Target type: molecularfunction
Enables the transmembrane transfer of an ion by a channel that opens in response to a temperature stimulus (e.g. exposure to a temperature range different than the optimal temperature for that organism). [GOC:ha, GOC:pr, PMID:23027824]
Temperature-gated ion channels are transmembrane proteins that mediate the flow of ions across cell membranes in response to changes in temperature. They are crucial for a wide range of physiological processes, including thermoregulation, sensory perception, and neuronal excitability. The molecular function of temperature-gated ion channels can be described as follows:
1. **Temperature Sensing:** These channels possess specific domains that act as temperature sensors. These domains undergo conformational changes in response to temperature fluctuations, leading to alterations in the channel's structure and function.
2. **Gate Opening and Closing:** Upon reaching a specific threshold temperature, the temperature sensor triggers a conformational change in the channel protein, causing the gate to open or close. This opening allows ions to pass through the channel, while closure prevents ion flow.
3. **Ion Selectivity:** Each type of temperature-gated ion channel exhibits selectivity for specific ions, such as sodium, potassium, calcium, or chloride. This selectivity is determined by the channel's structure and the interactions between the ion and the channel's pore.
4. **Signal Transduction:** The influx or efflux of ions through temperature-gated channels initiates a cascade of downstream signaling events. These signals can modulate various cellular processes, such as membrane potential changes, enzyme activation, gene expression, and neurotransmitter release.
5. **Thermoregulation:** Temperature-gated ion channels play a critical role in thermoregulation by sensing changes in body temperature and triggering appropriate physiological responses. For example, in response to cold temperatures, these channels may open to increase ion permeability and generate heat.
6. **Sensory Perception:** These channels are responsible for detecting temperature changes in the environment, providing us with the sensation of hot and cold. They are found in sensory neurons, where they transduce thermal stimuli into electrical signals that are transmitted to the brain.
7. **Neuronal Excitability:** Temperature-gated ion channels contribute to neuronal excitability by modulating the flow of ions across the neuronal membrane. This modulation can alter the firing rate of neurons and influence the transmission of signals within the nervous system.
In summary, temperature-gated ion channels are integral to a diverse range of physiological functions, acting as molecular sensors and mediators of thermal signals. Their intricate molecular mechanisms enable them to regulate ion flow, initiate signal transduction pathways, and contribute to essential processes such as thermoregulation, sensory perception, and neuronal excitability.'
"
Protein | Definition | Taxonomy |
---|---|---|
Transient receptor potential cation channel subfamily V member 1 | A transient receptor potential cation channel TRPV1 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q8NER1] | Homo sapiens (human) |
Compound | Definition | Classes | Roles |
---|---|---|---|
2-aminoethoxydiphenyl borate | 2-aminoethoxydiphenyl borate: is a novel membrane-penetrable modulator and transient receptor potential channel blocker; structure in first source; do not confuse with 2-APB cpd 2-aminoethoxydiphenylborane : An organoboron compound that is diphenylborane in which the borane hydrogen is replaced by a 2-aminoethoxy group. | organoboron compound; primary amino compound | calcium channel blocker; IP3 receptor antagonist; potassium channel opener |
