Page last updated: 2024-11-07

thyroxine and AIRE Deficiency

thyroxine has been researched along with AIRE Deficiency in 32 studies

Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.

Research Excerpts

ExcerptRelevanceReference
" Addison's disease should be ruled out in patients of hypothyroidism who are intolerant to levothyroxine."5.12Adrenocortical Crisis Triggered by Levothyroxine in an Unrecognized Autoimmune Polyglandular Syndrome Type-2: A Case Report with Review of the Literature. ( Gurumikhani, JK; Patel, DM; Patel, MM; Patel, MV; Patel, PN; Patel, SY, 2021)
" Initial investigations revealed subclinical autoimmune thyroid dysfunction, which progressed to overt hypothyroidism necessitating thyroxine replacement."4.12Adolescent onset of autoimmune polyglandular syndrome type 2. ( Mohd Din, FH; Murphy, SA; O'Grady, MJ, 2022)
" Type 1 diabetes mellitus had been diagnosed when he was 13 years old, hypothyroidism was treated with L-thyroxine for 2 years."3.72[Prerenal kidney failure in type 1 diabetes mellitus]. ( Hübinger, A; Scherbaum, WA; Schloot, NC, 2003)
" For the diagnosis of autoimmune thyroiditis, blood levels of thyrotropin (TSH), free thyroxine (FT4), and the titration of thyroid autoantibodies (TgAb and TmAb) were measured, and the thyroid gland was ultrasonographycally evaluated."3.72The presence of the antigliadin antibodies in autoimmune thyroid diseases. ( Akçay, G; Akçay, MN, 2003)
" Both Addison disease and Hashimoto thyroiditis were then confirmed by elevated serum levels of ACTH, TSH, and decreased levels of cortisol and L-thyroxine."3.71[Increasing pigmentation in Schmidt syndrome (polyglandular autoimmune syndrome type II]. ( Gärtner, R; Hesse, G; Sünkel, S; Wichmann-Hesse, A, 2001)
"patients with type 1 diabetes mellitus (T1DM) and autoimmune hypothyroidism (AH) alone, respectively."1.62Levothyroxine and insulin requirement in autoimmune polyglandular type 3 syndrome: a real-life study. ( Gambino, G; Giordano, C; Guarnotta, V; Pillitteri, G; Pizzolanti, G; Radellini, S; Vigneri, E, 2021)
"The pregnancy was achieved after the use of assisted reproductive technology."1.56Autoimmune Polyglandular Syndrome Type 2 and Pregnancy. ( Chaveeva, P; Milcheva, R; Staynova, R; Yanachkova, V, 2020)
"Addison's disease was diagnosed by management of cortisol, ACTH and adrenal antibodies."1.51[The Schmidt's Syndrome]. ( Scheit, L; Stahn, B, 2019)
"A 31-year-old lady, diagnosed to have premature ovarian failure in the gynecology clinic, was referred for endocrine assessment because of an abnormal thyroid function test."1.46Premature ovarian failure could be an alarming sign of polyglandular autoimmune dysfunction. ( Assem, M; Saif, A, 2017)
"Diabetic lipemia, although common in type 2 diabetes, is rare in type 1 diabetes mellitus."1.40Diabetic lipemia presenting as eruptive xanthomas in a child with autoimmune polyglandular syndrome type IIIa. ( Batra, P; Shah, D; Singhal, R, 2014)
" This report shows a rare case of APS-2 presented as polyneuropathy hypothyroidism, and reinforces the importance of dosing thyroid hormone in polyneuropathy syndromes."1.40[Hypothyroid polyneuropathy in a patient with autoimmune polyglandular syndrome type 2: case report]. ( Canuto, JM; Canuto, VM; Diniz, ET; Faria, AG; Ferreira, SM; Leite, SF; Magalhães, JE; Moreira, EL; Pascoal, AG; Pinto, IH, 2014)
"Chronic autoimmune thyroiditis was diagnosed in her mother, subsequently."1.35[19-year-old patient with adrenal cortex insufficiency--only the tip of the iceberg. Polyendocrine autoimmune syndrome type II (Schmidt syndrome)]. ( Brändle, M; Kehl, O; Lipowsky, C; Schorl-Schweikardt, BA, 2008)
"Hypothyroidism is a common condition."1.32Addisonian crisis precipitated by thyroxine therapy: a complication of type 2 autoimmune polyglandular syndrome. ( Graves, L; Klein, RM; Walling, AD, 2003)

