cytidylyl-(3'-5')-cytidine profile

Cytidylyl-(3'-5')-cytidine, also known as CpC, is a dinucleotide composed of two cytosine nucleotides linked by a phosphodiester bond. It is a common component of DNA and RNA and is involved in various biological processes. CpC is known to be a substrate for DNA polymerases and is also involved in the regulation of gene expression. The synthesis of CpC can be achieved through enzymatic reactions using DNA or RNA polymerases. CpC is studied extensively because of its role in DNA replication, transcription, and other cellular processes. Its presence in DNA can influence the stability of the double helix and affect the binding of transcription factors. Research on CpC is aimed at understanding its role in gene regulation, DNA repair, and other cellular processes. Studies have shown that CpC methylation can alter gene expression and be associated with various diseases. Further research is being conducted to develop therapies targeting CpC methylation for the treatment of cancer and other diseases.'

ID Source	ID
PubMed CID	94237
MeSH ID	M0064130

Synonym
cytidylyl-(3'-->5')-cytidine
cytidine-3'-phosphate-5'-cytidine
nsc 91550
cytidylyl-(3'-5')-cytidine
nsc 131650
cytidylyl-(3'.5')-cytidine
einecs 219-802-9
DTXSID901311479
((2r,3s,4r,5r)-5-(4-amino-2-oxopyrimidin-1(2h)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl ((2r,3s,4r,5r)-5-(4-amino-2-oxopyrimidin-1(2h)-yl)-4-hydroxy-2-(hydroxymethyl)tetrahydrofuran-3-yl) hydrogen phosphate

Class	Description
nucleobase-containing molecular entity	Any compound that has a nucleobase as a part.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	3 (25.00)	18.7374
1990's	4 (33.33)	18.2507
2000's	3 (25.00)	29.6817
2010's	1 (8.33)	24.3611
2020's	1 (8.33)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	15 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
cytosine [no description available]	1.97	1	aminopyrimidine; pyrimidine nucleobase; pyrimidone	Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
nitrous oxide Nitrous Oxide: Nitrogen oxide (N2O). A colorless, odorless gas that is used as an anesthetic and analgesic. High concentrations cause a narcotic effect and may replace oxygen, causing death by asphyxia. It is also used as a food aerosol in the preparation of whipping cream.. dinitrogen oxide : A nitrogen oxide consisting of linear unsymmetrical molecules with formula N2O. While it is the most used gaseous anaesthetic in the world, its major commercial use, due to its solubility under pressure in vegetable fats combined with its non-toxicity in low concentrations, is as an aerosol spray propellant and aerating agent for canisters of 'whipped' cream.	1.97	1	gas molecular entity; nitrogen oxide	analgesic; bacterial metabolite; food packaging gas; food propellant; general anaesthetic; greenhouse gas; inhalation anaesthetic; NMDA receptor antagonist; raising agent; refrigerant; vasodilator agent
glutaral Glutaral: One of the protein CROSS-LINKING REAGENTS that is used as a disinfectant for sterilization of heat-sensitive equipment and as a laboratory reagent, especially as a fixative.. glutaraldehyde : A dialdehyde comprised of pentane with aldehyde functions at C-1 and C-5.	1.99	1	dialdehyde	cross-linking reagent; disinfectant; fixative
cytidine monophosphate Cytidine Monophosphate: Cytidine (dihydrogen phosphate). A cytosine nucleotide containing one phosphate group esterified to the sugar moiety in the 2', 3' or 5' position.. cytidine 5'-monophosphate : A pyrimidine ribonucleoside 5'-monophosphate having cytosine as the nucleobase.	2.37	2	cytidine 5'-phosphate; pyrimidine ribonucleoside 5'-monophosphate	Escherichia coli metabolite; human metabolite; mouse metabolite
cytidine [no description available]	2.37	2	cytidines	Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
deoxycytidine [no description available]	1.97	1	pyrimidine 2'-deoxyribonucleoside	Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
tricalcium phosphate tricalcium phosphate: a form of tricalcium phosphate used as bioceramic bone replacement material; see also records for alpha-tricalcium phosphate, beta-tricalcium phosphate, calcium phosphate; apatitic tricalcium phosphate Ca9(HPO4)(PO4)5(OH) is the calcium orthophosphate leading to beta tricalcium phosphate Ca3(PO4)2 (b-TCP). calcium phosphate : A calcium salt composed of calcium and phosphate/diphosphate ions; present in milk and used for the mineralisation of calcified tissues.	2.41	1	calcium phosphate
7-aminodesacetoxycephalosporanic acid 7-amino-3-methyl-delta(3)-cephem-4-carboxylic acid: key intermediate in preparation of several semisynthetic beta-lactam antibiotics; structure. 7beta-aminodeacetoxycephalosporanic acid : A cephem monocarboxylic acid derivative having a structure based on cephalosporanic acid, deacetoxylated and carrying a 7beta-amino group.	2.01	1	cephalosporin; monocarboxylic acid
cephalosporin c cephalosporin C: RN given refers to parent cpd; structure in Merck, 9th ed, #1937. cephalosporin C : A cephalosporin antibiotic carrying a 3-acetoxymethyl substituent and a 6-oxo-N(6)-L-lysino group at position 7.	2.01	1	cephalosporin	fungal metabolite
glutaryl-7-aminocephalosporanic acid glutaryl-7-aminocephalosporanic acid: structure given in first source; product of the enzymatic oxidation of cephalosporin C using D-amino-acid oxidase	2.01	1	cephalosporin
3'-deamino-3'-(3-cyano-4-morpholinyl)doxorubicin 3'-deamino-3'-(3-cyano-4-morpholinyl)doxorubicin: more effective and has lower toxicity than doxorubicin	1.98	1
guanylyl-(3'-5')-guanosine [no description available]	2.38	2	nucleoside analogue; purines

