Compounds > yuanhuadine
Page last updated: 2024-12-11

yuanhuadine

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Cross-References

ID SourceID
PubMed CID6440572
CHEMBL ID1911631
CHEBI ID69565
SCHEMBL ID22366785
MeSH IDM0118601

Synonyms (11)

Synonym
simplexin, 12-(acetyloxy)-22,23,24,25-tetradehydro-, (12-beta,22e,24e)-
yuanhuadine
76402-66-9
chebi:69565 ,
CHEMBL1911631
SCHEMBL22366785
Q27137908
[(1r,2r,6s,7s,8r,10s,11s,12r,14s,16s,17r,18r)-6,7-dihydroxy-8-(hydroxymethyl)-4,18-dimethyl-14-[(1e,3e)-nona-1,3-dienyl]-5-oxo-16-prop-1-en-2-yl-9,13,15,19-tetraoxahexacyclo[12.4.1.01,11.02,6.08,10.012,16]nonadec-3-en-17-yl] acetate
DTXSID101318552
yuanhuadin
AKOS040754550
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
metaboliteAny intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (1)

ClassDescription
diterpenoidAny terpenoid derived from a diterpene. The term includes compounds in which the C20 skeleton of the parent diterpene has been rearranged or modified by the removal of one or more skeletal atoms (generally methyl groups).
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (94)

Assay IDTitleYearJournalArticle
AID627244Inhibition of MTOR-mediated 4EBP1 phosphorylation in human A549 cells at 20 nM after 24 to 48 hrs by Western blot analysis2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa.
AID627163Cell cycle arrest in human A549 cells assessed as accumulation at S phase at 20 nM after 48 hrs by propidium iodide staining-based flow cytometric analysis (Rvb = 31.6 %)2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa.
AID627172Downregulation of cyclin A expression in human A549 cells at G1 phase at 5 to 100 nM after 24 to 48 hrs by Western blot analysis2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa.
AID627040Antiproliferative activity against human NCI-H292 cells after 3 days by SRB assay2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa.
AID627113Cell cycle arrest in human A549 cells assessed as accumulation at Sub-G1 phase at 5 nM after 48 hrs by propidium iodide staining-based flow cytometric analysis (Rvb = 0.2 %)2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa.
AID627041Antiproliferative activity against human SK-MES cells after 3 days by SRB assay2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa.
AID627047Antiproliferative activity against human HCT116 cells after 3 days by SRB assay2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa.
AID627050Antiproliferative activity against human SNU638 cells after 3 days by SRB assay2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa.
AID627045Antiproliferative activity against gefitinib resistant human NCI-H292 cells after 3 days by SRB assay2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa.
AID749862Inhibition of melanin production in alpha-MSH stimulated mouse B16 cells after 72 hrs by spectrophotometry2013Bioorganic & medicinal chemistry letters, Jun-01, Volume: 23, Issue:11
Melanogenesis inhibitory daphnane diterpenoids from the flower buds of Daphne genkwa.
AID627102Cell cycle arrest in human A549 cells assessed as accumulation at G0/G1 phase at 5 nM after 24 hrs by propidium iodide staining-based flow cytometric analysis (Rvb = 49.6 %)2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa.
AID627177Downregulation of cyclin B1 expression in human A549 cells at G2/M phase at 5 to 100 nM after 24 to 48 hrs by Western blot analysis2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa.
AID627245Inhibition of EGFR phosphorylation in EFG-stimulated human A549 cells pretreated at 20 nM by Western blot analysis2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa.
AID627095Antiproliferative activity against human SKHEP1 cells after 3 days by SRB assay2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa.
AID749863Cytotoxicity against alpha-MSH stimulated mouse B16 cells after 72 hrs by MTT assay2013Bioorganic & medicinal chemistry letters, Jun-01, Volume: 23, Issue:11
Melanogenesis inhibitory daphnane diterpenoids from the flower buds of Daphne genkwa.
AID627097Antiproliferative activity against human MRC5 cells after 3 days by SRB assay2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa.
AID627048Antiproliferative activity against human SW480 cells after 3 days by SRB assay2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa.
AID627114Cell cycle arrest in human A549 cells assessed as accumulation at G0/G1 phase at 5 nM after 48 hrs by propidium iodide staining-based flow cytometric analysis (Rvb = 49.6 %)2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa.
