Page last updated: 2024-09-27

Chromosome Shattering

Massive number of chromosomal rearrangements and shattering that occurs in cancer cells. The breakpoints are located within one chromosome or chromosome arm.

Synonyms(2)

Synonym
Chromothripsis
Chromosome Shattering

Research Excerpts

Overview

ExcerptReference
"Chromothripsis is a form of genome instability by which a presumably single catastrophic event generates extensive genomic rearrangements of one or a few chromosomes."( Anzeneder, T; Bolkestein, M; Devens, F; Elgaafary, S; Ernst, A; Hirsch, S; Hlevnjak, M; Höfer, T; Kommoss, FKF; Körber, V; Lichter, P; Schneeweiss, A; Schröter, P; Schulze, M; Sinn, HP; Thewes, V; Wong, JKL; Zapatka, M, 2020)

Research

Studies (4)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's0 (0.00)18.1394
2010's1 (25.00)28.8240
2020's3 (75.00)9.53
DrugIndicatedRelationship StrengthStudiesTrials
nocodazole0low10
emerin0low10
osimertinib0low10
cyclin d10low10

Protein Targets (417)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE1001
Chain A, Glutathione-requiring prostaglandin D synthase0101
Luciferase1001
phosphopantetheinyl transferase1001
RAR-related orphan receptor gamma1001
ATAD5 protein, partial1001
Fumarate hydratase1001
USP1 protein, partial1001
NFKB1 protein, partial1001
PPM1D protein2002
TDP1 protein1001
GLI family zinc finger 31001
Microtubule-associated protein tau1001
Thrombopoietin1001
AR protein1001
Smad31001
caspase 7, apoptosis-related cysteine protease1001
aldehyde dehydrogenase 1 family, member A11001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)1001
thyroid stimulating hormone receptor1001
nuclear receptor subfamily 1, group I, member 31001
progesterone receptor1001
EWS/FLI fusion protein1001
glucocorticoid receptor [Homo sapiens]1001
retinoic acid nuclear receptor alpha variant 11001
retinoid X nuclear receptor alpha1001
estrogen-related nuclear receptor alpha1001
farnesoid X nuclear receptor1001
pregnane X nuclear receptor1001
estrogen nuclear receptor alpha1001
G2002
polyprotein1001
67.9K protein1001
peroxisome proliferator-activated receptor delta1001
vitamin D (1,25- dihydroxyvitamin D3) receptor1001
arylsulfatase A1001
caspase-31001
IDH11001
euchromatic histone-lysine N-methyltransferase 21001
aryl hydrocarbon receptor1001
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a1001
v-jun sarcoma virus 17 oncogene homolog (avian)1001
Histone H2A.x1001
Bloom syndrome protein isoform 11001
NPC intracellular cholesterol transporter 1 precursor1001
peripheral myelin protein 22 isoform 11001
nuclear receptor subfamily 0 group B member 10101
cellular tumor antigen p53 isoform a1001
cytochrome P450 2C9 precursor1001
chromobox protein homolog 11001
nuclear factor erythroid 2-related factor 2 isoform 21001
thyroid hormone receptor beta isoform 21001
histone deacetylase 9 isoform 31001
huntingtin isoform 21001
mitogen-activated protein kinase 11001
atrial natriuretic peptide receptor 2 precursor1001
serine/threonine-protein kinase mTOR isoform 11001
steroidogenic factor 10101
nuclear factor erythroid 2-related factor 2 isoform 11001
nuclear receptor ROR-gamma isoform 11001
geminin1001
peripheral myelin protein 221001
lethal factor (plasmid)1001
lamin isoform A-delta101001
neuropeptide S receptor isoform A1001
Tyrosine-protein kinase ABL10112
Interferon beta2002
HLA class I histocompatibility antigen, B alpha chain 2002
Tubulin alpha-1A chain0101
Tubulin beta chain0101