benzyl isothiocyanate | benzyl isothiocyanate: inhibits carcinogen-induced neoplasia; structure in Negwer, 5th ed, #715; also promotes urinary bladder carcinoma | benzenes; isothiocyanate | antibacterial drug |
cannabinol | Cannabinol: A physiologically inactive constituent of Cannabis sativa L. | dibenzopyran | |
palmidrol | palmidrol: a cannabinoid receptor-inactive eCB-related molecule used as prophylactic in helping to prevent respiratory viral infection palmitoyl ethanolamide : An N-(long-chain-acyl)ethanolamine that is the ethanolamide of palmitic (hexadecanoic) acid. | endocannabinoid; N-(long-chain-acyl)ethanolamine; N-(saturated fatty acyl)ethanolamine | anti-inflammatory drug; anticonvulsant; antihypertensive agent; neuroprotective agent |
allyl isothiocyanate | allyl isothiocyanate : An isothiocyanate with the formula CH2=CHCH2N=C=S. A colorless oil with boiling point 152degreeC, it is responsible for the pungent taste of mustard, horseradish, and wasabi. allyl isothiocyanate: used in the manufacture of flavors, war gases; medical use as a counterirritant; structure | alkenyl isothiocyanate; isothiocyanate | antimicrobial agent; antineoplastic agent; apoptosis inducer; lachrymator; metabolite |
citronellol | citronellol : A monoterpenoid that is oct-6-ene substituted by a hydroxy group at position 1 and methyl groups at positions 3 and 7. citronellol: alcohol form of citronellal; found in rose oil; RN given refers to parent cpd without isomeric designation; structure insect repellent : An insecticide that acts as a repellent to insects. | monoterpenoid | plant metabolite |
citronellyl acetate | citronellol acetate : A monoterpenoid that is the acetate ester of citronellol. It has been isolated from Citrus hystrix. citronellyl acetate: RN given refers to cpd without isomeric designation | acetate ester; monoterpenoid | plant metabolite |
phenethyl isothiocyanate | phenethyl isothiocyanate : An isothiocyanate having a phenethyl group attached to the nitrogen. It is a naturally occurring compound found in some cruciferous vegetables (e.g. watercress) and is known to possess anticancer properties. phenethyl isothiocyanate: a dietary liver aldehyde dehydrogenase inhibitor; promotes urinary bladder carcinoma | isothiocyanate | antineoplastic agent; EC 1.2.1.3 [aldehyde dehydrogenase (NAD(+))] inhibitor; metabolite |
cannabichromene | 1-benzopyran | ||
allicin | botanical anti-fungal agent; sulfoxide | antibacterial agent | |
voacamine | alkaloid ester; methyl ester; monoterpenoid indole alkaloid; organic heteropentacyclic compound; tertiary amino compound | angiogenesis inhibitor; antineoplastic agent; plant metabolite | |
(6ar-trans)-isomer of tetrahydrocannabivarin 9 | |||
cp-55,940 | |||
1,1'-biphenyl-4-yl-boronic acid | |||
4-hydroxybenzyl isothiocyanate | 4-hydroxybenzyl isothiocyanate: found in white mustard; structure in first source | phenols | |
Tetrahydropiperine | benzodioxoles | ||
geraniol | 3,7-dimethylocta-2,6-dien-1-ol; monoterpenoid; primary alcohol | allergen; fragrance; plant metabolite; volatile oil component | |
piperine | piperine : A N-acylpiperidine that is piperidine substituted by a (1E,3E)-1-(1,3-benzodioxol-5-yl)-5-oxopenta-1,3-dien-5-yl group at the nitrogen atom. It is an alkaloid isolated from the plant Piper nigrum. | benzodioxoles; N-acylpiperidine; piperidine alkaloid; tertiary carboxamide | food component; human blood serum metabolite; NF-kappaB inhibitor; plant metabolite |
ilepcimide | ilepcimide: structure given in first source; RN given refers to compound with no isomeric designation | benzodioxoles | |
nerol | nerol : The (2Z)-stereoisomer of 3,7-dimethylocta-2,6-dien-1-ol. It has been isolated from the essential oils from plants like lemon grass. | 3,7-dimethylocta-2,6-dien-1-ol | fragrance; plant metabolite; volatile oil component |
