cGMP binding

Definition

Target type: molecularfunction

Binding to cGMP, the nucleotide cyclic GMP (guanosine 3',5'-cyclophosphate). [GOC:ai]

cGMP binding is a molecular function that involves the specific interaction of a protein with cyclic guanosine monophosphate (cGMP). cGMP is a ubiquitous second messenger that plays critical roles in various cellular processes, including signal transduction, ion channel regulation, and gene expression. cGMP binding proteins typically contain a conserved cGMP-binding domain, often characterized by a specific arrangement of amino acids that facilitates the formation of a high-affinity binding site for cGMP. Upon binding to cGMP, these proteins undergo conformational changes that can modulate their activity, leading to downstream signaling events. For instance, cGMP binding to protein kinase G (PKG) activates its catalytic activity, enabling the phosphorylation of target proteins and the initiation of cellular responses. Similarly, cGMP binding to cyclic nucleotide-gated ion channels (CNGCs) opens the channels, allowing the influx of ions and modulating membrane potential. The specificity and affinity of cGMP binding are crucial for ensuring accurate and efficient cellular signaling. Mutations or alterations in cGMP-binding domains can disrupt these interactions, leading to impaired cellular function and potentially contributing to disease development.'
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Proteins (16)

Compounds (334)