Tubulin beta-4A chain0112
Cellular tumor antigen p531001
Tubulin beta chain0112
Tubulin alpha-3C chain0112
Amine oxidase [flavin-containing] A0101
Adenosine receptor A2a0202
Adenosine receptor A10202
5-hydroxytryptamine receptor 2B0202
Histamine H2 receptor1001
Tubulin alpha-1B chain0112
Tubulin alpha-4A chain0112
Tubulin beta-4B chain0112
Inositol monophosphatase 11001
Sodium-dependent dopamine transporter 0202
Tubulin beta-3 chain0112
Tubulin beta-2A chain0112
Tubulin beta-8 chain0112
Tubulin beta-2B chain0102
Tubulin alpha-3E chain0112
Tubulin alpha-1A chain0112
Similar to alpha-tubulin isoform 1 0102
Similar to alpha-tubulin isoform 1 0102
Inositol hexakisphosphate kinase 12002
CREB-binding protein1001
ATPase family AAA domain-containing protein 51001
Ataxin-21001
Tubulin alpha-1C chain0112
Tubulin beta-6 chain0112
Tubulin beta-2B chain0112
Tubulin beta-1 chain0112
cytochrome P450 2C9, partial2002
ATP-dependent phosphofructokinase1001
cytochrome P450 family 3 subfamily A polypeptide 41001
cytochrome P450 2D61001
Bone morphogenetic protein receptor type-1B0011
Membrane-associated progesterone receptor component 10011
Serine/threonine-protein kinase PLK40011
ATP-dependent RNA helicase DDX3X0011
Pyridoxal kinase0011
Citron Rho-interacting kinase0011
Serine/threonine-protein kinase Chk10011
Aurora kinase A0011
Cyclin-G-associated kinase0011
Ephrin type-B receptor 60011
Peroxisomal acyl-coenzyme A oxidase 30011
Histone deacetylase 30101
Receptor-interacting serine/threonine-protein kinase 20011
Mitotic checkpoint serine/threonine-protein kinase BUB10011
Dynamin-like 120 kDa protein, mitochondrial0011
Lysine-specific histone demethylase 1A0101
Putative nucleoside diphosphate kinase0011
Eukaryotic translation initiation factor 5B0011
Rho-associated protein kinase 20011
Serine/threonine-protein kinase ULK10011
Serine/threonine-protein kinase/endoribonuclease IRE10011
Ribosomal protein S6 kinase alpha-50011
U5 small nuclear ribonucleoprotein 200 kDa helicase0011
Ribosomal protein S6 kinase alpha-40011
Serine/threonine-protein kinase 160011
Cyclin-dependent kinase-like 50011
Serine/threonine-protein kinase 100011
Serine/threonine-protein kinase D30011
Structural maintenance of chromosomes protein 20011
Mitogen-activated protein kinase kinase kinase 60011
Mitogen-activated protein kinase kinase kinase kinase 40011
Serine/threonine-protein kinase LATS10011
Serine/threonine-protein kinase PAK 40011
Epidermal growth factor receptor0326
Receptor tyrosine-protein kinase erbB-20112
High affinity nerve growth factor receptor0011
Guanine nucleotide-binding protein G(i) subunit alpha-20011
ADP/ATP translocase 20011
Protein kinase C beta type0011
Insulin receptor0213
Tyrosine-protein kinase Lck0011
Tyrosine-protein kinase Fyn0011
Cyclin-dependent kinase 10011
Glycogen phosphorylase, liver form0011
Tyrosine-protein kinase Fes/Fps0011
Adenine phosphoribosyltransferase0011
Tyrosine-protein kinase Yes0011
Tyrosine-protein kinase Lyn0011
Proto-oncogene tyrosine-protein kinase receptor Ret0011
Insulin-like growth factor 1 receptor0213
Signal recognition particle receptor subunit alpha0011
Cytochrome c1, heme protein, mitochondrial0011
Hepatocyte growth factor receptor0101
Tyrosine-protein kinase HCK0011
Platelet-derived growth factor receptor beta0011
Replicase polyprotein 1ab0101
Serine/threonine-protein kinase A-Raf0011
Glycogen phosphorylase, brain form0011
Breakpoint cluster region protein0011