Research

Studies (32)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (6.25)18.2507
2000's10 (31.25)29.6817
2010's14 (43.75)24.3611
2020's6 (18.75)2.80

Authors

AuthorsStudies
Murphy, SA1
Mohd Din, FH1
O'Grady, MJ1
V, BV1
Hoener, K1
Sharma, T1
Stahn, B1
Scheit, L1
Yanachkova, V1
Chaveeva, P1
Staynova, R1
Milcheva, R1
Patel, DM1
Gurumikhani, JK1
Patel, MV1
Patel, MM1
Patel, SY1
Patel, PN1
Guarnotta, V1
Pillitteri, G1
Gambino, G1
Radellini, S1
Vigneri, E1
Pizzolanti, G1
Giordano, C1
Tso, M1
Nosib, S1
Saif, A1
Assem, M1
Arya P V, A1
Kumar, J1
Unnikrishnan, D1
Raj, R1
Banerjee, M1
Mondal, SK1
Maisnam, I1
Mukherjee, AK1
Karavelioglu, Y1
Baran, A1
Karapinar, H1
Küçükdurmaz, Z1
Yilmaz, A1
Watson, S1
Raj, S1
Eugster, E1
Sanchez, J1
Batra, P1
Singhal, R1
Shah, D1
Pascoal, AG1
Moreira, EL1
Faria, AG1
Leite, SF1
Pinto, IH1
Magalhães, JE1
Diniz, ET1
Canuto, JM1
Canuto, VM1
Ferreira, SM1
Roa, A1
Lew, L1
DiJohn, D1
Anderson, L1
Joseph, F1
Goenka, N1
Patel, V1
Ajzensztejn, M1
Krysiak, R2
Boldys, A1
Okopien, B1
Samborek, M1
Jaring, CV1
Rivera-Arkoncel, ML1
Lantion-Ang, FL1
Chakrabarti, D1
Mallik, K1
Bhattacharyya, AK1
Graves, L1
Klein, RM1
Walling, AD1
Schloot, NC1
Hübinger, A1
Scherbaum, WA1
Papi, G1
Salvatori, R1
Ferretti, G1
Roti, E1
Akçay, MN1
Akçay, G1
Lipowsky, C1
Schorl-Schweikardt, BA1
Kehl, O1
Brändle, M1
Hoek, A1
Renckens, CN1
Canbay, A1
Gieseler, R1
Ella, R1
Fink, H1
Saller, B1
Mann, K1
Benvenga, S1
Toscano, A1
Rodolico, C1
Vita, G1
Trimarchi, F1
Sünkel, S1
Wichmann-Hesse, A1
Gärtner, R1
Hesse, G1
Graber, MA1
Freed, HA1

Reviews

1 review available for thyroxine and AIRE Deficiency

ArticleYear
Adrenocortical Crisis Triggered by Levothyroxine in an Unrecognized Autoimmune Polyglandular Syndrome Type-2: A Case Report with Review of the Literature.
    Current drug safety, 2021, Volume: 16, Issue:1

    Topics: Addison Disease; Female; Hashimoto Disease; Humans; Polyendocrinopathies, Autoimmune; Thyroiditis, A

2021

Other Studies

31 other studies available for thyroxine and AIRE Deficiency

ArticleYear
Adolescent onset of autoimmune polyglandular syndrome type 2.
    BMJ case reports, 2022, May-20, Volume: 15, Issue:5

    Topics: Addison Disease; Adolescent; Autoantibodies; Autoimmune Diseases; Female; Humans; Hypothyroidism; Po

2022
A Case of Autoimmune Poly Glandular Glandular Syndrome Type 2 (Schmidt's Syndrome).
    The Journal of the Association of Physicians of India, 2023, Volume: 71, Issue:1

    Topics: Addison Disease; Adult; Diabetes Mellitus, Type 2; Female; Hashimoto Disease; Humans; Male; Polyendo

2023
Type II polyglandular autoimmune syndrome: a case of Addison's disease precipitated by use of levothyroxine.
    BMJ case reports, 2019, Aug-21, Volume: 12, Issue:8

    Topics: Diagnosis, Differential; Female; Humans; Hypothyroidism; Middle Aged; Polyendocrinopathies, Autoimmu

2019
[The Schmidt's Syndrome].
    Deutsche medizinische Wochenschrift (1946), 2019, Volume: 144, Issue:24