cannabidiol | cannabidiol : An cannabinoid that is cyclohexene which is substituted by a methyl group at position 1, a 2,6-dihydroxy-4-pentylphenyl group at position 3, and a prop-1-en-2-yl group at position 4. Cannabidiol: Compound isolated from Cannabis sativa extract. | olefinic compound; phytocannabinoid; resorcinols | antimicrobial agent; plant metabolite |
sb 366791 | N-(3-methoxyphenyl)-4-chlorocinnamanilide: a TRPV1 antagonist; structure in first source | ||
(e)-3-(4-t-butylphenyl)-n-(2,3-dihydrobenzo(b)(1,4)dioxin-6-yl)acrylamide | 3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo(b)(1,4)dioxin-6-yl)acrylamide: a vanilloid receptor 1 antagonist and antihyperalgesic agent; structure in first source | ||
hc 030031 | 2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide: a TRPA1 channel blocker | ||
zucapsaicin | methoxybenzenes; phenols | ||
capsaicin | ALGRX-4975: an injectable capsaicin (TRPV1 receptor agonist) formulation for longlasting pain relief capsaicinoid : A family of aromatic fatty amides produced as secondary metabolites by chilli peppers. | capsaicinoid | non-narcotic analgesic; TRPV1 agonist; voltage-gated sodium channel blocker |
geranyl acetate | geranyl acetate : A monoterpenoid that is the acetate ester derivative of geraniol. geranyl acetate: constituted about 90% of the palmarosa oil | acetate ester; monoterpenoid | plant metabolite |
capsazepine | capsazepine : A benzazepine that is 2,3,4,5-tetrahydro-1H-2-benzazepine which is substituted by hydroxy groups at positions 7 and 8 and on the nitrogen atom by a 2-(p-chlorophenyl)ethylaminothiocarbonyl group. A synthetic analogue of capsaicin, it was the first reported capsaicin receptor antagonist. capsazepine: modified capsaicin molecule; a capsaicin receptor antagonist | benzazepine; catechols; monochlorobenzenes; thioureas | capsaicin receptor antagonist |
phorbol 12-phenylacetate 13-acetate 20-homovanillate | phorbol 12-phenylacetate 13-acetate 20-homovanillate: behavior contrasts with resiniferatoxin and capsaicin in the lack of cooperativity in binding vanilloid (capsaicin) receptor | ||
6-iodonordihydrocapsaicin | 6-iodonordihydrocapsaicin: a TRPV1 antagonist | methoxybenzenes; phenols | |
pinosylvin | pinosylvin: phytoalexin found in pine and eucalyptus | pinosylvin | |
Pinosylvin methyl ether | stilbenoid | ||
pterostilbene | diether; methoxybenzenes; stilbenol | anti-inflammatory agent; antineoplastic agent; antioxidant; apoptosis inducer; hypoglycemic agent; neuroprotective agent; neurotransmitter; plant metabolite; radical scavenger | |
shogaol | shogaol: from ginger, ZINGIBER OFFICINALE; less mutagenic than GINGEROL; structure given in first source | enone; monomethoxybenzene; phenols | |
anandamide | anandamide : An N-acylethanolamine 20:4 resulting from the formal condensation of carboxy group of arachidonic acid with the amino group of ethanolamine. | endocannabinoid; N-acylethanolamine 20:4 | human blood serum metabolite; neurotransmitter; vasodilator agent |
arachidonyl dopamine | arachidonyl dopamine: a ligand for the vanilloid receptor VR1 | catechols; fatty amide; N-(fatty acyl)-dopamine; secondary carboxamide | |
4,4'-dihydroxystilbene | stilbene-4,4'-diol | ||
linoleoyl ethanolamide | linoleoyl ethanolamide : An N-acylethanolamine 18:2 that is the ethanolamide of linoleic acid. linoleoyl ethanolamide: RN given for (Z,Z)-isomer | N-acylethanolamine 18:2 | EC 3.5.1.99 (fatty acid amide hydrolase) inhibitor |
n-oleoylethanolamine | N-oleoylethanolamine: ceramidase inhibitor oleoyl ethanolamide : An N-(long-chain-acyl)ethanolamine that is the ethanolamide of oleic acid. The monounsaturated analogue of the endocannabinoid anandamide. | endocannabinoid; N-(long-chain-acyl)ethanolamine; N-acylethanolamine 18:1 | EC 3.5.1.23 (ceramidase) inhibitor; geroprotector; PPARalpha agonist |