Serine/threonine-protein kinase pim-10011
Fibroblast growth factor receptor 10011
DNA topoisomerase 2-alpha0011
Cyclin-dependent kinase 40011
ADP/ATP translocase 30011
Inosine-5'-monophosphate dehydrogenase 20011
Proto-oncogene tyrosine-protein kinase Src0011
cAMP-dependent protein kinase type II-alpha regulatory subunit0011
Serine/threonine-protein kinase B-raf0011
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform0011
Ribosyldihydronicotinamide dehydrogenase [quinone]0011
Tyrosine-protein kinase Fer0011
Protein kinase C alpha type0011
cAMP-dependent protein kinase catalytic subunit alpha0011
General transcription and DNA repair factor IIH helicase subunit XPD0011
Casein kinase II subunit alpha'0011
Ras-related protein Rab-6A0011
Ephrin type-A receptor 10011
Receptor tyrosine-protein kinase erbB-30101
Multifunctional protein ADE20011
Nucleoside diphosphate kinase B0011
cAMP-dependent protein kinase catalytic subunit gamma0011
cAMP-dependent protein kinase catalytic subunit beta0011
Ferrochelatase, mitochondrial0011
Ribosomal protein S6 kinase beta-10011
Tyrosine-protein kinase JAK10011
Cyclin-dependent kinase 20011
Beta-adrenergic receptor kinase 10011
Probable ATP-dependent RNA helicase DDX60011
Mitogen-activated protein kinase 3 0011
MAP/microtubule affinity-regulating kinase 30011
Deoxycytidine kinase0011
Mitogen-activated protein kinase 10011
Ephrin type-A receptor 20011
Ephrin type-B receptor 20011
Non-receptor tyrosine-protein kinase TYK20011
UMP-CMP kinase 0011
Phosphatidylethanolamine-binding protein 10011
Wee1-like protein kinase0011
Heme oxygenase 20011
S-adenosylmethionine synthase isoform type-20011
DnaJ homolog subfamily A member 10011
RAC-alpha serine/threonine-protein kinase0011
RAC-beta serine/threonine-protein kinase0011
DNA replication licensing factor MCM40011
Myosin-100011
Dual specificity mitogen-activated protein kinase kinase 20011
Receptor-type tyrosine-protein kinase FLT30011
Bone morphogenetic protein receptor type-1A0011
Activin receptor type-1B0011
TGF-beta receptor type-10011
Electron transfer flavoprotein subunit beta0011
von Hippel-Lindau disease tumor suppressor0101
Tyrosine-protein kinase CSK0011
Glycine--tRNA ligase0011
Protein kinase C iota type0011
Exosome RNA helicase MTR40011
Tyrosine-protein kinase Tec0011
Tyrosine-protein kinase ABL20011
Tyrosine-protein kinase FRK0011
G protein-coupled receptor kinase 60011
Tyrosine-protein kinase SYK0011
26S proteasome regulatory subunit 6B0011
Mitogen-activated protein kinase 80011
Mitogen-activated protein kinase 90011
Dual specificity mitogen-activated protein kinase kinase 30011
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha0011
Casein kinase I isoform alpha0011
Casein kinase I isoform delta0011
MAP kinase-activated protein kinase 20011
Elongation factor Tu, mitochondrial0011
Cysteine--tRNA ligase, cytoplasmic0011
Casein kinase I isoform epsilon0011
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial0011
Dual specificity protein kinase CLK10011
Dual specificity protein kinase CLK20011
Dual specificity protein kinase CLK30011
Glycogen synthase kinase-3 alpha0011
Glycogen synthase kinase-3 beta0011
Cyclin-dependent kinase 70011
Cyclin-dependent kinase 90011
Ras-related protein Rab-27A0011
Interleukin-1 receptor-associated kinase 10011
Ribosomal protein S6 kinase alpha-30011
Serine/threonine-protein kinase Nek20011
Serine/threonine-protein kinase Nek30011
