vigabatrin has been researched along with Angelman Syndrome in 2 studies
Angelman Syndrome: A syndrome characterized by multiple abnormalities, MENTAL RETARDATION, and movement disorders. Present usually are skull and other abnormalities, frequent infantile spasms (SPASMS, INFANTILE); easily provoked and prolonged paroxysms of laughter (hence happy); jerky puppetlike movements (hence puppet); continuous tongue protrusion; motor retardation; ATAXIA; MUSCLE HYPOTONIA; and a peculiar facies. It is associated with maternal deletions of chromosome 15q11-13 and other genetic abnormalities. (From Am J Med Genet 1998 Dec 4;80(4):385-90; Hum Mol Genet 1999 Jan;8(1):129-35)
| Excerpt | Relevance | Reference |
|---|---|---|
| "New antiepileptic drugs designed for enhancing GABAergic inhibition, such as vigabatrin (VGB) may be effective in Angelman syndrome (AS), because associated convulsions could be related to a reduced GABA-receptor density or receptor abnormality." | 7.70 | Adverse effects of vigabatrin in Angelman syndrome. ( Boltshauser, E; Kuenzle, C; Schmitt, B; Steinlin, M; Wohlrab, G, 1998) |
| "New antiepileptic drugs designed for enhancing GABAergic inhibition, such as vigabatrin (VGB) may be effective in Angelman syndrome (AS), because associated convulsions could be related to a reduced GABA-receptor density or receptor abnormality." | 3.70 | Adverse effects of vigabatrin in Angelman syndrome. ( Boltshauser, E; Kuenzle, C; Schmitt, B; Steinlin, M; Wohlrab, G, 1998) |
| "Angelman syndrome is a rare genetic disorder scarcely diagnosed before the age of two years." | 1.37 | Angelman syndrome and pseudo-hypsarrhythmia: a diagnostic pitfall. ( Convers, P; Darteyre, S; Lebrun, M; Mazzola, L; Ville, D, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Darteyre, S | 1 |
| Mazzola, L | 1 |
| Convers, P | 1 |
| Lebrun, M | 1 |
| Ville, D | 1 |
| Kuenzle, C | 1 |
| Steinlin, M | 1 |
| Wohlrab, G | 1 |
| Boltshauser, E | 1 |
| Schmitt, B | 1 |
2 other studies available for vigabatrin and Angelman Syndrome
| Article | Year |
|---|---|
Angelman syndrome and pseudo-hypsarrhythmia: a diagnostic pitfall.
Topics: Angelman Syndrome; Anticonvulsants; Chromosome Deletion; Chromosomes, Human, Pair 15; Diagnosis, Dif | 2011 |
Adverse effects of vigabatrin in Angelman syndrome.
Topics: Adult; Angelman Syndrome; Anticonvulsants; Child; Child, Preschool; Comorbidity; Epilepsy; Female; g | 1998 |