trihexyphenidyl has been researched along with Drooling in 10 studies
Trihexyphenidyl: One of the centrally acting MUSCARINIC ANTAGONISTS used for treatment of PARKINSONIAN DISORDERS and drug-induced extrapyramidal movement disorders and as an antispasmodic.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We report an unusual case of colonic pseudo-obstruction in an 8-year-old child with cerebral palsy and long-term hypomotility issues being treated for drooling with the anticholinergic medication trihexyphenidyl." | 7.81 | Acute colonic pseudo-obstruction in a child taking trihexyphenidyl for drooling: Prescribers beware. ( Begbie, F; Kubba, H; Sabharwal, A; Walker, G, 2015) |
| " This study sought to review the benefits and tolerability of trihexyphenidyl in children with cerebral palsy, treated for dystonia or sialorrhea or both in a pediatric tertiary care hospital, through a retrospective chart review." | 7.77 | Use of trihexyphenidyl in children with cerebral palsy. ( Carranza-del Rio, J; Clegg, NJ; Delgado, MR; Moore, A, 2011) |
| "Clozapine-induced sialorrhea (CIS) is a frequently occurring debilitating adverse effect." | 7.76 | Complete resolution of clozapine-induced sialorrhea with low dose trihexyphenidyl. ( Khanande, RV; Praharaj, SK; Sarkhel, S; Sinha, VK, 2010) |
| "Enuresis is an adverse event of clozapine treatment." | 7.69 | Trihexyphenidyl as a possible therapeutic option in clozapine-induced nocturnal enuresis. ( Modai, I; Poyurovsky, M; Weizman, A, 1996) |
| "To assess the effectiveness and safety of trihexyphenidyl, scopolamine and botulinum toxin infiltration in the treatment of drooling in children with neurological disorders." | 5.20 | [Drooling therapy in children with neurological disorders]. ( Alonso-Curcó, X; Badosa-Pagès, J; Muchart, J; Paredes-Mercado, C; Póo, P; Táboas-Pereira, MA, 2015) |
| "Benzhexol, glycopyrrolate, and scopolamine reduce drooling, but improvement is offset by adverse side effects." | 3.96 | Anticholinergic medications for reducing drooling in children with developmental disability. ( Guzys, AT; Reddihough, DS; Reid, SM; Westbury, C, 2020) |
| " We report an unusual case of colonic pseudo-obstruction in an 8-year-old child with cerebral palsy and long-term hypomotility issues being treated for drooling with the anticholinergic medication trihexyphenidyl." | 3.81 | Acute colonic pseudo-obstruction in a child taking trihexyphenidyl for drooling: Prescribers beware. ( Begbie, F; Kubba, H; Sabharwal, A; Walker, G, 2015) |
| " This study sought to review the benefits and tolerability of trihexyphenidyl in children with cerebral palsy, treated for dystonia or sialorrhea or both in a pediatric tertiary care hospital, through a retrospective chart review." | 3.77 | Use of trihexyphenidyl in children with cerebral palsy. ( Carranza-del Rio, J; Clegg, NJ; Delgado, MR; Moore, A, 2011) |
| "Clozapine-induced sialorrhea (CIS) is a frequently occurring debilitating adverse effect." | 3.76 | Complete resolution of clozapine-induced sialorrhea with low dose trihexyphenidyl. ( Khanande, RV; Praharaj, SK; Sarkhel, S; Sinha, VK, 2010) |
| "Enuresis is an adverse event of clozapine treatment." | 3.69 | Trihexyphenidyl as a possible therapeutic option in clozapine-induced nocturnal enuresis. ( Modai, I; Poyurovsky, M; Weizman, A, 1996) |
| "Drooling is a common dysfunction in children with cerebral palsy and may also affect neurologically unimpaired children." | 1.35 | An evidence-based approach to the child who drools saliva. ( Hussain, SS; Kubba, H; Little, SA, 2009) |