4-hydroxystilbene | 4-hydroxystilbene: RN given refers to cpd without isomeric designation stilben-4-ol : A phenol having the structure of stilbene with a hydroxy function at C-4 of one of the phenyl rings; the stereochemistry across the alkene bond is not specified. | stilben-4-ol | |
olvanil | methoxybenzenes; phenols | ||
cannabigerol | cannabigerol : A member of the class of resorcinols that is resorcinol which is substituted by a (2E)-3,7-dimethylocta-2,6-dien-1-yl group at position 2 and by a pentyl group at position 5. It is a natural product found in Cannabis sativa and Helichrysum species. cannabigerol: RN given refers to (E)-isomer; structure given in first source | phytocannabinoid; resorcinols | anti-inflammatory agent; antibacterial agent; antioxidant; appetite enhancer; cannabinoid receptor agonist; neuroprotective agent; plant metabolite |
3,5-dimethoxy-trans-stilbene | 3,5-dimethoxystilbene: structure in first source | stilbenoid | |
albaconol | albaconol: from the mushroom Albatrellus; structure in first source | ||
Piperanine | benzodioxoles | ||
piperlonguminine | piperlonguminine: from Piper longum; structure in first source | benzodioxoles | |
3,4',5-trimethoxystilbene | 3,4',5-trimethoxystilbene: structure in first source | ||
catharanthine | alkaloid ester; bridged compound; methyl ester; monoterpenoid indole alkaloid; organic heteropentacyclic compound; tertiary amino compound | ||
iodoresiniferatoxin | iodoresiniferatoxin: a vanilloid receptor 1 antagonist | ||
arvanil | arvanil: structure in first source | methoxybenzenes; phenols | |
am 404 | anilide | ||
1-isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea | 1-isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea: structure in first source | ||
sb 705498 | SB 705498: structure in first source | ||
n-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2h)-carboxamide | N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide: a vanilloid receptor 1 antagonist and analgesic; structure in first source | piperazines; pyridines | |
arachidonoylserotonin | arachidonoylserotonin: an NSAID with antinociceptive activity; fatty acid amide hydrolase inhibitor; structure in first source N-arachidonoylserotonin : An N-acylserotonin obtained by formal condensation of the carboxy group of arachidonic acid with the primary amino group of serotonin. | N-acylserotonin; phenols | anti-inflammatory agent; anticonvulsant; antioxidant; capsaicin receptor antagonist; EC 3.5.1.99 (fatty acid amide hydrolase) inhibitor; human metabolite; signalling molecule |
jyl 1421 | JYL 1421: a vanilloid receptor antagonist; structure in first source | ||
abt 102 | ABT 102: a TRPV1 antagonist; structure in first source | ||
jnj 17203212 | |||
a 784168 | 1-(3-(trifluoromethyl)pyridin-2-yl)-N-(4-(trifluoromethylsulfonyl)phenyl)-1,2,3,6-tetrahydropyridine-4-carboxamide: a TRPV1 antagonist | ||
ly2183240 | LY2183240: structure in first source | biphenyls | |
methylphenidate | N-phenyl-4-(quinolin-2-ylmethyl)piperazine-1-carboxamide: a fatty acid amide hydrolase inhibitor; structure in first source | ||
cannabidivarin | cannabidivarin: from Cannabis sativa | monoterpenoid | |
amg 517 | |||
a 803467 | A 803467: an Nav1.8 sodium channel blocker; structure in first source | ||
mavatrep | mavatrep: a transient receptor potential vanilloid 1 antagonist; structure in first source | ||
am 6701 | |||
voacristine | voacristine: indole alkaloid from leaves of Ervatamia coronaria; RN given for 20(S)-isomer; structure given in first source | ||
abt 116 | ABT 116: a TRPV1 antagonist with analgesic activity; structure in first source |