AID1546659Cytotoxicity against human MT4 cells incubated for 3 days by CellTiter-Glo luminescent assay
AID627258Antitumor activity against human A549 cells xenografted in BALB/c mouse assessed as inhibition of tumor growth at 0.2 mg/kg, po once daily for 14 days measured for 27 days relative to control2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa.
AID627039Antiproliferative activity against human A549 cells after 3 days by SRB assay2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa.
AID745222Cytotoxicity against human A549 cells after 48 hrs by MTT assay2013Bioorganic & medicinal chemistry letters, May-01, Volume: 23, Issue:9
Daphnane-type diterpenes with inhibitory activities against human cancer cell lines from Daphne genkwa.
AID627042Antiproliferative activity against human NCI-H1993 cells after 3 days by SRB assay2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa.
AID627164Cell cycle arrest in human A549 cells assessed as accumulation at G2/M phase at 20 nM after 48 hrs by propidium iodide staining-based flow cytometric analysis (Rvb = 18.9 %)2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa.
AID627098Antiproliferative activity against human A549 cells assessed as growth inhibition incubated for 24 hrs measured 24 hrs after compound washout by SRB assay2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa.
AID627170Downregulation of CDK2 expression in human A549 cells at G1 phase at 5 to 100 nM after 24 to 48 hrs by Western blot analysis2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa.
AID1546658Antiviral activity against HIV1 NL4-3 infected in human MT4 cells measured on day 3 post-infection by Nano-Glo luciferase assay
AID745217Cytotoxicity against human U937 cells after 48 hrs by MTT assay2013Bioorganic & medicinal chemistry letters, May-01, Volume: 23, Issue:9
Daphnane-type diterpenes with inhibitory activities against human cancer cell lines from Daphne genkwa.
AID1546660Selectivity index, ratio of CC50 for human MT4 cells to IC50 for antiviral activity against HIV1 NL4-3 infected in human MT4 cells to
AID627181Inhibition of GSK3-beta in human A549 cells after 24 hrs by Western blot analysis2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa.
AID745220Cytotoxicity against human HT1080 cells after 48 hrs by MTT assay2013Bioorganic & medicinal chemistry letters, May-01, Volume: 23, Issue:9
Daphnane-type diterpenes with inhibitory activities against human cancer cell lines from Daphne genkwa.
AID627176Downregulation of CDC2 expression in human A549 cells at G2/M phase at 5 to 100 nM after 24 to 48 hrs by Western blot analysis2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa.
AID627108Cell cycle arrest in human A549 cells assessed as accumulation at G2/M phase at 20 nM after 24 hrs by propidium iodide staining-based flow cytometric analysis (Rvb = 18.9 %)2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa.
AID627169Downregulation of CDK4 expression in human A549 cells at G1 phase at 5 to 100 nM after 24 to 48 hrs by Western blot analysis2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa.
AID627246Inhibition of EGFR-mediated Akt phosphorylation in EGF-stimulated human A549 cells pretreated at 20 nM by Western blot analysis2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa.
AID627254Inhibition of c-Met-mediated STAT3 phosphorylation in HGF-stimulated human A549 cells pretreated at 5 to 100 nM by Western blot analysis2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa.
AID627182Inhibition of STAT3 phosphorylation in human A549 cells after 24 hrs by Western blot analysis2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa.
AID627046Antiproliferative activity against gefitinib resistant human NCI-H1993 cells after 3 days by SRB assay2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa.
AID627242Inhibition of MTOR phosphorylation in human A549 cells at 20 nM after 24 to 48 hrs by Western blot analysis2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa.
AID627105Cell cycle arrest in human A549 cells assessed as accumulation at Sub-G1 phase at 20 nM after 24 hrs by propidium iodide staining-based flow cytometric analysis (Rvb = 0.2 %)2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa.
AID627160Cell cycle arrest in human A549 cells assessed as accumulation at G2/M phase at 5 nM after 48 hrs by propidium iodide staining-based flow cytometric analysis (Rvb = 18.9 %)2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa.
AID627110Cell cycle arrest in human A549 cells assessed as accumulation at G0/G1 phase at 100 nM after 24 hrs by propidium iodide staining-based flow cytometric analysis (Rvb = 49.6 %)2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa.
AID627259Antitumor activity against human A549 cells xenografted in BALB/c mouse assessed as inhibition of tumor growth at 0.5 mg/kg, po once daily for 14 days measured for 27 days relative to control2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa.
