Proceedings of the National Academy of Sciences of the United States of America, 2017, 02-21, Volume: 114, Issue:8
DNA methylation and specifically the DNA methyltransferase enzyme DNMT3A are involved in the pathogenesis of a variety of hematological diseases and in regulating the function of immune cells. Although altered DNA methylation patterns and mutations in Topics: Animals; Azacitidine; Cell Degranulation; Cell Proliferation; Cells, Cultured; Decitabine; Dermatitis, Contact; Disease Models, Animal; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3A; Down-Regulation; Enzyme-Linked Immunosorbent Assay; Epigenesis, Genetic; Female; Fluorescent Antibody Technique; Immunoglobulin E; Interleukin-3; Mast Cells; Mastocytosis, Systemic; Mice; Mice, Knockout; Mutation; Oxazolone; Passive Cutaneous Anaphylaxis; ras GTPase-Activating Proteins; RNA Interference; RNA, Small Interfering | 2017 |