Dual specificity mitogen-activated protein kinase kinase 60011
Dipeptidyl peptidase 10101
LIM domain kinase 10011
LIM domain kinase 20011
Mitogen-activated protein kinase 100011
Tyrosine--tRNA ligase, cytoplasmic0011
5'-AMP-activated protein kinase subunit gamma-10011
Ephrin type-B receptor 30011
Ephrin type-A receptor 50011
Ephrin type-B receptor 40011
Ephrin type-A receptor 40011
Adenylate kinase 2, mitochondrial0011
Adenosine kinase0011
Histone deacetylase 40101
Spike glycoprotein1001
Ras-related protein Rab-100011
Actin-related protein 30011
Actin-related protein 20011
GTP-binding nuclear protein Ran0011
Casein kinase I isoform gamma-20011
Fatty-acid amide hydrolase 10101
Cyclin-dependent kinase 30011
Cyclin-dependent kinase 60011
Cyclin-dependent-like kinase 5 0011
Cyclin-dependent kinase 160011
Cyclin-dependent kinase 170011
Epidermal growth factor receptor0202
ATP-dependent 6-phosphofructokinase, platelet type0011
Dual specificity mitogen-activated protein kinase kinase 10011
DNA topoisomerase 2-beta0011
Protein kinase C theta type0011
Activin receptor type-10011
Macrophage-stimulating protein receptor0011
Focal adhesion kinase 10011
Protein kinase C delta type0011
Tyrosine-protein kinase BTK0011
Activated CDC42 kinase 10011
Epithelial discoidin domain-containing receptor 10011
Potassium voltage-gated channel subfamily H member 20101
Mitogen-activated protein kinase kinase kinase kinase 20011
Serine/threonine-protein kinase 40011
5'-AMP-activated protein kinase catalytic subunit alpha-10011
Dual specificity mitogen-activated protein kinase kinase 50011
Mitogen-activated protein kinase 70011
Serine/threonine-protein kinase PAK 20011
Serine/threonine-protein kinase 30011
Mitogen-activated protein kinase kinase kinase 10011
Integrin-linked protein kinase0011
Rho-associated protein kinase 10011
Non-receptor tyrosine-protein kinase TNK10011
Histone deacetylase 10101
Calcium/calmodulin-dependent protein kinase type II subunit gamma0011
Calcium/calmodulin-dependent protein kinase type II subunit delta0011
Dual specificity tyrosine-phosphorylation-regulated kinase 1A0011
Activin receptor type-2B0011
Bone morphogenetic protein receptor type-20011
Protein-tyrosine kinase 60011
cGMP-dependent protein kinase 1 0011
Cyclin-dependent kinase 130011
Inhibitor of nuclear factor kappa-B kinase subunit epsilon0011
Protein-tyrosine kinase 2-beta0011
Maternal embryonic leucine zipper kinase0011
Structural maintenance of chromosomes protein 1A0011
Chromodomain-helicase-DNA-binding protein 40011
Peroxisomal acyl-coenzyme A oxidase 10011
Serine/threonine-protein kinase 380011
Receptor tyrosine-protein kinase erbB-40101
Ephrin type-A receptor 70011
Delta(24)-sterol reductase0011
Ribosomal protein S6 kinase alpha-10011
Myosin light chain kinase, smooth muscle0011
Mitogen-activated protein kinase 110011
Serine/threonine-protein kinase STK110011
Serine/threonine-protein kinase N10011
Serine/threonine-protein kinase N20011
Mitogen-activated protein kinase 140011
Calcium/calmodulin-dependent protein kinase type IV0011
Mitogen-activated protein kinase kinase kinase 110011
MAP kinase-activated protein kinase 30011
Discoidin domain-containing receptor 20011
AP2-associated protein kinase 10011
Myosin light chain kinase 30011
Putative heat shock protein HSP 90-beta 20011
Serine/threonine-protein kinase MRCK alpha0011
Serine/threonine-protein kinase MRCK gamma0011
Acyl-CoA dehydrogenase family member 100011
Serine/threonine-protein kinase N30011