AID627100Antiproliferative activity against human A549 cells assessed as reduction in colonies after treatment for 24 hrs measured after 14 days using Giemsa staining2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa.
AID627261Toxicity in BALB/c mouse xenografted with human A549 cells in assessed as overt signs at 0.5 mg/kg, po once daily for 14 days measured for 27 days relative to control2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa.
AID627162Cell cycle arrest in human A549 cells assessed as accumulation at G0/G1 phase at 20 nM after 48 hrs by propidium iodide staining-based flow cytometric analysis (Rvb = 49.6 %)2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa.
AID627104Cell cycle arrest in human A549 cells assessed as accumulation at G2/M phase at 5 nM after 24 hrs by propidium iodide staining-based flow cytometric analysis (Rvb = 18.9 %)2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa.
AID627043Antiproliferative activity against human H1299 cells after 3 days by SRB assay2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa.
AID627101Cell cycle arrest in human A549 cells assessed as accumulation at Sub-G1 phase at 5 nM after 24 hrs by propidium iodide staining-based flow cytometric analysis (Rvb = 0.2 %)2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa.
AID627173Downregulation of c-myc expression in human A549 cells at G1 phase at 5 to 100 nM after 24 to 48 hrs by Western blot analysis2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa.
AID627252Inhibition of c-Met-mediated FKHRL1 phosphorylation in HGF-stimulated human A549 cells pretreated at 5 to 100 nM by Western blot analysis2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa.
AID627248Inhibition of c-Met phosphorylation at Tyr1230/1234/1235 in HGF-stimulated human A549 cells pretreated at 5 to 100 nM for 2 hrs by Western blot analysis2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa.
AID627166Cell cycle arrest in human A549 cells assessed as accumulation at G0/G1 phase at 100 nM after 48 hrs by propidium iodide staining-based flow cytometric analysis (Rvb = 49.6 %)2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa.
AID627103Cell cycle arrest in human A549 cells assessed as accumulation at S phase at 5 nM after 24 hrs by propidium iodide staining-based flow cytometric analysis (Rvb = 31.6 %)2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa.
AID627247Inhibition of EGFR-mediated ERK1/2 phosphorylation in EGF-stimulated human A549 cells pretreated at 5 to 100 nM by Western blot analysis2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa.
AID627175Upregulation of p21 expression in human A549 cells at G1 phase at 5 to 100 nM after 24 to 48 hrs by Western blot analysis2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa.
AID627099Antiproliferative activity against human A549 cells assessed as growth inhibition incubated for 24 hrs measured 48 hrs after compound washout by SRB assay2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa.
AID627044Antiproliferative activity against human NCI-H358 cells after 3 days by SRB assay2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa.
AID627167Cell cycle arrest in human A549 cells assessed as accumulation at S phase at 100 nM after 48 hrs by propidium iodide staining-based flow cytometric analysis (Rvb = 31.6 %)2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa.
AID627255Inhibition of c-Met-mediated MTOR phosphorylation in HGF-stimulated human A549 cells pretreated at 5 to 100 nM by Western blot analysis2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa.
AID627243Inhibition of MTOR-mediated p70S6K activation in human A549 cells at 20 nM after 24 to 48 hrs by Western blot analysis2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa.
AID627112Cell cycle arrest in human A549 cells assessed as accumulation at G2/M phase at 100 nM after 24 hrs by propidium iodide staining-based flow cytometric analysis (Rvb = 18.9 %)2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa.
AID627251Inhibition of c-Met-mediated ERK1/2 phosphorylation in HGF-stimulated human A549 cells pretreated at 5 to 100 nM by Western blot analysis2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa.
AID745218Cytotoxicity against human HL60 cells after 48 hrs by MTT assay2013Bioorganic & medicinal chemistry letters, May-01, Volume: 23, Issue:9
Daphnane-type diterpenes with inhibitory activities against human cancer cell lines from Daphne genkwa.
AID627165Cell cycle arrest in human A549 cells assessed as accumulation at Sub-G1 phase at 100 nM after 48 hrs by propidium iodide staining-based flow cytometric analysis (Rvb = 0.2 %)2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa.
AID745223Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay2013Bioorganic & medicinal chemistry letters, May-01, Volume: 23, Issue:9
Daphnane-type diterpenes with inhibitory activities against human cancer cell lines from Daphne genkwa.
