ganaxolone has been researched along with Angelman-Syndrome* in 1 studies
1 other study(ies) available for ganaxolone and Angelman-Syndrome
| Article | Year |
|---|---|
Effects of the synthetic neurosteroid ganaxolone on seizure activity and behavioral deficits in an Angelman syndrome mouse model.
Angelman syndrome (AS) is a rare neurogenetic disorder characterized by severe developmental delay, motor impairments, and epilepsy. GABAergic dysfunction is believed to contribute to many of the phenotypic deficits seen in AS. We hypothesized that restoration of inhibitory tone mediated by extrasynaptic GABA Topics: Angelman Syndrome; Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Disease Models, Animal; Female; Hippocampus; Long-Term Potentiation; Male; Maze Learning; Memory, Short-Term; Mice, Knockout; Motor Activity; Pentylenetetrazole; Pregnanolone; Receptors, GABA-A; Seizures; Spatial Memory; Tissue Culture Techniques; Ubiquitin-Protein Ligases | 2017 |