    Topics: Addison Disease; Adult; Cortisone; Female; Hashimoto Disease; Humans; Hyperkalemia; Hyponatremia; Po

2019
Autoimmune Polyglandular Syndrome Type 2 and Pregnancy.
    Folia medica, 2020, Jun-30, Volume: 62, Issue:2

    Topics: Acute Disease; Addison Disease; Adult; Blood Glucose; Cesarean Section; Disease Management; Electroc

2020
Levothyroxine and insulin requirement in autoimmune polyglandular type 3 syndrome: a real-life study.
    Journal of endocrinological investigation, 2021, Volume: 44, Issue:7

    Topics: Adolescent; Adult; Aged; Biomarkers; Blood Glucose; Diabetes Mellitus, Type 1; Female; Follow-Up Stu

2021
Typical and reverse Takotsubo syndromes as initial manifestations of consecutive Addisonian crises in a 38-year-old patient: the heart has its reasons!
    BMJ case reports, 2021, Jan-28, Volume: 14, Issue:1

    Topics: Addison Disease; Adult; Disease Progression; Echocardiography; Female; Humans; Hydrocortisone; Hypot

2021
Premature ovarian failure could be an alarming sign of polyglandular autoimmune dysfunction.
    Endocrine regulations, 2017, Apr-25, Volume: 51, Issue:2

    Topics: Addison Disease; Adult; Candidiasis, Chronic Mucocutaneous; Female; Fludrocortisone; Glucocorticoids

2017
Case of autoimmune polyglandular syndrome type 2: how we uncovered the diagnosis.
    BMJ case reports, 2019, Feb-26, Volume: 12, Issue:2

    Topics: Adult; Anti-Inflammatory Agents; Diagnosis, Differential; Fludrocortisone; Humans; Hydrocortisone; M

2019
Jaundice and anaemia as presenting features of an incomplete autoimmune polyglandular syndrome type II.
    BMJ case reports, 2019, Apr-08, Volume: 12, Issue:4

    Topics: Addison Disease; Anemia, Pernicious; Hashimoto Disease; Humans; Jaundice; Male; Middle Aged; Polyend

2019
Reversible cardiomyopathy associated with autoimmune polyendocrine syndrome type II.
    Internal medicine (Tokyo, Japan), 2013, Volume: 52, Issue:9

    Topics: Adult; Cardiomyopathies; Delayed Diagnosis; Female; Fludrocortisone; Hormone Replacement Therapy; Hu

2013
Acute mental status change as the presenting feature of adrenal insufficiency in a patient with autoimmune polyglandular syndrome type II and stroke.
    Journal of pediatric endocrinology & metabolism : JPEM, 2014, Volume: 27, Issue:5-6

    Topics: Adolescent; Adrenal Insufficiency; Aggression; Anti-Inflammatory Agents; Confusion; Female; Humans;

2014
Diabetic lipemia presenting as eruptive xanthomas in a child with autoimmune polyglandular syndrome type IIIa.
    Journal of pediatric endocrinology & metabolism : JPEM, 2014, Volume: 27, Issue:5-6

    Topics: Child; Diabetes Mellitus, Type 1; Female; Humans; Hyperlipidemias; Hypoglycemic Agents; Hypothyroidi

2014
[Hypothyroid polyneuropathy in a patient with autoimmune polyglandular syndrome type 2: case report].
    Arquivos brasileiros de endocrinologia e metabologia, 2014, Volume: 58, Issue:3

    Topics: Addison Disease; Adult; Hashimoto Disease; Hormone Replacement Therapy; Humans; Hypothyroidism; Male

2014
Polyglandular syndrome type II in association with Epstein-Barr virus: a case report.
    Clinical pediatrics, 2008, Volume: 47, Issue:6

    Topics: Anti-Inflammatory Agents; Child; Epstein-Barr Virus Infections; Humans; Hydrocortisone; Male; Polyen

2008
Isolated thyroxine malabsorption treated with intramuscular thyroxine injections.
    The American journal of the medical sciences, 2009, Volume: 337, Issue:2

    Topics: Administration, Oral; Adolescent; Female; Humans; Hypothyroidism; Injections, Intramuscular; Malabso

2009
Stressful weight loss.
    Archives of disease in childhood. Education and practice edition, 2011, Volume: 96, Issue:2

    Topics: Addison Disease; Adolescent; Anorexia Nervosa; Eating; Female; Humans; Hyponatremia; Panic Disorder;