AID627111Cell cycle arrest in human A549 cells assessed as accumulation at S phase at 100 nM after 24 hrs by propidium iodide staining-based flow cytometric analysis (Rvb = 31.6 %)2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa.
AID627115Cell cycle arrest in human A549 cells assessed as accumulation at S phase at 5 nM after 48 hrs by propidium iodide staining-based flow cytometric analysis (Rvb = 31.6 %)2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa.
AID627257Inhibition of c-Met-mediated 4EBP1 phosphorylation in HGF-stimulated human A549 cells pretreated at 5 to 100 nM by Western blot analysis2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa.
AID627171Downregulation of cyclin E expression in human A549 cells at G1 phase at 5 to 100 nM after 24 to 48 hrs by Western blot analysis2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa.
AID745225Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay2013Bioorganic & medicinal chemistry letters, May-01, Volume: 23, Issue:9
Daphnane-type diterpenes with inhibitory activities against human cancer cell lines from Daphne genkwa.
AID745216Cytotoxicity against human K562 cells after 48 hrs by MTT assay2013Bioorganic & medicinal chemistry letters, May-01, Volume: 23, Issue:9
Daphnane-type diterpenes with inhibitory activities against human cancer cell lines from Daphne genkwa.
AID627250Inhibition of c-Met-mediated Akt phosphorylation in HGF-stimulated human A549 cells pretreated at 5 to 100 nM by Western blot analysis2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa.
AID1651907Cytotoxicity against human SW620 cells after 24 hrs by MTT assay
AID627256Inhibition of c-Met-mediated p70S6K phosphorylation in HGF-stimulated human A549 cells pretreated at 5 to 100 nM by Western blot analysis2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa.
AID627168Cell cycle arrest in human A549 cells assessed as accumulation at G2/M phase at 100 nM after 48 hrs by propidium iodide staining-based flow cytometric analysis (Rvb = 18.9 %)2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa.
AID627178Inhibition of Akt-signaling in human A549 cells at 5 to 40 nM after 24 hrs by Western blot analysis2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa.
AID627107Cell cycle arrest in human A549 cells assessed as accumulation at S phase at 20 nM after 24 hrs by propidium iodide staining-based flow cytometric analysis (Rvb = 31.6 %)2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa.
AID627096Antiproliferative activity against human PC3 cells after 3 days by SRB assay2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa.
AID627174Downregulation of phosphorylated Rb expression in human A549 cells at G1 phase at 5 to 100 nM after 24 to 48 hrs by Western blot analysis2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa.
AID745224Cytotoxicity against human HeLa cells after 48 hrs by MTT assay2013Bioorganic & medicinal chemistry letters, May-01, Volume: 23, Issue:9
Daphnane-type diterpenes with inhibitory activities against human cancer cell lines from Daphne genkwa.
AID627179Inhibition of ERK1/2 in human A549 cells at 5 to 40 nM after 24 hrs by Western blot analysis2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa.
AID627161Cell cycle arrest in human A549 cells assessed as accumulation at Sub-G1 phase at 20 nM after 48 hrs by propidium iodide staining-based flow cytometric analysis (Rvb = 0.2 %)2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa.
AID627260Toxicity in BALB/c mouse xenografted with human A549 cells in assessed as body weight at 0.5 mg/kg, po once daily for 14 days measured for 27 days relative to control2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa.
AID745219Cytotoxicity against human A375-S2 cells after 48 hrs by MTT assay2013Bioorganic & medicinal chemistry letters, May-01, Volume: 23, Issue:9
Daphnane-type diterpenes with inhibitory activities against human cancer cell lines from Daphne genkwa.
AID627249Inhibition of c-Met phosphorylation at Tyr1003 in HGF-stimulated human A549 cells pretreated at 5 to 100 nM for 2 hrs by Western blot analysis2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa.
AID627180Inhibition of PDK1 phosphorylation in human A549 cells after 24 hrs by Western blot analysis2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa.
AID627106Cell cycle arrest in human A549 cells assessed as accumulation at G0/G1 phase at 20 nM after 24 hrs by propidium iodide staining-based flow cytometric analysis (Rvb = 49.6 %)2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa.
AID627253Inhibition of c-Met-mediated FAK phosphorylation in HGF-stimulated human A549 cells pretreated at 5 to 100 nM by Western blot analysis2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa.