Serine/threonine-protein kinase ULK30011
Uncharacterized protein FLJ452520011
Serine/threonine-protein kinase/endoribonuclease IRE20011
Serine/threonine-protein kinase MARK20011
ATP-dependent RNA helicase DHX300011
Serine/threonine-protein kinase TAO10011
STE20-related kinase adapter protein alpha0011
Myosin-140011
AarF domain-containing protein kinase 10011
ATP-dependent RNA helicase DDX420011
Mitogen-activated protein kinase kinase kinase kinase 30011
MAP kinase-activated protein kinase 50011
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B0011
Misshapen-like kinase 10011
Atypical kinase COQ8A, mitochondrial0011
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma0011
Mitogen-activated protein kinase 150011
Serine/threonine-protein kinase Nek90011
Serine/threonine-protein kinase Nek70011
Histone deacetylase 70101
ATP-dependent RNA helicase DDX10011
Histone deacetylase 20101
Mitogen-activated protein kinase kinase kinase kinase 10011
Polyamine deacetylase HDAC100101
Histone deacetylase 11 0101
Aurora kinase B0011
MAP/microtubule affinity-regulating kinase 40011
Calcium/calmodulin-dependent protein kinase type 1G0011
Serine/threonine-protein kinase Nek10011
Calcium/calmodulin-dependent protein kinase kinase 20011
EKC/KEOPS complex subunit TP53RK0011
Dual specificity testis-specific protein kinase 20011
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase0011
Mitogen-activated protein kinase kinase kinase 50011
Mitogen-activated protein kinase kinase kinase 30011
Eukaryotic translation initiation factor 2-alpha kinase 10011
Histone deacetylase 80101
Nucleolar GTP-binding protein 10011
Serine/threonine-protein kinase D20011
NUAK family SNF1-like kinase 20011
RNA cytidine acetyltransferase0011
Serine/threonine-protein kinase SIK20011
STE20-like serine/threonine-protein kinase 0011
Serine/threonine-protein kinase TAO30011
dCTP pyrophosphatase 10011
Dual specificity protein kinase CLK40011
Echinoderm microtubule-associated protein-like 40011
Casein kinase I isoform gamma-10011
Phenylalanine--tRNA ligase beta subunit0011
Isoleucine--tRNA ligase, mitochondrial0011
BMP-2-inducible protein kinase0011
Obg-like ATPase 10011
Midasin0011
Interleukin-1 receptor-associated kinase 40011
Mitogen-activated protein kinase kinase kinase 200011
Cyclin-dependent kinase 120011
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 130011
Serine/threonine-protein kinase 260011
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial0011
Serine/threonine-protein kinase NLK0011
Histone deacetylase 60101
5'-AMP-activated protein kinase subunit gamma-20011
Serine/threonine-protein kinase TBK10011
Septin-90011
Ribosomal protein S6 kinase alpha-60011
TRAF2 and NCK-interacting protein kinase0011
Histone deacetylase 90101
Serine/threonine-protein kinase TAO20011
ALK tyrosine kinase receptor0112
Serine/threonine-protein kinase ICK0011
Histone deacetylase 50101
RAC-gamma serine/threonine-protein kinase0011
Serine/threonine-protein kinase SIK30011
Mitogen-activated protein kinase kinase kinase 20011
Thyroid hormone receptor-associated protein 30011
Mitogen-activated protein kinase kinase kinase kinase 50011
Receptor-interacting serine/threonine-protein kinase 30011
Serine/threonine-protein kinase MRCK beta0011
Interleukin-1 receptor-associated kinase 30011
Casein kinase I isoform gamma-30011
Mitogen-activated protein kinase kinase kinase 40011
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]