2011
Autoimmune polyglandular syndrome type 2 induced by treatment with interferon alpha.
    The American journal of the medical sciences, 2011, Volume: 341, Issue:6

    Topics: Adrenal Insufficiency; Adult; Antineoplastic Agents; Drug Administration Schedule; Estrogen Replacem

2011
Coexistence of autoimmune polyglandular syndrome type 2 and diabetes insipidus in pregnancy.
    The American journal of the medical sciences, 2011, Volume: 342, Issue:5

    Topics: Addison Disease; Adult; Diabetes Insipidus; Female; Humans; Polyendocrinopathies, Autoimmune; Pregna

2011
A Filipino woman with autoimmune polyglandular syndrome.
    BMJ case reports, 2012, Jan-10, Volume: 2012

    Topics: Diagnosis, Differential; Female; Filipin; Humans; Polyendocrinopathies, Autoimmune; Thyroid Function

2012
Schmidt syndrome--a rare polyendocrinopathy.
    Journal of the Indian Medical Association, 2012, Volume: 110, Issue:6

    Topics: Adult; Anti-Inflammatory Agents; Autoimmunity; Diagnosis, Differential; Dose-Response Relationship,

2012
Addisonian crisis precipitated by thyroxine therapy: a complication of type 2 autoimmune polyglandular syndrome.
    Southern medical journal, 2003, Volume: 96, Issue:8

    Topics: Addison Disease; Adrenocorticotropic Hormone; Adult; Autoantibodies; Autoantigens; B-Lymphocytes; Di

2003
[Prerenal kidney failure in type 1 diabetes mellitus].
    Deutsche medizinische Wochenschrift (1946), 2003, Dec-05, Volume: 128, Issue:49

    Topics: Addison Disease; Adult; Anti-Inflammatory Agents; Diabetes Mellitus, Type 1; Diagnosis, Differential

2003
Thyroid hemiagenesis and autoimmune polyglandular syndrome type III.
    Journal of endocrinological investigation, 2003, Volume: 26, Issue:11

    Topics: Adult; Female; Humans; Hypothyroidism; Polyendocrinopathies, Autoimmune; Radionuclide Imaging; Thyro

2003
The presence of the antigliadin antibodies in autoimmune thyroid diseases.
    Hepato-gastroenterology, 2003, Volume: 50 Suppl 2

    Topics: Antibodies; Gliadin; Graves Disease; Humans; Polyendocrinopathies, Autoimmune; Thyroiditis, Autoimmu

2003
[19-year-old patient with adrenal cortex insufficiency--only the tip of the iceberg. Polyendocrine autoimmune syndrome type II (Schmidt syndrome)].
    Praxis, 2008, Jan-23, Volume: 97, Issue:2

    Topics: Addison Disease; Adrenocorticotropic Hormone; Adult; Cortisone; Diagnosis, Differential; Drug Therap

2008
[Addisonian crisis precipitated by levothyroxine replacement therapy].
    Nederlands tijdschrift voor geneeskunde, 1999, Jan-30, Volume: 143, Issue:5

    Topics: Addison Disease; Adult; Female; Humans; Hypothyroidism; Menopause, Premature; Polyendocrinopathies,

1999
[Manifestation of adrenal insufficiency after administration of levothyroxine in a patient with polyglangular autoimmune syndrome type II (Schmidt-syndrome)].
    Der Internist, 2000, Volume: 41, Issue:6

    Topics: Adrenal Insufficiency; Autoantibodies; Diagnosis, Differential; Hormone Replacement Therapy; Humans;

2000
Endocrine evaluation for muscle pain.
    Journal of the Royal Society of Medicine, 2001, Volume: 94, Issue:8

    Topics: Addison Disease; Adolescent; Anti-Inflammatory Agents; Drug Therapy, Combination; Fludrocortisone; H

2001
[Increasing pigmentation in Schmidt syndrome (polyglandular autoimmune syndrome type II].
    Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 2001, Volume: 52, Issue:10 Pt 2

    Topics: Addison Disease; Adolescent; Anti-Inflammatory Agents; Biopsy; Drug Therapy, Combination; Fludrocort

2001
Polyglandular autoimmune syndrome: a cause of multiple and sequential endocrine emergencies.
    The American journal of emergency medicine, 1992, Volume: 10, Issue:2

    Topics: Adult; Emergencies; Female; Fludrocortisone; Humans; Hydrocortisone; Male; Middle Aged; Polyendocrin

1992