AID1651909Cytotoxicity against human LoVo cells after 24 hrs by MTT assay
AID1651908Cytotoxicity against human RKO cells after 24 hrs by MTT assay
AID627049Antiproliferative activity against human T47D cells after 3 days by SRB assay2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa.
AID745221Cytotoxicity against human HCT116 cells after 48 hrs by MTT assay2013Bioorganic & medicinal chemistry letters, May-01, Volume: 23, Issue:9
Daphnane-type diterpenes with inhibitory activities against human cancer cell lines from Daphne genkwa.
AID627109Cell cycle arrest in human A549 cells assessed as accumulation at Sub-G1 phase at 100 nM after 24 hrs by propidium iodide staining-based flow cytometric analysis (Rvb = 0.2 %)2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (10)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (10.00)18.7374
1990's0 (0.00)18.2507
2000's1 (10.00)29.6817
2010's6 (60.00)24.3611
2020's2 (20.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 17.48

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index17.48 (24.57)
Research Supply Index2.40 (2.92)
Research Growth Index4.70 (4.65)
Search Engine Demand Index10.37 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (17.48)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other10 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
acetic acid
Acetic Acid: Product of the oxidation of ethanol and of the destructive distillation of wood. It is used locally, occasionally internally, as a counterirritant and also as a reagent. (Stedman, 26th ed). acetic acid : A simple monocarboxylic acid containing two carbons.		2.0710monocarboxylic acidantimicrobial food preservative;
Daphnia magna metabolite;
food acidity regulator;
protic solvent
ellipticine
ellipticine : A organic heterotetracyclic compound that is pyrido[4,3-b]carbazole carrying two methyl substituents at positions 5 and 11.		2.0610indole alkaloid;
organic heterotetracyclic compound;
organonitrogen heterocyclic compound;
polycyclic heteroarene		antineoplastic agent;
plant metabolite
fluorouracil
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.. 5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.		2.0810nucleobase analogue;
organofluorine compound		antimetabolite;
antineoplastic agent;
environmental contaminant;
immunosuppressive agent;
radiosensitizing agent;
xenobiotic
kojic acid
[no description available]		2.08104-pyranones;
enol;
primary alcohol		Aspergillus metabolite;
EC 1.10.3.1 (catechol oxidase) inhibitor;
EC 1.10.3.2 (laccase) inhibitor;
EC 1.13.11.24 (quercetin 2,3-dioxygenase) inhibitor;
EC 1.14.18.1 (tyrosinase) inhibitor;
EC 1.4.3.3 (D-amino-acid oxidase) inhibitor;
NF-kappaB inhibitor;
skin lightening agent
simplexin
[no description available]		2.0810
gefitinib
[no description available]		2.5220aromatic ether;
monochlorobenzenes;
monofluorobenzenes;
morpholines;
quinazolines;
secondary amino compound;
tertiary amino compound		antineoplastic agent;
epidermal growth factor receptor antagonist
arbutin
hydroquinone O-beta-D-glucopyranoside : A monosaccharide derivative that is hydroquinone attached to a beta-D-glucopyranosyl residue at position 4 via a glycosidic linkage.		2.0810beta-D-glucoside;
monosaccharide derivative		Escherichia coli metabolite;
plant metabolite
osimertinib
osimertinib: an EGFR tyrosine kinase inhibitor. osimertinib : A member of the class of aminopyrimidines that is 4-(1-methylindol-3-yl)pyrimidin-2-amine in which one of the amino hydrogens is replaced by a 2-methoxy-4-[2-(dimethylamino)ethyl](methyl)amino-5-acrylamidophenyl group. Used (as the mesylate salt) for treatment of EGFR T790M mutation positive non-small cell lung cancer.		2.2110acrylamides;
aminopyrimidine;
biaryl;
indoles;
monomethoxybenzene;
secondary amino compound;
secondary carboxamide;
substituted aniline;
tertiary amino compound		antineoplastic agent;
epidermal growth factor receptor antagonist
yuanhuacin
[no description available]		2.7430
ConditionIndicatedRelationship StrengthStudiesTrials
Carcinoma, Non-Small Cell Lung
[description not available]		02.5220
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		02.0610
Carcinoma, Non-Small-Cell Lung
A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.		02.5220
Cancer of Lung
[description not available]		02.5120
Lung Neoplasms
Tumors or cancer of the LUNG.		02.5120
Pregnancy
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.		01.9610