumorigenesis. Recent studies have demonstrated that the inhibition of histone deacetylases (HDACs) will lead to compensated activation of a notorious cancer-related drug target, signal transducer and activator of transcription 3 (STAT3), in breast cancer through a cascade, which probably limits the anti-proliferation effect of HDAC inhibitors in solid tumors. By incorporating the pharmacophore of the HDAC inhibitor SAHA (vorinostat) into the STAT3 inhibitor pterostilbene, a series of potent pterostilbene hydroxamic acid derivatives with dual-target inhibition activity were synthesized. An excellent hydroxamate derivate, compound Topics: Animals; Antineoplastic Agents; Binding Sites; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Female; Half-Life; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; Molecular Docking Simulation; Rats; Rats, Sprague-Dawley; STAT3 Transcription Factor; Stilbenes; Structure-Activity Relationship; Vorinostat | 2021 |
Synthesis of a resveratrol analogue with high ceramide-mediated proapoptotic activity on human breast cancer cells.
Resveratrol, a natural product with a stilbene structure, exerts profound proapoptotic activity in human cancer cells, by triggering the accumulation of ceramide, a bioactive sphingolipid. We studied the biological effects of seven methoxylated and/or naphthalene-based resveratrol analogues and compared these compounds with resveratrol with the objective to identify an analogue with higher ceramide-mediated proapoptotic activity relative to resveratrol. Here we show that the compound with three hydroxyls and a naphthalene ring is the most effective in triggering apoptosis coupled to the induction of endogenous ceramide in human cancer cells. Topics: Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Ceramides; Drug Screening Assays, Antitumor; Female; Humans; Resveratrol; Stilbenes; Structure-Activity Relationship | 2005 |