| " Drooling was measured before treatment and then repeatedly until an optimal dosage of benzhexol hydrochloride was attained." | 1.28 | Use of benzhexol hydrochloride to control drooling of children with cerebral palsy. ( Exarchos, H; Hudson, I; Johnson, H; Reddihough, D; Staples, M, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (30.00) | 18.2507 |
| 2000's | 2 (20.00) | 29.6817 |
| 2010's | 4 (40.00) | 24.3611 |
| 2020's | 1 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Reid, SM | 1 |
| Westbury, C | 1 |
| Guzys, AT | 1 |
| Reddihough, DS | 1 |
| Begbie, F | 1 |
| Walker, G | 1 |
| Kubba, H | 2 |
| Sabharwal, A | 1 |
| Táboas-Pereira, MA | 1 |
| Paredes-Mercado, C | 1 |
| Alonso-Curcó, X | 1 |
| Badosa-Pagès, J | 1 |
| Muchart, J | 1 |
| Póo, P | 1 |
| Little, SA | 1 |
| Hussain, SS | 1 |
| Aggarwal, A | 1 |
| Garg, A | 1 |
| Jiloha, RC | 1 |
| Praharaj, SK | 1 |
| Sarkhel, S | 1 |
| Khanande, RV | 1 |
| Sinha, VK | 1 |
| Carranza-del Rio, J | 1 |
| Clegg, NJ | 1 |
| Moore, A | 1 |
| Delgado, MR | 1 |
| Poyurovsky, M | 1 |
| Modai, I | 1 |
| Weizman, A | 2 |
| Spivak, B | 1 |
| Adlersberg, S | 1 |
| Rosen, L | 1 |
| Gonen, N | 1 |
| Mester, R | 1 |
| Reddihough, D | 1 |
| Johnson, H | 1 |
| Staples, M | 1 |
| Hudson, I | 1 |
| Exarchos, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Single-Dose Pharmacokinetics of Atropine Oral Gel in Healthy Adults[NCT05164367] | Early Phase 1 | 10 participants (Anticipated) | Interventional | 2022-10-01 | Active, not recruiting | ||
| Prevalence Study of Sialorrhea in Inpatients and Outpatients Treated With Clozapine[NCT04197037] | 129 participants (Actual) | Observational | 2018-03-20 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for trihexyphenidyl and Drooling
| Article | Year |
|---|---|
[Drooling therapy in children with neurological disorders].
Topics: Acetylcholine Release Inhibitors; Adolescent; Botulinum Toxins, Type A; Child; Child, Preschool; Fem | 2015 |
Trihexyphenidyl treatment of clozapine-induced hypersalivation.
Topics: Adult; Antipsychotic Agents; Clozapine; Female; Humans; Male; Muscarinic Antagonists; Schizophrenia; | 1997 |
8 other studies available for trihexyphenidyl and Drooling
| Article | Year |
|---|---|
Anticholinergic medications for reducing drooling in children with developmental disability.
Topics: Adolescent; Child; Child, Preschool; Cholinergic Antagonists; Developmental Disabilities; Female; Gl | 2020 |
Acute colonic pseudo-obstruction in a child taking trihexyphenidyl for drooling: Prescribers beware.
Topics: Cerebral Palsy; Child; Colonic Pseudo-Obstruction; Humans; Male; Muscarinic Antagonists; Sialorrhea; | 2015 |
An evidence-based approach to the child who drools saliva.
Topics: Botulinum Toxins, Type A; Cerebral Palsy; Child; Cholinergic Antagonists; Evidence-Based Medicine; H | 2009 |
Trihexyphenidyl (benzhexol) in clozapine-induced nocturnal enuresis and sialorrhea.
Topics: Amitriptyline; Antipsychotic Agents; Clozapine; Humans; Male; Muscarinic Antagonists; Nocturnal Enur | 2009 |
Complete resolution of clozapine-induced sialorrhea with low dose trihexyphenidyl.
Topics: Adult; Antipsychotic Agents; Clozapine; Humans; Male; Muscarinic Antagonists; Sialorrhea; Treatment | 2010 |
Use of trihexyphenidyl in children with cerebral palsy.
Topics: Adolescent; Age Factors; Cerebral Palsy; Child; Child, Preschool; Dystonia; Female; Humans; Infant; | 2011 |
Trihexyphenidyl as a possible therapeutic option in clozapine-induced nocturnal enuresis.
Topics: Adult; Antipsychotic Agents; Clozapine; Enuresis; Humans; Male; Muscarinic Antagonists; Sialorrhea; | 1996 |
Use of benzhexol hydrochloride to control drooling of children with cerebral palsy.
Topics: Cerebral Palsy; Child; Child, Preschool; Dose-Response Relationship, Drug; Education, Special; Femal | 1990 |