Condition	Relationship Strength	Studies
Genetic Predisposition [description not available]	2.21	1
Diathesis [description not available]	2.21	1
Breast Cancer [description not available]	2.21	1
Aging The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.	2.21	1
Breast Neoplasms Tumors or cancer of the human BREAST.	2.21	1
Disomy, Uniparental [description not available]	2.03	1
Labhart-Willi Syndrome [description not available]	2.03	1
Happy Puppet Syndrome [description not available]	2.03	1
Prader-Willi Syndrome An autosomal dominant disorder caused by deletion of the proximal long arm of the paternal chromosome 15 (15q11-q13) or by inheritance of both of the pair of chromosomes 15 from the mother (UNIPARENTAL DISOMY) which are imprinted (GENETIC IMPRINTING) and hence silenced. Clinical manifestations include MENTAL RETARDATION; MUSCULAR HYPOTONIA; HYPERPHAGIA; OBESITY; short stature; HYPOGONADISM; STRABISMUS; and HYPERSOMNOLENCE. (Menkes, Textbook of Child Neurology, 5th ed, p229)	2.03	1
Angelman Syndrome A syndrome characterized by multiple abnormalities, MENTAL RETARDATION, and movement disorders. Present usually are skull and other abnormalities, frequent infantile spasms (SPASMS, INFANTILE); easily provoked and prolonged paroxysms of laughter (hence happy); jerky puppetlike movements (hence puppet); continuous tongue protrusion; motor retardation; ATAXIA; MUSCLE HYPOTONIA; and a peculiar facies. It is associated with maternal deletions of chromosome 15q11-13 and other genetic abnormalities. (From Am J Med Genet 1998 Dec 4;80(4):385-90; Hum Mol Genet 1999 Jan;8(1):129-35)	2.03	1

cytidylyl-(3'-5')-cytidine

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Synonyms (9)

Drug Classes (1)

Research

Studies (12)

Market Indicators

Research Demand Index: 11.90

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